{"id":58947,"date":"2024-02-28T05:35:29","date_gmt":"2024-02-28T05:35:29","guid":{"rendered":"https:\/\/medsname.com\/wysolone\/"},"modified":"2026-04-30T10:24:06","modified_gmt":"2026-04-30T10:24:06","slug":"wysolone","status":"publish","type":"product","link":"https:\/\/medsbase.com\/cs\/product\/wysolone\/","title":{"rendered":"Wysolone"},"content":{"rendered":"<p><!-- medsbase-tldr-answer --><\/p>\n<div style=\"background:#fff8e1;border-left:4px solid #f5a623;padding:18px 22px;margin:0 0 24px 0;border-radius:4px;\">\n<h3 class=\"wp-block-heading\" style=\"margin:0 0 8px 0;font-size:16px;font-weight:700;\">&#9889; Quick Answer &mdash; What is Wysolone?<\/h3>\n<p style=\"margin:0;\"><strong>Wysolone<\/strong> is an oral tablet from Wyeth \/ Pfizer containing <strong>prednisolone<\/strong> &mdash; a medium-potency <strong>synthetic glucocorticoid<\/strong> with strong anti-inflammatory and immunosuppressive activity and limited mineralocorticoid effect. Available at <strong>5 mg, 10 mg and 20 mg<\/strong>. Used across a very wide range of inflammatory and autoimmune conditions (asthma, COPD exacerbations, rheumatoid arthritis, SLE, vasculitis, IBD flares, allergic reactions, polymyalgia rheumatica, giant cell arteritis, and many more). Dose and duration depend entirely on the condition. <strong>Never stop suddenly after more than 2&ndash;3 weeks of daily use<\/strong> &mdash; abrupt withdrawal can precipitate adrenal crisis because the drug suppresses the body&#39;s own cortisol production (HPA-axis suppression). Always taper under medical supervision. Common side effects include weight gain, fluid retention, mood change, insomnia, raised blood sugar, raised blood pressure, bone loss (osteoporosis), cataract and glaucoma, and increased infection risk.<\/p>\n<\/div>\n<p><!-- medsbase-specialist-strip --><\/p>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:16px 20px;margin:0 0 24px 0;border-radius:4px;font-size:14px;\"><strong>\u2695 L\u00e9k vy\u017eaduj\u00edc\u00ed odborn\u00fd dohled \u2014 nutn\u00fd klinick\u00fd dohled.<\/strong> Toto je z\u00e1va\u017en\u00fd imunomodula\u010dn\u00ed l\u00e9k se specifick\u00fdmi po\u017eadavky na p\u0159edl\u00e9\u010debn\u00e9 vy\u0161et\u0159en\u00ed, \u010dern\u00fdmi v\u00fdstrahami a povinn\u00fdm laboratorn\u00edm monitorov\u00e1n\u00edm. M\u011bl by b\u00fdt p\u0159edepisov\u00e1n a sledov\u00e1n revmatologem, gastroenterologem, dermatologem nebo jin\u00fdm odborn\u00edkem zku\u0161en\u00fdm s jeho u\u017e\u00edv\u00e1n\u00edm. Ne <strong>ne<\/strong> p\u0159edepisujte si ho sami, neupravujte d\u00e1vku ani neza\u010d\u00ednejte\/nep\u0159est\u00e1vejte bez pokyn\u016f p\u0159edepisuj\u00edc\u00edho l\u00e9ka\u0159e. V\u017edy poskytn\u011bte sv\u00e9mu o\u0161et\u0159uj\u00edc\u00edmu l\u00e9ka\u0159i aktu\u00e1ln\u00ed p\u0159edpis p\u0159ed objedn\u00e1n\u00edm z MedsBase.<\/div>\n<div class=\"medsbase-trust-strip\" style=\"background:#f4f6f8;border:1px solid #e1e4e8;border-radius:4px;padding:14px 18px;margin:18px 0;display:flex;flex-wrap:wrap;gap:14px;font-size:0.95em;\"><span>\u2705 <strong>WHO-GMP certifikov\u00e1no<\/strong> v\u00fdrobce<\/span><span>\ud83d\udce6 <strong>Diskr\u00e9tn\u00ed balen\u00ed<\/strong><\/span><span>\ud83c\udf0d <strong>Dod\u00e1n\u00ed po cel\u00e9m sv\u011bt\u011b<\/strong><\/span><span>\ud83d\udcac <a href=\"\/cs\/reviews\/\">1,400+ recenz\u00ed z\u00e1kazn\u00edk\u016f<\/a><\/span><\/div>\n<p class=\"medsbase-reship-line\" style=\"font-size:14px;color:#444;margin:8px 0 18px;\">\ud83d\udce6 Ka\u017ed\u00e1 objedn\u00e1vka je pokryta na\u0161\u00ed <a href=\"https:\/\/medsbase.com\/cs\/medsbase-re-shipment-assurance-policy\/\"><strong>Z\u00e1rukou op\u011btovn\u00e9ho odesl\u00e1n\u00ed<\/strong><\/a> \u2014 pokud va\u0161e z\u00e1silka nedoraz\u00ed do 20 pracovn\u00edch dn\u016f, p\u0159epos\u00edl\u00e1me ji.<\/p>\n<h3>Pro\u010d objedn\u00e1vat z MedsBase<\/h3>\n<p>Na\u0161e generick\u00e9 l\u00e9ky poch\u00e1zej\u00ed od v\u00fdrobc\u016f certifikovan\u00fdch WHO-GMP a jsou expedov\u00e1ny po cel\u00e9m sv\u011bt\u011b v diskr\u00e9tn\u00edm, nen\u00e1padn\u00e9m balen\u00ed \u2013 na vn\u011bj\u0161\u00ed stran\u011b bal\u00edku nen\u00ed uveden n\u00e1zev l\u00e9ku. Platby kartou jsou sm\u011brov\u00e1ny prost\u0159ednictv\u00edm regulovan\u00e9ho procesoru (popisky na v\u00fdpisu zahrnuj\u00ed regulovan\u00e9ho procesora plateb kartou \u2013 nikdy \u201cMedsBase\u201d nebo n\u00e1zev l\u00e9ku). P\u0159ij\u00edm\u00e1me tak\u00e9 kryptom\u011bny a bankovn\u00ed p\u0159evody SEPA. Ka\u017ed\u00e1 objedn\u00e1vka je zaji\u0161t\u011bna na\u0161\u00ed politikou p\u0159eposl\u00e1n\u00ed.