{"id":58789,"date":"2024-02-28T05:28:20","date_gmt":"2024-02-28T05:28:20","guid":{"rendered":"https:\/\/medsname.com\/folitrax\/"},"modified":"2026-04-30T10:24:08","modified_gmt":"2026-04-30T10:24:08","slug":"folitrax","status":"publish","type":"product","link":"https:\/\/medsbase.com\/cs\/product\/folitrax\/","title":{"rendered":"Folitrax"},"content":{"rendered":"<p><!-- medsbase-tldr-answer --><\/p>\n<div style=\"background:#fff8e1;border-left:4px solid #f5a623;padding:18px 22px;margin:0 0 24px 0;border-radius:4px;\">\n<h3 class=\"wp-block-heading\" style=\"margin:0 0 8px 0;font-size:16px;font-weight:700;\">\u26a1 Rychl\u00e1 odpov\u011b\u010f \u2014 Co je Folitrax?<\/h3>\n<p style=\"margin:0;\"><strong>Folitrax<\/strong> je peror\u00e1ln\u00ed tableta od spole\u010dnosti Ipca Laboratories obsahuj\u00edc\u00ed <strong>methotrex\u00e1t 7,5 mg<\/strong> \u2014 antimetabolit (inhibitor dihydrofol\u00e1tredukt\u00e1zy) pou\u017e\u00edvan\u00fd k <strong>udr\u017eovac\u00ed terapii akutn\u00ed lymfoblastick\u00e9 leuk\u00e9mie (ALL)<\/strong>, <strong>n\u011bkter\u00e9 lymfomy<\/strong>, <strong>t\u011b\u017ek\u00e1 revmatoidn\u00ed artritida<\/strong>, <strong>t\u011b\u017ek\u00e1 psori\u00e1za<\/strong>, a dal\u0161\u00ed imunomediovan\u00e1 onemocn\u011bn\u00ed. Udr\u017eovac\u00ed d\u00e1vka v onkologii: obvykle <strong>15\u201330 mg\/m\u00b2 t\u00fddn\u011b<\/strong> (NE denn\u011b) \u2014 t\u00fddenn\u00ed d\u00e1vkov\u00e1n\u00ed je nejd\u016fle\u017eit\u011bj\u0161\u00edm bezpe\u010dnostn\u00edm opat\u0159en\u00edm. <strong>N\u00e1hodn\u00e9 denn\u00ed d\u00e1vkov\u00e1n\u00ed methotrex\u00e1tu je jedn\u00edm z nej\u010dast\u011bj\u0161\u00edch preventabiln\u00edch z\u00e1va\u017en\u00fdch medika\u010dn\u00edch omyl\u016f a m\u016f\u017ee b\u00fdt fat\u00e1ln\u00ed.<\/strong> Povinn\u00e9: <strong>kyselina listov\u00e1 5 mg t\u00fddn\u011b<\/strong> v jin\u00fd den; z\u00e1kladn\u00ed + pr\u016fb\u011b\u017en\u00e9 vy\u0161et\u0159en\u00ed FBC, LFT, U&amp;E, RTG hrudn\u00edku. Absolutn\u00ed kontraindikace v t\u011bhotenstv\u00ed a p\u0159i kojen\u00ed (siln\u00fd teratogen).<\/p>\n<\/div>\n<div class=\"medsbase-trust-strip\" style=\"background:#f4f8fb;border:1px solid #d8e3eb;padding:12px 16px;margin:16px 0;border-radius:4px;font-size:14px;\">\n<strong>Co z\u00edsk\u00e1te s MedsBase:<\/strong> V\u00fdrobce certifikovan\u00fd WHO-GMP \u00b7 Diskr\u00e9tn\u00ed balen\u00ed \u00b7 Celosv\u011btov\u00e1 doprava \u00b7 V\u00edce ne\u017e 1 400 ov\u011b\u0159en\u00fdch <a href=\"https:\/\/medsbase.com\/cs\/reviews\/\">recenz\u00ed z\u00e1kazn\u00edk\u016f<\/a>\n<\/div>\n<p class=\"medsbase-reship-line\" style=\"font-size:14px;color:#444;margin:8px 0 18px;\">\ud83d\udce6 Ka\u017ed\u00e1 objedn\u00e1vka je pokryta na\u0161\u00ed <a href=\"https:\/\/medsbase.com\/cs\/medsbase-re-shipment-assurance-policy\/\"><strong>Z\u00e1rukou op\u011btovn\u00e9ho odesl\u00e1n\u00ed<\/strong><\/a> \u2014 pokud va\u0161e z\u00e1silka nedoraz\u00ed do 20 pracovn\u00edch dn\u016f, p\u0159epos\u00edl\u00e1me ji.