{"id":58706,"date":"2024-02-28T05:24:13","date_gmt":"2024-02-28T05:24:13","guid":{"rendered":"https:\/\/medsname.com\/diligan\/"},"modified":"2026-05-20T05:24:59","modified_gmt":"2026-05-20T05:24:59","slug":"diligan","status":"publish","type":"product","link":"https:\/\/medsbase.com\/cs\/product\/diligan\/","title":{"rendered":"Diligan"},"content":{"rendered":"<p><!-- medsbase-tldr-answer --><\/p>\n<div style=\"background:#fff8e1;border-left:4px solid #f5a623;padding:18px 22px;margin:0 0 24px 0;border-radius:4px;\">\n<h3 class=\"wp-block-heading\" style=\"margin:0 0 8px 0;font-size:16px;font-weight:700;\">\u26a1 Quick Answer &mdash; What is Diligan?<\/h3>\n<p style=\"margin:0;\"><strong>Diligan<\/strong> je <strong>meclizine 25 mg<\/strong> tablet from a <strong>first-generation H<sub>1<\/sub> antihistamine<\/strong> with anticholinergic and central anti-emetic action. It is taken <strong>1 hour before travel<\/strong> to <strong>prevent motion sickness<\/strong> (cars, boats, planes), and short-course (\u2264 72 h) to suppress acute peripheral vertigo from labyrinthitis or vestibular neuritis. Typical adult dose is <strong>25&ndash;50 mg one hour before travel<\/strong>, repeated every 24 hours if needed. Causes drowsiness &mdash; do not drive or operate machinery for 8&ndash;12 hours after a dose.<\/p>\n<\/div>\n<div class=\"medsbase-trust-strip\" style=\"background:#f4f6f8;border-left:4px solid #2c7cb0;padding:14px 18px;margin:24px 0;border-radius:4px;font-size:14px;line-height:1.55;\">\n<strong>\ud83d\udee1\ufe0f Pro\u010d objedn\u00e1vat z MedsBase<\/strong> \u2014 dod\u00e1v\u00e1no od v\u00fdrobce certifikovan\u00e9ho WHO-GMP <strong>, diskr\u00e9tn\u00ed balen\u00ed, celosv\u011btov\u00e1 doprava, ka\u017ed\u00e1 objedn\u00e1vka kryta na\u0161\u00ed<\/strong>, . D\u016fv\u011b\u0159uje n\u00e1m p\u0159es 1 400 z\u00e1kazn\u00edk\u016f \u2014 viz skute\u010dn\u00e9 <a href=\"https:\/\/medsbase.com\/cs\/medsbase-re-shipment-assurance-policy\/\">Z\u00e1rukou op\u011btovn\u00e9ho odesl\u00e1n\u00ed<\/a>. je Sun Pharma <a href=\"https:\/\/medsbase.com\/cs\/reviews\/\">recenz\u00ed z\u00e1kazn\u00edk\u016f<\/a>.\n<\/div>\n<h3>Pro\u010d objedn\u00e1vat z MedsBase<\/h3>\n<p class=\"medsbase-reship-line\" style=\"font-size:14px;color:#444;margin:8px 0 18px;\">\ud83d\udce6 Ka\u017ed\u00e1 objedn\u00e1vka je pokryta na\u0161\u00ed <a href=\"https:\/\/medsbase.com\/cs\/medsbase-re-shipment-assurance-policy\/\"><strong>Z\u00e1rukou op\u011btovn\u00e9ho odesl\u00e1n\u00ed<\/strong><\/a> \u2014 pokud va\u0161e z\u00e1silka nedoraz\u00ed do 20 pracovn\u00edch dn\u016f, p\u0159epos\u00edl\u00e1me ji.<\/p>\n<p><strong>Diligan<\/strong> is the WHO-GMP generic equivalent of Antivert \/ Bonine, supplied as 25 mg tablets and chewable tablets. Meclizine has a 60+ year track record for motion sickness and is one of the few drugs with FDA Pregnancy Category B status for nausea\/vomiting in pregnancy when other agents are contraindicated.<\/p>\n<h2 class=\"wp-block-heading\">What Diligan Is Used For<\/h2>\n<ul>\n<li><strong>Motion sickness prevention<\/strong> &mdash; first-line for car, sea, and air travel; take 1 hour before exposure<\/li>\n<li><strong>Acute peripheral vertigo<\/strong> &mdash; vestibular neuritis, labyrinthitis, BPPV first attack &mdash; short course (\u2264 72 hours) only, then stop to allow central compensation<\/li>\n<li><strong>Acute Meniere&#8217;s vertigo episode<\/strong> &mdash; rescue dose; chronic management uses betahistine instead<\/li>\n<li><strong>Post-operative nausea<\/strong> &mdash; off-label adjunct after middle-ear surgery<\/li>\n<\/ul>\n<p>Meclizine is <strong>ne<\/strong> the right drug for chronic Meniere&#8217;s disease (use <a href=\"https:\/\/medsbase.com\/cs\/vertin\/\">Vertin<\/a> nebo <a href=\"https:\/\/medsbase.com\/cs\/betavert\/\">Betavert<\/a>), central vertigo (brain-origin), or general lightheadedness from postural drop or cardiac arrhythmia.