{"id":59363,"date":"2024-02-28T05:54:24","date_gmt":"2024-02-28T05:54:24","guid":{"rendered":"https:\/\/medsname.com\/leemigran\/"},"modified":"2026-05-01T10:49:15","modified_gmt":"2026-05-01T10:49:15","slug":"leemigran","status":"publish","type":"product","link":"https:\/\/medsbase.com\/cs\/product\/leemigran\/","title":{"rendered":"Leemigran"},"content":{"rendered":"<p><!-- medsbase-tldr-answer --><\/p>\n<div style=\"background:#fff8e1;border-left:4px solid #f5a623;padding:18px 22px;margin:0 0 24px 0;border-radius:4px;\">\n<h3 class=\"wp-block-heading\" style=\"margin:0 0 8px 0;font-size:16px;font-weight:700;\">&#9889; Quick Answer &mdash; What is Leemigran?<\/h3>\n<p style=\"margin:0;\"><strong>Leemigran<\/strong> je <strong>50 mg \/ 100 mg sumatriptan oral tablet<\/strong> from Leeford Healthcare &mdash; a <strong>l\u00e9k t\u0159\u00eddy triptan\u016f pro abortivn\u00ed l\u00e9\u010dbu<\/strong> po dobu <strong>akutn\u00ed migren\u00f3zn\u00ed z\u00e1chvaty, s aurou nebo bez n\u00ed, u dosp\u011bl\u00fdch<\/strong>. sumatriptan is the original first-generation selective 5-HT<sub>1B\/1D<\/sub> receptor agonist, introduced in 1991. Take <strong>p\u0159i prvn\u00edch p\u0159\u00edznac\u00edch migr\u00e9ny nebo aury<\/strong> \u2014 \u010d\u00edm d\u0159\u00edve u\u017eijete d\u00e1vku, t\u00edm vy\u0161\u0161\u00ed je pravd\u011bpodobnost \u00fapln\u00e9ho vymizen\u00ed bolesti. N\u00e1stup \u00falevy: <strong>30-60 minut<\/strong>. V p\u0159\u00edpad\u011b opakov\u00e1n\u00ed migr\u00e9ny (b\u011b\u017en\u00e9 \u2014 u ~30 % pacient\u016f se migr\u00e9na do 24 hodin vrac\u00ed) lze po 2 hodin\u00e1ch opakovat. <strong>Maximum 200 mg (tablet) in 24 hours<\/strong>. Triptany jsou <strong>kontraindikov\u00e1ny u ischemick\u00e9 choroby srde\u010dn\u00ed, p\u0159edchoz\u00edho infarktu myokardu, nekontrolovan\u00e9 hypertenze, Prinzmetalovy anginy, hemiplegick\u00e9 nebo bazil\u00e1rn\u00ed migr\u00e9ny, ned\u00e1vn\u00e9ho u\u017e\u00edv\u00e1n\u00ed ergotaminu nebo inhibitor\u016f MAO a t\u011b\u017ek\u00e9ho po\u0161kozen\u00ed jater.<\/strong> U\u017e\u00edvejte triptany maxim\u00e1ln\u011b <strong>10 dn\u00ed v m\u011bs\u00edci<\/strong> \u2014 nad tuto hranici zp\u016fsobuj\u00ed paradoxn\u00ed bolest hlavy z nadu\u017e\u00edv\u00e1n\u00ed l\u00e9k\u016f. Pokud pot\u0159ebujete akutn\u00ed l\u00e9\u010dbu \u010dast\u011bji, p\u0159idejte preventivn\u00ed l\u00e9k (<a href=\"https:\/\/medsbase.com\/cs\/topicon\/\">topiram\u00e1t<\/a>, <a href=\"https:\/\/medsbase.com\/cs\/inderal\/\">propranolol<\/a>, <a href=\"https:\/\/medsbase.com\/cs\/sibelium\/\">flunarizin<\/a>, <a href=\"https:\/\/medsbase.com\/cs\/encorate\/\">valpro\u00e1t<\/a>).<\/p>\n<\/div>\n<div class=\"medsbase-trust-strip\" style=\"background:#f4f8fb;border:1px solid #d8e3eb;padding:12px 16px;margin:16px 0;border-radius:4px;font-size:14px;\">\n<strong>Co z\u00edsk\u00e1te s MedsBase:<\/strong> V\u00fdrobce certifikovan\u00fd WHO-GMP \u00b7 Diskr\u00e9tn\u00ed balen\u00ed \u00b7 Celosv\u011btov\u00e1 doprava \u00b7 V\u00edce ne\u017e 1 400 ov\u011b\u0159en\u00fdch <a href=\"https:\/\/medsbase.com\/cs\/reviews\/\">recenz\u00ed z\u00e1kazn\u00edk\u016f<\/a>\n<\/div>\n<h2 class=\"wp-block-heading\">What Is Leemigran?