{"id":59333,"date":"2024-02-28T05:52:45","date_gmt":"2024-02-28T05:52:45","guid":{"rendered":"https:\/\/medsname.com\/torvate\/"},"modified":"2026-04-30T10:23:59","modified_gmt":"2026-04-30T10:23:59","slug":"torvate","status":"publish","type":"product","link":"https:\/\/medsbase.com\/cs\/product\/torvate\/","title":{"rendered":"Torvate"},"content":{"rendered":"

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\u26a1 Rychl\u00e1 odpov\u011b\u010f<\/h3>\n

Torvate (Valpro\u00e1t sodn\u00fd 200\/300\/500 mg) je antikonvulzivum a stabiliz\u00e1tor n\u00e1lady pou\u017e\u00edvan\u00fd p\u0159i epilepsii, bipol\u00e1rn\u00ed m\u00e1nii a profylaxi migr\u00e9ny. Absolutn\u00ed kontraindikace v t\u011bhotenstv\u00ed a u \u017een v reproduk\u010dn\u00edm v\u011bku bez p\u0159\u00edsn\u00fdch opat\u0159en\u00ed k prevenci t\u011bhotenstv\u00ed<\/strong> \u2014 vysok\u00e9 teratogenn\u00ed riziko a riziko neurov\u00fdvojov\u00fdch poruch.<\/p>\n<\/div>\n

\nCo z\u00edsk\u00e1te s MedsBase:<\/strong> V\u00fdrobce certifikovan\u00fd WHO-GMP \u00b7 Diskr\u00e9tn\u00ed balen\u00ed \u00b7 Celosv\u011btov\u00e1 doprava \u00b7 V\u00edce ne\u017e 1 400 ov\u011b\u0159en\u00fdch recenz\u00ed z\u00e1kazn\u00edk\u016f<\/a>\n<\/div>\n

\ud83d\udce6 Ka\u017ed\u00e1 objedn\u00e1vka je pokryta na\u0161\u00ed Z\u00e1rukou op\u011btovn\u00e9ho odesl\u00e1n\u00ed<\/strong><\/a> \u2014 pokud va\u0161e z\u00e1silka nedoraz\u00ed do 20 pracovn\u00edch dn\u016f, p\u0159epos\u00edl\u00e1me ji.<\/p>\n

Pro\u010d objedn\u00e1vat z MedsBase<\/h3>\n

Torvate na MedsBase je dod\u00e1v\u00e1n p\u0159\u00edmo od v\u00fdrobce certifikovan\u00e9ho WHO-GMP v jednoduch\u00e9m, diskr\u00e9tn\u00edm balen\u00ed. Ka\u017ed\u00e1 objedn\u00e1vka je pokryta na\u0161\u00edm Z\u00e1rukou op\u011btovn\u00e9ho odesl\u00e1n\u00ed<\/a> \u2014 20pracovn\u00edchdenn\u00ed lh\u016fta pro doru\u010den\u00ed, nebo v\u00e1m z\u00e1silku zdarma p\u0159epo\u0161leme \u2014 a oprav\u0148uje v\u00e1s k \u00fa\u010dasti v na\u0161em v\u011brnostn\u00edm programu<\/a>. Dod\u00e1v\u00e1me do v\u011bt\u0161iny zem\u00ed po cel\u00e9m sv\u011bt\u011b.<\/p>\n

Co je Torvate a jak funguje<\/h2>\n

Torvate je tabletka sodn\u00e9 soli valpro\u00e1tu vyr\u00e1b\u011bn\u00e1 spole\u010dnost\u00ed Torrent. Dostupn\u00e9 s\u00edly: 200 \/ 300 \/ 500 mg<\/strong>. Valpro\u00e1t je \u0161irokospektr\u00e9 antikonvulzivum, jeho\u017e protiz\u00e1chvatov\u00e9 mechanismy zahrnuj\u00ed blok\u00e1du sod\u00edkov\u00fdch kan\u00e1l\u016f, modulaci T-typem kalciov\u00fdch kan\u00e1l\u016f a zv\u00fd\u0161enou dostupnost GABA. Protimanick\u00fd mechanismus nen\u00ed dob\u0159e pochopen, ale je dob\u0159e dolo\u017een v klinick\u00fdch studi\u00edch.<\/p>\n

\nT\u011bhotenstv\u00ed \u2014 absolutn\u00ed kontraindikace mimo epilepsii<\/strong><\/p>\n

Valpro\u00e1t pat\u0159\u00ed mezi nejv\u00edce teratogenn\u00ed l\u00e9ky b\u011b\u017en\u011b u\u017e\u00edvan\u00e9 v praxi.<\/strong> Expozice v prvn\u00edm trimestru zp\u016fsobuje defekty neur\u00e1ln\u00ed trubice (~ 1\u20132% absolutn\u00ed riziko), srde\u010dn\u00ed a kostern\u00ed malformace a v\u00fdrazn\u00e9 sn\u00ed\u017een\u00ed d\u011btsk\u00e9ho IQ (pr\u016fm\u011brn\u011b o 7\u201310 bod\u016f ni\u017e\u0161\u00ed v 6 letech). Britsk\u00fd MHRA, EMA a FDA vy\u017eaduj\u00ed p\u0159\u00edsn\u00e9 programy prevence t\u011bhotenstv\u00ed u \u017een v reproduk\u010dn\u00edm v\u011bku. Mimo refraktern\u00ed epilepsii, kde neexistuje alternativa, nezahajujte ani nepokra\u010dujte v pod\u00e1v\u00e1n\u00ed valproate u \u017e\u00e1dn\u00e9 \u017eeny v reproduk\u010dn\u00edm v\u011bku bez \u00fa\u010dinn\u00e9 antikoncepce a programu prevence t\u011bhotenstv\u00ed<\/strong>. P\u0159ejd\u011bte na lithium, lamotrigin nebo atypick\u00e9 antipsychotikum pro udr\u017eovac\u00ed l\u00e9\u010dbu bipol\u00e1rn\u00ed poruchy u \u017een p\u0159ed menopauzou.<\/p>\n<\/div>\n