<\/p>\n<h2 class=\"wp-block-heading\">What Is Wysolone?<\/h2>\n<p>Wysolone is an oral tablet manufactured by Wyeth \/ Pfizer containing <strong>prednisolone<\/strong> &mdash; a synthetic corticosteroid in the glucocorticoid class. Glucocorticoids are the most powerful broad-spectrum anti-inflammatory and immunosuppressive drugs available, with effects across almost every tissue and organ system.<\/p>\n<p>Wysolone is Wyeth\/Pfizer&#8217;s branded prednisolone &mdash; probably the most widely-prescribed oral corticosteroid in India and many other markets. The three strengths cover everything from physiological replacement to high-dose immunosuppression, allowing the same brand to be used across the full dosing range during titration and taper. Prednisolone has mostly glucocorticoid (anti-inflammatory) activity and minimal mineralocorticoid (fluid-retaining) activity, so it is preferred over hydrocortisone when the goal is to suppress inflammation rather than replace adrenal function. Prednisolone 5 mg is the standard reference dose. The physiological daily cortisol output of a healthy adult is approximately 5&ndash;7.5 mg prednisolone per day &mdash; any dose above that is &ldquo;supraphysiological&rdquo; and begins to suppress the hypothalamic-pituitary-adrenal (HPA) axis.<\/p>\n<h2 class=\"wp-block-heading\">How Does Wysolone Work?<\/h2>\n<p>Prednisolone enters cells, binds the <strong>intracellular glucocorticoid receptor<\/strong>, and the receptor-drug complex translocates to the nucleus where it alters transcription of hundreds of genes. The end result is a broad dampening of the inflammatory cascade:<\/p>\n<ul>\n<li><strong>Suppresses pro-inflammatory cytokines<\/strong> (IL-1, IL-6, TNF-&alpha;, IFN-&gamma;) and chemokines.<\/li>\n<li><strong>Stabilises lysosomal membranes<\/strong>, reducing release of proteolytic enzymes into tissue.<\/li>\n<li><strong>Inhibits phospholipase A<sub>2<\/sub><\/strong> via lipocortin, cutting off the prostaglandin and leukotriene pathways upstream.<\/li>\n<li><strong>Reduces capillary permeability<\/strong> and tissue oedema.<\/li>\n<li><strong>Suppresses B- and T-lymphocyte function<\/strong> and circulating lymphocyte counts (relative lymphopenia).<\/li>\n<li><strong>Reduces eosinophil and basophil activity<\/strong>, partially explaining the rapid effect in asthma, allergy and eosinophilic conditions.<\/li>\n<\/ul>\n<p>Clinical onset: symptomatic relief within <strong>hours to 1&ndash;2 days<\/strong> for most inflammatory conditions. Peak anti-inflammatory effect within 4&ndash;72 hours depending on dose and indication.<\/p>\n<h2 class=\"wp-block-heading\">Pou\u017eit\u00ed a indikace<\/h2>\n<p>Wysolone is used across an unusually wide range of clinical conditions because inflammation and immune over-activation underlie so many diseases:<\/p>\n<ul>\n<li><strong>Asthma exacerbations<\/strong> &mdash; short course (5&ndash;7 days) to break a flare<\/li>\n<li><strong>Exacerbace CHOPN<\/strong> &mdash; typically 5 days<\/li>\n<li><strong>Allergic reactions, angioedema, urticaria, severe contact dermatitis<\/strong><\/li>\n<li><strong>Revmatoidn\u00ed artritida<\/strong> &mdash; low-dose adjunct to DMARDs, bridge therapy during DMARD initiation<\/li>\n<li><strong>Syst\u00e9mov\u00fd lupus erythematodes (SLE)<\/strong> &mdash; flare management and maintenance<\/li>\n<li><strong>Polymyalgia rheumatica<\/strong> &mdash; medium-dose induction, slow taper over 18&ndash;24 months<\/li>\n<li><strong>Giant cell (temporal) arteritis<\/strong> &mdash; urgent high-dose therapy to prevent vision loss<\/li>\n<li><strong>Inflammatory bowel disease (IBD) flares<\/strong> &mdash; short courses for Crohn&#39;s or ulcerative colitis<\/li>\n<li><strong>Vasculitis<\/strong> (including ANCA-associated vasculitis) &mdash; induction and maintenance with steroid-sparing agents<\/li>\n<li><strong>Minimal-change disease and other nephrotic syndromes<\/strong><\/li>\n<li><strong>Autoimmune hepatitis, autoimmune haemolytic anaemia, ITP<\/strong><\/li>\n<li><strong>Bullous skin diseases<\/strong> (pemphigus vulgaris, bullous pemphigoid)<\/li>\n<li><strong>Optic neuritis, MS relapses<\/strong> (typically IV methylprednisolone followed by oral taper)<\/li>\n<li><strong>Covid-19 hospitalisation requiring oxygen<\/strong> (RECOVERY trial protocol)<\/li>\n<li><strong>Adren\u00e1ln\u00ed insuficience<\/strong> &mdash; hydrocortisone is preferred, but prednisolone is used when once-daily dosing is needed<\/li>\n<\/ul>\n<p>Wysolone is <strong>ne<\/strong> appropriate for: undiagnosed joint pain (treat the diagnosis, not the symptom), isolated mild eczema (topicals first), or long-term management of conditions where safer disease-modifying alternatives exist.