{"id":59004,"date":"2024-02-28T05:37:46","date_gmt":"2024-02-28T05:37:46","guid":{"rendered":"https:\/\/medsname.com\/reglan\/"},"modified":"2026-04-30T10:24:05","modified_gmt":"2026-04-30T10:24:05","slug":"reglan","status":"publish","type":"product","link":"https:\/\/medsbase.com\/cs\/product\/reglan\/","title":{"rendered":"Reglan"},"content":{"rendered":"<p><!-- medsbase-tldr-answer --><\/p>\n<div style=\"background:#fff8e1;border-left:4px solid #f5a623;padding:18px 22px;margin:0 0 24px 0;border-radius:4px;\">\n<h3 class=\"wp-block-heading\" style=\"margin:0 0 8px 0;font-size:16px;font-weight:700;\">\u26a1 Rychl\u00e1 odpov\u011b\u010f \u2014 Co je Reglan?<\/h3>\n<p style=\"margin:0;\"><strong>Reglan<\/strong> je metoclopramid 10 mg \u2014 centr\u00e1ln\u011b a perifern\u011b p\u016fsob\u00edc\u00ed antagonista dopaminov\u00e9ho receptoru D2 pou\u017e\u00edvan\u00fd jako antiemetikum a prokinetikum. Zrychluje vyprazd\u0148ov\u00e1n\u00ed \u017ealudku, zvy\u0161uje tonus doln\u00edho j\u00edcnov\u00e9ho sv\u011bra\u010de a blokuje spou\u0161t\u011bc\u00ed z\u00f3nu chemoreceptor\u016f. Indikace zahrnuj\u00ed nevolnost\/zvracen\u00ed (poopera\u010dn\u00ed, jako dopln\u011bk chemoterapie, spojen\u00e9 s migr\u00e9nou), gastroparezi a prevenci aspirace. Standardn\u00ed d\u00e1vka: <strong>10 mg t\u0159ikr\u00e1t denn\u011b p\u0159ed j\u00eddlem, maxim\u00e1ln\u011b po dobu 5 dn\u016f (FDA) nebo 12 t\u00fddn\u016f (v\u00fdjimka EMA pro gastroparezi)<\/strong>. V\u00fdrobce certifikovan\u00fd WHO-GMP.<\/p>\n<\/div>\n<div class=\"medsbase-trust-strip\" style=\"background:#f5f6f8;border:1px solid #e1e4e8;border-radius:6px;padding:14px 18px;margin:24px 0;font-size:14px;\"><strong>Pro\u010d objedn\u00e1vat z MedsBase:<\/strong> \u2714 <strong>v\u00fdrobce certifikovan\u00e9ho WHO-GMP<\/strong> \u2714 Diskr\u00e9tn\u00ed balen\u00ed \u2714 Celosv\u011btov\u00e1 doprava \u2714 <a href=\"https:\/\/medsbase.com\/cs\/reviews\/\">Ov\u011b\u0159en\u00e9 recenze z\u00e1kazn\u00edk\u016f (1 400+ z\u00e1kazn\u00edk\u016f)<\/a><\/div>\n<p class=\"medsbase-reship-line\" style=\"font-size:14px;color:#444;margin:8px 0 18px;\">\ud83d\udce6 Ka\u017ed\u00e1 objedn\u00e1vka je pokryta na\u0161\u00ed <a href=\"https:\/\/medsbase.com\/cs\/medsbase-re-shipment-assurance-policy\/\"><strong>Z\u00e1rukou op\u011btovn\u00e9ho odesl\u00e1n\u00ed<\/strong><\/a> \u2014 pokud va\u0161e z\u00e1silka nedoraz\u00ed do 20 pracovn\u00edch dn\u016f, p\u0159epos\u00edl\u00e1me ji.<\/p>\n<h3>Pro\u010d objedn\u00e1vat z MedsBase<\/h3>\n<p>Na\u0161e generick\u00e9 l\u00e9ky poch\u00e1zej\u00ed od v\u00fdrobc\u016f certifikovan\u00fdch WHO-GMP a jsou expedov\u00e1ny po cel\u00e9m sv\u011bt\u011b v diskr\u00e9tn\u00edm, nen\u00e1padn\u00e9m balen\u00ed \u2013 na vn\u011bj\u0161\u00ed stran\u011b bal\u00edku nen\u00ed uveden n\u00e1zev l\u00e9ku. Platby kartou jsou sm\u011brov\u00e1ny prost\u0159ednictv\u00edm regulovan\u00e9ho procesoru (popisky na v\u00fdpisu zahrnuj\u00ed regulovan\u00e9ho procesora plateb kartou \u2013 nikdy \u201cMedsBase\u201d nebo n\u00e1zev l\u00e9ku). P\u0159ij\u00edm\u00e1me tak\u00e9 kryptom\u011bny a bankovn\u00ed p\u0159evody SEPA. Ka\u017ed\u00e1 objedn\u00e1vka je zaji\u0161t\u011bna na\u0161\u00ed politikou p\u0159eposl\u00e1n\u00ed.