{"id":58813,"date":"2024-02-28T05:29:33","date_gmt":"2024-02-28T05:29:33","guid":{"rendered":"https:\/\/medsname.com\/gr8-od\/"},"modified":"2026-04-30T10:24:07","modified_gmt":"2026-04-30T10:24:07","slug":"gr8-od","status":"publish","type":"product","link":"https:\/\/medsbase.com\/cs\/product\/gr8-od\/","title":{"rendered":"GR8-OD"},"content":{"rendered":"

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⚡ Quick Answer — What is GR8-OD?<\/h3>\n

GR8-OD<\/strong> is a fixed-dose oral capsule combining a proton pump inhibitor (Pantoprazole 40 mg)<\/strong> with the prokinetic dopamine antagonist domperidone 30 mg sustained-release<\/strong>. The PPI suppresses gastric acid secretion through irreversible inhibition of the parietal-cell H+\/K+-ATPase; domperidone speeds gastric emptying and tightens lower-oesophageal sphincter tone, which is useful when GERD is accompanied by regurgitation, gastroparesis, or functional dyspepsia<\/strong>. Take 30–60 minutes before the first meal<\/strong>, swallow whole, do not crush the SR pellet. Manufactured by Mankind Pharma under WHO-GMP standards.<\/p>\n<\/div>\n

Pro\u010d objedn\u00e1vat z MedsBase:<\/strong> \u2714 v\u00fdrobce certifikovan\u00e9ho WHO-GMP<\/strong> \u2714 Diskr\u00e9tn\u00ed balen\u00ed \u2714 Celosv\u011btov\u00e1 doprava \u2714 Ov\u011b\u0159en\u00e9 recenze z\u00e1kazn\u00edk\u016f (1 400+ z\u00e1kazn\u00edk\u016f)<\/a><\/div>\n

\ud83d\udce6 Ka\u017ed\u00e1 objedn\u00e1vka je pokryta na\u0161\u00ed Z\u00e1rukou op\u011btovn\u00e9ho odesl\u00e1n\u00ed<\/strong><\/a> \u2014 pokud va\u0161e z\u00e1silka nedoraz\u00ed do 20 pracovn\u00edch dn\u016f, p\u0159epos\u00edl\u00e1me ji.<\/p>\n

Pro\u010d objedn\u00e1vat z MedsBase<\/h3>\n

Na\u0161e generick\u00e9 l\u00e9ky poch\u00e1zej\u00ed od v\u00fdrobc\u016f certifikovan\u00fdch WHO-GMP a jsou expedov\u00e1ny po cel\u00e9m sv\u011bt\u011b v diskr\u00e9tn\u00edm, nen\u00e1padn\u00e9m balen\u00ed \u2013 na vn\u011bj\u0161\u00ed stran\u011b bal\u00edku nen\u00ed uveden n\u00e1zev l\u00e9ku. Platby kartou jsou sm\u011brov\u00e1ny prost\u0159ednictv\u00edm regulovan\u00e9ho procesoru (popisky na v\u00fdpisu zahrnuj\u00ed regulovan\u00e9ho procesora plateb kartou \u2013 nikdy \u201cMedsBase\u201d nebo n\u00e1zev l\u00e9ku). P\u0159ij\u00edm\u00e1me tak\u00e9 kryptom\u011bny a bankovn\u00ed p\u0159evody SEPA. Ka\u017ed\u00e1 objedn\u00e1vka je zaji\u0161t\u011bna na\u0161\u00ed politikou p\u0159eposl\u00e1n\u00ed.<\/p>\n

⚠️ EMA-restricted domperidone QT prolongation signal.<\/strong> Following a 2014 European review, domperidone is restricted to symptom relief of nausea\/vomiting at the lowest effective dose for the shortest duration (typically ≤ 7 days, max 30 mg\/day). Avoid in age > 60 unless benefits outweigh, in known QT prolongation, electrolyte disturbance (low K+\/Mg++), severe hepatic impairment, or with concurrent QT-prolonging or strong CYP3A4-inhibiting drugs (clarithromycin, ketoconazole, ritonavir). Hyperprolactinaemia and galactorrhoea may occur on prolonged use. Avoid in Parkinson’s disease (D2 antagonism worsens motor symptoms).<\/div>\n

When is the PPI + domperidone combination preferred over a PPI alone?<\/h2>\n

Plain PPI monotherapy (Omez, Pan, Razo etc.) is the standard for uncomplicated GERD or peptic ulcer. Adding domperidone helps when the dominant symptom is regurgitation<\/strong>, postprandial fullness<\/strong>, nausea<\/strong>, or when there is delayed gastric emptying<\/strong> (diabetic gastroparesis, post-vagotomy, idiopathic). For uncomplicated heartburn the simpler PPI is preferred — domperidone has a small but real cardiac signal that does not justify routine use.<\/p>\n

Pro\u010d objedn\u00e1vat z MedsBase<\/h3>\n

GR8-OD is supplied from a v\u00fdrobce certifikovan\u00e9ho WHO-GMP<\/strong>. Ka\u017ed\u00e1 objedn\u00e1vka je diskr\u00e9tn\u011b zas\u00edl\u00e1na po cel\u00e9m sv\u011bt\u011b a je pokryta na\u0161\u00ed Z\u00e1rukou op\u011btovn\u00e9ho odesl\u00e1n\u00ed<\/a> — if it does not arrive within 20 business days, we reship at no cost. Pantoprazole is one of the most prescribed PPIs worldwide and the SR-domperidone fraction adds gastric-emptying support without the IR-domperidone’s pulse-and-trough exposure profile.<\/p>\n

Mechanismus \u00fa\u010dinku<\/h2>\n

Pantoprazol<\/strong> is a substituted benzimidazole PPI that is activated by the acidic environment of the parietal-cell secretory canaliculus. Once activated it covalently binds Cys813 (and other cysteines) on the α-subunit of the H+\/K+-ATPase, irreversibly inhibiting acid secretion. Recovery requires synthesis of new pump protein (~24–48 h half-life of the pump itself).<\/p>\n

Domperidon<\/strong> is a peripheral dopamine D2 receptor antagonist that does not cross the blood-brain barrier in significant amounts (so it lacks the central D2-antagonism extrapyramidal signature of metoclopramide). In the gut it increases lower-oesophageal sphincter tone, accelerates gastric emptying, and improves antroduodenal coordination. It also blocks D2 receptors in the chemoreceptor trigger zone (which sits outside the BBB) producing antiemetic effect.<\/p>\n

Indikace<\/h2>\n