<\/p>\n<h3 class=\"wp-block-heading\">Pro\u010d objedn\u00e1vat z MedsBase<\/h3>\n<p>Diligan is dispensed from a WHO-GMP-certified manufacturer, blister-packed and discreetly shipped worldwide. Every order is covered by our <a href=\"https:\/\/medsbase.com\/cs\/medsbase-re-shipment-assurance-policy\/\">Z\u00e1rukou op\u011btovn\u00e9ho odesl\u00e1n\u00ed<\/a> \u2014 pokud nedoraz\u00ed do 20 pracovn\u00edch dn\u016f, p\u0159epos\u00edl\u00e1me na n\u00e1\u0161 \u00fa\u010det. V\u00edce ne\u017e 1 400 ov\u011b\u0159en\u00fdch z\u00e1kazn\u00edk\u016f \u2014 <a href=\"https:\/\/medsbase.com\/cs\/reviews\/\">\u010d\u00edst recenze<\/a>.<\/p>\n<h2 class=\"wp-block-heading\">How Diligan Works<\/h2>\n<p>Meclizine is a piperazine-class first-generation H<sub>1<\/sub> antihistamine that crosses the blood-brain barrier. In the central vestibular pathways it dampens the firing of the vestibular nuclei in response to abnormal sensory input, which is what produces the spinning sensation in motion sickness and acute peripheral vertigo. Its anticholinergic activity also blunts the autonomic component (nausea, sweating, pallor) that accompanies vestibular stimulation.<\/p>\n<p>Onset is <strong>30\u201360 minut<\/strong>, peak effect at 1&ndash;2 hours, duration <strong>8&ndash;12 hours<\/strong>. This is why dosing is one hour before travel and repeated daily on long journeys.<\/p>\n<h2 class=\"wp-block-heading\">D\u00e1vkov\u00e1n\u00ed<\/h2>\n<table>\n<thead>\n<tr>\n<th>Indikace<\/th>\n<th>D\u00e1vka<\/th>\n<th>Pozn\u00e1mky<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td><strong>Motion sickness prevention<\/strong><\/td>\n<td>25&ndash;50 mg, 1 hour before travel<\/td>\n<td>Repeat every 24 h on long trips; max 100 mg\/day<\/td>\n<\/tr>\n<tr>\n<td><strong>Acute peripheral vertigo<\/strong><\/td>\n<td>25&ndash;50 mg twice daily<\/td>\n<td>Maximum 72 hours &mdash; longer use delays vestibular compensation<\/td>\n<\/tr>\n<tr>\n<td><strong>Meniere&#8217;s acute episode<\/strong><\/td>\n<td>25 mg as needed<\/td>\n<td>Add to betahistine maintenance during attack only<\/td>\n<\/tr>\n<tr>\n<td><strong>Children &lt; 12 years<\/strong><\/td>\n<td>Vyhnout se<\/td>\n<td>Limited paediatric data; use dimenhydrinate or cinnarizine instead<\/td>\n<\/tr>\n<tr>\n<td><strong>Star\u0161\u00ed pacienti<\/strong><\/td>\n<td>Start 12.5&ndash;25 mg<\/td>\n<td>Higher anticholinergic-burden risk; falls and confusion are real concerns<\/td>\n<\/tr>\n<tr>\n<td><strong>T\u011bhotenstv\u00ed<\/strong><\/td>\n<td>25 mg as needed<\/td>\n<td>FDA Category B; one of the safer antiemetic options when first-line doxylamine + B6 fails<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2 class=\"wp-block-heading\">Important &mdash; Do Not Use Beyond 72 Hours for Vertigo<\/h2>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:14px 18px;margin:18px 0;border-radius:4px;\">For acute peripheral vertigo (vestibular neuritis, labyrinthitis, BPPV), continued meclizine use beyond <strong>48&ndash;72 hours delays central compensation<\/strong> &mdash; the brain re-calibration that ultimately resolves the symptoms. Use it only for the first 2&ndash;3 days while symptoms are most severe, then stop and allow vestibular rehabilitation exercises (Cawthorne-Cooksey, Brandt-Daroff, Epley for BPPV) to finish the recovery. This is why meclizine is a rescue drug, not a maintenance therapy.