<\/p>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:14px 18px;margin:0 0 24px 0;border-radius:4px;font-size:14px;\"><strong>\u26a0 Vy\u017eaduje se odborn\u00fd dohled.<\/strong> L\u00e9ky na rakovinu mus\u00ed b\u00fdt p\u0159edeps\u00e1ny o\u0161et\u0159uj\u00edc\u00edm onkologem s potvrzenou diagn\u00f3zou, vstupn\u00edm stagingem a definovan\u00fdm l\u00e9\u010debn\u00fdm pl\u00e1nem. Nikdy neza\u010d\u00ednejte, nep\u0159eru\u0161ujte, nem\u011b\u0148te d\u00e1vkov\u00e1n\u00ed ani neu\u017e\u00edvejte l\u00e9ky na rakovinu mimo onkologick\u00fd l\u00e9\u010debn\u00fd pl\u00e1n. V\u011bt\u0161ina l\u00e9k\u016f na rakovinu vy\u017eaduje pravideln\u00e9 monitorov\u00e1n\u00ed krevn\u00edch test\u016f (krevn\u00ed obraz, jatern\u00ed testy, funkce ledvin), je absolutn\u011b kontraindikov\u00e1na v t\u011bhotenstv\u00ed a m\u00e1 v\u00fdznamn\u00e9 l\u00e9kov\u00e9 interakce.<\/div>\n<div style=\"background:#f4f8fb;border:1px solid #d6e4ec;padding:12px 18px;margin:14px 0;border-radius:4px;font-size:14px;color:#3a5160;text-align:center;\">\n<strong>\ud83d\udd12 \u0160ifrovan\u00e9 platby<\/strong> \u00b7 <strong>\ud83d\udcb3 Ov\u011b\u0159en\u00fd platebn\u00ed procesor<\/strong> \u00b7 <strong>\ud83d\ude9a Doprava do cel\u00e9ho sv\u011bta<\/strong> \u00b7 <strong>\u2b50 4,9\/5 od 1 400+ z\u00e1kazn\u00edk\u016f<\/strong>\n<\/div>\n<h2 class=\"wp-block-heading\">Co je Folitrax?<\/h2>\n<p>Folitrax je peror\u00e1ln\u00ed tableta od spole\u010dnosti Ipca Laboratories obsahuj\u00edc\u00ed <strong>methotrex\u00e1t 7,5 mg<\/strong>. Methotrex\u00e1t je antagonista fol\u00e1tu (inhibitor dihydrofol\u00e1tredukt\u00e1zy) pou\u017e\u00edvan\u00fd v n\u00edzk\u00fdch d\u00e1vk\u00e1ch pro <strong>udr\u017eovac\u00ed terapii akutn\u00ed lymfoblastick\u00e9 leuk\u00e9mie (ALL)<\/strong>, n\u011bkolik lymfom\u016f, n\u011bkter\u00e9 solidn\u00ed n\u00e1dory a v podobn\u00fdch n\u00edzk\u00fdch d\u00e1vk\u00e1ch pro t\u011b\u017ekou revmatoidn\u00ed artritidu, psori\u00e1zu, Crohnovu chorobu a dal\u0161\u00ed imunitn\u011b zprost\u0159edkovan\u00e9 stavy.<\/p>\n<h2 class=\"wp-block-heading\">Pou\u017eit\u00ed a indikace<\/h2>\n<ul>\n<li><strong>Udr\u017eovac\u00ed f\u00e1ze akutn\u00ed lymfoblastick\u00e9 leuk\u00e9mie<\/strong> (peror\u00e1ln\u00ed methotrex\u00e1t t\u00fddn\u011b s mercaptopurinem denn\u011b)<\/li>\n<li><strong>Trofoblastick\u00e9 onemocn\u011bn\u00ed (gesta\u010dn\u00ed choriokarcinom)<\/strong> \u2014 specializovan\u00e1 onkologie<\/li>\n<li><strong>Kut\u00e1nn\u00ed T-bun\u011b\u010dn\u00fd lymfom, mycosis fungoides<\/strong><\/li>\n<li><strong>T\u011b\u017ek\u00e1 revmatoidn\u00ed artritida<\/strong> \u2014 DMARD prvn\u00ed volby<\/li>\n<li><strong>T\u011b\u017ek\u00e1 psori\u00e1za, psoriatick\u00e1 artritida<\/strong><\/li>\n<li><strong>Udr\u017eovac\u00ed l\u00e9\u010dba t\u011b\u017ek\u00e9 Crohnovy choroby<\/strong><\/li>\n<li><strong>N\u011bkolik dal\u0161\u00edch imunomediovan\u00fdch stav\u016f:<\/strong> ANCA vaskulitida, dermatomyozitida, juveniln\u00ed idiopatick\u00e1 artritida<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">D\u00e1vkov\u00e1n\u00ed a zp\u016fsob u\u017e\u00edv\u00e1n\u00ed \u2014 KRITICK\u00c9<\/h2>\n<p>Standardn\u00ed <strong>udr\u017eovac\u00ed onkologick\u00e1 l\u00e9\u010dba<\/strong> d\u00e1vka: <strong>15\u201330 mg\/m\u00b2 t\u00fddn\u011b<\/strong> (obvykle 20\u201325 mg\/t\u00fdden pro dosp\u011bl\u00e9ho). Standardn\u00ed <strong>revmatologie\/dermatologie<\/strong> d\u00e1vka: 7,5\u201325 mg t\u00fddn\u011b.