{"id":59055,"date":"2024-02-28T05:40:03","date_gmt":"2024-02-28T05:40:03","guid":{"rendered":"https:\/\/medsname.com\/qutan-sr-400\/"},"modified":"2026-04-30T10:24:04","modified_gmt":"2026-04-30T10:24:04","slug":"qutan-sr-400","status":"publish","type":"product","link":"https:\/\/medsbase.com\/cs\/product\/qutan-sr-400\/","title":{"rendered":"Qutan SR 400"},"content":{"rendered":"

<\/p>\n

\n

\u26a1 Rychl\u00e1 odpov\u011b\u010f<\/h3>\n

Qutan SR 400 (Quetiapine 400 mg SR, prodlou\u017een\u00e9\/\u0159\u00edzen\u00e9 uvol\u0148ov\u00e1n\u00ed) je atypick\u00e9 antipsychotikum pro l\u00e9\u010dbu schizofrenie, bipol\u00e1rn\u00ed m\u00e1nie, bipol\u00e1rn\u00ed deprese, jako dopln\u011bk u MDD a GAD. Siln\u011b sedativn\u00ed a metabolicky zat\u011b\u017euj\u00edc\u00ed \u2014 ale v\u00fdjime\u010dn\u011b \u00fa\u010dinn\u00e9 u bipol\u00e1rn\u00ed deprese. \u010casto zneu\u017e\u00edvan\u00e9 jako \u201cpr\u00e1\u0161ek na span\u00ed\u201d \u2014 nedoporu\u010duje se kv\u016fli metabolick\u00e9 z\u00e1t\u011b\u017ei.<\/p>\n<\/div>\n

\nCo z\u00edsk\u00e1te s MedsBase:<\/strong> V\u00fdrobce certifikovan\u00fd WHO-GMP \u00b7 Diskr\u00e9tn\u00ed balen\u00ed \u00b7 Celosv\u011btov\u00e1 doprava \u00b7 V\u00edce ne\u017e 1 400 ov\u011b\u0159en\u00fdch recenz\u00ed z\u00e1kazn\u00edk\u016f<\/a>\n<\/div>\n

\ud83d\udce6 Ka\u017ed\u00e1 objedn\u00e1vka je pokryta na\u0161\u00ed Z\u00e1rukou op\u011btovn\u00e9ho odesl\u00e1n\u00ed<\/strong><\/a> \u2014 pokud va\u0161e z\u00e1silka nedoraz\u00ed do 20 pracovn\u00edch dn\u016f, p\u0159epos\u00edl\u00e1me ji.<\/p>\n

Pro\u010d objedn\u00e1vat z MedsBase<\/h3>\n

Qutan SR 400 na MedsBase je dod\u00e1v\u00e1n p\u0159\u00edmo od v\u00fdrobce certifikovan\u00e9ho WHO-GMP v jednoduch\u00e9m, diskr\u00e9tn\u00edm balen\u00ed. Ka\u017ed\u00e1 objedn\u00e1vka je pokryta na\u0161\u00edm Z\u00e1rukou op\u011btovn\u00e9ho odesl\u00e1n\u00ed<\/a> \u2014 20pracovn\u00edchdenn\u00ed lh\u016fta pro doru\u010den\u00ed, nebo v\u00e1m z\u00e1silku zdarma p\u0159epo\u0161leme \u2014 a oprav\u0148uje v\u00e1s k \u00fa\u010dasti v na\u0161em v\u011brnostn\u00edm programu<\/a>. Dod\u00e1v\u00e1me do v\u011bt\u0161iny zem\u00ed po cel\u00e9m sv\u011bt\u011b.<\/p>\n