<\/div>\n<h2 class=\"wp-block-heading\">Vedlej\u0161\u00ed \u00fa\u010dinky<\/h2>\n<table>\n<thead>\n<tr>\n<th>Frekvence<\/th>\n<th>\u00da\u010dinek<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td><strong>Common (&gt; 10%)<\/strong><\/td>\n<td>Drowsiness, sedation, dry mouth<\/td>\n<\/tr>\n<tr>\n<td><strong>Common (1&ndash;10%)<\/strong><\/td>\n<td>Blurred vision, constipation, urinary hesitancy, fatigue<\/td>\n<\/tr>\n<tr>\n<td><strong>M\u00e9n\u011b \u010dast\u00e9<\/strong><\/td>\n<td>Tachycardia, palpitations, restlessness in elderly (paradoxical), headache<\/td>\n<\/tr>\n<tr>\n<td><strong>Vz\u00e1cn\u00e9<\/strong><\/td>\n<td>Acute angle-closure glaucoma, urinary retention, anaphylaxis<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2 class=\"wp-block-heading\">Kontraindikace a upozorn\u011bn\u00ed<\/h2>\n<ul>\n<li><strong>Closed-angle glaucoma<\/strong> &mdash; anticholinergic effect can precipitate acute angle-closure attack<\/li>\n<li><strong>Prostatic hypertrophy \/ urinary retention<\/strong> &mdash; worsens outflow obstruction<\/li>\n<li><strong>Severe asthma \/ COPD<\/strong> &mdash; thickens bronchial secretions<\/li>\n<li><strong>D\u011bti do 12 let<\/strong> &mdash; insufficient data; alternatives exist<\/li>\n<li><strong>Concurrent sedatives or alcohol<\/strong> \u2014 kumulativn\u00ed \u00fatlum CNS<\/li>\n<li><strong>T\u011bhotenstv\u00ed a kojen\u00ed<\/strong> &mdash; FDA Category B; small amounts in breast milk &mdash; preferred over scopolamine if needed<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Interakce s l\u00e9\u010divy<\/h2>\n<table>\n<thead>\n<tr>\n<th>L\u00e9\u010divo \/ T\u0159\u00edda<\/th>\n<th>Interakce<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td><strong>Alcohol, opioids, benzodiazepines, hypnotics<\/strong><\/td>\n<td>Additive sedation; avoid combining at full motion-sickness doses<\/td>\n<\/tr>\n<tr>\n<td><strong>Other anticholinergics (oxybutynin, scopolamine, TCAs, first-gen antihistamines)<\/strong><\/td>\n<td>Cumulative anticholinergic burden &mdash; dry mouth, constipation, urinary retention, confusion in elderly<\/td>\n<\/tr>\n<tr>\n<td><strong>Inhibitory MAO<\/strong><\/td>\n<td>Prolong and intensify anticholinergic effects<\/td>\n<\/tr>\n<tr>\n<td><strong>Levodopa<\/strong><\/td>\n<td>Antihistamine may reduce levodopa effect; rarely clinically important at single doses<\/td>\n<\/tr>\n<tr>\n<td><strong>Cinnarizine, betahistine<\/strong><\/td>\n<td>Pharmacological antagonism; do not combine routinely &mdash; pick one strategy<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2 class=\"wp-block-heading\">Skladov\u00e1n\u00ed<\/h2>\n<ul>\n<li>Pod 25 \u00b0C na such\u00e9m m\u00edst\u011b, mimo p\u0159\u00edm\u00e9 slune\u010dn\u00ed sv\u011btlo<\/li>\n<li>Uchov\u00e1vejte v p\u016fvodn\u00edm blistru, mimo dosah d\u011bt\u00ed<\/li>\n<li>Nepou\u017e\u00edvejte po uplynut\u00ed doby pou\u017eitelnosti<\/li>\n<\/ul>\n<h2 id=\"faqs\">\u010casto kladen\u00e9 dotazy<\/h2>\n<h3 class=\"wp-block-heading\">When should I take Diligan before travel?<\/h3>\n<p>One hour before exposure to motion. The 25&ndash;50 mg dose reaches peak plasma level at 1&ndash;2 hours and lasts 8&ndash;12 hours, so a single dose covers a full day of travel. For multi-day journeys, repeat once every 24 hours.<\/p>\n<h3 class=\"wp-block-heading\">Diligan vs Vertin &mdash; which one do I need?<\/h3>\n<p><strong>Diligan (meclizine)<\/strong> je ur\u010den pro <em>acute, short-term<\/em> vestibular suppression: motion sickness, the first 48&ndash;72 hours of a peripheral vertigo episode, or a Meniere&#8217;s acute attack. <strong>Vertin \/ Betavert (betahistine)<\/strong> je ur\u010den pro <em>chronic maintenance<\/em> of Meniere&#8217;s disease &mdash; reducing the frequency of future attacks over weeks to months. They have opposite roles.