<\/p>\n<ol>\n<li><strong>POUZE T\u00ddDENN\u00cd D\u00c1VKOV\u00c1N\u00cd.<\/strong> Methotrex\u00e1t se pod\u00e1v\u00e1 jednou t\u00fddn\u011b, NE denn\u011b. Zvolte jeden pevn\u00fd den v t\u00fddnu (nap\u0159. pond\u011bl\u00ed) a v\u0161echny tablety u\u017eijte spole\u010dn\u011b v tento den. <strong>N\u00e1hodn\u00e9 denn\u00ed d\u00e1vkov\u00e1n\u00ed m\u016f\u017ee b\u00fdt potenci\u00e1ln\u011b smrteln\u00e9.<\/strong> Toto je nej\u010dast\u011bj\u0161\u00ed preventabiln\u00ed z\u00e1va\u017en\u00e1 medikament\u00f3zn\u00ed chyba spojen\u00e1 s methotrex\u00e1tem.<\/li>\n<li><strong>Kyselina listov\u00e1 5 mg t\u00fddn\u011b<\/strong> v jin\u00fd den (nap\u0159. v p\u00e1tek) sni\u017euje nevolnost, afty a zv\u00fd\u0161en\u00ed jatern\u00edch test\u016f bez v\u00fdznamn\u00e9ho sn\u00ed\u017een\u00ed \u00fa\u010dinnosti.<\/li>\n<li>U\u017e\u00edvejte s j\u00eddlem nebo bez j\u00eddla.<\/li>\n<li><strong>Povinn\u00e9 monitorov\u00e1n\u00ed:<\/strong> vstupn\u00ed vy\u0161et\u0159en\u00ed: krevn\u00ed obraz (FBC), jatern\u00ed testy (AST, ALT), mo\u010dovina a elektrolyty + kreatinin, RTG plic. Opakovat FBC + jatern\u00ed testy ka\u017ed\u00e9 2 t\u00fddny prvn\u00ed 3 m\u011bs\u00edce, pot\u00e9 m\u011bs\u00ed\u010dn\u011b. Ro\u010dn\u00ed sledov\u00e1n\u00ed kumulativn\u00ed d\u00e1vky pro riziko jatern\u00ed fibr\u00f3zy (specialista).<\/li>\n<li>P\u0159eru\u0161it a vyhledat t\u00e9ho\u017e dne vy\u0161et\u0159en\u00ed p\u0159i: t\u011b\u017ek\u00fdch aft\u00e1ch, t\u011b\u017ek\u00e9m pr\u016fjmu, nov\u00e9 du\u0161nosti nebo ka\u0161li, hore\u010dce, \u017eloutence, snadn\u00e9 tvorb\u011b mod\u0159in nebo krv\u00e1cen\u00ed, nebo neobvykl\u00e9 vyr\u00e1\u017ece.<\/li>\n<\/ol>\n<h2 class=\"wp-block-heading\">Vedlej\u0161\u00ed \u00fa\u010dinky<\/h2>\n<p><strong>\u010cast\u00e9:<\/strong> nevolnost, afty, \u00fanava, \u0159\u00eddnut\u00ed vlas\u016f, m\u00edrn\u00e9 zv\u00fd\u0161en\u00ed jatern\u00edch test\u016f, m\u00edrn\u00e1 cytopenie.<\/p>\n<p><strong>D\u016fle\u017eit\u00e9:<\/strong><\/p>\n<ul>\n<li><strong>Myelosuprese<\/strong> \u2014 neutropenie, trombocytopenie, an\u00e9mie. T\u011b\u017ek\u00e1 pancytopenie m\u016f\u017ee nastat p\u0159i chyb\u00e1ch v denn\u00edm d\u00e1vkov\u00e1n\u00ed.<\/li>\n<li><strong>Hepatotoxicita<\/strong> \u2014 zv\u00fd\u0161en\u00ed jatern\u00edch test\u016f je b\u011b\u017en\u00e9; kumulativn\u00ed d\u00e1vka vede k jatern\u00ed fibr\u00f3ze p\u0159i dlouhodob\u00e9m u\u017e\u00edv\u00e1n\u00ed<\/li>\n<li><strong>Pneumonitida<\/strong> \u2014 idiosynkratick\u00e1 reakce; nov\u00e1 du\u0161nost nebo such\u00fd ka\u0161el vy\u017eaduje p\u0159eru\u0161en\u00ed a p\u0159ezkoum\u00e1n\u00ed<\/li>\n<li>Ren\u00e1ln\u00ed selh\u00e1n\u00ed \u2014 riziko kumulace a toxicity<\/li>\n<li>Mukozitida \u2014 \u010dasto limituj\u00edc\u00ed vedlej\u0161\u00ed \u00fa\u010dinek p\u0159i vy\u0161\u0161\u00edch d\u00e1vk\u00e1ch<\/li>\n<li>Fotosensitivita<\/li>\n<li>T\u011b\u017ek\u00e9 ko\u017en\u00ed reakce (Stevens-Johnson\u016fv syndrom) \u2014 vz\u00e1cn\u00e9, ale dokumentovan\u00e9<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Varov\u00e1n\u00ed \u2014 KRITICK\u00c9<\/h2>\n<ul>\n<li><strong>T\u011bhotenstv\u00ed: ABSOLUTN\u00cd KONTRAINDIKACE (FDA kategorie t\u011bhotenstv\u00ed X).<\/strong> Methotrex\u00e1t je siln\u00fd teratogen a abortivum. Spolehliv\u00e1 antikoncepce po celou dobu l\u00e9\u010dby A alespo\u0148 <strong>3 m\u011bs\u00edce po posledn\u00ed d\u00e1vce u \u017een, 6 m\u011bs\u00edc\u016f u mu\u017e\u016f<\/strong> (n\u011bkter\u00e9 sm\u011brnice vy\u017eaduj\u00ed 6 m\u011bs\u00edc\u016f u obou pohlav\u00ed).<\/li>\n<li><strong>Kojen\u00ed: kontraindikov\u00e1no<\/strong> \u2014 methotrex\u00e1t se vylu\u010duje do mate\u0159sk\u00e9ho ml\u00e9ka.<\/li>\n<li><strong>Porucha funkce ledvin:<\/strong> sn\u00ed\u017eit d\u00e1vku p\u0159i eGFR &lt; 60 ml\/min; vyhnout se pod\u00e1n\u00ed p\u0159i eGFR &lt; 30. Methotrex\u00e1t se vylu\u010duje ledvinami a p\u0159i ren\u00e1ln\u00edm selh\u00e1n\u00ed rychle kumuluje s rizikem t\u011b\u017ek\u00e9 toxicity.<\/li>\n<li><strong>T\u011b\u017ek\u00e9 jatern\u00ed posti\u017een\u00ed, aktivn\u00ed alkoholismus, hepatitida B\/C:<\/strong> vyhnout se pod\u00e1n\u00ed \u2014 vysok\u00e9 riziko t\u011b\u017ek\u00e9 hepatotoxicity.<\/li>\n<li><strong>Aktivn\u00ed infekce:<\/strong> p\u0159eru\u0161it pod\u00e1v\u00e1n\u00ed methotrex\u00e1tu p\u0159i z\u00e1va\u017en\u00e9 infekci.<\/li>\n<li><strong>\u017div\u00e9 vakc\u00edny<\/strong> (MMR, \u017elut\u00e1 zimnice, BCG, or\u00e1ln\u00ed polio): kontraindikov\u00e1no b\u011bhem l\u00e9\u010dby methotrex\u00e1tem.<\/li>\n<li><strong>Pleur\u00e1ln\u00ed v\u00fdpotek nebo ascites:<\/strong> methotrexate se hromad\u00ed v tzv. t\u0159et\u00edm prostoru a n\u00e1sledn\u011b se uvol\u0148uje, co\u017e zp\u016fsobuje prodlou\u017eenou toxicitu. P\u0159ed zah\u00e1jen\u00edm l\u00e9\u010dby odstra\u0148te v\u00fdpotky.<\/li>\n<li><strong>Riziko interakce s NSAID:<\/strong> viz tabulka l\u00e9kov\u00fdch interakc\u00ed.<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Interakce s l\u00e9\u010divy<\/h2>\n<table style=\"border-collapse:collapse;width:100%;margin:12px 0;\">\n<thead>\n<tr style=\"background:#2c7cb0;color:#fff;\">\n<th style=\"padding:10px;border:1px solid #ddd;\">Kombinujte s<\/th>\n<th style=\"padding:10px;border:1px solid #ddd;\">\u00da\u010dinek<\/th>\n<th style=\"padding:10px;border:1px solid #ddd;\">Co d\u011blat<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td style=\"padding:10px;border:1px solid #ddd;\">NSAID (ibuprofen, naproxen, diklofenak), aspirin (analgetick\u00e1 d\u00e1vka)<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Sni\u017euj\u00ed clearance methotrex\u00e1tu \u2014 riziko toxicity; z\u00e1va\u017en\u00e9 p\u0159i vysok\u00fdch d\u00e1vk\u00e1ch MTX, m\u00edrn\u00e9 p\u0159i n\u00edzk\u00fdch udr\u017eovac\u00edch d\u00e1vk\u00e1ch<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Obecn\u011b p\u0159ijateln\u00e9 p\u0159i stabiln\u00edch n\u00edzk\u00fdch peror\u00e1ln\u00edch d\u00e1vk\u00e1ch MTX za p\u0159edpokladu monitorov\u00e1n\u00ed; vyvarujte se kombinace s vysok\u00fdmi d\u00e1vkami MTX pod\u00e1van\u00fdmi intraven\u00f3zn\u011b. Paracetamol je bezpe\u010dn\u011bj\u0161\u00ed.