{"id":58731,"date":"2024-02-28T05:25:22","date_gmt":"2024-02-28T05:25:22","guid":{"rendered":"https:\/\/medsname.com\/endace\/"},"modified":"2026-04-30T10:24:09","modified_gmt":"2026-04-30T10:24:09","slug":"endace","status":"publish","type":"product","link":"https:\/\/medsbase.com\/cs\/product\/endace\/","title":{"rendered":"Endace"},"content":{"rendered":"<p><!-- medsbase-tldr-answer --><\/p>\n<div style=\"background:#fff8e1;border-left:4px solid #f5a623;padding:18px 22px;margin:0 0 24px 0;border-radius:4px;\">\n<h3 class=\"wp-block-heading\" style=\"margin:0 0 8px 0;font-size:16px;font-weight:700;\">&#9889; Quick Answer &mdash; What is Endace?<\/h3>\n<p style=\"margin:0;\"><strong>Endace<\/strong> je peror\u00e1ln\u00ed tableta od spole\u010dnosti Cipla obsahuj\u00edc\u00ed <strong>megestrol acetate<\/strong> na <strong>40 mg and 160 mg<\/strong> &mdash; a synthetic progestin used as <strong>appetite stimulant<\/strong> in cancer cachexia and HIV-related anorexia, and as palliative endocrine therapy in advanced hormone-receptor-positive breast cancer and endometrial cancer. Standard appetite-stimulant dose: <strong>400&ndash;800 mg\/day<\/strong> (typically 800 mg\/day in cancer cachexia). Onset of appetite improvement at 1&ndash;2 weeks; weight gain (mostly fat, not muscle) at 4&ndash;6 weeks. <strong>Increased venous thromboembolism risk<\/strong> &mdash; caution in immobilised cancer patients; consider DVT prophylaxis. Other warnings: adrenal suppression with prolonged use (mineralocorticoid effect), hyperglycaemia, fluid retention.<\/p>\n<\/div>\n<div class=\"medsbase-trust-strip\" style=\"background:#f4f8fb;border:1px solid #d8e3eb;padding:12px 16px;margin:16px 0;border-radius:4px;font-size:14px;\">\n<strong>Co z\u00edsk\u00e1te s MedsBase:<\/strong> V\u00fdrobce certifikovan\u00fd WHO-GMP \u00b7 Diskr\u00e9tn\u00ed balen\u00ed \u00b7 Celosv\u011btov\u00e1 doprava \u00b7 V\u00edce ne\u017e 1 400 ov\u011b\u0159en\u00fdch <a href=\"https:\/\/medsbase.com\/cs\/reviews\/\">recenz\u00ed z\u00e1kazn\u00edk\u016f<\/a>\n<\/div>\n<p class=\"medsbase-reship-line\" style=\"font-size:14px;color:#444;margin:8px 0 18px;\">\ud83d\udce6 Ka\u017ed\u00e1 objedn\u00e1vka je pokryta na\u0161\u00ed <a href=\"https:\/\/medsbase.com\/cs\/medsbase-re-shipment-assurance-policy\/\"><strong>Z\u00e1rukou op\u011btovn\u00e9ho odesl\u00e1n\u00ed<\/strong><\/a> \u2014 pokud va\u0161e z\u00e1silka nedoraz\u00ed do 20 pracovn\u00edch dn\u016f, p\u0159epos\u00edl\u00e1me ji.<\/p>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:14px 18px;margin:0 0 24px 0;border-radius:4px;font-size:14px;\"><strong>\u26a0 Vy\u017eaduje se odborn\u00fd dohled.<\/strong> L\u00e9ky na rakovinu mus\u00ed b\u00fdt p\u0159edeps\u00e1ny o\u0161et\u0159uj\u00edc\u00edm onkologem s potvrzenou diagn\u00f3zou, vstupn\u00edm stagingem a definovan\u00fdm l\u00e9\u010debn\u00fdm pl\u00e1nem. Nikdy neza\u010d\u00ednejte, nep\u0159eru\u0161ujte, nem\u011b\u0148te d\u00e1vkov\u00e1n\u00ed ani neu\u017e\u00edvejte l\u00e9ky na rakovinu mimo onkologick\u00fd l\u00e9\u010debn\u00fd pl\u00e1n. V\u011bt\u0161ina l\u00e9k\u016f na rakovinu vy\u017eaduje pravideln\u00e9 monitorov\u00e1n\u00ed krevn\u00edch test\u016f (krevn\u00ed obraz, jatern\u00ed testy, funkce ledvin), je absolutn\u011b kontraindikov\u00e1na v t\u011bhotenstv\u00ed a m\u00e1 v\u00fdznamn\u00e9 l\u00e9kov\u00e9 interakce.