<\/p>\n<h3 class=\"wp-block-heading\">Can I take Diligan during pregnancy?<\/h3>\n<p>Meclizine has FDA Pregnancy Category B classification &mdash; one of the safer antiemetics when first-line doxylamine + pyridoxine fails. Discuss with your obstetrician before regular use.<\/p>\n<h3 class=\"wp-block-heading\">Does Diligan make you drowsy?<\/h3>\n<p>Yes &mdash; sedation is the most common side effect, occurring in over 10% of users. Do not drive or operate machinery for 8&ndash;12 hours after a dose. Take the first dose at home before travel day to learn your individual reaction.<\/p>\n<h3 class=\"wp-block-heading\">How is Diligan different from Phenergan \/ Avomine?<\/h3>\n<p>Promethazine (Phenergan, Avomine) is a phenothiazine with stronger sedation and antiemetic effect &mdash; preferred when nausea is the dominant symptom, but more sedating and not safe in children under 2 years. Meclizine has a milder sedation profile and longer duration, making it more practical for an adult travel day.<\/p>\n<h3 class=\"wp-block-heading\">Can children take Diligan?<\/h3>\n<p>Meclizine is not recommended for children under 12 years &mdash; safety data are limited. For paediatric motion sickness, dimenhydrinate or cinnarizine are typically used instead, under medical guidance.<\/p>\n<h3 class=\"wp-block-heading\">Will Diligan stop a Meniere&#8217;s attack?<\/h3>\n<p>It blunts the vertigo and nausea of an active episode but does not change the underlying disease. For chronic Meniere&#8217;s management, betahistine (<a href=\"https:\/\/medsbase.com\/cs\/vertin\/\">Vertin<\/a> nebo <a href=\"https:\/\/medsbase.com\/cs\/betavert\/\">Betavert<\/a>), salt restriction, and hydration are the maintenance strategy. Meclizine is rescue only.<\/p>\n<h3 class=\"wp-block-heading\">Is Diligan addictive?<\/h3>\n<p>No &mdash; meclizine is not a controlled substance and has no dependence potential. The main long-term concern is the anticholinergic burden in elderly users (dry mouth, constipation, cognitive effects).<\/p>\n<h3 class=\"wp-block-heading\">Does Diligan help BPPV?<\/h3>\n<p>Only short-term during the most severe symptoms. <strong>BPPV is mechanical<\/strong> &mdash; a displaced otolith crystal in a semicircular canal &mdash; and the definitive treatment is a canalith-repositioning manoeuvre (Epley, Semont). Meclizine masks symptoms; it does not relocate the crystal. Use it for the first 24&ndash;48 hours, then have someone perform the Epley manoeuvre.<\/p>\n<h3 class=\"wp-block-heading\">Can I drink alcohol on Diligan?<\/h3>\n<p>Avoid alcohol while taking meclizine. Combined CNS depression worsens drowsiness, balance, and reaction time &mdash; a real fall and accident risk, especially in older adults.<\/p>\n<h3 class=\"wp-block-heading\">How long does Diligan take to start working?<\/h3>\n<p>30&ndash;60 minutes to perceptible effect; peak at 1&ndash;2 hours; duration 8&ndash;12 hours. Take it 1 hour before exposure for prevention &mdash; taking it after motion sickness is established is much less effective than preventing it before.<\/p>\n<p class=\"medsbase-link-boost-2026-05-20\" data-marker=\"mb-link-boost-avimax\" style=\"margin:16px 0;padding:12px 16px;background:#f4f8fb;border-left:3px solid #2c7cb0;font-size:14px;line-height:1.6;\">Meclizine in <a href=\"https:\/\/medsbase.com\/cs\/diligan\/\">Diligan<\/a> is a longer-acting, less-sedating option for daytime motion sickness, but when stronger sedation is wanted overnight on a ferry or coach a single <a href=\"https:\/\/medsbase.com\/cs\/avimax\/\">Avimax (promethazine 25 mg)<\/a> taken pre-travel delivers heavier antihistamine antiemetic cover with reliable drowsiness.