<\/td>\n<\/tr>\n<tr>\n<td style=\"padding:10px;border:1px solid #ddd;\">Trimetoprim, kotrimoxazol (Septrin)<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Aditivn\u00ed antifol\u00e1tov\u00fd \u00fa\u010dinek \u2014 z\u00e1va\u017en\u00e1 pancytopenie<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">VYH\u00ddBEJTE SE. Pou\u017eijte alternativn\u00ed antibiotikum.<\/td>\n<\/tr>\n<tr>\n<td style=\"padding:10px;border:1px solid #ddd;\">\u017div\u00e9 vakc\u00edny (MMR, \u017elut\u00e1 zimnice, BCG, varicella)<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Diseminovan\u00e1 infekce z \u017eiv\u00e9 vakc\u00edny<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Kontraindikov\u00e1no.<\/td>\n<\/tr>\n<tr>\n<td style=\"padding:10px;border:1px solid #ddd;\">PPI (omeprazol) p\u0159i vysok\u00fdch d\u00e1vk\u00e1ch MTX pod\u00e1van\u00fdch intraven\u00f3zn\u011b<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Sni\u017euj\u00ed clearance MTX<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Vysadit PPI b\u011bhem pod\u00e1v\u00e1n\u00ed vysokod\u00e1vkov\u00e9ho MTX i.v. (specialista). Obecn\u011b bezpe\u010dn\u00e9 p\u0159i n\u00edzk\u00fdch peror\u00e1ln\u00edch d\u00e1vk\u00e1ch.<\/td>\n<\/tr>\n<tr>\n<td style=\"padding:10px;border:1px solid #ddd;\">Alkohol<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Aditivn\u00ed hepatotoxicita<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Omezte na p\u0159\u00edle\u017eitostn\u00e9 mal\u00e9 mno\u017estv\u00ed. Ne v\u00edce ne\u017e 1\u20132 n\u00e1poje t\u00fddn\u011b.<\/td>\n<\/tr>\n<tr>\n<td style=\"padding:10px;border:1px solid #ddd;\">Probenecid, peniciliny (vysok\u00e1 d\u00e1vka)<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Sni\u017euje ren\u00e1ln\u00ed clearance MTX \u2014 toxicita<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Vyhn\u011bte se kombinaci.<\/td>\n<\/tr>\n<tr>\n<td style=\"padding:10px;border:1px solid #ddd;\">Kyselina listov\u00e1 5 mg t\u00fddn\u011b<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Sni\u017euje toxicitu (mukozitida, GI, zv\u00fd\u0161en\u00ed jatern\u00edch test\u016f) bez v\u00fdznamn\u00e9ho sn\u00ed\u017een\u00ed \u00fa\u010dinnosti<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">STANDARDN\u00cd \u2014 u\u017e\u00edvejte 5 mg t\u00fddn\u011b v jin\u00fd den ne\u017e MTX.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2 class=\"wp-block-heading\">Skladov\u00e1n\u00ed<\/h2>\n<ul>\n<li>P\u0159i pokojov\u00e9 teplot\u011b, 15\u201325\u00b0C, v p\u016fvodn\u00edm blistru.<\/li>\n<li>Uchov\u00e1vejte mimo dosah d\u011bt\u00ed, \u017een v reproduk\u010dn\u00edm v\u011bku a dom\u00e1c\u00edch zv\u00ed\u0159at \u2014 methotrex\u00e1t je siln\u00fd teratogen.