{"id":59095,"date":"2024-02-28T05:41:43","date_gmt":"2024-02-28T05:41:43","guid":{"rendered":"https:\/\/medsname.com\/mirtaz\/"},"modified":"2026-04-30T10:24:04","modified_gmt":"2026-04-30T10:24:04","slug":"mirtaz","status":"publish","type":"product","link":"https:\/\/medsbase.com\/cs\/product\/mirtaz\/","title":{"rendered":"Mirtaz"},"content":{"rendered":"

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\u26a1 Rychl\u00e1 odpov\u011b\u010f<\/h3>\n

Mirtaz (Mirtazapin 7,5\/15\/30\/45 mg) je tetracyklick\u00e9 antidepresivum (NaSSA) pro l\u00e9\u010dbu t\u011b\u017ek\u00e9 deprese, zejm\u00e9na kdy\u017e dominuj\u00ed p\u0159\u00edznaky jako nespavost, \u00fazkost, \u00fabytek hmotnosti nebo anorexie. V n\u00edzk\u00fdch d\u00e1vk\u00e1ch siln\u011b sedativn\u00ed, ve vy\u0161\u0161\u00edch d\u00e1vk\u00e1ch m\u00e9n\u011b sedativn\u00ed (paradoxn\u00ed \u00fa\u010dinek \u2014 viz n\u00ed\u017ee).<\/p>\n<\/div>\n

\nCo z\u00edsk\u00e1te s MedsBase:<\/strong> V\u00fdrobce certifikovan\u00fd WHO-GMP \u00b7 Diskr\u00e9tn\u00ed balen\u00ed \u00b7 Celosv\u011btov\u00e1 doprava \u00b7 V\u00edce ne\u017e 1 400 ov\u011b\u0159en\u00fdch recenz\u00ed z\u00e1kazn\u00edk\u016f<\/a>\n<\/div>\n

\ud83d\udce6 Ka\u017ed\u00e1 objedn\u00e1vka je pokryta na\u0161\u00ed Z\u00e1rukou op\u011btovn\u00e9ho odesl\u00e1n\u00ed<\/strong><\/a> \u2014 pokud va\u0161e z\u00e1silka nedoraz\u00ed do 20 pracovn\u00edch dn\u016f, p\u0159epos\u00edl\u00e1me ji.<\/p>\n

Pro\u010d objedn\u00e1vat z MedsBase<\/h3>\n

Mirtaz na MedsBase je dod\u00e1v\u00e1n p\u0159\u00edmo od v\u00fdrobce certifikovan\u00e9ho WHO-GMP v prost\u00e9m, diskr\u00e9tn\u00edm balen\u00ed. Ka\u017ed\u00e1 objedn\u00e1vka je kryta na\u0161\u00ed Z\u00e1rukou op\u011btovn\u00e9ho odesl\u00e1n\u00ed<\/a> \u2014 20pracovn\u00edchdenn\u00ed lh\u016fta pro doru\u010den\u00ed, nebo v\u00e1m z\u00e1silku zdarma p\u0159epo\u0161leme \u2014 a oprav\u0148uje v\u00e1s k \u00fa\u010dasti v na\u0161em v\u011brnostn\u00edm programu<\/a>. Dod\u00e1v\u00e1me do v\u011bt\u0161iny zem\u00ed po cel\u00e9m sv\u011bt\u011b.<\/p>\n

Co je Mirtaz a jak funguje<\/h2>\n

Mirtaz je tableta mirtazapinu 7,5\/15\/30\/45 mg dod\u00e1van\u00e1 spole\u010dnost\u00ed Sun Pharma. Mirtazapin se strukturou a mechanismem \u00fa\u010dinku li\u0161\u00ed od SSRI\/SNRI\/TCA. Jde o noradrenergn\u00ed a specifick\u00e9 serotonergn\u00ed antidepresivum (NaSSA): blokuje centr\u00e1ln\u00ed \u03b12-adrenergn\u00ed autoreceptory (nep\u0159\u00edmo zvy\u0161uje uvol\u0148ov\u00e1n\u00ed NA a 5-HT), receptory 5-HT2A a 5-HT2C (anxiolytick\u00fd \u00fa\u010dinek, podpora sp\u00e1nku, \u017e\u00e1dn\u00e1 sexu\u00e1ln\u00ed dysfunkce) a H1 histaminov\u00e9 receptory (sedace a stimulace chuti k j\u00eddlu).<\/p>\n

\nKontraintuitivn\u00ed k\u0159ivka d\u00e1vka-sedace<\/strong><\/p>\n

P\u0159i d\u00e1vce 7,5\u201315 mg je mirtazapin nejv\u00edce sedativn\u00ed. P\u0159i d\u00e1vce 30 mg+ za\u010d\u00edn\u00e1 noradrenergn\u00ed slo\u017eka (kter\u00e1 m\u00e1 line\u00e1rn\u011bj\u0161\u00ed vztah k d\u00e1vce ne\u017e antihistaminergn\u00ed H1 slo\u017eka) vyva\u017eovat sedaci zp\u016fsobenou H1. Mnoho pacient\u016f popisuje 30 mg jako \u201cv\u00edce energizuj\u00edc\u00ed\u201d ne\u017e 15 mg. Pokud pacient chce v\u00edce sp\u00e1t, sni\u017ete d\u00e1vku \u2014 nezvy\u0161ujte ji.<\/p>\n<\/div>\n

