{"id":58688,"date":"2024-02-28T05:23:07","date_gmt":"2024-02-28T05:23:07","guid":{"rendered":"https:\/\/medsname.com\/lupimeb\/"},"modified":"2026-05-07T07:15:50","modified_gmt":"2026-05-07T07:15:50","slug":"lupimeb","status":"publish","type":"product","link":"https:\/\/medsbase.com\/cs\/product\/lupimeb\/","title":{"rendered":"Lupimeb"},"content":{"rendered":"<p><!-- medsbase-tldr-answer --><\/p>\n<div class=\"medsbase-tldr-answer\" style=\"margin:0 0 22px;padding:16px 20px;background:#fff8e1;border-left:4px solid #f5a623;border-radius:4px;\">\n<h3 class=\"wp-block-heading\" style=\"margin:0 0 8px;font-size:18px;color:#2c3e50;\">Quick Answer &mdash; What is Lupimeb?<\/h3>\n<div style=\"margin:0;font-size:15px;line-height:1.55;color:#333;\">\n<p><strong>Lupimeb<\/strong> je peror\u00e1ln\u00ed <strong>mebendazole 100&nbsp;mg chewable tablet<\/strong> od <strong>Lupin<\/strong>. Mebendazole is a WHO Essential Medicine for <strong>pinworm, roundworm, hookworm, and whipworm<\/strong>. Standardn\u00ed d\u00e1vka pro dosp\u011bl\u00e9: <strong>100&nbsp;mg as a single dose for pinworm, repeat in 2 weeks<\/strong>. For mixed infection or whipworm: <strong>100&nbsp;mg twice daily for 3 days<\/strong>.<\/p>\n<\/div>\n<\/div>\n<div class=\"medsbase-trust-strip\" style=\"margin:24px 0;padding:14px 18px;background:#f4f4f4;border:1px solid #e1e1e1;border-radius:4px;font-size:14px;color:#444;line-height:1.55;\"><strong>Pro\u010d objedn\u00e1vat z MedsBase:<\/strong> \u2713 Zdrojeno od <strong>WHO-GMP certifikovan\u00fdch v\u00fdrobc\u016f<\/strong> \u00b7 \u2713 Diskr\u00e9tn\u00ed balen\u00ed \u00b7 \u2713 Doprava do cel\u00e9ho sv\u011bta \u00b7 \u2713 <strong>1,400+ recenz\u00ed z\u00e1kazn\u00edk\u016f<\/strong> na <a href=\"https:\/\/medsbase.com\/cs\/reviews\/\">medsbase.com\/reviews<\/a><\/div>\n<p class=\"medsbase-reship-line\" style=\"font-size:14px;color:#444;margin:8px 0 18px;\">\ud83d\udce6 Ka\u017ed\u00e1 objedn\u00e1vka je pokryta na\u0161\u00ed <a href=\"https:\/\/medsbase.com\/cs\/medsbase-re-shipment-assurance-policy\/\"><strong>Z\u00e1rukou op\u011btovn\u00e9ho odesl\u00e1n\u00ed<\/strong><\/a> \u2014 pokud va\u0161e z\u00e1silka nedoraz\u00ed do 20 pracovn\u00edch dn\u016f, p\u0159epos\u00edl\u00e1me ji.<\/p>\n<h3>Pro\u010d objedn\u00e1vat z MedsBase<\/h3>\n<p>Na\u0161e generick\u00e9 l\u00e9ky poch\u00e1zej\u00ed od v\u00fdrobc\u016f certifikovan\u00fdch WHO-GMP a jsou expedov\u00e1ny po cel\u00e9m sv\u011bt\u011b v diskr\u00e9tn\u00edm, nen\u00e1padn\u00e9m balen\u00ed \u2013 na vn\u011bj\u0161\u00ed stran\u011b bal\u00edku nen\u00ed uveden n\u00e1zev l\u00e9ku. Platby kartou jsou sm\u011brov\u00e1ny prost\u0159ednictv\u00edm regulovan\u00e9ho procesoru (popisky na v\u00fdpisu zahrnuj\u00ed regulovan\u00e9ho procesora plateb kartou \u2013 nikdy \u201cMedsBase\u201d nebo n\u00e1zev l\u00e9ku). P\u0159ij\u00edm\u00e1me tak\u00e9 kryptom\u011bny a bankovn\u00ed p\u0159evody SEPA. Ka\u017ed\u00e1 objedn\u00e1vka je zaji\u0161t\u011bna na\u0161\u00ed politikou p\u0159eposl\u00e1n\u00ed.<\/p>\n<h2 class=\"wp-block-heading\">What is Lupimeb?