<\/h2>\n<p>Leemigran is an oral oral tablet containing <strong>sumatriptan 50 mg \/ 100 mg<\/strong> from Leeford Healthcare, supplied in 30-180 tablet packs. Sumatriptan is the original first-generation selective 5-HT<sub>1B\/1D<\/sub> receptor agonist, introduced in 1991 &mdash; one of the core drug classes for the <strong>l\u00e9\u010dbu migren\u00f3zn\u00ed bolesti hlavy. Rizatriptan m\u00e1 nejrychlej\u0161\u00ed n\u00e1stup \u00fa\u010dinku mezi triptany v peror\u00e1ln\u00ed tabletov\u00e9 form\u011b (Tmax ~1 hodina) a podle s\u00ed\u0165ov\u00e9 meta-anal\u00fdzy (Cameron 2015) nejvy\u0161\u0161\u00ed pravd\u011bpodobnost \u00falevy od bolesti do 2 hodin. Prvn\u00ed volba, kdy\u017e je d\u016fle\u017eit\u00e1 rychlost, ale nosn\u00ed sprej nen\u00ed tolerov\u00e1n.<\/strong> treatment of migraine headache. Sumatriptan is the most evidence-rich triptan (largest clinical-trial database) and the price-anchor of the class. Subcutaneous sumatriptan (6 mg) remains the fastest-acting and most effective triptan for severe attacks and cluster headache.<\/p>\n<h2 class=\"wp-block-heading\">How sumatriptan Works on Migraine<\/h2>\n<p>trigeminovaskul\u00e1rn\u00edho syst\u00e9mu <strong>\u2014 vl\u00e1kna trojklann\u00e9ho nervu inervuj\u00edc\u00ed tvrdou plenu mozkovou a nitrolebn\u00ed c\u00e9vy uvol\u0148uj\u00ed peptid souvisej\u00edc\u00ed s genem pro kalcitonin (CGRP), substance P a neurokinin A, co\u017e zp\u016fsobuje neurogenn\u00ed z\u00e1n\u011bt, vazodilataci a centr\u00e1ln\u00ed senzibilizaci.<\/strong> Triptany jako rizatriptan selektivn\u011b v\u00e1\u017eou.<\/p>\n<p>Triptans like sumatriptan bind selectively to <strong>5-HT<sub>1B<\/sub> receptory<\/strong> na hladk\u00e9m svalstvu lebe\u010dn\u00edch c\u00e9v (zp\u016fsobuj\u00edc\u00ed vazokonstrikci roz\u0161\u00ed\u0159en\u00fdch bolestiv\u00fdch tepen) a <strong>5-HT<sub>1D<\/sub> receptory<\/strong> na zakon\u010den\u00ed trigemin\u00e1ln\u00edho nervu (inhibuj\u00edc\u00ed uvol\u0148ov\u00e1n\u00ed proz\u00e1n\u011btliv\u00fdch neuropeptid\u016f). Kombinovan\u00fd vaskul\u00e1rn\u00ed + nervov\u00fd \u00fa\u010dinek reverzuje migren\u00f3zn\u00ed ataku, obvykle do 30-120 minut.<\/p>\n<p>N\u00e1stup \u00fa\u010dinku p\u0159i peror\u00e1ln\u00edm pod\u00e1n\u00ed: <strong>30-60 minut<\/strong>. Plasma peak: 2-3 hours (tablet), 10-15 minutes (nasal), 10-15 minutes (subcutaneous). Elimination half-life: 2 hours.<\/p>\n<h2 class=\"wp-block-heading\">Schv\u00e1len\u00e9 indikace<\/h2>\n<ul>\n<li><strong>Akutn\u00ed l\u00e9\u010dba migr\u00e9ny s aurou nebo bez aury<\/strong> u dosp\u011bl\u00fdch 18+ (prim\u00e1rn\u00ed indikace)<\/li>\n<li><strong>Cluster headache<\/strong> &mdash; injectable sumatriptan 6 mg subcutaneous; oral formulations less effective for cluster<\/li>\n<li><strong>Menstrua\u010dn\u00ed migr\u00e9na<\/strong> \u2014 stejn\u00e9 d\u00e1vkov\u00e1n\u00ed jako u b\u011b\u017en\u00e9 migr\u00e9ny; existuj\u00ed d\u016fkazy pro kr\u00e1tkodobou profylaxi v obdob\u00ed menstrua\u010dn\u00edho okna<\/li>\n<\/ul>\n<p><strong>Triptany NEJSOU vhodn\u00e9 pro:<\/strong> tenzn\u00ed bolesti hlavy (ne\u00fa\u010dinn\u00e9), bolest jin\u00e9ho p\u016fvodu (sinusov\u00e1, muskuloskelet\u00e1ln\u00ed, trigemin\u00e1ln\u00ed neuralgie), preventivn\u00ed u\u017eit\u00ed bez migren\u00f3zn\u00ed bolesti, hemiplegickou migr\u00e9nu, bazil\u00e1rn\u00ed migr\u00e9nu, oftalmoplegickou migr\u00e9nu nebo migren\u00f3zn\u00ed infarkt.