{"id":58748,"date":"2024-02-28T05:26:30","date_gmt":"2024-02-28T05:26:30","guid":{"rendered":"https:\/\/medsname.com\/melorise\/"},"modified":"2026-05-01T10:49:14","modified_gmt":"2026-05-01T10:49:14","slug":"melorise","status":"publish","type":"product","link":"https:\/\/medsbase.com\/cs\/product\/melorise\/","title":{"rendered":"Melorise"},"content":{"rendered":"

<\/p>\n

\n

\u26a1 Rychl\u00e1 odpov\u011b\u010f \u2014 Co je Melorise?<\/h3>\n

Melorise<\/strong> je meloxicam tablety<\/strong> dostupn\u00fd v 7,5 mg a 15 mg<\/strong> s\u00edly. Meloxicam je preferen\u010dn\u00ed COX-2 NSAID<\/strong> s dlouh\u00fdm polo\u010dasem (~20 hodin), kter\u00fd umo\u017e\u0148uje denn\u00ed d\u00e1vkov\u00e1n\u00ed<\/strong>. Pou\u017e\u00edv\u00e1 se p\u0159i osteoartr\u00f3ze (7,5 mg\/den), revmatoidn\u00ed artritid\u011b a ankylozuj\u00edc\u00ed spondylitid\u011b (15 mg\/den) a poskytuje siln\u00fd protiz\u00e1n\u011btliv\u00fd \u00fa\u010dinek s m\u00edrn\u011b lep\u0161\u00edm gastrointestin\u00e1ln\u00edm profilem ne\u017e neselektivn\u00ed NSAID. U\u017e\u00edvejte s j\u00eddlem.<\/p>\n<\/div>\n

\nCo z\u00edsk\u00e1te s MedsBase:<\/strong> V\u00fdrobce certifikovan\u00fd WHO-GMP \u00b7 Diskr\u00e9tn\u00ed balen\u00ed \u00b7 Celosv\u011btov\u00e1 doprava \u00b7 V\u00edce ne\u017e 1 400 ov\u011b\u0159en\u00fdch recenz\u00ed z\u00e1kazn\u00edk\u016f<\/a>\n<\/div>\n

\ud83d\udce6 Ka\u017ed\u00e1 objedn\u00e1vka je pokryta na\u0161\u00ed Z\u00e1rukou op\u011btovn\u00e9ho odesl\u00e1n\u00ed<\/strong><\/a> \u2014 pokud va\u0161e z\u00e1silka nedoraz\u00ed do 20 pracovn\u00edch dn\u016f, p\u0159epos\u00edl\u00e1me ji.<\/p>\n

Pro\u010d objedn\u00e1vat z MedsBase<\/h3>\n

Na\u0161e generick\u00e9 l\u00e9ky poch\u00e1zej\u00ed od v\u00fdrobc\u016f certifikovan\u00fdch WHO-GMP a jsou expedov\u00e1ny po cel\u00e9m sv\u011bt\u011b v diskr\u00e9tn\u00edm, nen\u00e1padn\u00e9m balen\u00ed \u2013 na vn\u011bj\u0161\u00ed stran\u011b bal\u00edku nen\u00ed uveden n\u00e1zev l\u00e9ku. Platby kartou jsou sm\u011brov\u00e1ny prost\u0159ednictv\u00edm regulovan\u00e9ho procesoru (popisky na v\u00fdpisu zahrnuj\u00ed regulovan\u00e9ho procesora plateb kartou \u2013 nikdy \u201cMedsBase\u201d nebo n\u00e1zev l\u00e9ku). P\u0159ij\u00edm\u00e1me tak\u00e9 kryptom\u011bny a bankovn\u00ed p\u0159evody SEPA. Ka\u017ed\u00e1 objedn\u00e1vka je zaji\u0161t\u011bna na\u0161\u00ed politikou p\u0159eposl\u00e1n\u00ed.<\/p>\n

Melorise<\/strong> je peror\u00e1ln\u00ed tableta meloxicam<\/strong>, NSAID ze t\u0159\u00eddy oxikam\u016f s preferen\u010dn\u00ed aktivitou proti COX-2. V terapeutick\u00fdch d\u00e1vk\u00e1ch (7,5\u201315 mg\/den) meloxicam inhibuje COX-2 (forma zodpov\u011bdn\u00e1 za z\u00e1n\u011bt) v\u00fdrazn\u011b v\u00edce ne\u017e COX-1 (forma chr\u00e1n\u00edc\u00ed \u017ealudek), co\u017e poskytuje m\u00edrn\u00e9, ale re\u00e1ln\u00e9 sn\u00ed\u017een\u00ed rizika \u017ealude\u010dn\u00edch v\u0159ed\u016f ve srovn\u00e1n\u00ed s klasick\u00fdmi neselektivn\u00edmi NSAID, jako je diklofenak, ibuprofen a naproxen.<\/p>\n

Meloxicam m\u00e1 dlouh\u00fd plazmatick\u00fd polo\u010das p\u0159ibli\u017en\u011b 20 hodin, co\u017e umo\u017e\u0148uje jednoduch\u00e9 denn\u00ed d\u00e1vkov\u00e1n\u00ed<\/strong> a stabiln\u00ed 24hodinov\u00e9 protiz\u00e1n\u011btliv\u00e9 p\u016fsoben\u00ed \u2014 praktick\u00e1 v\u00fdhoda u chronick\u00fdch z\u00e1n\u011btliv\u00fdch artritid, kde je d\u016fle\u017eit\u00e1 adherence.<\/p>\n