<\/h2>\n<p><strong>Lupimeb<\/strong> is mebendazole 100&nbsp;mg chewable from <strong>Lupin<\/strong>. Mebendazole was the first benzimidazole anthelmintic in routine human use and remains a WHO Essential Medicine. Albendazole has overtaken it as first-line in most settings, but mebendazole has a niche role: it is preferred in patients with concurrent moderate-to-severe hepatic impairment (less hepatic metabolism) and is the agent of choice in some paediatric whipworm protocols.<\/p>\n<h2 class=\"wp-block-heading\">Mechanismus \u00fa\u010dinku<\/h2>\n<p>Mebendazole binds <strong>\u03b2-tubulin<\/strong> in parasite cells, preventing microtubule polymerisation. This blocks parasite glucose uptake and depletes glycogen stores &mdash; the worm starves over 2&ndash;3 days. Mebendazole&rsquo;s oral bioavailability is very low (&lt; 10%), which is therapeutically useful: high concentrations stay in the gut lumen where intestinal worms live, with minimal systemic exposure.<\/p>\n<h2 class=\"wp-block-heading\">Lupimeb indications and dose<\/h2>\n<table style=\"width:100%;border-collapse:collapse;margin:14px 0;font-size:14px;\">\n<thead>\n<tr style=\"background:#2c7cb0;color:#fff;\">\n<th style=\"padding:8px;text-align:left;border:1px solid #ddd;\">Indikace<\/th>\n<th style=\"padding:8px;text-align:left;border:1px solid #ddd;\">D\u00e1vka<\/th>\n<th style=\"padding:8px;text-align:left;border:1px solid #ddd;\">D\u00e1vkovac\u00ed sch\u00e9ma<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td style=\"padding:8px;border:1px solid #ddd;\">Pinworm (Enterobius)<\/td>\n<td style=\"padding:8px;border:1px solid #ddd;\">100 mg<\/td>\n<td style=\"padding:8px;border:1px solid #ddd;\">Single dose, repeat at 2 weeks<\/td>\n<\/tr>\n<tr style=\"background:#f9f9f9;\">\n<td style=\"padding:8px;border:1px solid #ddd;\">Roundworm (Ascaris)<\/td>\n<td style=\"padding:8px;border:1px solid #ddd;\">100&nbsp;mg BID<\/td>\n<td style=\"padding:8px;border:1px solid #ddd;\">For 3 days<\/td>\n<\/tr>\n<tr>\n<td style=\"padding:8px;border:1px solid #ddd;\">Hookworm (Ancylostoma, Necator)<\/td>\n<td style=\"padding:8px;border:1px solid #ddd;\">100&nbsp;mg BID<\/td>\n<td style=\"padding:8px;border:1px solid #ddd;\">For 3 days<\/td>\n<\/tr>\n<tr style=\"background:#f9f9f9;\">\n<td style=\"padding:8px;border:1px solid #ddd;\">Tenkohlavec (Trichuris)<\/td>\n<td style=\"padding:8px;border:1px solid #ddd;\">100&nbsp;mg BID<\/td>\n<td style=\"padding:8px;border:1px solid #ddd;\">For 3 days; may extend to 5&ndash;7 days for heavy load<\/td>\n<\/tr>\n<tr>\n<td style=\"padding:8px;border:1px solid #ddd;\">Mixed nematode infection<\/td>\n<td style=\"padding:8px;border:1px solid #ddd;\">100&nbsp;mg BID<\/td>\n<td style=\"padding:8px;border:1px solid #ddd;\">For 3 days<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>Tablets can be chewed, swallowed whole, or crushed and mixed with food.<\/p>\n<div style=\"background:#eef7ee;border-left:4px solid #4caf50;padding:14px 18px;margin:18px 0;border-radius:4px;font-size:14px;line-height:1.55;color:#444;\"><strong>Pinworm protocol.<\/strong> Pinworm requires a second 100&nbsp;mg dose at 2 weeks because eggs already laid before the first dose hatch and complete a new cycle. Treat all household contacts on the same days. Wash bedding, towels, and underwear in hot water. Trim and scrub fingernails morning and night during the treatment window.