<\/p>\n<h2 class=\"wp-block-heading\">Leemigran Dosage<\/h2>\n<ol>\n<li><strong>U\u017e\u00edvejte p\u0159i prvn\u00edch zn\u00e1mk\u00e1ch migren\u00f3zn\u00ed bolesti nebo aury.<\/strong> Triptany funguj\u00ed nejl\u00e9pe, kdy\u017e se u\u017eij\u00ed brzy; pozdn\u00ed u\u017eit\u00ed b\u011bhem rozvinut\u00e9ho z\u00e1chvatu sni\u017euje \u00fa\u010dinnost p\u0159ibli\u017en\u011b o 30 %.<\/li>\n<li>Polykejte cel\u00e9 a zapijte vodou; j\u00eddlo nem\u00e1 v\u00fdznamn\u00fd vliv na vst\u0159eb\u00e1v\u00e1n\u00ed.<\/li>\n<li>Pokud dojde k \u00falev\u011b, ale bolest hlavy se vr\u00e1t\u00ed do 24 hodin, je vhodn\u00e1 <strong>druh\u00e1 d\u00e1vka 2 hodiny po prvn\u00ed<\/strong> .<\/li>\n<li><strong>Pokud prvn\u00ed d\u00e1vka v\u016fbec nezabere, druh\u00e1 d\u00e1vka pro tent\u00fd\u017e z\u00e1chvat pravd\u011bpodobn\u011b nepom\u016f\u017ee.<\/strong> P\u0159epn\u011bte na z\u00e1chrann\u00e9 NSAID (naproxen 500 mg) nebo kombinovanou terapii.<\/li>\n<li>Maxim\u00e1ln\u00ed jednor\u00e1zov\u00e1 d\u00e1vka: <strong>100 mg (tablet)<\/strong>. Maxim\u00e1ln\u011b za 24 hodin: <strong>200 mg (tablet)<\/strong>.<\/li>\n<li><strong>Maxim\u00e1ln\u011b 10 dn\u00ed v m\u011bs\u00edci<\/strong> u v\u0161ech triptan\u016f\/ergotamin\u016f\/kombinovan\u00fdch analgetik, aby se p\u0159ede\u0161lo bolestem hlavy z nadu\u017e\u00edv\u00e1n\u00ed l\u00e9k\u016f.<\/li>\n<\/ol>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:16px 20px;margin:18px 0;border-radius:4px;\">\n<strong>\u26a0\ufe0f Varov\u00e1n\u00ed p\u0159ed bolestmi hlavy z nadu\u017e\u00edv\u00e1n\u00ed l\u00e9k\u016f.<\/strong> P\u0159\u00edli\u0161 \u010dast\u00e9 u\u017e\u00edv\u00e1n\u00ed akutn\u00edch l\u00e9k\u016f na migr\u00e9nu zp\u016fsobuje paradoxn\u00ed rebound bolest hlavy zvanou <em>bolest hlavy z nadu\u017e\u00edv\u00e1n\u00ed l\u00e9k\u016f (MOH)<\/em>. Limity: <strong>triptany, ergotaminy nebo kombinovan\u00e1 analgetika \u2264 10 dn\u00ed v m\u011bs\u00edci<\/strong>; <strong>jednoduch\u00e1 NSAID nebo paracetamol \u2264 15 dn\u00ed v m\u011bs\u00edci<\/strong>. Pokud pot\u0159ebujete akutn\u00ed l\u00e9\u010dbu \u010dast\u011bji, pot\u0159ebujete <strong>preventivn\u00ed l\u00e9k<\/strong> (propranolol, topiram\u00e1t, valpro\u00e1t, flunarizin, amitriptylin nebo antagonista CGRP).\n<\/div>\n<h2 class=\"wp-block-heading\">Vedlej\u0161\u00ed \u00fa\u010dinky<\/h2>\n<p><strong>\u010cast\u00e9 (&gt;5%), obvykle p\u0159echodn\u00e9, vrchol\u00edc\u00ed v prvn\u00edch 30-60 minut\u00e1ch:<\/strong><\/p>\n<ul>\n<li><strong>Triptanov\u00e9 pocity<\/strong> \u2014 brn\u011bn\u00ed\/teplo\/tlak\/t\u00edha na hrudi, krku, \u010delisti nebo kon\u010detin\u00e1ch. U v\u011bt\u0161iny u\u017eivatel\u016f ne\u0161kodn\u00e9 a odli\u0161n\u00e9 od ischemick\u00e9 bolesti na hrudi, ale klinicky nerozli\u0161iteln\u00e9 \u2014 viz \u201cP\u0159\u00edznaky na hrudi\u201d n\u00ed\u017ee.<\/li>\n<li>Z\u00e1vrat\u011b, ospalost, \u00fanava<\/li>\n<li>Nevolnost (odd\u011blen\u00e1 od migr\u00e9nov\u00e9 nevolnosti)<\/li>\n<li>N\u00e1valy horka, pocit tepla<\/li>\n<li>Sucho v \u00fastech<\/li>\n<\/ul>\n<p><strong>M\u00e9n\u011b \u010dast\u00e9:<\/strong> palpitace, \u00fazkost, nespavost, bolesti sval\u016f, m\u00edrn\u00e1 hypertenze.