K \u010demu se Melorise pou\u017e\u00edv\u00e1?<\/h2>\n
    \n
  • Osteoartritida<\/strong> \u2014 7,5 mg jednou denn\u011b (15 mg\/den v p\u0159\u00edpad\u011b pot\u0159eby a tolerance)<\/li>\n
  • Revmatoidn\u00ed artritida<\/strong> \u2014 15 mg jednou denn\u011b<\/li>\n
  • Ankylozuj\u00edc\u00ed spondylitida<\/strong> \u2014 15 mg jednou denn\u011b<\/li>\n
  • Akutn\u00ed bolest pohybov\u00e9ho apar\u00e1tu a poran\u011bn\u00ed<\/strong><\/li>\n
  • Juveniln\u00ed idiopatick\u00e1 artritida<\/strong> (odborn\u00fd dohled, d\u00e1vkov\u00e1n\u00ed podle hmotnosti)<\/li>\n
  • Prim\u00e1rn\u00ed dysmenorea<\/strong> (mimo schv\u00e1len\u00e9 indikace, kr\u00e1tkodob\u00e9 u\u017e\u00edv\u00e1n\u00ed)<\/li>\n<\/ul>\n

    Jak funguje Meloxicam?<\/h2>\n

    Meloxicam je preferen\u010dn\u00ed inhibitor COX-2. V terapeutick\u00fdch d\u00e1vk\u00e1ch vykazuje p\u0159ibli\u017en\u011b 10kr\u00e1t vy\u0161\u0161\u00ed selektivitu pro COX-2 ne\u017e pro COX-1, co\u017e jej \u0159ad\u00ed mezi neselektivn\u00ed NSAID (ibuprofen, diklofenak, naproxen) a vysoce selektivn\u00ed koxiby (celecoxib, etoricoxib). Klinick\u00e9 studie a metaanal\u00fdzy potvrzuj\u00ed m\u00edrn\u00e9, ale v\u00fdznamn\u00e9 sn\u00ed\u017een\u00ed v\u00fdskytu GI v\u0159ed\u016f a krv\u00e1cen\u00ed ve srovn\u00e1n\u00ed s neselektivn\u00edmi NSAID, p\u0159i\u010dem\u017e \u00fa\u010dinnost v \u00falev\u011b od bolesti je srovnateln\u00e1.<\/p>\n

    D\u00e1vkov\u00e1n\u00ed Melorise<\/h2>\n
      \n
    • Osteoartr\u00f3za:<\/strong> 7,5 mg jednou denn\u011b s j\u00eddlem (lze zv\u00fd\u0161it na 15 mg\/den)<\/li>\n
    • Revmatoidn\u00ed artritida a ankylozuj\u00edc\u00ed spondylitida:<\/strong> 15 mg jednou denn\u011b s j\u00eddlem<\/li>\n
    • Star\u0161\u00ed pacienti:<\/strong> za\u010dn\u011bte 7,5 mg jednou denn\u011b<\/li>\n
    • Maxim\u00e1ln\u00ed d\u00e1vka:<\/strong> 15 mg\/den<\/li>\n
    • Porucha funkce ledvin (m\u00edrn\u00e1 a\u017e st\u0159edn\u00ed):<\/strong> Maxim\u00e1ln\u011b 7,5 mg\/den; vyvarujte se pod\u00e1v\u00e1n\u00ed p\u0159i CrCl < 30 ml\/min<\/li>\n
    • Porucha funkce jater:<\/strong> 7,5 mg\/den; vyvarujte se pod\u00e1v\u00e1n\u00ed p\u0159i t\u011b\u017ek\u00e9 ren\u00e1ln\u00ed insuficienci<\/li>\n<\/ul>\n

      Polykejte cel\u00e9 s vodou. V\u017edy u\u017e\u00edvejte s j\u00eddlem. Pokud d\u00e1vku vynech\u00e1te, u\u017eijte ji co nejd\u0159\u00edve, kdy\u017e si vzpomenete, pokud nen\u00ed dal\u0161\u00ed d\u00e1vka napl\u00e1nov\u00e1na do 8 hodin - v tom p\u0159\u00edpad\u011b vynechejte.<\/p>\n

      \n

      GI, kardiovaskul\u00e1rn\u00ed a ren\u00e1ln\u00ed bezpe\u010dnost.<\/strong> Meloxicam nese v\u0161echna standardn\u00ed rizika NSAID (GI v\u0159edy, infarkt, mrtvice, akutn\u00ed po\u0161kozen\u00ed ledvin, zv\u00fd\u0161en\u00fd krevn\u00ed tlak). U\u017e\u00edvejte v nejni\u017e\u0161\u00ed \u00fa\u010dinn\u00e9 d\u00e1vce po nejkrat\u0161\u00ed klinicky rozumnou dobu. Zva\u017ete p\u0159id\u00e1n\u00ed inhibitoru protonov\u00e9 pumpy p\u0159i l\u00e9\u010db\u011b del\u0161\u00ed ne\u017e 2\u20134 t\u00fddny. Pacienti se zaveden\u00fdm kardiovaskul\u00e1rn\u00edm onemocn\u011bn\u00edm by se m\u011bli p\u0159ed zah\u00e1jen\u00edm l\u00e9\u010dby poradit s l\u00e9ka\u0159em.<\/p>\n<\/div>\n

      Kdo by nem\u011bl u\u017e\u00edvat Melorise?<\/h2>\n