<\/div>\n<h2 class=\"wp-block-heading\">Vedlej\u0161\u00ed \u00fa\u010dinky<\/h2>\n<ul>\n<li><strong>\u010cast\u00e9:<\/strong> mild abdominal pain, transient diarrhoea, flatulence as worms pass<\/li>\n<li><strong>M\u00e9n\u011b \u010dast\u00e9:<\/strong> headache, dizziness, mild rash<\/li>\n<li><strong>Vz\u00e1cn\u00e9:<\/strong> reversible neutropenia (high-dose long courses), elevated transaminases, alopecia (very rare)<\/li>\n<li><strong>Velmi vz\u00e1cn\u011b:<\/strong> Stevens-Johnson syndrome, toxic epidermal necrolysis<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Interakce l\u00e9k\u016f<\/h2>\n<ul>\n<li><strong>Cimetidin<\/strong> &mdash; raises mebendazole plasma levels modestly; clinically relevant only in long courses for tissue parasites<\/li>\n<li><strong>Fenytoin, karbamazepin, rifampicin<\/strong> &mdash; reduce mebendazole levels (CYP induction)<\/li>\n<li><strong>Metronidazol<\/strong> &mdash; case reports of Stevens-Johnson syndrome with concurrent use; avoid if possible<\/li>\n<\/ul>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:14px 18px;margin:18px 0;border-radius:4px;font-size:14px;line-height:1.55;color:#444;\"><strong>T\u011bhotenstv\u00ed &amp; kojen\u00ed.<\/strong> Albendazol a mebendazol se v prvn\u00edm trimestru NEdoporu\u010duj\u00ed (\u00fadaje o teratogenit\u011b u zv\u00ed\u0159at). Pou\u017eit\u00ed je p\u0159ijateln\u00e9 ve 2. a 3. trimestru p\u0159i st\u0159edn\u00ed a\u017e t\u011b\u017ek\u00e9 helmintick\u00e9 z\u00e1t\u011b\u017ei. \u00dadaje o ivermektinu v t\u011bhotenstv\u00ed jsou omezen\u00e9, ale v programech hromadn\u00e9 l\u00e9\u010dby WHO jsou uklid\u0148uj\u00edc\u00ed; vyhn\u011bte se v prvn\u00edm trimestru, pokud existuj\u00ed alternativy. Praziquantel a pyrantel jsou kompatibiln\u00ed s t\u011bhotenstv\u00edm.<\/div>\n<div style=\"background:#f4f8fb;border-left:4px solid #2c7cb0;padding:14px 18px;margin:18px 0;border-radius:4px;font-size:14px;line-height:1.55;color:#444;\"><strong>Pozn\u00e1mka pro pediatrii.<\/strong> V\u011bt\u0161ina antihelmintik je bezpe\u010dn\u00e1 od v\u011bku 2 let a v\u00fd\u0161e; ivermektin je schv\u00e1len od t\u011blesn\u00e9 hmotnosti 15 kg; albendazol 400 mg v jedn\u00e9 d\u00e1vce je standard WHO od v\u011bku 1 roku v programech hromadn\u00e9 l\u00e9\u010dby. U d\u011bt\u00ed mlad\u0161\u00edch 2 let zvolte pediatrick\u00e9 suspenze a konzultujte klinika pro d\u00e1vkov\u00e1n\u00ed podle hmotnosti.<\/div>\n<h2 class=\"wp-block-heading\">Kontraindikace<\/h2>\n<ul>\n<li>Hypersensitivity to mebendazole or other benzimidazoles<\/li>\n<li>D\u011bti &lt; 1 rok<\/li>\n<li>Prvn\u00ed trimestr t\u011bhotenstv\u00ed<\/li>\n<li>T\u011b\u017ek\u00e9 jatern\u00ed po\u0161kozen\u00ed<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Skladov\u00e1n\u00ed<\/h2>\n<p>Store Lupimeb below 30&deg;C in the original blister, away from light and moisture.<\/p>\n<h3 class=\"wp-block-heading\">Pro\u010d objedn\u00e1vat z MedsBase<\/h3>\n<p>Lupimeb is supplied from a <strong>v\u00fdrobce certifikovan\u00e9ho WHO-GMP<\/strong>, balen diskr\u00e9tn\u011b a expedov\u00e1n po cel\u00e9m sv\u011bt\u011b. Ka\u017ed\u00e1 objedn\u00e1vka je kryta na\u0161\u00edm <a href=\"https:\/\/medsbase.com\/cs\/medsbase-re-shipment-assurance-policy\/\">Z\u00e1rukou op\u011btovn\u00e9ho odesl\u00e1n\u00ed<\/a> \u2014 nikdy nenese\u0161 n\u00e1klady za ztracenou z\u00e1silku.