<\/p>\n<p><!-- medsbase-related-alts-v1 --><\/p>\n<h3 class=\"wp-block-heading\">Dal\u0161\u00ed l\u00e9\u010dba z\u00e1vrat\u00ed a kinet\u00f3zy<\/h3>\n<ul>\n<li><a href=\"https:\/\/medsbase.com\/cs\/vertin\/\">Vertin (betahistine 8 mg) &mdash; chronic Meniere&#8217;s disease maintenance<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/betavert\/\">Betavert (betahistine 8 \/ 16 mg) &mdash; alternative betahistine brand<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/betavert-tab\/\">Betavert Tab (betahistine 24 mg) &mdash; higher-strength once-daily option<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/avomine\/\">Avomine (promethazine 25 mg) &mdash; alternative motion-sickness antihistamine<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/stemetil-md\/\">Stemetil MD (prochlorperazine 5 mg ODT) &mdash; acute vertigo &amp; nausea rescue<\/a><\/li>\n<\/ul>\n<h3 class=\"wp-block-heading\">L\u00e9ka\u0159sk\u00e9 upozorn\u011bn\u00ed<\/h3>\n<p style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:14px 18px;margin:18px 0;border-radius:4px;font-size:14px;line-height:1.55;\">Tato str\u00e1nka slou\u017e\u00ed pouze pro informa\u010dn\u00ed \u00fa\u010dely a nenahrazuje rady kvalifikovan\u00e9ho l\u00e9ka\u0159e. N\u00e1hl\u00e9 siln\u00e9 z\u00e1vrat\u011b s neurologick\u00fdmi p\u0159\u00edznaky (n\u00e1hl\u00e1 ztr\u00e1ta sluchu, dvojit\u00e9 vid\u011bn\u00ed, nesrozumiteln\u00e1 \u0159e\u010d, slabost, necitlivost, siln\u00e1 bolest hlavy nebo nestabiln\u00ed ch\u016fze) vy\u017eaduj\u00ed neodkladn\u00e9 l\u00e9ka\u0159sk\u00e9 vy\u0161et\u0159en\u00ed \u2014 mohou signalizovat c\u00e9vn\u00ed mozkovou p\u0159\u00edhodu nebo centr\u00e1ln\u00ed patologii sp\u00ed\u0161e ne\u017e probl\u00e9m vnit\u0159n\u00edho ucha. P\u0159ed samol\u00e9\u010dbou nov\u00fdch p\u0159\u00edznak\u016f z\u00e1vrat\u00ed se pora\u010fte s l\u00e9ka\u0159em.<\/p>","protected":false},"excerpt":{"rendered":"<p>\u2705 Zm\u00edr\u0148uje nevolnost z pohybu<br \/>\n\u2705 Relieves vertigo symptoms<br \/>\n\u2705 Reduces nausea<br \/>\n\u2705 Controls dizziness<br \/>\n\u2705 Treats vomiting<\/p>\n<p>Diligan contains Meclizine.<\/p>","protected":false},"featured_media":58707,"comment_status":"open","ping_status":"open","template":"","meta":[],"product_brand":[],"product_cat":[3141,3448,3449,5894],"product_tag":[4548,4549],"class_list":{"0":"post-58706","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-category-overview","7":"product_cat-travel-health-category-overview","8":"product_cat-travel-sickness-tablets","9":"product_cat-vertigo-motion-sickness-treatment","10":"product_tag-diligan","11":"product_tag-meclizine","13":"first","14":"instock","15":"shipping-taxable","16":"purchasable","17":"product-type-variable","18":"has-default-attributes"},"acf":[],"_links":{"self":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product\/58706","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/comments?post=58706"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/media\/58707"}],"wp:attachment":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/media?parent=58706"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product_brand?post=58706"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product_cat?post=58706"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product_tag?post=58706"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}