<\/li>\n<li>Po manipulaci s tabletami si umyjte ruce.<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Souvisej\u00edc\u00ed alternativy na MedsBase<\/h2>\n<p>Dal\u0161\u00ed onkologick\u00e9 l\u00e9ky skladem vedle tohoto produktu:<\/p>\n<ul>\n<li><a href=\"https:\/\/medsbase.com\/cs\/imutrex\/\"><strong>Imutrex (methotrexate 2,5 mg)<\/strong><\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/noltrexate\/\"><strong>Noltrexate (methotrex\u00e1t 2,5 mg)<\/strong><\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/leetrexate\/\"><strong>Leetrexate (methotrex\u00e1t 2,5 mg)<\/strong><\/a><\/li>\n<\/ul>\n<p><a href=\"https:\/\/medsbase.com\/cs\/anti-cancer-medication\/\">Prohl\u00e9dn\u011bte v\u0161echny protin\u00e1dorov\u00e9 l\u00e9ky \u2192<\/a><\/p>\n<h2 id=\"faqs\">\u010casto kladen\u00e9 dotazy<\/h2>\n<h3 class=\"wp-block-heading\">Pro\u010d se methotrex\u00e1t pod\u00e1v\u00e1 t\u00fddn\u011b, a ne denn\u011b?<\/h3>\n<p><strong>Methotrex\u00e1t se pod\u00e1v\u00e1 jednou t\u00fddn\u011b (ne denn\u011b) p\u0159i n\u00edzk\u00fdch d\u00e1vk\u00e1ch pro onkologickou udr\u017eovac\u00ed l\u00e9\u010dbu a revmatologii.<\/strong> Denn\u00ed pod\u00e1v\u00e1n\u00ed methotrex\u00e1tu omylem je potenci\u00e1ln\u011b smrteln\u00e9 \u2014 zp\u016fsobilo ji\u017e mnoho z\u00e1va\u017en\u00fdch ne\u017e\u00e1douc\u00edch \u00fa\u010dink\u016f na cel\u00e9m sv\u011bt\u011b a je jedn\u00edm z nej\u010dast\u011bj\u0161\u00edch preventabiln\u00edch z\u00e1va\u017en\u00fdch l\u00e9kov\u00fdch chyb. Vyberte si jeden pevn\u00fd den v t\u00fddnu (nap\u0159. pond\u011bl\u00ed), u\u017eijte v\u0161echny tablety spole\u010dn\u011b v tento den a nikdy ned\u00e1vejte d\u00e1vky \u010dast\u011bji. Informujte ka\u017ed\u00e9ho l\u00e9ka\u0159e a l\u00e9k\u00e1rn\u00edka o sv\u00e9m t\u00fddenn\u00edm re\u017eimu.<\/p>\n<h3 class=\"wp-block-heading\">Pro\u010d u\u017e\u00edvat kyselinu listovou?<\/h3>\n<p>Kyselina listov\u00e1 5 mg jednou t\u00fddn\u011b (v jin\u00fd den ne\u017e methotrex\u00e1t, nap\u0159. v p\u00e1tek) sni\u017euje nej\u010dast\u011bj\u0161\u00ed vedlej\u0161\u00ed \u00fa\u010dinky methotrex\u00e1tu \u2014 nevolnost, v\u0159edy v \u00fastech, GI pot\u00ed\u017ee, zv\u00fd\u0161en\u00ed jatern\u00edch test\u016f \u2014 bez v\u00fdznamn\u00e9ho sn\u00ed\u017een\u00ed \u00fa\u010dinnosti. Je standardn\u00ed sou\u010d\u00e1st\u00ed ka\u017ed\u00e9ho dlouhodob\u00e9ho re\u017eimu s methotrex\u00e1tem.<\/p>\n<h3 class=\"wp-block-heading\">Jak\u00e9 krevn\u00ed testy pot\u0159ebuji?<\/h3>\n<p>V\u00fdchoz\u00ed vy\u0161et\u0159en\u00ed: FBC, jatern\u00ed testy (AST, ALT), U&amp;E + kreatinin, RTG hrudn\u00edku. Pot\u00e9 FBC + jatern\u00ed testy ka\u017ed\u00e9 2 t\u00fddny po prvn\u00ed 3 m\u011bs\u00edce, pot\u00e9 m\u011bs\u00ed\u010dn\u011b. Ro\u010dn\u00ed p\u0159ehled kumulativn\u00ed d\u00e1vky pro riziko jatern\u00ed fibr\u00f3zy (specialista). Informujte sv\u00e9ho l\u00e9ka\u0159e o jak\u00e9koli infekci, v\u0159edech v \u00fastech, snadn\u00e9 tvorb\u011b mod\u0159in nebo \u017eloutence.