Co je Qutan SR 400 a jak funguje<\/h2>\n

Qutan SR 400 je tableta quetiapinu s prodlou\u017een\u00fdm\/\u0159\u00edzen\u00fdm uvol\u0148ov\u00e1n\u00edm dod\u00e1van\u00e1 spole\u010dnost\u00ed Cipla. Dostupn\u00e9 s\u00edly: 400 mg SR<\/strong>. Quetiapin m\u00e1 volnou vazbu na D2 (rychl\u00e9 disociace vysv\u011btluj\u00ed n\u00edzk\u00fd v\u00fdskyt EPS), silnou antagonii 5-HT2A, velmi siln\u00e9 H1 antihistaminikum (sedace, p\u0159\u00edr\u016fstek hmotnosti), \u03b11-adrenergn\u00ed antagonii (ortost\u00e1za) a \u03b12 antagonii. Jeho aktivn\u00ed metabolit, norquetiapin, inhibuje noradrenalinov\u00fd transport\u00e9r \u2014 z\u00e1klad antidepresivn\u00edho \u00fa\u010dinku u bipol\u00e1rn\u00ed deprese.<\/p>\n

Formulace SR\/XR se pod\u00e1v\u00e1 jednou denn\u011b, obvykle p\u0159ed span\u00edm. Formulace IR se d\u011bl\u00ed na dv\u011b d\u00e1vky. SR m\u00e1 m\u00edrn\u011b ni\u017e\u0161\u00ed vrchol sedace a m\u016f\u017ee b\u00fdt l\u00e9pe tolerov\u00e1na pro denn\u00ed fungov\u00e1n\u00ed.<\/p>\n

Indikace a d\u00e1vkov\u00e1n\u00ed<\/h2>\n\n\n\n\n\n\n\n\n\n\n
Indikace<\/th>\nPo\u010d\u00e1te\u010dn\u00ed d\u00e1vka<\/th>\nC\u00edlov\u00e1 d\u00e1vka<\/th>\nMaxim\u00e1ln\u00ed d\u00e1vka<\/th>\n<\/tr>\n<\/thead>\n
Schizofrenie (SR)<\/td>\n50 mg p\u0159ed span\u00edm<\/td>\n400\u2013800 mg\/den<\/td>\n800 mg<\/td>\n<\/tr>\n
Bipol\u00e1rn\u00ed m\u00e1nie<\/td>\n50 mg 2x denn\u011b (IR) nebo 300 mg p\u0159ed span\u00edm (SR)<\/td>\n400\u2013800 mg\/den<\/td>\n800 mg<\/td>\n<\/tr>\n
Bipol\u00e1rn\u00ed deprese<\/td>\n50 mg p\u0159ed span\u00edm<\/td>\n300 mg p\u0159ed span\u00edm<\/td>\n600 mg<\/td>\n<\/tr>\n
Dopln\u011bk u MDD (SR)<\/td>\n50 mg p\u0159ed span\u00edm<\/td>\n150\u2013300 mg p\u0159ed span\u00edm<\/td>\n300 mg<\/td>\n<\/tr>\n
Adjuvans u GAD (mimo schv\u00e1len\u00e9 indikace)<\/td>\n50 mg p\u0159ed span\u00edm<\/td>\n50\u2013150 mg p\u0159ed span\u00edm<\/td>\n\u2014<\/td>\n<\/tr>\n
Star\u0161\u00ed dosp\u011bl\u00ed<\/td>\n25 mg p\u0159ed span\u00edm<\/td>\n50\u2013200 mg\/den<\/td>\ndle sn\u00e1\u0161enlivosti<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

D\u016fle\u017eit\u00e9 bezpe\u010dnostn\u00ed aspekty<\/h2>\n
\nFDA black-box \u2014 psych\u00f3za spojen\u00e1 s demenc\u00ed<\/strong><\/p>\n

