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Colospa<\/strong> obsahuje mebeverine hydrochloride<\/strong> (135 mg), a gut-selective musculotropic antispasmodic<\/strong> pou\u017e\u00edv\u00e1 se k irritable bowel syndrome (IBS) and functional bowel disorders<\/strong> — abdominal cramps, pain, spasm, bloating, and altered bowel habit. Mebeverine works directly on the smooth muscle of the gut wall<\/strong>, relaxing spasm without blocking normal peristalsis — unlike anticholinergic antispasmodics (hyoscine, dicyclomine), mebeverine does ne<\/strong> cause dry mouth, urinary retention, blurred vision, or tachycardia. Standard dose: 135 mg three times daily, 20 minutes before meals. Onset 30–60 minutes; effect lasts 4–6 hours. Safe for long-term daily use. Effective for cramping\/pain; less useful for bloating or constipation-dominant symptoms. First-line pharmacological option for IBS pain in NICE and BSG guidelines.<\/p>\n<\/div>\n \ud83d\udce6 Ka\u017ed\u00e1 objedn\u00e1vka je pokryta na\u0161\u00ed Z\u00e1rukou op\u011btovn\u00e9ho odesl\u00e1n\u00ed<\/strong><\/a> \u2014 pokud va\u0161e z\u00e1silka nedoraz\u00ed do 20 pracovn\u00edch dn\u016f, p\u0159epos\u00edl\u00e1me ji.<\/p>\n Na\u0161e generick\u00e9 l\u00e9ky poch\u00e1zej\u00ed od v\u00fdrobc\u016f certifikovan\u00fdch WHO-GMP a jsou expedov\u00e1ny po cel\u00e9m sv\u011bt\u011b v diskr\u00e9tn\u00edm, nen\u00e1padn\u00e9m balen\u00ed \u2013 na vn\u011bj\u0161\u00ed stran\u011b bal\u00edku nen\u00ed uveden n\u00e1zev l\u00e9ku. Platby kartou jsou sm\u011brov\u00e1ny prost\u0159ednictv\u00edm regulovan\u00e9ho procesoru (popisky na v\u00fdpisu zahrnuj\u00ed regulovan\u00e9ho procesora plateb kartou \u2013 nikdy \u201cMedsBase\u201d nebo n\u00e1zev l\u00e9ku). P\u0159ij\u00edm\u00e1me tak\u00e9 kryptom\u011bny a bankovn\u00ed p\u0159evody SEPA. Ka\u017ed\u00e1 objedn\u00e1vka je zaji\u0161t\u011bna na\u0161\u00ed politikou p\u0159eposl\u00e1n\u00ed.<\/p>\n Colospa is an oral antispasmodic containing mebeverine hydrochloride<\/strong> (135 mg), manufactured by Abbott India. Supplied in packs of 30, 60, 90 or 180 tablets. Originator brand: Colofac<\/strong> (Abbott \/ Mylan \/ Viatris). In clinical use since the 1960s and one of the most widely prescribed drugs for IBS globally.<\/p>\n Unlike older antispasmodics (hyoscine butylbromide, dicyclomine, propantheline) that work by blocking muscarinic acetylcholine receptors and cause dry mouth, blurred vision, urinary retention, and palpitations, mebeverine is a musculotropic antispasmodic<\/strong> — it acts directly on smooth muscle cells without engaging the autonomic nervous system. This means essentially no anticholinergic side effects at standard doses.<\/p>\n Mebeverine treats the spasm and pain<\/em> component of IBS. It does not address bloating, gas, constipation, or the psychological component — these may need additional strategies (peppermint oil, dietary FODMAP modification, psyllium, PEG laxatives, central modulators like low-dose amitriptyline).<\/p>\n The precise molecular mechanism of mebeverine is still debated, but the best-characterised actions include:<\/p>\n Mebeverine is highly metabolised on first-pass through the liver. Plasma concentrations of the parent drug are very low; activity is largely from the metabolite veratric acid<\/em> and direct smooth-muscle action during first intestinal passage.<\/p>\n Farmakokinetika:<\/strong> onset 30–60 minutes. Peak 1–3 hours. Duration of effect 4–6 hours. No meaningful accumulation; no dose adjustment needed for renal impairment.<\/p>\n Adults and children aged 10+:<\/strong> 135 mg three times daily, approximately 20 minutes before each main meal.<\/strong> Modified-release 200 mg capsules (twice daily) are available in some markets but are an alternative to the three-times-daily standard tablet.<\/p>\n Once symptoms are controlled, the dose may be reduced gradually or taken only as needed for flare-ups.<\/p>\n Mebeverine is one of the best-tolerated IBS medicines because it avoids anticholinergic effects.<\/p>\n \u010cast\u00e9:<\/strong><\/p>\n M\u00e9n\u011b \u010dast\u00e9:<\/strong><\/p>\n Mebeverine does not cause drowsiness and does not impair driving.<\/p>\n Mebeverine has few clinically significant interactions. It is metabolised by esterases rather than CYP enzymes, so it is relatively interaction-free.<\/p>\n Store Colospa below 30°C in a dry place, in the original blister. Keep out of reach of children.<\/p>\n Yes — Colospa contains the same active ingredient (mebeverine hydrochloride) at the same strength as Colofac (Abbott \/ Viatris). Bioequivalence to the originator is required by regulatory authorities, so clinical effect is the same at the same dose.