<\/p>\n<p><strong>Vz\u00e1cn\u00e9, ale z\u00e1va\u017en\u00e9:<\/strong> koron\u00e1rn\u00ed vazospazmus \/ angina \/ infarkt myokardu (p\u0159edev\u0161\u00edm u pacient\u016f s nediagnostikovan\u00fdm onemocn\u011bn\u00edm koron\u00e1rn\u00edch tepen), ischemick\u00e1 kolitida, c\u00e9vn\u00ed mozkov\u00e1 p\u0159\u00edhoda, serotoninov\u00fd syndrom (p\u0159i kombinaci se SSRI\/SNRI\/MAOI \u2014 viz Interakce).<\/p>\n<h3 class=\"wp-block-heading\">P\u0159\u00edznaky na hrudi p\u0159i u\u017eit\u00ed triptanu \u2014 co d\u011blat<\/h3>\n<p>T\u011bsnost, tlak nebo nepohodl\u00ed na hrudi po d\u00e1vce triptanu je <strong>b\u011b\u017en\u00e9 a obvykle ne\u0161kodn\u00e9<\/strong> (pocity vyvolan\u00e9 triptany). Klinicky v\u0161ak nelze odli\u0161it od \u010dasn\u00e9 anginy. <strong>Pravidla:<\/strong><\/p>\n<ul>\n<li>Prvn\u00ed d\u00e1vka triptanu \u2014 pokud se objev\u00ed nov\u00e9 p\u0159\u00edznaky na hrudi, prove\u010fte EKG a konzultaci s kardiologem p\u0159ed dal\u0161\u00edm u\u017eit\u00edm triptanu. Je nutn\u00e9 vylou\u010dit zaveden\u00e9 srde\u010dn\u00ed onemocn\u011bn\u00ed.<\/li>\n<li>Jak\u00e1koli bolest na hrudi spojen\u00e1 s pocen\u00edm, du\u0161nost\u00ed, bolest\u00ed v pa\u017ei nebo trvaj\u00edc\u00ed d\u00e9le ne\u017e 20 minut \u2014 pova\u017eujte za potenci\u00e1ln\u00ed akutn\u00ed koron\u00e1rn\u00ed syndrom; volejte z\u00e1chrannou slu\u017ebu.<\/li>\n<li>Ne\u0161kodn\u00e9 pocity vyvolan\u00e9 triptany obvykle ustoup\u00ed do 20-30 minut po pod\u00e1n\u00ed d\u00e1vky.<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Kontraindikace &amp; Opat\u0159en\u00ed<\/h2>\n<p><strong>Absolute contraindications (do NOT take Leemigran):<\/strong><\/p>\n<ul>\n<li>Ischemick\u00e1 choroba srde\u010dn\u00ed, anamn\u00e9za infarktu myokardu, zn\u00e1m\u00e9 onemocn\u011bn\u00ed koron\u00e1rn\u00edch tepen<\/li>\n<li>Prinzmetalova angina \/ variantn\u00ed angina<\/li>\n<li>Nekontrolovan\u00e1 hypertenze<\/li>\n<li>P\u0159edchoz\u00ed c\u00e9vn\u00ed mozkov\u00e1 p\u0159\u00edhoda (ischemick\u00e1 nebo hemoragick\u00e1) nebo p\u0159echodn\u00e1 ischemick\u00e1 ataka<\/li>\n<li>Onemocn\u011bn\u00ed perifern\u00edch c\u00e9v<\/li>\n<li>Hemiplegick\u00e1 migr\u00e9na, bazil\u00e1rn\u00ed migr\u00e9na, oftalmoplegick\u00e1 migr\u00e9na, migren\u00f3zn\u00ed infarkt<\/li>\n<li>T\u011b\u017ek\u00e9 jatern\u00ed po\u0161kozen\u00ed (Child-Pugh C)<\/li>\n<li>Pou\u017eit\u00ed v pr\u016fb\u011bhu <strong>24 hodin<\/strong> po pod\u00e1n\u00ed jin\u00e9ho triptanu nebo jak\u00e9hokoli alkaloidu n\u00e1melu (dihydroergotamin, ergotamin, methysergid)<\/li>\n<li>Pou\u017eit\u00ed v pr\u016fb\u011bhu <strong>14 dn\u00ed<\/strong> po pod\u00e1n\u00ed inhibitoru monoaminooxid\u00e1zy (fenelzin, tranylcypromin, moklobemid, selegilin) pro zolmitriptan, rizatriptan, sumatriptan<\/li>\n<li>P\u0159ecitliv\u011blost na triptany<\/li>\n<\/ul>\n<p><strong>Opatrn\u011b:<\/strong><\/p>\n<ul>\n<li>Rizikov\u00e9 faktory kardiovaskul\u00e1rn\u00edch onemocn\u011bn\u00ed (hypertenze, hyperlipidemie, kou\u0159en\u00ed, diabetes, \u017eeny po menopauze, mu\u017ei nad 40 let) - zva\u017ete kardiologick\u00e9 vy\u0161et\u0159en\u00ed p\u0159ed prvn\u00edm pou\u017eit\u00edm triptanu<\/li>\n<li>St\u0159edn\u011b t\u011b\u017ek\u00e9 