<\/p>\n<h2 class=\"wp-block-heading\">Wysolone Dosage and How to Take<\/h2>\n<p>Wysolone is supplied at <strong>5 mg, 10 mg and 20 mg<\/strong>. Dose varies enormously by indication &mdash; these are typical adult starting ranges; always follow the prescriber&#39;s regimen for the specific condition.<\/p>\n<h3 class=\"wp-block-heading\">Typical dosing by indication (prednisolone equivalent)<\/h3>\n<table style=\"border-collapse:collapse;width:100%;margin:12px 0;\">\n<thead>\n<tr style=\"background:#2c7cb0;color:#fff;\">\n<th style=\"padding:10px;border:1px solid #ddd;text-align:left;\">Indikace<\/th>\n<th style=\"padding:10px;border:1px solid #ddd;text-align:left;\">Typical starting dose<\/th>\n<th style=\"padding:10px;border:1px solid #ddd;text-align:left;\">D\u00e9lka<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td style=\"padding:10px;border:1px solid #ddd;\">Asthma \/ COPD exacerbation<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">40&ndash;50 mg once daily<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">5&ndash;7 days, no taper needed<\/td>\n<\/tr>\n<tr>\n<td style=\"padding:10px;border:1px solid #ddd;\">Polymyalgia rheumatica<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">15&ndash;20 mg once daily<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Slow taper over 18&ndash;24 months<\/td>\n<\/tr>\n<tr>\n<td style=\"padding:10px;border:1px solid #ddd;\">Giant cell arteritis (no visual symptoms)<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">40&ndash;60 mg once daily<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Slow taper over 18&ndash;24 months<\/td>\n<\/tr>\n<tr>\n<td style=\"padding:10px;border:1px solid #ddd;\">SLE flare (moderate)<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">20&ndash;40 mg once daily<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Taper to lowest effective dose<\/td>\n<\/tr>\n<tr>\n<td style=\"padding:10px;border:1px solid #ddd;\">Rheumatoid arthritis (low-dose adjunct)<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">5&ndash;7.5 mg once daily<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Bridge during DMARD initiation; taper off over 3&ndash;6 months<\/td>\n<\/tr>\n<tr>\n<td style=\"padding:10px;border:1px solid #ddd;\">IBD flare (moderate)<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">40&ndash;60 mg once daily<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Taper over 8&ndash;12 weeks<\/td>\n<\/tr>\n<tr>\n<td style=\"padding:10px;border:1px solid #ddd;\">T\u011b\u017ek\u00e1 alergick\u00e1 reakce \/ angioed\u00e9m<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">40&ndash;50 mg once daily<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">3\u20135 dn\u00ed<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h3 class=\"wp-block-heading\">How to Take Wysolone Properly<\/h3>\n<ol>\n<li><strong>U\u017e\u00edvejte celou denn\u00ed d\u00e1vku r\u00e1no s sn\u00eddan\u00ed<\/strong> (usually 7&ndash;9 a.m.). Morning dosing mimics the body&#39;s natural cortisol peak, minimises HPA-axis suppression, and reduces insomnia.<\/li>\n<li><strong>V\u017edy u\u017e\u00edvejte s j\u00eddlem<\/strong> &mdash; substantially reduces gastric irritation and GI bleed risk.<\/li>\n<li><strong>Tablety polykejte vcelku se sklenic\u00ed vody.<\/strong> Tablets may be split if scored. Enteric-coated variants (EC prednisolone) must not be crushed.<\/li>\n<li><strong>Never stop abruptly after more than 2&ndash;3 weeks<\/strong> of daily use. Abrupt withdrawal can precipitate an adrenal crisis (hypotension, weakness, nausea, hypoglycaemia, potentially death). Always taper under medical supervision.<\/li>\n<li><strong>Never skip a dose during acute illness<\/strong> &mdash; the body&#39;s cortisol demand rises during infection, injury or surgery. In fact, you may need a temporary dose increase (&ldquo;sick-day rules&rdquo;); ask your prescriber for written guidance.<\/li>\n<li><strong>M\u011bjte u sebe steroidn\u00ed kartu<\/strong> if taking any corticosteroid for more than 3 weeks &mdash; it alerts emergency clinicians to your HPA suppression risk if you are incapacitated.<\/li>\n<li><strong>Ochrana kost\u00ed od za\u010d\u00e1tku<\/strong> &mdash; for courses expected to last 3+ months at 7.5 mg\/day or higher, calcium + vitamin D are standard, and a bisphosphonate should be considered from day one in post-menopausal women and older men. Do not wait for a DEXA scan to start protection.<\/li>\n<li><strong>Monitor blood sugar, blood pressure and weight.