Indikace a d\u00e1vkov\u00e1n\u00ed<\/h2>\n\n\n\n\n\n\n\n\n\n
Indikace<\/th>\nPo\u010d\u00e1te\u010dn\u00ed d\u00e1vka<\/th>\nC\u00edlov\u00e1 d\u00e1vka<\/th>\nC\u00edlov\u00e1 hladina<\/th>\n<\/tr>\n<\/thead>\n
10\u201315 mg\/kg\/den ve 2 d\u00e1vk\u00e1ch<\/td>\n10\u201315 mg\/kg\/day in 2 doses<\/td>\n20\u201360 mg\/kg\/den<\/td>\n50\u2013100 \u00b5g\/ml<\/td>\n<\/tr>\n
Bipol\u00e1rn\u00ed m\u00e1nie (akutn\u00ed)<\/td>\n20\u201330 mg\/kg\/den ve 2 d\u00e1vk\u00e1ch<\/td>\n20\u201360 mg\/kg\/den<\/td>\n50\u2013125 \u00b5g\/ml<\/td>\n<\/tr>\n
Bipol\u00e1rn\u00ed udr\u017eovac\u00ed l\u00e9\u010dba<\/td>\n\u2014<\/td>\n500\u20132500 mg\/den<\/td>\n50\u2013100 \u00b5g\/ml<\/td>\n<\/tr>\n
Profylaxe migr\u00e9ny<\/td>\n250 mg 2\u00d7 denn\u011b<\/td>\n500\u20131500 mg\/den<\/td>\n\u2014<\/td>\n<\/tr>\n
Star\u0161\u00ed dosp\u011bl\u00ed \/ jatern\u00ed probl\u00e9my<\/td>\npolovi\u010dn\u00ed d\u00e1vka<\/td>\n\u2014<\/td>\n\u2014<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

D\u016fle\u017eit\u00e9 bezpe\u010dnostn\u00ed aspekty<\/h2>\n
\nHepatotoxicita<\/strong><\/p>\n

Idiosynkratick\u00e1 fat\u00e1ln\u00ed hepatitida je zn\u00e1mou komplikac\u00ed valpro\u00e1tu, nejvy\u0161\u0161\u00ed riziko je u d\u011bt\u00ed 3\u00d7 ULN.<\/p>\n<\/div>\n

\nPankreatitida (vz\u00e1cn\u011b)<\/strong><\/p>\n

Byla pops\u00e1na akutn\u00ed hemoragick\u00e1 pankreatitida v\u010detn\u011b fat\u00e1ln\u00edch pediatrick\u00fdch p\u0159\u00edpad\u016f. Vysadit p\u0159i nevysv\u011btlen\u00e9 bolesti b\u0159icha, zvracen\u00ed, anorexii.<\/p>\n<\/div>\n

\nHyperamonemie<\/strong><\/p>\n

Valpro\u00e1t inhibuje mo\u010dovinov\u00fd cyklus; hyperamonemie m\u016f\u017ee nastat i p\u0159i norm\u00e1ln\u00edch jatern\u00edch testech a zp\u016fsobuje ospalost, zmatenost a (vz\u00e1cn\u011b) encefalopatii. Zkontrolovat hladinu amoniaku u pacient\u016f s nov\u011b vzniklou letargi\u00ed nebo kognitivn\u00edmi zm\u011bnami.<\/p>\n<\/div>\n

\nSyndrom polycystick\u00fdch ovari\u00ed a metabolick\u00e9 \u00fa\u010dinky<\/strong><\/p>\n

Dlouhodob\u00e9 u\u017e\u00edv\u00e1n\u00ed valpro\u00e1tu je spojeno s p\u0159ib\u00fdv\u00e1n\u00edm na v\u00e1ze, inzulinovou rezistenc\u00ed a PCOS u mlad\u00fdch \u017een \u2014 dal\u0161\u00ed d\u016fvod preferovat alternativy u \u017een p\u0159ed menopauzou.<\/p>\n<\/div>\n

\nTrombocytopenie a dysfunkce trombocyt\u016f<\/strong><\/p>\n

M\u00edrn\u00e1 trombocytopenie je b\u011b\u017en\u00e1; kontrolujte krevn\u00ed obraz na za\u010d\u00e1tku, po 3 m\u011bs\u00edc\u00edch a po 6 m\u011bs\u00edc\u00edch. V\u00fdrazn\u00e1 trombocytopenie je vz\u00e1cn\u00e1.<\/p>\n<\/div>\n

\u010cast\u00e9 ne\u017e\u00e1douc\u00ed \u00fa\u010dinky<\/h2>\n