<\/div>\n<div style=\"background:#f4f8fb;border:1px solid #d6e4ec;padding:12px 18px;margin:14px 0;border-radius:4px;font-size:14px;color:#3a5160;text-align:center;\">\n<strong>\ud83d\udd12 \u0160ifrovan\u00e9 platby<\/strong> \u00b7 <strong>\ud83d\udcb3 Ov\u011b\u0159en\u00fd platebn\u00ed procesor<\/strong> \u00b7 <strong>\ud83d\ude9a Doprava do cel\u00e9ho sv\u011bta<\/strong> \u00b7 <strong>\u2b50 4,9\/5 od 1 400+ z\u00e1kazn\u00edk\u016f<\/strong>\n<\/div>\n<h2 class=\"wp-block-heading\">What Is Endace?<\/h2>\n<p>Endace is an oral tablet from Cipla containing <strong>megestrol acetate<\/strong> (40 mg and 160 mg). Megestrol is a synthetic progestin with potent appetite-stimulant effects. The dominant modern use is as supportive care for <strong>cancer cachexia<\/strong> &mdash; the involuntary weight loss that affects most patients with advanced cancer and significantly worsens quality of life and treatment tolerance. It also retains a niche role in palliative endocrine therapy for advanced hormone-receptor-positive breast and endometrial cancer.<\/p>\n<h2 class=\"wp-block-heading\">Pou\u017eit\u00ed a indikace<\/h2>\n<ul>\n<li><strong>Cancer cachexia<\/strong> &mdash; appetite stimulation and weight gain<\/li>\n<li><strong>HIV-related anorexia and weight loss<\/strong> (less commonly used in 2026 with modern ART)<\/li>\n<li><strong>Palliative endocrine therapy in advanced HR+ breast cancer<\/strong> &mdash; later-line after AI and tamoxifen<\/li>\n<li><strong>Advanced endometrial cancer<\/strong> palliation<\/li>\n<li><strong>Mimo indikaci:<\/strong> hot flushes in patients who cannot use HRT<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">D\u00e1vkov\u00e1n\u00ed a zp\u016fsob u\u017e\u00edv\u00e1n\u00ed<\/h2>\n<ul>\n<li><strong>Cancer cachexia \/ HIV anorexia:<\/strong> 400&ndash;800 mg\/day (often 800 mg\/day) of suspension or tablet equivalent<\/li>\n<li><strong>Breast cancer palliation:<\/strong> 160 mg\/day in divided doses<\/li>\n<li><strong>Endometrial cancer palliation:<\/strong> 80&ndash;320 mg\/day in divided doses<\/li>\n<\/ul>\n<ol>\n<li>Take with food to improve absorption and reduce nausea.<\/li>\n<li>Once daily or in divided doses depending on indication.<\/li>\n<li><strong>Povinn\u00e9 monitorov\u00e1n\u00ed:<\/strong> baseline weight, blood glucose (megestrol commonly raises glucose); BP; signs of DVT; symptoms of adrenal suppression. Periodic FBC.<\/li>\n<li>For cachexia, expect appetite improvement at 1&ndash;2 weeks and weight gain at 4&ndash;6 weeks. Most weight gain is fat (not muscle), and adding nutritional support and resistance exercise where possible amplifies benefit.<\/li>\n<li><strong>Nep\u0159est\u00e1vejte n\u00e1hle<\/strong> after prolonged use &mdash; risk of adrenal crisis from progestin-mediated adrenal suppression. Taper under specialist guidance.<\/li>\n<\/ol>\n<h2 class=\"wp-block-heading\">Vedlej\u0161\u00ed \u00fa\u010dinky<\/h2>\n<p><strong>\u010cast\u00e9:<\/strong> weight gain (the desired effect in cachexia), increased appetite, fluid retention, hyperglycaemia, breakthrough vaginal bleeding, mood changes, insomnia, sweating, hot flushes (paradoxically, in some patients).