<\/strong> Steroids raise all three. Pre-existing diabetes usually needs temporary insulin or tighter oral-hypoglycaemic adjustment during a course.<\/li>\n<li><strong>Vaccinations<\/strong> &mdash; avoid live vaccines during and for 3 months after stopping a course of 20 mg\/day or more for 2 weeks or longer. Inactivated vaccines (flu, pneumococcal, COVID-19) are fine and recommended.<\/li>\n<li><strong>Tell every healthcare provider you take steroids<\/strong> &mdash; especially before surgery, anaesthesia, or in any emergency.<\/li>\n<\/ol>\n<h2 class=\"wp-block-heading\">Stopping Wysolone &mdash; Why Tapering Matters<\/h2>\n<p>Exogenous corticosteroids suppress the hypothalamic-pituitary-adrenal (HPA) axis &mdash; the brain stops signalling the adrenal glands to make cortisol because the incoming drug is doing the job. When treatment lasts long enough for suppression to set in, the adrenal glands atrophy and need weeks to months to recover. If the drug is stopped abruptly, the patient has no cortisol &mdash; a life-threatening adrenal crisis can follow.<\/p>\n<ul>\n<li><strong>Courses shorter than 2&ndash;3 weeks<\/strong> at any dose &mdash; can usually be stopped without a taper.<\/li>\n<li><strong>Any course longer than 3 weeks<\/strong>, nebo <strong>any course above 40 mg\/day<\/strong> for more than 1 week &mdash; requires a supervised taper.<\/li>\n<li><strong>Typick\u00e9 sni\u017eov\u00e1n\u00ed d\u00e1vky<\/strong>: reduce by 10&ndash;20% of current dose every 1&ndash;2 weeks until reaching physiological replacement (approximately 5&ndash;7.5 mg prednisolone per day), then smaller steps of 1 mg every 2&ndash;4 weeks. Total taper duration depends on original course length.<\/li>\n<li><strong>Pokud se objev\u00ed abstinen\u010dn\u00ed p\u0159\u00edznaky<\/strong> (\u00fanava, nevolnost, bolesti kloub\u016f, z\u00e1vrat\u011b, n\u00e1vrat onemocn\u011bn\u00ed), vra\u0165te se o jeden krok zp\u011bt a sni\u017eujte d\u00e1vku pomaleji.<\/li>\n<li><strong>After long courses (&gt; 3 months)<\/strong>, HPA recovery may take 6&ndash;12 months. Synacthen (ACTH stimulation) testing can guide when physiological replacement can safely be stopped.<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Side Effects of Wysolone<\/h2>\n<p>Corticosteroid side effects are generally dose- and duration-dependent. Short courses (&lt; 2 weeks) cause few problems; long-term use causes progressive metabolic, bone, skin, eye and infection changes.<\/p>\n<p><strong>Short-term (days to weeks), common:<\/strong><\/p>\n<ul>\n<li>Zv\u00fd\u0161en\u00e1 chu\u0165 k j\u00eddlu, p\u0159ib\u00fdv\u00e1n\u00ed na v\u00e1ze<\/li>\n<li>Mood elevation, occasionally agitation, insomnia, psychosis (higher doses)<\/li>\n<li>Raised blood sugar (may unmask or worsen diabetes)<\/li>\n<li>Raised blood pressure, fluid retention<\/li>\n<li>P\u00e1len\u00ed \u017e\u00e1hy a dyspepsie<\/li>\n<li>Vzplanut\u00ed akn\u00e9<\/li>\n<li>Menstrua\u010dn\u00ed nepravidelnost<\/li>\n<li>Mild raised white cell count (especially neutrophils) &mdash; not infection<\/li>\n<\/ul>\n<p><strong>St\u0159edn\u011bdob\u00e9 \u00fa\u010dinky (t\u00fddny a\u017e m\u011bs\u00edce):<\/strong><\/p>\n<ul>\n<li>Cushingoidn\u00ed vzhled \u2014 m\u011bs\u00ed\u010dkovit\u00fd obli\u010dej, centr\u00e1ln\u00ed obezita, buvol\u00ed hrb<\/li>\n<li>Thinning of skin, easy bruising, striae, delayed wound healing<\/li>\n<li>Muscle weakness (steroid myopathy &mdash; proximal leg weakness characteristic)<\/li>\n<li>Increased susceptibility to infection &mdash; bacterial, viral, fungal, opportunistic<\/li>\n<li>Cataract (especially posterior subcapsular)<\/li>\n<li>Raised intraocular pressure and steroid-induced glaucoma<\/li>\n<li>Avascular necrosis of the femoral head (especially high doses, alcohol co-use)<\/li>\n<\/ul>\n<p><strong>Dlouhodob\u00e9 \u00fa\u010dinky (m\u011bs\u00edce a\u017e roky):<\/strong><\/p>\n<ul>\n<li>Osteoporosis and fragility fractures &mdash; begins within the first 6 months; most rapid bone loss is in the first year<\/li>\n<li>P\u0159etrv\u00e1vaj\u00edc\u00ed diabetes mellitus<\/li>\n<li>Adrenal atrophy and HPA-axis suppression<\/li>\n<li>Potla\u010den\u00ed r\u016fstu u d\u011bt\u00ed<\/li>\n<li>Persistent hypertension and cardiovascular risk<\/li>\n<li>Severe immunosuppression with opportunistic infection (Pneumocystis, TB reactivation, atypical fungal)<\/li>\n<\/ul>\n<p><strong>Vz\u00e1cn\u00e9, ale z\u00e1va\u017en\u00e9 \u2014 vy\u017eaduje neodkladn\u00e9 vy\u0161et\u0159en\u00ed:<\/strong><\/p>\n<ul>\n<li>Gastrointestin\u00e1ln\u00ed krv\u00e1cen\u00ed nebo perforace (zejm\u00e9na p\u0159i sou\u010dasn\u00e9m