<\/p>\n<h3 class=\"wp-block-heading\">M\u016f\u017eu p\u00edt alkohol p\u0159i u\u017e\u00edv\u00e1n\u00ed methotrex\u00e1tu?<\/h3>\n<p>Omezte alkohol na 1\u20132 standardn\u00ed drinky t\u00fddn\u011b nebo m\u00e9n\u011b \u2014 jak alkohol, tak methotrex\u00e1t jsou hepatotoxick\u00e9. Siln\u011bj\u0161\u00ed pit\u00ed v\u00fdrazn\u011b zvy\u0161uje riziko po\u0161kozen\u00ed jater zp\u016fsoben\u00e9ho methotrex\u00e1tem a jatern\u00ed fibr\u00f3zy p\u0159i dlouhodob\u00e9 terapii.<\/p>\n<h3 class=\"wp-block-heading\">M\u016f\u017eu ot\u011bhotn\u011bt p\u0159i u\u017e\u00edv\u00e1n\u00ed methotrex\u00e1tu?<\/h3>\n<p><strong>Ne \u2014 methotrex\u00e1t je podle FDA v t\u011bhotensk\u00e9 kategorii X.<\/strong> Methotrex\u00e1t je teratogenn\u00ed a abortivn\u00ed. Spolehliv\u00e1 antikoncepce je povinn\u00e1 po celou dobu l\u00e9\u010dby a nejm\u00e9n\u011b <strong>3 m\u011bs\u00edce po posledn\u00ed d\u00e1vce u \u017een<\/strong> a nejm\u00e9n\u011b <strong>6 m\u011bs\u00edc\u016f u mu\u017e\u016f<\/strong> (n\u011bkter\u00e9 sm\u011brnice prodlu\u017euj\u00ed obdob\u00ed pro \u017eeny tak\u00e9 na 6 m\u011bs\u00edc\u016f). Proberte pl\u00e1nov\u00e1n\u00ed rodiny se sv\u00fdm specialistou p\u0159ed zah\u00e1jen\u00edm l\u00e9\u010dby; p\u0159ejd\u011bte na neteratogenn\u00ed alternativu (azathioprin, sulfasalazin u n\u011bkter\u00fdch indikac\u00ed), pokud pl\u00e1nujete t\u011bhotenstv\u00ed.<\/p>\n<h3 class=\"wp-block-heading\">M\u016f\u017eu dostat \u017eiv\u00e9 vakc\u00edny p\u0159i u\u017e\u00edv\u00e1n\u00ed methotrex\u00e1tu?<\/h3>\n<p>\u017div\u00e9 vakc\u00edny (MMR, \u017elut\u00e1 zimnice, BCG, or\u00e1ln\u00ed polio, varicella) jsou kontraindikov\u00e1ny b\u011bhem l\u00e9\u010dby methotrex\u00e1tem \u2014 riziko diseminovan\u00e9 infekce z vakcina\u010dn\u00edho viru. Inaktivovan\u00e9 vakc\u00edny (ka\u017edoro\u010dn\u00ed ch\u0159ipka, pneumokokov\u00e1, COVID-19, hepatitida B) jsou nejen bezpe\u010dn\u00e9, ale doporu\u010den\u00e9. Napl\u00e1nujte \u017eiv\u00e9 vakc\u00edny alespo\u0148 4 t\u00fddny p\u0159ed zah\u00e1jen\u00edm methotrex\u00e1tu nebo 3 m\u011bs\u00edce po jeho ukon\u010den\u00ed.<\/p>\n<h3 class=\"wp-block-heading\">Jak\u00e1 antibiotika jsou nebezpe\u010dn\u00e1 s methotrex\u00e1tem?<\/h3>\n<p><strong>Trimethoprim a kotrimoxazol (Septrin\/Bactrim)<\/strong> jsou nejnebezpe\u010dn\u011bj\u0161\u00ed \u2014 maj\u00ed aditivn\u00ed antifol\u00e1tov\u00e9 \u00fa\u010dinky s methotrex\u00e1tem a zp\u016fsobily fat\u00e1ln\u00ed pancytopenii. VYH\u00ddBEJTE SE jim. Pou\u017e\u00edvejte alternativn\u00ed antibiotika \u2014 amoxicilin, doxycyklin, cefalexin atd. jsou bezpe\u010dn\u00e9. Informujte ka\u017ed\u00e9ho l\u00e9ka\u0159e o sv\u00e9m methotrex\u00e1tu p\u0159ed p\u0159edeps\u00e1n\u00edm jak\u00e9hokoli antibiotika.<\/p>\n<h3 class=\"wp-block-heading\">Pro\u010d mus\u00edm informovat sv\u00e9ho l\u00e9ka\u0159e p\u0159ed jakoukoli operac\u00ed?<\/h3>\n<p>Methotrex\u00e1t naru\u0161uje hojen\u00ed ran a zvy\u0161uje riziko infekce. P\u0159i pl\u00e1novan\u00e9 v\u011bt\u0161\u00ed operaci se methotrex\u00e1t n\u011bkdy vysazuje 1\u20132 t\u00fddny p\u0159ed v\u00fdkonem a obnovuje a\u017e po zahojen\u00ed r\u00e1ny. P\u0159i men\u0161\u00edch v\u00fdkonech (ko\u017en\u00ed biopsie, zubn\u00ed z\u00e1krok) lze obvykle pokra\u010dovat. Odborn\u00e9 doporu\u010den\u00ed.