<\/p>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:14px 18px;margin:18px 0;border-radius:4px;\"><strong>\u26a0\ufe0f FDA varov\u00e1n\u00ed v \u010dern\u00e9 sk\u0159\u00ed\u0148ce \u2014 tardivn\u00ed dyskineze.<\/strong> Metoclopramid m\u016f\u017ee zp\u016fsobit tardivn\u00ed dyskinezi, mimovoln\u00ed pohybovou poruchu, kter\u00e1 m\u016f\u017ee b\u00fdt nevratn\u00e1. Riziko stoup\u00e1 s kumulativn\u00ed d\u00e1vkou a d\u00e9lkou l\u00e9\u010dby a je vy\u0161\u0161\u00ed u star\u0161\u00edch dosp\u011bl\u00fdch, \u017een a pacient\u016f s diabetem. Pou\u017eijte nejni\u017e\u0161\u00ed \u00fa\u010dinnou d\u00e1vku po nejkrat\u0161\u00ed dobu. FDA omezuje rutinn\u00ed u\u017e\u00edv\u00e1n\u00ed na 5 dn\u00ed (USA) a EMA na 5 dn\u00ed pro nevolnost\/zvracen\u00ed (12 t\u00fddn\u016f pro gastroparezi pod odborn\u00fdm dohledem). Dal\u0161\u00ed extrapyramidov\u00e9 \u00fa\u010dinky: akutn\u00ed dystonie (zejm\u00e9na u mlad\u00fdch mu\u017e\u016f, l\u00e9\u010d\u00ed se IV anticholinergiky), akatizie, parkinsonismus, malign\u00ed neuroleptick\u00fd syndrom.<\/div>\n<h3 class=\"wp-block-heading\">Pro\u010d objedn\u00e1vat z MedsBase<\/h3>\n<p>Reglan je dod\u00e1v\u00e1n z <strong>v\u00fdrobce certifikovan\u00e9ho WHO-GMP<\/strong>. Ka\u017ed\u00e1 objedn\u00e1vka je diskr\u00e9tn\u011b zas\u00edl\u00e1na po cel\u00e9m sv\u011bt\u011b a je pokryta na\u0161\u00ed <a href=\"https:\/\/medsbase.com\/cs\/medsbase-re-shipment-assurance-policy\/\">Z\u00e1rukou op\u011btovn\u00e9ho odesl\u00e1n\u00ed<\/a> \u2014 pokud nedoraz\u00ed do 20 pracovn\u00edch dn\u016f, p\u0159epos\u00edl\u00e1me zdarma. Metoclopramid z\u016fst\u00e1v\u00e1 l\u00e9kem prvn\u00ed volby u n\u011bkolika specifick\u00fdch indikac\u00ed (nevolnost spojen\u00e1 s migr\u00e9nou, prevence poopera\u010dn\u00edho ileu, podpora laktace), kde je jeho centr\u00e1ln\u00ed \u00fa\u010dinek na D2 receptory prosp\u011b\u0161n\u00fd.<\/p>\n<h2 class=\"wp-block-heading\">Mechanismus \u00fa\u010dinku<\/h2>\n<p>Metoclopramid blokuje dopaminov\u00e9 D2 receptory centr\u00e1ln\u011b (v chemorecep\u010dn\u00ed spou\u0161t\u011bc\u00ed z\u00f3n\u011b, nigrostriatu a tuberoinfundibul\u00e1rn\u00edm syst\u00e9mu) i perifern\u011b (v za\u017e\u00edvac\u00edm traktu). Ve vy\u0161\u0161\u00edch d\u00e1vk\u00e1ch tak\u00e9 blokuje 5-HT3 a stimuluje 5-HT4 receptory v tr\u00e1vic\u00edm traktu, co\u017e p\u0159isp\u00edv\u00e1 k jeho prokinetick\u00e9mu \u00fa\u010dinku. Pronik\u00e1n\u00ed do CNS jej odli\u0161uje od domperidonu a vysv\u011btluje jak jeho vy\u0161\u0161\u00ed antiemetickou \u00fa\u010dinnost, tak jeho extrapyramidov\u00fd ne\u017e\u00e1douc\u00ed \u00fa\u010dinky.