u\u017e\u00edv\u00e1n\u00ed NSAID)<\/li>\n<li>Severe psychiatric reaction, psychosis, mania<\/li>\n<li>Severe infection (TB reactivation, disseminated VZV, Pneumocystis pneumonia)<\/li>\n<li>Adrenal crisis during\/after withdrawal (hypotension, weakness, severe nausea, confusion)<\/li>\n<li>Sudden vision changes &mdash; possible steroid-induced glaucoma or cataract<\/li>\n<li>Unexpected hip or knee pain &mdash; possible avascular necrosis<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Varov\u00e1n\u00ed a opat\u0159en\u00ed<\/h2>\n<ul>\n<li><strong>Active infection<\/strong> &mdash; steroids mask signs of infection and worsen outcomes. Do not use for undiagnosed fever. In established infection, steroids may still be indicated (e.g. severe COVID-19) but require specialist judgement.<\/li>\n<li><strong>Latentn\u00ed TBC<\/strong> &mdash; screen before any long course; consider isoniazid cover if positive.<\/li>\n<li><strong>Diabetes<\/strong> &mdash; expect significant worsening; up-titrate oral hypoglycaemics or insulin during the course.<\/li>\n<li><strong>Hypertenze, srde\u010dn\u00ed selh\u00e1n\u00ed<\/strong> &mdash; steroids retain fluid and raise BP; increase diuretic or antihypertensive as needed.<\/li>\n<li><strong>Peptic ulcer disease, history of GI bleed, NSAID co-prescription<\/strong> &mdash; co-prescribe a PPI for any moderate-to-long course.<\/li>\n<li><strong>Riziko osteopor\u00f3zy<\/strong> &mdash; post-menopausal women, older men, prior fragility fracture, low BMI. Start calcium + vitamin D immediately; consider bisphosphonate from day one for courses &gt; 3 months at &gt; 7.5 mg\/day.<\/li>\n<li><strong>Glaucoma and cataract history<\/strong> \u2014 ro\u010dn\u00ed kontrola u oftalmologa u dlouhodob\u00fdch u\u017eivatel\u016f.<\/li>\n<li><strong>Psychiatrick\u00e1 anamn\u00e9za<\/strong> &mdash; steroids can trigger mania, depression, psychosis. Use the lowest effective dose; warn the patient and family.<\/li>\n<li><strong>T\u011bhotenstv\u00ed<\/strong> &mdash; prednisolone crosses the placenta in small amounts (about 10%) because of extensive metabolism; considered compatible with pregnancy when indicated, particularly for maternal autoimmune disease. Prednisolone is preferred over dexamethasone or betamethasone in pregnancy for maternal indications.<\/li>\n<li><strong>Kojen\u00ed<\/strong> &mdash; compatible at doses up to 20 mg\/day; higher doses transfer in small amounts into milk but clinical significance is minimal.<\/li>\n<li><strong>D\u011bti<\/strong> &mdash; growth suppression is a real concern with prolonged use; monitor height and weight, use minimum effective dose for minimum duration.<\/li>\n<li><strong>Star\u0161\u00ed pacienti<\/strong> &mdash; higher risk of osteoporosis, diabetes, infection, psychiatric effects. Lower doses and shorter durations when possible.<\/li>\n<li><strong>\u017div\u00e9 vakc\u00edny<\/strong> &mdash; contraindicated at doses &ge; 20 mg\/day for 2+ weeks, and for 3 months after stopping.<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Contraindications &mdash; Who Should NOT Take Wysolone<\/h2>\n<ul>\n<li>Known hypersensitivity to prednisolone or any tablet excipient<\/li>\n<li>Systemic fungal infection (unless specifically covered by antifungal therapy)<\/li>\n<li>Untreated active infection (bacterial, viral, mycobacterial, parasitic) without appropriate treatment<\/li>\n<li>Recent administration of a live vaccine (or planned live vaccine) at immunosuppressive doses<\/li>\n<li>Cerebr\u00e1ln\u00ed mal\u00e1rie (kortikosteroidy zhor\u0161uj\u00ed progn\u00f3zu)<\/li>\n<li>T\u011b\u017ek\u00e1, nestabiln\u00ed psychiatrick\u00e1 porucha bez psychiatrick\u00e9ho spolup\u00e9rov\u00e1n\u00ed (relativn\u00ed)<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Interakce s l\u00e9\u010divy<\/h2>\n<table style=\"border-collapse:collapse;width:100%;margin:12px 0;\">\n<thead>\n<tr style=\"background:#2c7cb0;color:#fff;\">\n<th style=\"padding:10px;border:1px solid #ddd;text-align:left;\">Kombinujte s<\/th>\n<th style=\"padding:10px;border:1px solid #ddd;text-align:left;\">\u00da\u010dinek<\/th>\n<th style=\"padding:10px;border:1px solid #ddd;text-align:left;\">Co d\u011blat<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td style=\"padding:10px;border:1px solid #ddd;\">NSAID (ibuprofen, diklofenak, naproxen)<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Major additive GI ulceration and bleed risk<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">P\u0159edepi\u0161te sou\u010dasn\u011b PPI; vyhn\u011bte se dlouhodob\u00e9 kombinaci.