<\/p>\n<p><strong>D\u016fle\u017eit\u00e9:<\/strong><\/p>\n<ul>\n<li><strong>Venous thromboembolism (DVT, PE)<\/strong> &mdash; consider prophylactic anticoagulation in immobilised cancer patients<\/li>\n<li>Adrenal suppression with prolonged high-dose use<\/li>\n<li>New-onset diabetes or worsening glycaemic control<\/li>\n<li>Hypertenze<\/li>\n<li>Cushingoid features at high doses<\/li>\n<li>Menstrual irregularities<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Varov\u00e1n\u00ed<\/h2>\n<ul>\n<li><strong>T\u011bhotenstv\u00ed:<\/strong> contraindicated. Reliable contraception throughout treatment.<\/li>\n<li><strong>Kojen\u00ed:<\/strong> vyhnout se.<\/li>\n<li><strong>Active VTE or recent thrombosis:<\/strong> avoid; alternatives include corticosteroids for cachexia (short-term) or omega-3.<\/li>\n<li><strong>Diabetes:<\/strong> monitor glucose carefully; insulin or hypoglycaemic dose adjustment likely.<\/li>\n<li><strong>Adrenal insufficiency:<\/strong> taper, do not stop abruptly after prolonged use.<\/li>\n<li><strong>Cardiovascular risk factors:<\/strong> caution &mdash; fluid retention, hypertension.<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Interakce s l\u00e9\u010divy<\/h2>\n<table style=\"border-collapse:collapse;width:100%;margin:12px 0;\">\n<thead>\n<tr style=\"background:#2c7cb0;color:#fff;\">\n<th style=\"padding:10px;border:1px solid #ddd;\">Kombinujte s<\/th>\n<th style=\"padding:10px;border:1px solid #ddd;\">\u00da\u010dinek<\/th>\n<th style=\"padding:10px;border:1px solid #ddd;\">Co d\u011blat<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td style=\"padding:10px;border:1px solid #ddd;\">Insulin or oral hypoglycaemics<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Megestrol raises blood glucose &mdash; reduced control<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Monitor glucose; adjust diabetic medication.<\/td>\n<\/tr>\n<tr>\n<td style=\"padding:10px;border:1px solid #ddd;\">Warfarin<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Possible INR change<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Monitor INR.<\/td>\n<\/tr>\n<tr>\n<td style=\"padding:10px;border:1px solid #ddd;\">Other progestins, oestrogens<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Stacked progestin \/ VTE effects<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Vyhn\u011bte se kombinaci.<\/td>\n<\/tr>\n<tr>\n<td style=\"padding:10px;border:1px solid #ddd;\">Inhibitory aromat\u00e1zy<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Megestrol provides exogenous progestin &mdash; rarely used together; sequence appropriately<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Specialist judgment.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2 class=\"wp-block-heading\">Skladov\u00e1n\u00ed<\/h2>\n<ul>\n<li>P\u0159i pokojov\u00e9 teplot\u011b, 15\u201325\u00b0C, v p\u016fvodn\u00edm blistru.<\/li>\n<li>Out of reach of children and pets.<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Souvisej\u00edc\u00ed alternativy na MedsBase<\/h2>\n<p>Dal\u0161\u00ed onkologick\u00e9 l\u00e9ky skladem vedle tohoto produktu:<\/p>\n<ul>\n<li><a href=\"https:\/\/medsbase.com\/cs\/endoxan\/\"><strong>Endoxan (cyklofosfamid 50 mg)<\/strong><\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/celkeran\/\"><strong>Celkeran (chlorambucil 2 \/ 5 mg)<\/strong><\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/temotero\/\"><strong>Temotero (temozolomid 