<\/p>\n Onset of smooth-muscle relaxation is 30–60 minutes after a dose; noticeable reduction in cramps usually within the first day or two. Full effect on symptom frequency often takes 1–2 weeks of regular dosing. If there is no improvement after 4 weeks at full dose, reconsider the diagnosis or add a second IBS strategy (dietary FODMAP, peppermint oil, central modulator).<\/p>\n No — mebeverine is not sedating and does not have anticholinergic effects at therapeutic doses. This is the main reason it is preferred over hyoscine or dicyclomine for long-term IBS management, especially in drivers, older adults, or patients on other medications.<\/p>\n Yes — long-term daily use of mebeverine is safe and commonly continued for months or years in chronic IBS. Many patients use it daily during symptomatic periods and pause when symptoms settle.<\/p>\n Yes — the combination is a sensible stacking strategy for IBS pain. Peppermint oil has a different mechanism (calcium-channel blockade in smooth muscle) and adds modest benefit. Take enteric-coated peppermint oil before meals, ideally at the same time as mebeverine.<\/p>\n Mebeverine’s strength is cramping and pain. It has little direct effect on bloating or constipation. For bloating, consider dietary FODMAP restriction and simethicone; for IBS-C (constipation-predominant), consider fibre modulation, PEG laxatives, or linaclotide.<\/p>\n Yes, moderate alcohol is fine with mebeverine. Be aware that alcohol is a common IBS trigger and may worsen symptoms independent of the medicine.<\/p>\n You can order Colospa (135 mg) from MedsBase in packs of 30, 60, 90 or 180 tablets. We ship worldwide with discreet packaging and genuine WHO-GMP certified manufacturer stock.<\/p>\n <\/p>\n Dal\u0161\u00ed produkty v Chronick\u00e1 onemocn\u011bn\u00ed<\/strong> kter\u00e9 z\u00e1kazn\u00edci tak\u00e9 prohl\u00ed\u017eej\u00ed:<\/p>\n \u2705 Relieves abdominal pain Colospa contains Mebeverine.<\/p>","protected":false},"featured_media":58701,"comment_status":"open","ping_status":"open","template":"","meta":[],"product_brand":[],"product_cat":[3141,3223,3565],"product_tag":[4546,4547],"class_list":{"0":"post-58700","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-category-overview","7":"product_cat-chronic-conditions","8":"product_cat-irritable-bowel-syndrome-ibs-treatment","9":"product_tag-colospa","10":"product_tag-mebeverine","12":"first","13":"instock","14":"shipping-taxable","15":"purchasable","16":"product-type-variable","17":"has-default-attributes"},"acf":[],"_links":{"self":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product\/58700","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/comments?post=58700"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/media\/58701"}],"wp:attachment":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/media?parent=58700"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product_brand?post=58700"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product_cat?post=58700"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product_tag?post=58700"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}Pro\u010d objedn\u00e1vat z MedsBase<\/h3>\n
What Is Colospa?<\/h2>\n
What Is Colospa Used For?<\/h2>\n
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How Does Colospa Work?<\/h2>\n
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D\u00e1vkov\u00e1n\u00ed a pod\u00e1n\u00ed<\/h2>\n
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Vedlej\u0161\u00ed \u00fa\u010dinky<\/h2>\n
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Interakce s l\u00e9\u010divy<\/h2>\n
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Who Should Not Take Colospa?<\/h2>\n
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Skladov\u00e1n\u00ed<\/h2>\n
\u010casto kladen\u00e9 dotazy<\/h2>\n
Is Colospa the same as Colofac?<\/h3>\n
How long does it take Colospa to work?<\/h3>\n
Does Colospa cause drowsiness or dry mouth?<\/h3>\n
Can I take Colospa every day long-term?<\/h3>\n
Can I take Colospa with peppermint oil capsules?<\/h3>\n
Does Colospa help with bloating or constipation?<\/h3>\n
Can I drink alcohol while taking Colospa?<\/h3>\n
Where can I buy Colospa online?<\/h3>\n
Souvisej\u00edc\u00ed l\u00e9ky na IBS a IBD<\/h2>\n
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Souvisej\u00edc\u00ed alternativy<\/h3>\n
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\n\u2705 Treats irritable bowel syndrome
\n\u2705 Reduces gastrointestinal spasms
\n\u2705 Improves bowel movements
\n\u2705 Minimizes digestive discomfort<\/p>\n