<\/p>\n<h2 class=\"wp-block-heading\">Indikace<\/h2>\n<ul>\n<li>Nevolnost a zvracen\u00ed (chemoterapi\u00ed vyvolan\u00e9, poopera\u010dn\u00ed, spojen\u00e9 s migr\u00e9nou)<\/li>\n<li>Diabetick\u00e1 a idiopatick\u00e1 gastropareza (maxim\u00e1ln\u011b 12 t\u00fddn\u016f dle EMA)<\/li>\n<li>Prevence aspirace p\u0159ed anestezi\u00ed (pomocn\u00fd prost\u0159edek p\u0159i rychl\u00e9 sekven\u010dn\u00ed indukci)<\/li>\n<li>Pomocn\u00fd prost\u0159edek v radiologii pro urychlen\u00ed pr\u016fchodu baria<\/li>\n<li>Mimo indikaci: galaktagogum<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">D\u00e1vka<\/h2>\n<p>Dosp\u011bl\u00ed: 10 mg a\u017e t\u0159ikr\u00e1t denn\u011b, 30 minut p\u0159ed j\u00eddlem a v p\u0159\u00edpad\u011b pot\u0159eby p\u0159ed span\u00edm. Maxim\u00e1ln\u00ed celkov\u00e1 doba pod\u00e1v\u00e1n\u00ed: 5 dn\u016f pro nevolnost\/zvracen\u00ed (FDA), 12 t\u00fddn\u016f pro gastroparezu (EMA, specialista). CrCl &lt; 60: sn\u00ed\u017eit d\u00e1vku o 50 procent. Jatern\u00ed selh\u00e1n\u00ed: sn\u00ed\u017eit d\u00e1vku. D\u011bti: vyvarovat se pod\u00e1v\u00e1n\u00ed  1 rok pro chemoterapi\u00ed vyvolanou nebo poopera\u010dn\u00ed nevolnost, d\u00e1vkov\u00e1n\u00ed podle hmotnosti.<\/p>\n<h2 class=\"wp-block-heading\">Vedlej\u0161\u00ed \u00fa\u010dinky<\/h2>\n<ul>\n<li>B\u011b\u017en\u00e9: ospalost, neklid, \u00fanava, pr\u016fjem<\/li>\n<li>Extrapyramidov\u00e9: akutn\u00ed dystonie, akatizie, parkinsonismus, tardivn\u00ed dyskineze (\u010cERN\u00c9 VAROV\u00c1N\u00cd)<\/li>\n<li>Hyperprolaktin\u00e9mie: galaktorea, gynekomastie, menstrua\u010dn\u00ed poruchy<\/li>\n<li>Vz\u00e1cn\u00e9: neuroleptick\u00fd malign\u00ed syndrom, z\u00e1chvaty, methemoglobin\u00e9mie (u kojenc\u016f s deficitem G6PD)<\/li>\n<li>Srde\u010dn\u00ed: bradykardie a hypotenze po rychl\u00e9m IV pod\u00e1n\u00ed<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Interakce l\u00e9k\u016f<\/h2>\n<ul>\n<li>Anticholinergika, opioidy: p\u016fsob\u00ed proti prokinetick\u00e9mu \u00fa\u010dinku.<\/li>\n<li>Jin\u00e9 dopaminov\u00e9 antagonist\u00e9 (haloperidol, risperidon, prochlorperazin): zv\u00fd\u0161en\u00e9 riziko extrapyramidov\u00fdch \u00fa\u010dink\u016f \u2014 vyvarujte se kombinaci.<\/li>\n<li>MAO inhibitory: hypertenzn\u00ed krize \u2014 vyvarujte se.<\/li>\n<li>SSRI, SNRI: serotoninov\u00fd syndrom (vz\u00e1cn\u011b).<\/li>\n<li>Levodopa: vz\u00e1jemn\u011b blokuj\u00ed \u00fa\u010dinky \u2014 nep\u0159edepisujte sou\u010dasn\u011b.<\/li>\n<li>Digoxin: urychlen\u00ed vyprazd\u0148ov\u00e1n\u00ed \u017ealudku m\u016f\u017ee sn\u00ed\u017eit absorpci digoxinu.<\/li>\n<\/ul>\n<h2 id=\"faqs\">\u010casto kladen\u00e9 dotazy<\/h2>\n<h3 class=\"wp-block-heading\">Jak se Reglan li\u0161\u00ed od domperidonu?<\/h3>\n<p>Oba blokuj\u00ed D2 receptory. Metoklopramid pronik\u00e1 hematoencefalickou bari\u00e9rou a je \u00fa\u010dinn\u011bj\u0161\u00ed jako antiemetikum, ale zp\u016fsobuje extrapyramidov\u00e9 ne\u017e\u00e1douc\u00ed \u00fa\u010dinky (FDA black-box). Domperidon p\u016fsob\u00ed pouze perifern\u011b s minim\u00e1ln\u00edmi EPS, ale m\u00e1 sign\u00e1l pro prodlou\u017een\u00ed QT intervalu.