Indikace a d\u00e1vkov\u00e1n\u00ed<\/h2>\n\n\n\n\n\n\n\n\n\n
Indikace<\/th>\nPo\u010d\u00e1te\u010dn\u00ed d\u00e1vka<\/th>\nC\u00edlov\u00e1 d\u00e1vka<\/th>\nMaxim\u00e1ln\u00ed d\u00e1vka<\/th>\n<\/tr>\n<\/thead>\n
Hlavn\u00ed deprese<\/td>\n15 mg HS<\/td>\n30 mg HS<\/td>\n45 mg<\/td>\n<\/tr>\n
Deprese s nespavost\u00ed<\/td>\n7,5\u201315 mg HS<\/td>\n15 mg HS (\u010dasto posta\u010duje)<\/td>\n30 mg<\/td>\n<\/tr>\n
Deprese s \u00fabytkem hmotnosti\/anorexi\u00ed<\/td>\n15 mg HS<\/td>\n30\u201345 mg HS<\/td>\n45 mg<\/td>\n<\/tr>\n
Pos\u00edlen\u00ed SSRI<\/td>\n7,5\u201315 mg HS p\u0159idan\u00e9 k SSRI<\/td>\n15 mg HS<\/td>\n30 mg<\/td>\n<\/tr>\n
Star\u0161\u00ed dosp\u011bl\u00ed<\/td>\n7,5 mg HS<\/td>\n15 mg HS<\/td>\n30 mg<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

D\u016fle\u017eit\u00e9 bezpe\u010dnostn\u00ed aspekty<\/h2>\n
\nP\u0159ib\u00fdv\u00e1n\u00ed na v\u00e1ze a metabolick\u00e9 \u00fa\u010dinky<\/strong><\/p>\n

Mirtazapin pat\u0159\u00ed mezi antidepresiva s nejv\u00fdrazn\u011bj\u0161\u00edm \u00fa\u010dinkem na p\u0159ib\u00fdv\u00e1n\u00ed na v\u00e1ze \u2014 typicky 4\u20137 kg za 6 m\u011bs\u00edc\u016f. U\u017eite\u010dn\u00fd u pacient\u016f s depres\u00ed spojenou s \u00fabytkem hmotnosti; problematick\u00fd u ob\u00e9zn\u00edch pacient\u016f nebo pacient\u016f s metabolick\u00fdm syndromem. Kontrolujte hladinu lipid\u016f nala\u010dno a HbA1c po 6 m\u011bs\u00edc\u00edch.<\/p>\n<\/div>\n

\nAgranulocyt\u00f3za (vz\u00e1cn\u011b)<\/strong><\/p>\n

Byla pops\u00e1na reverzibiln\u00ed neutropenie a vz\u00e1cn\u011b agranulocyt\u00f3za \u2014 incidence p\u0159ibli\u017en\u011b 1 z 1000. Okam\u017eit\u011b vysa\u010fte a prove\u010fte vy\u0161et\u0159en\u00ed krevn\u00edho obrazu (FBC), pokud se v prvn\u00edch 8 t\u00fddnech objev\u00ed hore\u010dka, bolest v krku, afty nebo jin\u00e9 zn\u00e1mky infekce.<\/strong> Rutinn\u00ed vy\u0161et\u0159en\u00ed krevn\u00edho obrazu (FBC) nen\u00ed nutn\u00e9.<\/p>\n<\/div>\n

\nSyndrom neklidn\u00fdch nohou a periodick\u00e9 pohyby kon\u010detin ve sp\u00e1nku (PLM)<\/strong><\/p>\n

Mirtazapin \u010dasto zhor\u0161uje syndrom neklidn\u00fdch nohou a periodick\u00e9 pohyby kon\u010detin ve sp\u00e1nku \u2014 relevantn\u00ed u pacient\u016f s p\u0159edchoz\u00edmi pot\u00ed\u017eemi s RLS nebo sp\u00e1nkem.<\/p>\n<\/div>\n

\n\u010cern\u00e9 varov\u00e1n\u00ed ohledn\u011b sebevra\u017eednosti (u osob do 25 let)<\/strong><\/p>\n

V\u0161echna antidepresiva nesou \u010dern\u00e9 varov\u00e1n\u00ed FDA ohledn\u011b zv\u00fd\u0161en\u00e9ho rizika sebevra\u017eedn\u00fdch my\u0161lenek u pacient\u016f mlad\u0161\u00edch 25 let.<\/p>\n<\/div>\n

\u010cast\u00e9 ne\u017e\u00e1douc\u00ed \u00fa\u010dinky<\/h2>\n