<\/p>\n<h2 id=\"faqs\">\u010casto kladen\u00e9 dotazy<\/h2>\n<h3 class=\"wp-block-heading\">Can I just take one tablet?<\/h3>\n<p>For pinworm, yes &mdash; one 100&nbsp;mg dose, then a second at 2 weeks. For roundworm, hookworm, whipworm, or mixed infection, the standard course is 100&nbsp;mg twice daily for 3 days.<\/p>\n<h3 class=\"wp-block-heading\">Do I need to fast before Lupimeb?<\/h3>\n<p>No. Mebendazole works locally in the gut lumen and absorption is intentionally low. Take with or without food.<\/p>\n<h3 class=\"wp-block-heading\">Can my child chew Lupimeb?<\/h3>\n<p>Yes &mdash; the tablet is designed to be chewed, swallowed whole, or crushed into food. Chewing is fine for children old enough to spit out anything they dislike (typically age 4+).<\/p>\n<h3 class=\"wp-block-heading\">How is mebendazole different from albendazole?<\/h3>\n<p>Both are benzimidazoles with the same mechanism. Albendazole has higher systemic absorption (better for tissue-dwelling parasites like echinococcus), while mebendazole stays mostly in the gut lumen (preferred for some paediatric protocols and patients with hepatic impairment). For routine intestinal nematodes, both work.<\/p>\n<h3 class=\"wp-block-heading\">Will Lupimeb treat tapeworm?<\/h3>\n<p>Mebendazole has activity against some intestinal cestodes (Hymenolepis nana) but is NOT first-line for tapeworm. Use niclosamide or praziquantel for confirmed Taenia infection.<\/p>\n<h3 class=\"wp-block-heading\">How long until the worms are gone?<\/h3>\n<p>Adult worms are paralysed within 24&ndash;48&nbsp;hours and pass in faeces over the following 3&ndash;5 days. Visible worms in stool are normal and a sign the drug is working. Itching and other symptoms resolve within 1&ndash;2 weeks.<\/p>\n<h3 class=\"wp-block-heading\">Is Lupimeb safe in pregnancy?<\/h3>\n<p>Avoid in the first trimester. After week 13, mebendazole is acceptable for moderate-to-heavy worm burden &mdash; discuss with a clinician.<\/p>\n<h3 class=\"wp-block-heading\">Can I drink alcohol with Lupimeb?<\/h3>\n<p>There is no specific alcohol interaction. Heavy alcohol use stresses the liver, and if the worm load is heavy enough to cause transient transaminase rise, abstaining for the treatment course is prudent.<\/p>\n<h3 class=\"wp-block-heading\">Does Lupimeb treat lice or scabies?<\/h3>\n<p>No. Mebendazole has no activity against ectoparasites &mdash; use ivermectin or permethrin for scabies and pediculicide shampoos or oral ivermectin for lice.<\/p>\n<h3 class=\"wp-block-heading\">Should I retest after treatment?<\/h3>\n<p>For routine pinworm or hookworm in an immunocompetent person with symptom resolution, no follow-up testing is needed. Persistent eosinophilia, weight loss, or recurring symptoms warrant repeat stool ova-and-parasite testing 2&ndash;4 weeks after treatment.<\/p>\n<p class=\"medsbase-link-boost-2026-05-07\" data-marker=\"mb-link-boost-wormentel\">Patients seeking extended parasite coverage beyond <a href=\"\/cs\/lupimeb\/\">Lupimeb<\/a> (mebendazole 100&nbsp;mg) may consider <a href=\"\/cs\/wormentel\/\">Wormentel (fenbendazole 222&nbsp;\/&nbsp;500&nbsp;mg)<\/a> as a fenbendazole alternative in the same benzimidazole class but with a broader organism spectrum covering Giardia, tapeworm, and Trichinella.