<\/p>\n<p><!-- medsbase-why-order --><\/p>\n<h3>Pro\u010d objedn\u00e1vat z MedsBase<\/h3>\n<p>Ka\u017ed\u00e1 \u0161ar\u017ee je dod\u00e1v\u00e1na od <strong>v\u00fdrobce certifikovan\u00e9ho WHO-GMP<\/strong>. Objedn\u00e1vky jsou expedov\u00e1ny v nen\u00e1padn\u00fdch obalech bez loga od na\u0161ich partnersk\u00fdch sklad\u016f a jsou pokryty na\u0161\u00ed <a href=\"\/cs\/medsbase-re-shipment-assurance-policy\/\">Z\u00e1rukou op\u011btovn\u00e9ho odesl\u00e1n\u00ed<\/a>: pokud z\u00e1silka nedoraz\u00ed do 20 pracovn\u00edch dn\u016f, za\u0161leme zdarma n\u00e1hradn\u00ed z\u00e1silku, bez dotaz\u016f.<\/p>\n<p><!-- medsbase-related-alts-v1 --><\/p>\n<h3 class=\"wp-block-heading\">Souvisej\u00edc\u00ed protin\u00e1dorov\u00e9 l\u00e9ky<\/h3>\n<p>Dal\u0161\u00ed onkologick\u00e9 l\u00e9ky skladem vedle tohoto produktu:<\/p>\n<ul>\n<li><a href=\"https:\/\/medsbase.com\/cs\/imutrex\/\">Imutrex (methotrex\u00e1t 2,5\/7,5\/10 mg)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/leetrexate\/\">Leetrexate (methotrex\u00e1t 2,5\/7,5\/10 mg)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/noltrexate\/\">Noltrexate (methotrex\u00e1t 2,5\/7,5\/10 mg)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/endoxan\/\">Endoxan (cyklofosfamid 50 mg)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/hydrosar\/\">Hydrosar (hydroxyurea 500 mg)<\/a><\/li>\n<\/ul>","protected":false},"excerpt":{"rendered":"<p>\u2705 L\u00e9\u010d\u00ed revmatoidn\u00ed artritidu<br \/>\n\u2705 Sni\u017euje z\u00e1n\u011bt kloub\u016f<br \/>\n\u2705 Zpomaluje progresi onemocn\u011bn\u00ed<br \/>\n\u2705 Kontroluje autoimunitn\u00ed onemocn\u011bn\u00ed<br \/>\n\u2705 Zlep\u0161uje p\u0159\u00edznaky<\/p>\n<p>Folitrax obsahuje methotrex\u00e1t.<\/p>","protected":false},"featured_media":58790,"comment_status":"open","ping_status":"open","template":"","meta":[],"product_brand":[],"product_cat":[3595,3141,3223],"product_tag":[4570,4466],"class_list":{"0":"post-58789","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-anti-cancer-medication","7":"product_cat-category-overview","8":"product_cat-chronic-conditions","9":"product_tag-folitrax","10":"product_tag-methotrexate","12":"first","13":"instock","14":"shipping-taxable","15":"purchasable","16":"product-type-variable","17":"has-default-attributes"},"acf":[],"_links":{"self":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product\/58789","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/comments?post=58789"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/media\/58790"}],"wp:attachment":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/media?parent=58789"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product_brand?post=58789"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product_cat?post=58789"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product_tag?post=58789"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}