<\/p>\n<h3 class=\"wp-block-heading\">Co pro m\u011b znamen\u00e1 FDA black-box?<\/h3>\n<p>Pou\u017e\u00edvejte nejni\u017e\u0161\u00ed d\u00e1vku po nejkrat\u0161\u00ed mo\u017enou dobu. Okam\u017eit\u011b informujte p\u0159edepisuj\u00edc\u00edho l\u00e9ka\u0159e o jak\u00fdchkoli mimovoln\u00edch pohybech jazyka, \u010delisti, rt\u016f nebo kon\u010detin \u2014 m\u016f\u017ee se jednat o \u010dasnou tardivn\u00ed dyskinezi a l\u00e9k mus\u00ed b\u00fdt vysazen.<\/p>\n<h3 class=\"wp-block-heading\">M\u016f\u017eu ho u\u017e\u00edvat na cestovn\u00ed nevolnost?<\/h3>\n<p>Existuj\u00ed l\u00e9pe sn\u00e1\u0161en\u00e9 alternativy (cinnarizin, hyoscin, antihistaminika). Metoklopramid nen\u00ed prvn\u00ed volbou pro kinet\u00f3zu, proto\u017ee nep\u016fsob\u00ed na vestibul\u00e1rn\u00ed syst\u00e9m.<\/p>\n<h3 class=\"wp-block-heading\">Je bezpe\u010dn\u00fd v t\u011bhotenstv\u00ed?<\/h3>\n<p>Kategorie B v USA. Pou\u017e\u00edv\u00e1 se p\u0159i nevolnosti\/zvracen\u00ed v t\u011bhotenstv\u00ed jako druh\u00e1 volba po pyridoxinu-doxylaminu, pokud prvn\u00ed volba sel\u017ee. Proberte s p\u0159edepisuj\u00edc\u00edm l\u00e9ka\u0159em.<\/p>\n<h3 class=\"wp-block-heading\">Mohu \u0159\u00eddit pod vlivem tohoto l\u00e9ku?<\/h3>\n<p>\u00danava je b\u011b\u017en\u00e1, zejm\u00e9na v prvn\u00edch dnech. Ne\u0159i\u010fte ani neobsluhujte stroje, dokud nev\u00edte, jak na v\u00e1s p\u016fsob\u00ed.<\/p>\n<h3 class=\"wp-block-heading\">Co kdy\u017e se mi objev\u00ed ztuhlost \u0161\u00edje nebo podivn\u00e9 pohyby \u010delisti?<\/h3>\n<p>P\u0159esta\u0148te u\u017e\u00edvat l\u00e9k a vyhledejte l\u00e9ka\u0159skou pomoc. Akutn\u00ed dystonie je l\u00e9\u010dena IV anticholinergiky (procyklidin nebo benztropin) a je po vysazen\u00ed pln\u011b reverzibiln\u00ed.<\/p>\n<h3 class=\"wp-block-heading\">Pro\u010d m\u00e1m p\u0159i u\u017e\u00edv\u00e1n\u00ed tohoto l\u00e9ku v\u00fdtok z prsou?<\/h3>\n<p>U\u017e\u00edvejte p\u0159ed dal\u0161\u00edm j\u00eddlem, pak pokra\u010dujte. Nezdvojujte.<\/p>\n<h3 class=\"wp-block-heading\">Dompewal \u2014 Domperidon (perifern\u00ed antagonista D2)<\/h3>\n<p>Ano \u2014 metoclopramide blokuje centr\u00e1ln\u00ed D2 receptory a m\u016f\u017ee dramaticky zhor\u0161it motorick\u00e9 p\u0159\u00edznaky Parkinsonovy nemoci. Vyhn\u011bte se mu u Parkinsonovy nemoci.<\/p>\n<h3 class=\"wp-block-heading\">Skladov\u00e1n\u00ed<\/h3>\n<p>P\u0159i teplot\u011b pod 25\u00b0C na such\u00e9m m\u00edst\u011b. Uchov\u00e1vejte mimo dosah d\u011bt\u00ed.<\/p>\n<h3 class=\"wp-block-heading\">Co kdy\u017e vynech\u00e1m d\u00e1vku?<\/h3>\n<p>Doxinate \u2014 Doxylamin + B6 (NVP prvn\u00ed volba).<\/p>\n<p><!