20\/100 mg)<\/strong><\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/temozol-20\/\"><strong>Temozol (temozolomid 20 mg)<\/strong><\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/lomoother\/\"><strong>Lomoother (lomustin 40 mg)<\/strong><\/a><\/li>\n<\/ul>\n<p><a href=\"https:\/\/medsbase.com\/cs\/anti-cancer-medication\/\">Prohl\u00e9dn\u011bte v\u0161echny protin\u00e1dorov\u00e9 l\u00e9ky \u2192<\/a><\/p>\n<h2 id=\"faqs\">\u010casto kladen\u00e9 dotazy<\/h2>\n<h3 class=\"wp-block-heading\">When will I notice the appetite-stimulant effect?<\/h3>\n<p>Improved appetite typically starts at <strong>1\u20132 t\u00fddny<\/strong>. Measurable weight gain (mostly fat, with smaller fluid component) at <strong>4\u20136 t\u00fddnech<\/strong>. Most weight gain is fat &mdash; megestrol does not significantly increase lean muscle mass. Adding nutritional support and gentle resistance exercise where possible amplifies the benefit.<\/p>\n<h3 class=\"wp-block-heading\">Why is venous thromboembolism a risk?<\/h3>\n<p>Megestrol is a progestin and shares the VTE risk of all hormonal contraceptives + progestins, particularly in cancer patients (who already carry a 5&ndash;10&times; increased baseline VTE risk). Be alert for unilateral leg swelling, sudden chest pain or breathlessness; seek same-day care if these occur. Consider prophylactic anticoagulation in immobilised cancer patients on megestrol.<\/p>\n<h3 class=\"wp-block-heading\">Will Endace raise my blood sugar?<\/h3>\n<p>Yes &mdash; commonly. Megestrol mimics some of the metabolic effects of corticosteroids (impairs insulin action, raises hepatic glucose output). Diabetic patients usually need their hypoglycaemic medication adjusted upward; new-onset diabetes can occur in non-diabetic patients on long-term high-dose megestrol. Monitor capillary glucose weekly initially.<\/p>\n<h3 class=\"wp-block-heading\">Why must I taper rather than stop Endace?<\/h3>\n<p>Long-term high-dose megestrol suppresses the adrenal axis (mineralocorticoid effect on the hypothalamic-pituitary-adrenal axis). Abrupt discontinuation after &gt; 4&ndash;6 weeks of high-dose use risks <strong>adrenal crisis<\/strong> &mdash; nausea, vomiting, hypotension, hypoglycaemia. Taper down over 2&ndash;4 weeks under specialist supervision.<\/p>\n<h3 class=\"wp-block-heading\">Are there alternatives to Endace for cancer cachexia?<\/h3>\n<p>Limited options with strong evidence. <strong>Kortikosteroidy<\/strong> (dexamethasone 4 mg\/day) provide short-term appetite stimulation but have severe long-term toxicity. <strong>Cannabinoids<\/strong> (dronabinol where legal) have modest evidence. <strong>Anamorelin<\/strong> (ghrelin agonist) is approved in Japan and some other markets. <strong>Olanzapine<\/strong> low-dose has emerging supportive evidence. <strong>Nutritional and exercise interventions<\/strong> remain first-line. Discuss with the palliative care team.<\/p>\n<h3 class=\"wp-block-heading\">Can Endace treat my breast cancer?<\/h3>\n<p>Megestrol has a niche role in palliative endocrine therapy for HR+ advanced breast cancer &mdash; usually <strong>later-line after aromatase inhibitor and tamoxifen failure<\/strong>. It is no longer a first or second-line endocrine choice in most modern practice; CDK4\/6 inhibitors + AI \/ fulvestrant have largely replaced it. Specialist oncology decision.