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Admenta<\/strong> je peror\u00e1ln\u00ed tableta od Sun Pharma obsahuj\u00edc\u00ed memantin 5 mg<\/strong> \u2014 jeden nekompetitivn\u00ed antagonista NMDA receptor\u016f<\/strong> pou\u017e\u00edvan\u00fd k symptomatick\u00e9 l\u00e9\u010db\u011b st\u0159edn\u011b t\u011b\u017ekou a\u017e t\u011b\u017ekou Alzheimerovu chorobu<\/strong>. Memantin je ne<\/strong> indikov\u00e1n u m\u00edrn\u00e9 Alzheimerovy choroby. Postupn\u00e9 zvy\u0161ov\u00e1n\u00ed d\u00e1vky po dobu 4 t\u00fddn\u016f: 5 mg 1. t\u00fdden, 10 mg 2. t\u00fdden (5 mg dvakr\u00e1t denn\u011b), 15 mg 3. t\u00fdden, 20 mg od 4. t\u00fddne (10 mg dvakr\u00e1t denn\u011b)<\/strong>. Obecn\u011b dob\u0159e sn\u00e1\u0161en \u2014 hlavn\u00ed ne\u017e\u00e1douc\u00ed \u00fa\u010dinky jsou z\u00e1vrat\u011b, bolesti hlavy, z\u00e1cpa a zmatenost. Sni\u017ete d\u00e1vku, pokud eGFR < 30 ml\/min<\/strong>. \u010casto kombinov\u00e1n s donepezilem u st\u0159edn\u011b t\u011b\u017ek\u00e9 a\u017e t\u011b\u017ek\u00e9 choroby pro aditivn\u00ed kognitivn\u00ed benefit.<\/p>\n<\/div>\n \ud83d\udce6 Ka\u017ed\u00e1 objedn\u00e1vka je pokryta na\u0161\u00ed Z\u00e1rukou op\u011btovn\u00e9ho odesl\u00e1n\u00ed<\/strong><\/a> \u2014 pokud va\u0161e z\u00e1silka nedoraz\u00ed do 20 pracovn\u00edch dn\u016f, p\u0159epos\u00edl\u00e1me ji.<\/p>\n Na\u0161e generick\u00e9 l\u00e9ky poch\u00e1zej\u00ed od v\u00fdrobc\u016f certifikovan\u00fdch WHO-GMP a jsou expedov\u00e1ny po cel\u00e9m sv\u011bt\u011b v diskr\u00e9tn\u00edm, nen\u00e1padn\u00e9m balen\u00ed \u2013 na vn\u011bj\u0161\u00ed stran\u011b bal\u00edku nen\u00ed uveden n\u00e1zev l\u00e9ku. Platby kartou jsou sm\u011brov\u00e1ny prost\u0159ednictv\u00edm regulovan\u00e9ho procesoru (popisky na v\u00fdpisu zahrnuj\u00ed regulovan\u00e9ho procesora plateb kartou \u2013 nikdy \u201cMedsBase\u201d nebo n\u00e1zev l\u00e9ku). P\u0159ij\u00edm\u00e1me tak\u00e9 kryptom\u011bny a bankovn\u00ed p\u0159evody SEPA. Ka\u017ed\u00e1 objedn\u00e1vka je zaji\u0161t\u011bna na\u0161\u00ed politikou p\u0159eposl\u00e1n\u00ed.<\/p>\n Admenta je peror\u00e1ln\u00ed tableta od Sun Pharma obsahuj\u00edc\u00ed memantin hydrochlorid 5 mg<\/strong>. Memantin je n\u00edzkomolekul\u00e1rn\u00ed, nap\u011b\u0165ov\u011b z\u00e1visl\u00fd, nekompetitivn\u00ed antagonista N-methyl-D-aspart\u00e1tov\u00e9ho (NMDA) glutam\u00e1tov\u00e9ho receptoru<\/strong>. Mechanisticky se li\u0161\u00ed od inhibitor\u016f cholinester\u00e1zy (donepezil, galantamin, rivastigmin) a p\u016fsob\u00ed prost\u0159ednictv\u00edm druh\u00e9 hlavn\u00ed dr\u00e1hy spojen\u00e9 s Alzheimerovou chorobou \u2013 excitotoxicity glutam\u00e1tu.