<\/p>\n
Reglan<\/strong> is metoclopramide 10 mg — a centrally and peripherally acting dopamine D2 receptor antagonist used as an antiemetic and prokinetic. It accelerates gastric emptying, increases LES tone, and blocks the chemoreceptor trigger zone. Indications include nausea\/vomiting (post-operative, chemotherapy adjunct, migraine-associated), gastroparesis, and prevention of aspiration. Standard dose: 10 mg three times daily before meals, for a maximum of 5 days (FDA) or 12 weeks (EMA gastroparesis exception)<\/strong>. V\u00fdrobce certifikovan\u00fd WHO-GMP.<\/p>\n<\/div>\n \ud83d\udce6 Ka\u017ed\u00e1 objedn\u00e1vka je pokryta na\u0161\u00ed Z\u00e1rukou op\u011btovn\u00e9ho odesl\u00e1n\u00ed<\/strong><\/a> \u2014 pokud va\u0161e z\u00e1silka nedoraz\u00ed do 20 pracovn\u00edch dn\u016f, p\u0159epos\u00edl\u00e1me ji.<\/p>\n Na\u0161e generick\u00e9 l\u00e9ky poch\u00e1zej\u00ed od v\u00fdrobc\u016f certifikovan\u00fdch WHO-GMP a jsou expedov\u00e1ny po cel\u00e9m sv\u011bt\u011b v diskr\u00e9tn\u00edm, nen\u00e1padn\u00e9m balen\u00ed \u2013 na vn\u011bj\u0161\u00ed stran\u011b bal\u00edku nen\u00ed uveden n\u00e1zev l\u00e9ku. Platby kartou jsou sm\u011brov\u00e1ny prost\u0159ednictv\u00edm regulovan\u00e9ho procesoru (popisky na v\u00fdpisu zahrnuj\u00ed regulovan\u00e9ho procesora plateb kartou \u2013 nikdy \u201cMedsBase\u201d nebo n\u00e1zev l\u00e9ku). P\u0159ij\u00edm\u00e1me tak\u00e9 kryptom\u011bny a bankovn\u00ed p\u0159evody SEPA. Ka\u017ed\u00e1 objedn\u00e1vka je zaji\u0161t\u011bna na\u0161\u00ed politikou p\u0159eposl\u00e1n\u00ed.<\/p>\n Reglan is supplied from a v\u00fdrobce certifikovan\u00e9ho WHO-GMP<\/strong>. Ka\u017ed\u00e1 objedn\u00e1vka je diskr\u00e9tn\u011b zas\u00edl\u00e1na po cel\u00e9m sv\u011bt\u011b a je pokryta na\u0161\u00ed Z\u00e1rukou op\u011btovn\u00e9ho odesl\u00e1n\u00ed<\/a> — if it does not arrive within 20 business days, we reship at no cost. Metoclopramide remains a first-line agent for several niche indications (migraine-associated nausea, post-operative ileus prevention, lactation enhancement) where its central D2 effect is helpful.<\/p>\n Metoclopramide blocks dopamine D2 receptors centrally (in the chemoreceptor trigger zone, the nigrostriatum, and the tuberoinfundibular system) and peripherally (gut). At higher doses it also blocks 5-HT3 and stimulates 5-HT4 receptors in the gut, which contributes to its prokinetic effect. CNS penetration distinguishes it from domperidone and explains both its higher antiemetic potency and its extrapyramidal side-effect profile.<\/p>\n Adults: 10 mg up to three times daily, 30 minutes before meals and at bedtime if needed. Maximum cumulative duration: 5 days for nausea\/vomiting (FDA), 12 weeks for gastroparesis (EMA, specialist). CrCl < 60: reduce dose 50 percent. Hepatic impairment: reduce dose. Children: avoid < 1 year; restricted use in > 1 year for chemo-induced or post-op nausea, weight-based.<\/p>\n Both block D2 receptors. Metoclopramide crosses the blood-brain barrier and is more potent as an antiemetic but causes extrapyramidal side effects (FDA black-box). Domperidone is peripheral-only with minimal EPS but has a QT-prolongation signal.<\/p>\n Use the lowest dose for the shortest time. Tell the prescriber immediately about any involuntary tongue, jaw, lip, or limb movements — these may be early tardive dyskinesia and the drug must be stopped.