po\u0161kozen\u00ed jater \u2014 m\u016f\u017ee b\u00fdt nutn\u00e1 \u00faprava d\u00e1vkov\u00e1n\u00ed<\/li>\n<li>Epilepsie nebo stavy sni\u017euj\u00edc\u00ed pr\u00e1h pro z\u00e1chvaty<\/li>\n<li>Alergie na sulfonamidy (u sumatriptanu, kter\u00fd obsahuje sulfonylovou skupinu \u2014 zk\u0159\u00ed\u017een\u00e1 reakce je vz\u00e1cn\u00e1, ale byla hl\u00e1\u0161ena)<\/li>\n<\/ul>\n<p><strong>T\u011bhotenstv\u00ed:<\/strong> sumatriptan m\u00e1 nejv\u00edce \u00fadaj\u016f o bezpe\u010dnosti v t\u011bhotenstv\u00ed (FDA kategorie C; \u00fadaje z registr\u016f jsou uklid\u0148uj\u00edc\u00ed). Zolmitriptan a rizatriptan maj\u00ed m\u00e9n\u011b \u00fadaj\u016f. Obecn\u011b p\u0159ijateln\u00e9, pokud je migr\u00e9na z\u00e1va\u017en\u00e1 a nel\u00e9kov\u00e9 metody sel\u017eou; proberte se sv\u00fdm gynekologem.<\/p>\n<p><strong>Kojen\u00ed:<\/strong> mal\u00e1 mno\u017estv\u00ed v mate\u0159sk\u00e9m ml\u00e9ce (~3-5% mate\u0159sk\u00e9 d\u00e1vky). Obecn\u011b pova\u017eov\u00e1no za kompatibiln\u00ed; n\u011bkte\u0159\u00ed doporu\u010duj\u00ed \u201codst\u0159\u00edkat a vyhodit\u201d po dobu 8 hodin po d\u00e1vce jako dal\u0161\u00ed opat\u0159en\u00ed.<\/p>\n<p><strong>D\u011bti:<\/strong> b\u011b\u017en\u011b se nepou\u017e\u00edv\u00e1 u d\u011bt\u00ed mlad\u0161\u00edch 12 let. Nosn\u00ed sumatriptan a rizatriptan ODS maj\u00ed indikace pro dosp\u00edvaj\u00edc\u00ed v n\u011bkter\u00fdch jurisdikc\u00edch; pou\u017e\u00edvejte pouze pod veden\u00edm d\u011btsk\u00e9ho neurologa.<\/p>\n<p><strong>Star\u0161\u00ed pacienti (nad 65 let):<\/strong> kardiovaskul\u00e1rn\u00ed riziko je vy\u0161\u0161\u00ed; mnoh\u00e9 sm\u011brnice nedoporu\u010duj\u00ed prvn\u00ed pou\u017eit\u00ed triptan\u016f u pacient\u016f star\u0161\u00edch 65 let bez kardiologick\u00e9ho vy\u0161et\u0159en\u00ed.<\/p>\n<h2 class=\"wp-block-heading\">Interakce s l\u00e9\u010divy<\/h2>\n<ul>\n<li><strong>Alkaloidy n\u00e1melu<\/strong> (dihydroergotamin, ergotamin, methysergid) \u2014 nekombinujte; riziko prodlou\u017een\u00e9ho vazospazmu. Odd\u011blte alespo\u0148 24 hodinami.<\/li>\n<li><strong>Jin\u00e9 triptany<\/strong> \u2014 nekombinujte ani nepou\u017e\u00edvejte do 24 hodin od sebe.<\/li>\n<li><strong>MAOI<\/strong> \u2014 kontraindikov\u00e1no (viz v\u00fd\u0161e).<\/li>\n<li><strong>SSRI a SNRI<\/strong> (fluoxetin, sertralin, citalopram, venlafaxin, duloxetin) \u2014 vz\u00e1cn\u00e1 riziko serotoninov\u00e9ho syndromu p\u0159i kombinaci s triptanem. FDA varovala v roce 2006, ale aktu\u00e1ln\u00ed re\u00e1ln\u00e9 d\u016fkazy nazna\u010duj\u00ed, \u017ee riziko je velmi n\u00edzk\u00e9 a kombinace je \u010dasto p\u0159ijateln\u00e1 \u2014 sledujte p\u0159\u00edznaky serotoninov\u00e9ho syndromu (zm\u011bny ment\u00e1ln\u00edho stavu, autonomn\u00ed nestabilita, neuromuskul\u00e1rn\u00ed hyperaktivita).<\/li>\n<li><strong>Lithium<\/strong> \u2014 opatrnost; teoretick\u00e9 riziko serotoninov\u00e9ho syndromu.<\/li>\n<li><strong>T\u0159ezalka te\u010dkovan\u00e1<\/strong> \u2014 vyvarujte se; riziko serotoninov\u00e9ho syndromu.