<\/p>\n<h3 class=\"wp-block-heading\">Is Endace safe in pregnancy?<\/h3>\n<p>No &mdash; contraindicated. Megestrol is a progestin and may cause fetal masculinisation and other developmental effects. Reliable contraception throughout treatment.<\/p>\n<h3 class=\"wp-block-heading\">Can I drink alcohol on Endace?<\/h3>\n<p>Occasional small amounts are tolerable but heavy drinking compounds the metabolic side effects (hyperglycaemia, hypertension, fluid retention). Discuss with the supportive care team in the context of overall cancer care.<\/p>\n<p><!-- medsbase-why-order --><\/p>\n<h3>Pro\u010d objedn\u00e1vat z MedsBase<\/h3>\n<p>Ka\u017ed\u00e1 \u0161ar\u017ee je dod\u00e1v\u00e1na od <strong>v\u00fdrobce certifikovan\u00e9ho WHO-GMP<\/strong>. Objedn\u00e1vky jsou expedov\u00e1ny v nen\u00e1padn\u00fdch obalech bez loga od na\u0161ich partnersk\u00fdch sklad\u016f a jsou pokryty na\u0161\u00ed <a href=\"\/cs\/medsbase-re-shipment-assurance-policy\/\">Z\u00e1rukou op\u011btovn\u00e9ho odesl\u00e1n\u00ed<\/a>: pokud z\u00e1silka nedoraz\u00ed do 20 pracovn\u00edch dn\u016f, za\u0161leme zdarma n\u00e1hradn\u00ed z\u00e1silku, bez dotaz\u016f.<\/p>\n<p><!-- medsbase-related-alts-v1 --><\/p>\n<h3 class=\"wp-block-heading\">Souvisej\u00edc\u00ed protin\u00e1dorov\u00e9 l\u00e9ky<\/h3>\n<p>Dal\u0161\u00ed onkologick\u00e9 l\u00e9ky skladem vedle tohoto produktu:<\/p>\n<ul>\n<li><a href=\"https:\/\/medsbase.com\/cs\/cytomid\/\">Cytomid (flutamide 250 mg)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/bicalumutide\/\">Bicalumutid (bikalutamid 50 mg)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/bdenza\/\">Bdenza (enzalutamid 40 mg)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/tamilong\/\">Tamilong (tamoxifen 10\/20 mg)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/xtane\/\">Xtane (exemestan 25 mg)<\/a><\/li>\n<\/ul>","protected":false},"excerpt":{"rendered":"<p>\u2705 Manages appetite loss<br \/>\n\u2705 Treats breast cancer<br \/>\n\u2705 Kontroluje rakovinu endometria<br \/>\n\u2705 Aids weight gain<br \/>\n\u2705 Zlep\u0161uje kvalitu \u017eivota<\/p>\n<p>Endace contains Megestrol Acetate.<\/p>","protected":false},"featured_media":58732,"comment_status":"open","ping_status":"open","template":"","meta":[],"product_brand":[],"product_cat":[3595,3141,3223],"product_tag":[4556,4557],"class_list":{"0":"post-58731","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-anti-cancer-medication","7":"product_cat-category-overview","8":"product_cat-chronic-conditions","9":"product_tag-endace","10":"product_tag-megestrol","12":"first","13":"instock","14":"shipping-taxable","15":"purchasable","16":"product-type-variable","17":"has-default-attributes"},"acf":[],"_links":{"self":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product\/58731","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/comments?post=58731"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/media\/58732"}],"wp:attachment":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/media?parent=58731"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product_brand?post=58731"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product_cat?post=58731"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product_tag?post=58731"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}