<\/td>\n<\/tr>\n<tr>\n<td style=\"padding:10px;border:1px solid #ddd;\">Warfarin, DOAC<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Variable &mdash; steroids can raise or lower INR; increased GI bleed risk<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Monitor INR more frequently during dose changes.<\/td>\n<\/tr>\n<tr>\n<td style=\"padding:10px;border:1px solid #ddd;\">Diabetes medications (insulin, metformin, sulfonylureas, GLP-1 agonists, SGLT2 inhibitors)<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Steroidy v\u00fdznamn\u011b zvy\u0161uj\u00ed hladinu gluk\u00f3zy v krvi<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Expect 1.5&ndash;3&times; higher insulin needs during course; up-titrate orals. Drop back down as dose tapers.<\/td>\n<\/tr>\n<tr>\n<td style=\"padding:10px;border:1px solid #ddd;\">Antihypertensives, diuretics<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Steroids retain fluid, raise BP<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Monitor BP; up-titrate antihypertensives as needed.<\/td>\n<\/tr>\n<tr>\n<td style=\"padding:10px;border:1px solid #ddd;\">L\u00e9ky zp\u016fsobuj\u00edc\u00ed ztr\u00e1tu drasl\u00edku (thiazidy, kli\u010dkov\u00e1 diuretika, amfotericin)<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Aditivn\u00ed hypokal\u00e9mie<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Monitor potassium; supplement as needed.<\/td>\n<\/tr>\n<tr>\n<td style=\"padding:10px;border:1px solid #ddd;\">Siln\u00e9 inhibitory CYP3A4 (ketokonazol, ritonavir, klarithromycin)<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Raise prednisolone levels<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Watch for amplified steroid side effects; consider lower dose.<\/td>\n<\/tr>\n<tr>\n<td style=\"padding:10px;border:1px solid #ddd;\">Siln\u00ed induktory CYP3A4 (rifampicin, fenytoin, karbamazepin, t\u0159ezalka te\u010dkovan\u00e1)<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Lower prednisolone levels &mdash; loss of disease control<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">May need 2&ndash;3&times; higher steroid dose; specialist review.<\/td>\n<\/tr>\n<tr>\n<td style=\"padding:10px;border:1px solid #ddd;\">\u017div\u00e9 vakc\u00edny (MMR, plan\u00e9 ne\u0161tovice, \u017elut\u00e1 zimnice, BCG, Zostavax, \u017eiv\u00e1 nosn\u00ed ch\u0159ipka)<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Risk of disseminated vaccine-strain infection at immunosuppressive doses<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Contraindicated at &ge; 20 mg\/day for 2+ weeks, and for 3 months after. Inactivated vaccines are fine.<\/td>\n<\/tr>\n<tr>\n<td style=\"padding:10px;border:1px solid #ddd;\">Digoxin<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Hypokalaemia from steroids increases digoxin toxicity risk<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Monitor potassium; consider potassium-sparing diuretic.<\/td>\n<\/tr>\n<tr>\n<td style=\"padding:10px;border:1px solid #ddd;\">Other immunosuppressants (methotrexate, azathioprine, cyclosporine, biologics, JAK inhibitors)<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Aditivn\u00ed riziko infekce<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Combinations are common and often necessary (e.g. steroid + DMARD) &mdash; specialist supervision, infection-prophylaxis consideration.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2 class=\"wp-block-heading\">Pokyny k uchov\u00e1v\u00e1n\u00ed<\/h2>\n<ul>\n<li>Skladujte p\u0159i pokojov\u00e9 teplot\u011b, <strong>pod 25\u00b0C<\/strong>, chr\u00e1n\u011bno p\u0159ed sv\u011btlem a vlhkost\u00ed.<\/li>\n<li>Tablety uchov\u00e1vejte v p\u016fvodn\u00edm blistru a\u017e do pou\u017eit\u00ed.<\/li>\n<li>Neskladujte v koupeln\u011b \u2013 vlhkost zkracuje trvanlivost.<\/li>\n<li>Uchov\u00e1vejte mimo dosah d\u011bt\u00ed.<\/li>\n<li>Nepou\u017e\u00edvejte po uplynut\u00ed data expirace uveden\u00e9ho na obalu.<\/li>\n<li>Nepou\u017eit\u00e9 tablety vra\u0165te do l\u00e9k\u00e1rny k likvidaci.