V\u0161echna atypick\u00e1 antipsychotika nesou varov\u00e1n\u00ed FDA black-box pro zv\u00fd\u0161enou mortalitu (p\u0159edev\u0161\u00edm kardiovaskul\u00e1rn\u00ed a infek\u010dn\u00ed) p\u0159i pou\u017eit\u00ed k l\u00e9\u010db\u011b behavior\u00e1ln\u00edch poruch u star\u0161\u00edch dosp\u011bl\u00fdch s demenc\u00ed. Atypick\u00e1 antipsychotika nejsou schv\u00e1lena pro psych\u00f3zu nebo agitovanost spojenou s demenc\u00ed<\/strong>. Pou\u017eit\u00ed u t\u00e9to populace je off-label, posledn\u00ed mo\u017enost\u00ed, \u010dasov\u011b omezen\u00e9 a vy\u017eaduje explicitn\u00ed rozhovor o rizic\u00edch a p\u0159\u00ednosech.<\/p>\n<\/div>\n

\nVysok\u00e1 metabolick\u00e1 z\u00e1t\u011b\u017e<\/strong><\/p>\n

P\u0159ib\u00fdv\u00e1n\u00ed na v\u00e1ze, inzulinov\u00e1 rezistence, dyslipid\u00e9mie \u2014 mezi atypick\u00fdmi antipsychotiky druh\u00e9 nejhor\u0161\u00ed po olanzapinu a klozapinu. Povinn\u00e9 monitorov\u00e1n\u00ed p\u0159i zah\u00e1jen\u00ed l\u00e9\u010dby, po 12 t\u00fddnech a pot\u00e9 ka\u017ed\u00fdch 6 m\u011bs\u00edc\u016f: hmotnost, glyk\u00e9mie nala\u010dno\/HbA1c, lipidy nala\u010dno, TK. Poradenstv\u00ed ohledn\u011b stravy\/cvi\u010den\u00ed od za\u010d\u00e1tku l\u00e9\u010dby.<\/p>\n<\/div>\n

\nOrtostatick\u00e1 hypotenze<\/strong><\/p>\n

Antagonismus \u03b11 zp\u016fsobuje ortostatickou hypotenzi, zejm\u00e9na u star\u0161\u00edch pacient\u016f a p\u0159i zah\u00e1jen\u00ed l\u00e9\u010dby. Titrujte pomalu. Kontrolujte TK vsed\u011b a vestoje p\u0159i kontrol\u00e1ch.<\/p>\n<\/div>\n

\n\u201cHypnotikum mimo schv\u00e1len\u00e9 indikace\u201d \u2014 nedoporu\u010duje se<\/strong><\/p>\n

N\u00edzk\u00e9 d\u00e1vky kvetiapinu (25\u201350 mg p\u0159ed span\u00edm) se \u010dasto pou\u017e\u00edvaj\u00ed mimo schv\u00e1len\u00e9 indikace jako hypnotikum. Metabolick\u00e1 z\u00e1t\u011b\u017e je stejn\u00e1 bez ohledu na indikaci \u2014 pacienti u\u017e\u00edvaj\u00edc\u00ed kvetiapin na span\u00ed p\u0159ib\u00fdvaj\u00ed na v\u00e1ze a vyv\u00edjej\u00ed inzulinovou rezistenci stejn\u011b jako pacienti u\u017e\u00edvaj\u00edc\u00ed kvetiapin pro psych\u00f3zu. Specializovan\u00e1 hypnotika (Z-l\u00e1tky, n\u00edzk\u00e9 d\u00e1vky doxepinu, agonist\u00e9 melatoninu, behavior\u00e1ln\u00ed terapie sp\u00e1nku) jsou obvykle bezpe\u010dn\u011bj\u0161\u00ed volbou pro prim\u00e1rn\u00ed insomnii.<\/p>\n<\/div>\n

\nSebevra\u017eedn\u00e9 my\u0161lenky (u osob do 25 let, adjuvans u MDD)<\/strong><\/p>\n

P\u0159i pou\u017eit\u00ed jako dopln\u011bk k antidepresiv\u016fm plat\u00ed varov\u00e1n\u00ed ohledn\u011b zv\u00fd\u0161en\u00e9ho rizika sebevra\u017eednosti u pacient\u016f do 25 let.<\/p>\n<\/div>\n

\u010cast\u00e9 ne\u017e\u00e1douc\u00ed \u00fa\u010dinky<\/h2>\n