<\/p>\n Admenta od spole\u010dnosti Sun Pharma je 5 mg tableta memantinu \u2013 d\u00e1vka pou\u017e\u00edvan\u00e1 b\u011bhem povinn\u00e9ho 4t\u00fddenn\u00edho titrov\u00e1n\u00ed na udr\u017eovac\u00ed d\u00e1vku 20 mg\/den. Udr\u017eovac\u00ed d\u00e1vkov\u00e1n\u00ed jsou dv\u011b 5 mg tablety dvakr\u00e1t denn\u011b (celkem 4 tablety denn\u011b). Memantin je schv\u00e1len pouze pro st\u0159edn\u011b t\u011b\u017ekou a\u017e t\u011b\u017ekou Alzheimerovu chorobu<\/strong> \u2013 nikoli m\u00edrn\u00e9. Je standardn\u00edm dopl\u0148kem k inhibitoru cholinester\u00e1zy (obvykle donepezilu), kdy\u017e pacienti p\u0159ekro\u010d\u00ed m\u00edrn\u00e9 stadium, a p\u0159in\u00e1\u0161\u00ed aditivn\u00ed kognitivn\u00ed a funk\u010dn\u00ed benefit s minim\u00e1ln\u00edm n\u00e1r\u016fstem vedlej\u0161\u00edch \u00fa\u010dink\u016f.<\/p>\n Alzheimerova choroba zp\u016fsobuje chronickou nadm\u011brnou signalizaci glutam\u00e1tu na NMDA receptorech \u2013 proces naz\u00fdvan\u00fd excitotoxicita glutam\u00e1tu<\/strong>. Konstantn\u00ed n\u00edzk\u00e1 aktivace NMDA po\u0161kozuje neurony a naru\u0161uje pom\u011br sign\u00e1lu k \u0161umu, kter\u00fd mozek pot\u0159ebuje pro u\u010den\u00ed a pam\u011b\u0165. Memantin to \u0159e\u0161\u00ed jedine\u010dn\u00fdm mechanismem:<\/p>\n N\u00e1stup kognitivn\u00edho p\u0159\u00ednosu: viditeln\u00fd p\u0159i 4\u201312 t\u00fddn\u016f<\/strong> po dosa\u017een\u00ed udr\u017eovac\u00ed d\u00e1vky 20 mg\/den; maxim\u00e1ln\u00ed benefit po 6 m\u011bs\u00edc\u00edch.<\/p>\n Admenta je indikov\u00e1na u ne<\/strong> indikov\u00e1n pro: m\u00edrn\u00e9 Alzheimerovy choroby<\/strong> (inhibitory cholinester\u00e1zy jsou v t\u00e9to f\u00e1zi prvn\u00ed volbou), m\u00edrn\u00e9 kognitivn\u00ed posti\u017een\u00ed bez demence, frontotempor\u00e1ln\u00ed demence nebo jako kognitivn\u00ed enhancer u zdrav\u00fdch dosp\u011bl\u00fdch.<\/p>\n Admenta je dostupn\u00e1 ve form\u011b 5 mg<\/strong> tablet. Postupn\u00e1 titrace je povinn\u00e1 \u2014 p\u0159echod p\u0159\u00edmo na d\u00e1vku 20 mg\/den zp\u016fsobuje u v\u011bt\u0161iny pacient\u016f nesnesiteln\u00e9 zmaten\u00ed a z\u00e1vrat\u011b.<\/p>\n Standardn\u00ed titrace po 4 t\u00fddny:<\/strong><\/p>\n B\u011b\u017en\u00e9 (nejhor\u0161\u00ed b\u011bhem titrace, ust\u00e1l\u00ed se p\u0159i udr\u017eovac\u00ed d\u00e1vce):<\/strong><\/p>\n M\u00e9n\u011b \u010dast\u00e9:<\/strong><\/p>\n Vz\u00e1cn\u00e9, ale vy\u017eaduj\u00ed l\u00e9ka\u0159skou kontrolu:<\/strong><\/p>\nPro\u010d objedn\u00e1vat z MedsBase<\/h3>\n
Co je Admenta?<\/h2>\n
Jak Admenta funguje?<\/h2>\n
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Pou\u017eit\u00ed a indikace<\/h2>\n
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D\u00e1vkov\u00e1n\u00ed Admenty a zp\u016fsob u\u017e\u00edv\u00e1n\u00ed \u2014 POSTUPN\u00c1 TITRACE<\/h2>\n
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Jak spr\u00e1vn\u011b u\u017e\u00edvat Admenta<\/h3>\n
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Vedlej\u0161\u00ed \u00fa\u010dinky p\u0159\u00edpravku Admenta<\/h2>\n
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Varov\u00e1n\u00ed a opat\u0159en\u00ed<\/h2>\n
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Kontraindikace \u2014 Kdo by NEM\u011aL u\u017e\u00edvat Admenta<\/h2>\n
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Interakce s l\u00e9\u010divy<\/h2>\n