<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Souvisej\u00edc\u00ed alternativy na MedsBase<\/h2>\n<p>Dal\u0161\u00ed l\u00e9ky pou\u017e\u00edvan\u00e9 v protiz\u00e1n\u011btliv\u00e9 a autoimunitn\u00ed p\u00e9\u010di skladem vedle tohoto produktu:<\/p>\n<ul>\n<li><a href=\"https:\/\/medsbase.com\/cs\/barinat\/\"><strong>Barinat (baricitinib 2 \/ 4 mg) \u2014 inhibitor JAK1\/2 pro RA<\/strong><\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/tofe\/\"><strong>Tofe (tofacitinib 5 mg) \u2014 inhibitor JAK1\/3 pro RA, UC, PsA<\/strong><\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/azoran\/\"><strong>Azoran (azathioprin 50 mg) \u2014 klasick\u00e9 imunosupresivum DMARD<\/strong><\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/lefuheal\/\"><strong>Lefuheal (leflunomid) \u2014 peror\u00e1ln\u00ed DMARD pro revmatoidn\u00ed artritidu<\/strong><\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/conimune-me\/\"><strong>Conimune ME (cyklosporin) \u2014 inhibitor kalcineurinu<\/strong><\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/medrol\/\"><strong>Medrol (methylprednisolon 4 \/ 8 \/ 16 mg) \u2014 peror\u00e1ln\u00ed kortikosteroid<\/strong><\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/predniheal\/\"><strong>Predniheal (prednisolon) \u2014 peror\u00e1ln\u00ed kortikosteroid<\/strong><\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/hisone\/\"><strong>Hisone (hydrokortizon) \u2014 fyziologick\u00e1 n\u00e1hradn\u00ed terapie steroidy<\/strong><\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/budez-cr\/\"><strong>Budez CR (budesonid) \u2014 st\u0159evn\u011b p\u016fsob\u00edc\u00ed kortikosteroid pro Crohnovu chorobu<\/strong><\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/kenacort\/\"><strong>Kenacort (triamcinolon) \u2014 syst\u00e9mov\u00fd kortikosteroid<\/strong><\/a><\/li>\n<\/ul>\n<p>Prozkoumejte celou <a href=\"https:\/\/medsbase.com\/cs\/anti-inflammatory-autoimmune-care\/\">Protiz\u00e1n\u011btliv\u00e1 a autoimunitn\u00ed p\u00e9\u010de<\/a> kategorie.<\/p>\n<h2 id=\"faqs\">\u010casto kladen\u00e9 dotazy<\/h2>\n<h3 class=\"wp-block-heading\">What is the &ldquo;steroid equivalent dose&rdquo; of Wysolone?<\/h3>\n<p>Glucocorticoids are compared by their anti-inflammatory potency. Rough equivalents: <strong>hydrocortisone 20 mg &asymp; prednisolone 5 mg &asymp; methylprednisolone 4 mg &asymp; dexamethasone 0.75 mg &asymp; betamethasone 0.75 mg<\/strong>. Prednisolone 5 mg is the standard reference dose. When switching between oral steroids (for example, hospital dexamethasone to outpatient prednisolone), use this conversion to keep the anti-inflammatory dose the same.<\/p>\n<h3 class=\"wp-block-heading\">Why must I take Wysolone in the morning?<\/h3>\n<p>The body&#39;s own cortisol peaks between 6 and 9 a.m. Morning dosing mimics this natural pattern, causes less HPA-axis suppression than evening dosing, and reduces insomnia. Once-daily morning dosing is standard; twice-daily dosing is reserved for severe or rapidly-worsening disease, at the cost of more HPA suppression.<\/p>\n<h3 class=\"wp-block-heading\">Why can&#39;t I just stop Wysolone if I feel better?<\/h3>\n<p>After more than about 2&ndash;3 weeks of daily dosing, the adrenal glands stop making their own cortisol because the pituitary sees plenty of it arriving from the tablet. If you stop abruptly, the adrenal glands cannot switch back on fast enough &mdash; you have no cortisol for hours to days, which can cause an adrenal crisis (collapse, low blood pressure, severe nausea, confusion, potentially death). Always taper under medical supervision.<\/p>\n<h3 class=\"wp-block-heading\">How do I protect my bones on Wysolone?<\/h3>\n<p>Start calcium 1,000&ndash;1,200 mg\/day + vitamin D 800&ndash;1,000 IU\/day from day one. For courses expected to last more than 3 months at 7.5 mg\/day or higher, a weekly bisphosphonate (alendronate or risedronate) or annual zoledronic acid should be considered from the start in post-menopausal women and older men &mdash; do not wait for a DEXA scan. Weight-bearing exercise, smoking cessation, moderate alcohol, and adequate protein intake all help.<\/p>\n<h3 class=\"wp-block-heading\">Will Wysolone give me diabetes?<\/h3>\n<p>Corticosteroids raise blood glucose and can unmask latent diabetes or worsen existing diabetes. Expect fasting glucose to rise within days of starting any moderate-dose course. Check fasting glucose or HbA1c before starting; monitor during; and be ready to up-titrate oral hypoglycaemics or add temporary insulin. Steroid-induced diabetes during a short course usually resolves within weeks of tapering off; steroid use for months to years can cause persistent diabetes.<\/p>\n<h3 class=\"wp-block-heading\">Can I drink alcohol on Wysolone?<\/h3>\n<p>Moderate alcohol (up to 1&ndash;2 units\/day) is generally safe on short-to-medium steroid courses, but combined steroid + NSAID + alcohol is a major risk factor for GI bleed and ulcer. Higher alcohol intake during long-term steroid therapy also increases risk of avascular necrosis of the hip. Keep alcohol low during any steroid course &mdash; and avoid entirely if taking concomitant NSAIDs or if you have a history of GI bleed.<\/p>\n<h3 class=\"wp-block-heading\">What if I get an infection while on Wysolone?