<\/p>\n There are better-tolerated alternatives (cinnarizine, hyoscine, antihistamines). Metoclopramide is not first-line for motion sickness because it does not act on the vestibular system.<\/p>\n Category B in the US. Used in pregnancy for nausea\/vomiting and is the second-line after pyridoxine-doxylamine when first-line fails. Discuss with obstetric prescriber.<\/p>\n Drowsiness is common, especially in the first few days. Do not drive or operate machinery until you know how it affects you.<\/p>\n Stop the drug and seek medical help. Acute dystonia is treated with IV anticholinergic (procyclidine or benztropine) and is fully reversible.<\/p>\n Metoclopramide raises prolactin via pituitary D2 blockade. The effect is reversible on discontinuation.<\/p>\n Yes — metoclopramide blocks central D2 receptors and can dramatically worsen Parkinson’s motor symptoms. Avoid in Parkinson’s disease.<\/p>\n Below 25°C in a dry place. Keep out of reach of children.<\/p>\n Take it before the next meal, then continue. Do not double up.<\/p>\n <\/p>\n Reglan (Metoclopramide 10 mg) \u2014 central + peripheral D2 antagonist prokinetic and antiemetic. Carries FDA black-box for tardive dyskinesia (12-week max). For nausea, vomiting, gastroparesis, migraine-associated nausea. Worldwide shipping from MedsBase.<\/p>","protected":false},"featured_media":59005,"comment_status":"open","ping_status":"open","template":"","meta":[],"product_brand":[],"product_cat":[3141,3542,3342],"product_tag":[4610,4611],"class_list":{"0":"post-59004","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-category-overview","7":"product_cat-gastro-health","8":"product_cat-general-health","9":"product_tag-metoclopramide","10":"product_tag-reglan","12":"first","13":"instock","14":"shipping-taxable","15":"purchasable","16":"product-type-variable","17":"has-default-attributes"},"acf":[],"_links":{"self":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product\/59004","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/comments?post=59004"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/media\/59005"}],"wp:attachment":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/media?parent=59004"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product_brand?post=59004"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product_cat?post=59004"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product_tag?post=59004"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}Pro\u010d objedn\u00e1vat z MedsBase<\/h3>\n
Pro\u010d objedn\u00e1vat z MedsBase<\/h3>\n
Mechanismus \u00fa\u010dinku<\/h2>\n
Indikace<\/h2>\n
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D\u00e1vka<\/h2>\n
Vedlej\u0161\u00ed \u00fa\u010dinky<\/h2>\n
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Interakce l\u00e9k\u016f<\/h2>\n
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\u010casto kladen\u00e9 dotazy<\/h2>\n
How is Reglan different from domperidone?<\/h3>\n
What does the FDA black-box mean for me?<\/h3>\n
Can I take it for travel sickness?<\/h3>\n
Je bezpe\u010dn\u00fd v t\u011bhotenstv\u00ed?<\/h3>\n
Can I drive on this?<\/h3>\n
What if I develop a stiff neck or strange jaw movements?<\/h3>\n
Why do I have leaky breasts on this medication?<\/h3>\n
Can it interact with my Parkinson’s drugs?<\/h3>\n
Skladov\u00e1n\u00ed<\/h3>\n
Co kdy\u017e vynech\u00e1m d\u00e1vku?<\/h3>\n
Dal\u0161\u00ed l\u00e9ky na za\u017e\u00edvac\u00ed pot\u00ed\u017ee<\/h3>\n
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