-- medsbase-related-alts-v1 --><\/p>\n<h3 class=\"wp-block-heading\">Dal\u0161\u00ed l\u00e9ky na za\u017e\u00edvac\u00ed pot\u00ed\u017ee<\/h3>\n<ul>\n<li><a href=\"https:\/\/medsbase.com\/cs\/dompewal-tablet\/\">Omez D \u2014 Omeprazol + Domperidon SR<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/stemetil\/\">GR8-OD \u2014 Pantoprazol + Domperidon SR<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/doxinate\/\">Doxinate \u2014 Doxylamine + B6 (NVP first-line)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/omez-d\/\">Omez D \u2014 Omeprazole + Domperidone SR<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/gr8-od\/\">GR8-OD \u2014 Pantoprazole + Domperidone SR<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/gastro-health\/\"><strong>Prohl\u00e9dnout v\u0161echny l\u00e9ky na za\u017e\u00edvac\u00ed pot\u00ed\u017ee<\/strong><\/a><\/li>\n<\/ul>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:16px 20px;margin:24px 0;border-radius:4px;\"><strong>\u2695 L\u00e9ka\u0159sk\u00e9 upozorn\u011bn\u00ed.<\/strong> Tato str\u00e1nka slou\u017e\u00ed pouze pro informa\u010dn\u00ed \u00fa\u010dely a nenahrazuje l\u00e9ka\u0159skou p\u00e9\u010di kvalifikovan\u00e9ho zdravotnick\u00e9ho pracovn\u00edka. Informujte p\u0159edepisuj\u00edc\u00edho l\u00e9ka\u0159e o v\u0161ech neurologick\u00fdch nebo psychiatrick\u00fdch l\u00e9c\u00edch, kter\u00e9 u\u017e\u00edv\u00e1te. Vyvarujte se u\u017e\u00edv\u00e1n\u00ed p\u0159i Parkinsonov\u011b chorob\u011b a p\u0159i osobn\u00ed\/rodinn\u00e9 anamn\u00e9ze tardivn\u00ed dyskineze.<\/div>","protected":false},"excerpt":{"rendered":"<p>Reglan (Metoclopramid 10 mg) \u2014 centr\u00e1ln\u00ed + perifern\u00ed D2 antagonistick\u00fd prokinetikum a antiemetikum. Nese FDA \u010dernou sk\u0159\u00ed\u0148ku pro tardivn\u00ed dyskinezi (maxim\u00e1ln\u011b 12 t\u00fddn\u016f). Pro nevolnost, zvracen\u00ed, gastroparezi, nevolnost spojenou s migr\u00e9nou. Celosv\u011btov\u00e1 doprava od MedsBase.<\/p>","protected":false},"featured_media":59005,"comment_status":"open","ping_status":"open","template":"","meta":[],"product_brand":[],"product_cat":[3141,3542,3342],"product_tag":[4610,4611],"class_list":{"0":"post-59004","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-category-overview","7":"product_cat-gastro-health","8":"product_cat-general-health","9":"product_tag-metoclopramide","10":"product_tag-reglan","12":"first","13":"instock","14":"shipping-taxable","15":"purchasable","16":"product-type-variable","17":"has-default-attributes"},"acf":[],"_links":{"self":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product\/59004","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/comments?post=59004"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/media\/59005"}],"wp:attachment":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/media?parent=59004"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product_brand?post=59004"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product_cat?post=59004"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product_tag?post=59004"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}