<\/h3>\n<p>Steroids suppress both the immune response and the outward signs of infection (fever may be blunted, symptoms less obvious). Any unexplained fever, productive cough, new pain, severe fatigue or malaise on Wysolone should be reviewed promptly by a clinician. During acute illness you may need a temporary DOSE INCREASE (&ldquo;stress dose&rdquo;) rather than a dose reduction &mdash; your prescriber should have given you sick-day rules. Do not stop the steroid when you are ill.<\/p>\n<h3 class=\"wp-block-heading\">Can I have live vaccines on Wysolone?<\/h3>\n<p><strong>No &mdash; at immunosuppressive doses.<\/strong> Live vaccines (MMR, varicella, yellow fever, BCG, live nasal flu, live Zostavax shingles vaccine) are contraindicated at 20 mg\/day or more of prednisolone for 2 weeks or longer, and for 3 months after stopping. Inactivated vaccines &mdash; annual flu jab, pneumococcal, COVID-19, Shingrix recombinant shingles vaccine, HPV &mdash; are fine and recommended. Plan your travel vaccinations and Shingrix dose before starting a prolonged course.<\/p>\n<h3 class=\"wp-block-heading\">What is a &ldquo;steroid card&rdquo; and do I need one?<\/h3>\n<p>A steroid card is a small card you carry stating that you are on long-term corticosteroid therapy. It warns emergency clinicians and anaesthetists that you have HPA-axis suppression and may need stress-dose steroid cover during surgery, trauma or severe illness. You should carry one if you have been on any oral corticosteroid for more than 3 weeks. Pharmacies can issue one on request.<\/p>\n<h3 class=\"wp-block-heading\">Pro\u010d objedn\u00e1vat z MedsBase<\/h3>\n<p>Wysolone is supplied through a WHO-GMP certified manufacturer with full COA documentation. We ship worldwide in plain, discreet packaging, and every order is covered by our <a href=\"\/cs\/medsbase-re-shipment-assurance-policy\/\">Z\u00e1rukou op\u011btovn\u00e9ho odesl\u00e1n\u00ed<\/a>. V\u00e1\u0161 popis transakce p\u0159i platb\u011b kartou zobrazuje regulovan\u00e9ho zpracovatele plateb (regulovan\u00e9ho zpracovatele plateb kartou), nikdy \u201cMedsBase\u201d nebo n\u00e1zev l\u00e9ku.<\/p>\n<p><!-- medsbase-related-alts-v1 --><\/p>\n<h3 class=\"wp-block-heading\">Dal\u0161\u00ed protiz\u00e1n\u011btliv\u00e9 a autoimunitn\u00ed l\u00e9ky<\/h3>\n<p>If Wysolone does not suit your situation, the following options are available in this category:<\/p>\n<ul>\n<li><a href=\"https:\/\/medsbase.com\/cs\/predniheal\/\">Predniheal (Prednisolone 5\/10\/20\/40 mg, Healing Pharma) \u2014 wider strength range<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/medrol\/\">Medrol (Methylprednisolone 4\/8\/16 mg, Pfizer) \u2014 slightly more potent<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/kenacort\/\">Kenacort (Triamcinolone 4 mg, Abbott) \u2014 no fluid retention<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/tricort\/\">Tricort (Triamcinolon 4 mg, Cipla)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/hisone\/\">Hisone (Hydrocortisone 5\/10\/20 mg) \u2014 physiological replacement<\/a><\/li>\n<\/ul>","protected":false},"excerpt":{"rendered":"<p>\u2705 Sni\u017euje z\u00e1n\u011bt<br \/>\n\u2705 Manages autoimmune conditions<br \/>\n\u2705 Zm\u00edr\u0148uje alergick\u00e9 reakce<br \/>\n\u2705 Kontroluje p\u0159\u00edznaky astmatu<br \/>\n\u2705 L\u00e9\u010d\u00ed ko\u017en\u00ed poruchy<\/p>\n<p>Wysolone contains Prednisolone.<\/p>","protected":false},"featured_media":58948,"comment_status":"open","ping_status":"open","template":"","meta":[],"product_brand":[],"product_cat":[3897,3141,3223],"product_tag":[4598,4600],"class_list":{"0":"post-58947","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-anti-inflammatory-autoimmune-care","7":"product_cat-category-overview","8":"product_cat-chronic-conditions","9":"product_tag-prednisolone","10":"product_tag-wysolone","12":"first","13":"instock","14":"shipping-taxable","15":"purchasable","16":"product-type-variable","17":"has-default-attributes"},"acf":[],"_links":{"self":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product\/58947","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/comments?post=58947"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/media\/58948"}],"wp:attachment":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/media?parent=58947"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product_brand?post=58947"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product_cat?post=58947"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product_tag?post=58947"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}