<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Leemigran vs Other Triptans<\/h2>\n<table style=\"width:100%;border-collapse:collapse;margin:14px 0;\">\n<thead>\n<tr style=\"background:#2c7cb0;color:#fff;\">\n<th style=\"padding:10px;border:1px solid #ddd;text-align:left;\">Triptan<\/th>\n<th style=\"padding:10px;border:1px solid #ddd;text-align:left;\">N\u00e1stup \u00fa\u010dinku (peror\u00e1ln\u00ed)<\/th>\n<th style=\"padding:10px;border:1px solid #ddd;text-align:left;\">Polo\u010das<\/th>\n<th style=\"padding:10px;border:1px solid #ddd;text-align:left;\">Nejvhodn\u011bj\u0161\u00ed pro<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td style=\"padding:10px;border:1px solid #ddd;\"><strong>Rizatriptan 10 mg<\/strong> (<a href=\"https:\/\/medsbase.com\/cs\/maxtan\/\">Maxtan<\/a> \/ <a href=\"https:\/\/medsbase.com\/cs\/rizatop\/\">Rizatop<\/a>)<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">~30-60 min<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">2-3 h<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Nejrychlej\u0161\u00ed n\u00e1stup \u00fa\u010dinku u peror\u00e1ln\u00edch forem; nejvy\u0161\u0161\u00ed m\u00edra \u00falevy od bolesti za 2 hodiny<\/td>\n<\/tr>\n<tr style=\"background:#f9f9f9;\">\n<td style=\"padding:10px;border:1px solid #ddd;\"><strong>Sumatriptan 50-100 mg<\/strong> (<a href=\"https:\/\/medsbase.com\/cs\/sumitop\/\">Sumitop<\/a> \/ <a href=\"https:\/\/medsbase.com\/cs\/leemigran\/\">Leemigran<\/a>)<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">~30-60 min<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">2 h<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Nejv\u00edce klinick\u00fdch dat; cenov\u00fd benchmark t\u0159\u00eddy<\/td>\n<\/tr>\n<tr>\n<td style=\"padding:10px;border:1px solid #ddd;\"><strong>Zolmitriptan 2,5-5 mg<\/strong> (<a href=\"https:\/\/medsbase.com\/cs\/zolitas-ods\/\">Zolitas ODS<\/a> \/ <a href=\"https:\/\/medsbase.com\/cs\/zolmist-nasal-spray\/\">Zolmist nosn\u00ed sprej<\/a>)<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">~30-60 min (peror\u00e1ln\u00ed), 10-15 min (nosn\u00ed)<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">3 h<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Vhodn\u00e9 pro migr\u00e9nu s v\u00fdrazn\u00fdmi CNS p\u0159\u00edznaky; ODS u\u017eite\u010dn\u00e9 p\u0159i nevolnosti<\/td>\n<\/tr>\n<tr style=\"background:#f9f9f9;\">\n<td style=\"padding:10px;border:1px solid #ddd;\">Naratriptan 2,5 mg<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">2-4 h (nejpomalej\u0161\u00ed)<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">6 h (nejdel\u0161\u00ed)<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Dlouhotrvaj\u00edc\u00ed z\u00e1chvaty; ni\u017e\u0161\u00ed m\u00edra recidivy<\/td>\n<\/tr>\n<tr>\n<td style=\"padding:10px;border:1px solid #ddd;\">Eletriptan 40-80 mg<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">~30-60 min<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">4 h<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Vysok\u00e1 \u00fa\u010dinnost; druh\u00e1 volba p\u0159i selh\u00e1n\u00ed jin\u00fdch<\/td>\n<\/tr>\n<tr style=\"background:#f9f9f9;\">\n<td style=\"padding:10px;border:1px solid #ddd;\">Sumatriptan-naproxen (<a href=\"https:\/\/medsbase.com\/cs\/headset\/\">Trinicalm Plus<\/a>)<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">~30-60 min<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Kompozitn\u00ed<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">V RCTs prok\u00e1z\u00e1na vy\u0161\u0161\u00ed \u00fa\u010dinnost ne\u017e jednotliv\u00e9 slo\u017eky samostatn\u011b<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p><strong>Pokud jeden triptan nezab\u00edr\u00e1, m\u016f\u017ee zabrat jin\u00fd.