<\/p>\n<p><!-- medsbase-related-alts-v1 --><\/p>\n<h3 class=\"wp-block-heading\">Dal\u0161\u00ed antiparazit\u00e1rn\u00ed l\u00e9ky<\/h3>\n<ul>\n<li><a href=\"https:\/\/medsbase.com\/cs\/mebex\/\">Mebex (mebendazol 100 mg)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/lupimeb\/\">Lupimeb (mebendazole 100 mg)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/abd-400-albendazole\/\">ABD 400 (albendazol 400 mg)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/nemocid\/\">Nemocid (pyrantel pamoate)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/iverheal\/\">Iverheal (ivermectin)<\/a><\/li>\n<\/ul>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:14px 18px;margin:22px 0;border-radius:4px;font-size:14px;color:#444;\"><strong>Zdravotn\u00ed prohl\u00e1\u0161en\u00ed.<\/strong> Tato str\u00e1nka slou\u017e\u00ed pouze pro vzd\u011bl\u00e1vac\u00ed \u00fa\u010dely a nenahrazuje odborn\u00e9 l\u00e9ka\u0159sk\u00e9 poradenstv\u00ed. P\u0159ed zah\u00e1jen\u00edm jak\u00e9koli l\u00e9\u010dby proti parazit\u016fm se pora\u010fte s kvalifikovan\u00fdm l\u00e9ka\u0159em, zejm\u00e9na pokud jste t\u011bhotn\u00e1 nebo koj\u00edte, m\u00e1te oslabenou imunitu, l\u00e9\u010d\u00edte d\u00edt\u011b mlad\u0161\u00ed 2 let, nebo pokud p\u0159\u00edznaky p\u0159etrv\u00e1vaj\u00ed po ukon\u010den\u00ed l\u00e9\u010dby. Eozinofilie, \u00fabytek hmotnosti, p\u0159etrv\u00e1vaj\u00edc\u00ed bolesti b\u0159icha nebo p\u0159\u00edznaky spojen\u00e9 s cestov\u00e1n\u00edm vy\u017eaduj\u00ed klinick\u00e9 vy\u0161et\u0159en\u00ed. Z\u00e1va\u017en\u00e1 parazit\u00e1rn\u00ed onemocn\u011bn\u00ed (neurocysticerk\u00f3za, hyperinfekce strongyloidy, schistosom\u00f3za s posti\u017een\u00edm org\u00e1n\u016f) vy\u017eaduj\u00ed specializovanou p\u00e9\u010di.<\/div>","protected":false},"excerpt":{"rendered":"<p>Lupimeb (mebendazole 100 mg chewable, Lupin) \u2014 benzimidazole anthelmintic for pinworm, roundworm, hookworm, and whipworm. Single-dose for pinworm; 3-day course for roundworm and whipworm.<\/p>","protected":false},"featured_media":58689,"comment_status":"open","ping_status":"closed","template":"","meta":[],"product_brand":[],"product_cat":[3141,3342,3856],"product_tag":[4543,4544],"class_list":{"0":"post-58688","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-category-overview","7":"product_cat-general-health","8":"product_cat-threadworm-treatment","9":"product_tag-lupimeb","10":"product_tag-mebendazole","12":"first","13":"instock","14":"shipping-taxable","15":"purchasable","16":"product-type-variable","17":"has-default-attributes"},"acf":[],"_links":{"self":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product\/58688","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/comments?post=58688"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/media\/58689"}],"wp:attachment":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/media?parent=58688"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product_brand?post=58688"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product_cat?post=58688"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product_tag?post=58688"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}