<\/strong> S\u00ed\u0165ov\u00e1 metaanal\u00fdza \u010dasopisu The Lancet z roku 2021 o migr\u00e9n\u011b ukazuje, \u017ee p\u0159ibli\u017en\u011b 25 % nereaguj\u00edc\u00edch na jeden triptan bude reagovat na jin\u00fd triptan nebo jinou formu (nap\u0159. nosn\u00ed m\u00edsto peror\u00e1ln\u00ed). Vyzkou\u0161ejte alespo\u0148 2 triptany v adekv\u00e1tn\u00edch d\u00e1vk\u00e1ch, ne\u017e usoud\u00edte, \u017ee v\u00e1m nevyhovuj\u00ed.<\/p>\n<h2 class=\"wp-block-heading\">Skladov\u00e1n\u00ed<\/h2>\n<p>Store Leemigran below 25&deg;C in the original blister or bottle. Protect from light and moisture. Keep out of reach of children. Use before the expiry date.<\/p>\n<h2 id=\"faqs\">\u010casto kladen\u00e9 dotazy<\/h2>\n<h3 class=\"wp-block-heading\">When should I take Leemigran?<\/h3>\n<p>P\u0159i prvn\u00edch zn\u00e1mk\u00e1ch migren\u00f3zn\u00ed bolesti nebo aury. Triptany jsou nej\u00fa\u010dinn\u011bj\u0161\u00ed, kdy\u017e se u\u017e\u00edvaj\u00ed brzy \u2014 \u010d\u00edm d\u0159\u00edve u\u017eijete d\u00e1vku, t\u00edm vy\u0161\u0161\u00ed je pravd\u011bpodobnost \u00fapln\u00e9ho vymizen\u00ed bolesti. \u010cek\u00e1n\u00ed, zda bolest hlavy sama odezn\u00ed, sni\u017euje m\u00edru odpov\u011bdi p\u0159ibli\u017en\u011b o 30 %.<\/p>\n<h3 class=\"wp-block-heading\">Can I take Leemigran for a tension headache or sinus pain?<\/h3>\n<p>No &mdash; triptans only work on migraine pain. They are not effective for tension headache, sinus pain, or non-migraine headache types. Many &#8220;sinus headaches&#8221; are actually migraines with nasal symptoms, so if your &#8220;sinus headache&#8221; responds to Leemigran, it is probably migraine; get a diagnostic review.<\/p>\n<h3 class=\"wp-block-heading\">What if Leemigran doesn&#8217;t work on an attack?<\/h3>\n<p>Pokud prvn\u00ed d\u00e1vka po 2 hodin\u00e1ch nezabere, je nepravd\u011bpodobn\u00e9, \u017ee by druh\u00e1 d\u00e1vka p\u0159i stejn\u00e9m z\u00e1chvatu pomohla. P\u0159epn\u011bte na z\u00e1chrann\u00e9 NSAID (<a href=\"https:\/\/medsbase.com\/cs\/naprosyn\/\">naproxen 500 mg<\/a>) nebo jinou strategii pro p\u0159eru\u0161en\u00ed z\u00e1chvatu. P\u0159i p\u0159\u00ed\u0161t\u00edm z\u00e1chvatu vyzkou\u0161ejte jin\u00fd triptan nebo jinou formu (nosn\u00ed sprej, ODS); p\u0159ibli\u017en\u011b 25 % nereaguj\u00edc\u00edch na jeden triptan reaguje na jin\u00fd.<\/p>\n<h3 class=\"wp-block-heading\">How often can I use Leemigran?<\/h3>\n<p>Maxim\u00e1ln\u011b <strong>10 dn\u00ed v m\u011bs\u00edci<\/strong> u v\u0161ech triptan\u016f, ergotamin\u016f a kombinovan\u00fdch analgetik dohromady. P\u0159i p\u0159ekro\u010den\u00ed t\u00e9to hranice triptany zp\u016fsobuj\u00ed bolest hlavy z nadu\u017e\u00edv\u00e1n\u00ed l\u00e9k\u016f \u2014 paradoxn\u00ed rebound bolest hlavy nav\u00edc k z\u00e1kladn\u00ed migr\u00e9n\u011b. Pokud u\u017e\u00edv\u00e1te akutn\u00ed l\u00e9ky v\u00edce ne\u017e 10 dn\u00ed\/m\u011bs\u00edc, pot\u0159ebujete preventivn\u00ed l\u00e9k (<a href=\"https:\/\/medsbase.com\/cs\/topicon\/\">topiram\u00e1t<\/a>, <a href=\"https:\/\/medsbase.com\/cs\/inderal\/\">propranolol<\/a>, <a href=\"https:\/\/medsbase.com\/cs\/sibelium\/\">flunarizin<\/a>, <a href=\"https:\/\/medsbase.com\/cs\/encorate\/\">valpro\u00e1t<\/a>, amitriptylin nebo antagonista CGRP).<\/p>\n<h3 class=\"wp-block-heading\">Po prvn\u00ed d\u00e1vce jsem c\u00edtil tlak na hrudi \u2014 m\u00e1m p\u0159estat?<\/h3>\n<p>Tlak, sta\u017een\u00ed nebo pocit tepla na hrudi po u\u017eit\u00ed triptanu je b\u011b\u017en\u00fd (tzv. triptanov\u00e9 pocity) a obvykle ne\u0161kodn\u00fd u pacient\u016f bez srde\u010dn\u00edho onemocn\u011bn\u00ed. Jen podle p\u0159\u00edznak\u016f v\u0161ak nelze klinicky odli\u0161it od anginy pectoris. Po prvn\u00ed epizod\u011b hrudn\u00edch p\u0159\u00edznak\u016f je nutn\u00e9 p\u0159ed dal\u0161\u00edm u\u017eit\u00edm triptanu prov\u00e9st EKG a konzultaci s kardiologem. Pokud je bolest na hrudi siln\u00e1, vyst\u0159eluj\u00edc\u00ed, trv\u00e1 d\u00e9le ne\u017e 20 minut nebo je doprov\u00e1zena pocen\u00edm \u010di du\u0161nost\u00ed, pova\u017eujte ji za potenci\u00e1ln\u00ed srde\u010dn\u00ed p\u0159\u00edhodu.<\/p>\n<h3 class=\"wp-block-heading\">Can I take Leemigran with my antidepressant?<\/h3>\n<p>V\u011bt\u0161inou ano, ale s opatrnost\u00ed. MAOI (fenelzin, tranylcypromin) jsou <strong>absolutn\u00ed kontraindikac\u00ed<\/strong> \u2014 nesm\u00ed se kombinovat. SSRI a SNRI (fluoxetin, sertralin, citalopram, venlafaxin, duloxetin) podle doporu\u010den\u00ed FDA z roku 2006 teoreticky nesou mal\u00e9 riziko serotoninov\u00e9ho syndromu, ale re\u00e1ln\u00e1 data ukazuj\u00ed, \u017ee toto riziko je velmi n\u00edzk\u00e9. V\u011bt\u0161ina neurolog\u016f kombinaci povoluje za p\u0159edpokladu monitorov\u00e1n\u00ed. Vyvarujte se t\u0159ezalky te\u010dkovan\u00e9.<\/p>\n<h3 class=\"wp-block-heading\">Is Leemigran safe in pregnancy?<\/h3>\n<p>Sumatriptan m\u00e1 nejv\u00edce \u00fadaj\u016f o u\u017e\u00edv\u00e1n\u00ed v t\u011bhotenstv\u00ed; \u00fadaje z registr\u016f jsou obecn\u011b uklid\u0148uj\u00edc\u00ed (FDA kategorie C). Zolmitriptan a rizatriptan maj\u00ed m\u00e9n\u011b dat. P\u0159i t\u011b\u017ek\u00e9 migr\u00e9n\u011b v t\u011bhotenstv\u00ed, kdy nefarmakologick\u00e9 metody sel\u017eou, je sumatriptan obvykle prvn\u00ed volbou. P\u0159ed u\u017eit\u00edm jak\u00e9hokoli triptanu v t\u011bhotenstv\u00ed se pora\u010fte se sv\u00fdm gynekologem.<\/p>\n<h3 class=\"wp-block-heading\">Co jsou antagonist\u00e9 CGRP a pot\u0159ebuji je m\u00edsto triptan\u016f?<\/h3>\n<p>Antagonist\u00e9 CGRP (erenumab, galcanezumab, fremanezumab, eptinezumab injek\u010dn\u00ed monoklon\u00e1ln\u00ed protil\u00e1tky; rimegepant, ubrogepant, atogepant peror\u00e1ln\u00ed gepanty) jsou nov\u011bj\u0161\u00ed t\u0159\u00eddou l\u00e9k\u016f, kter\u00e9 nezp\u016fsobuj\u00ed vazokonstrikci a jsou bezpe\u010dn\u00e9 u pacient\u016f s kardiovaskul\u00e1rn\u00edmi kontraindikacemi pro triptany. Obvykle jsou vyhrazeny pro: (a) pacienty, kte\u0159\u00ed nemohou u\u017e\u00edvat triptany kv\u016fli kardiovaskul\u00e1rn\u00edmu onemocn\u011bn\u00ed, (b) pacienty, kte\u0159\u00ed pot\u0159ebuj\u00ed preventivn\u00ed l\u00e9\u010dbu nad r\u00e1mec propranololu\/topiram\u00e1tu\/amitriptylinu, nebo (c) pacienty s 4 a v\u00edce dny migr\u00e9ny m\u011bs\u00ed\u010dn\u011b. V\u011bt\u0161ina pacient\u016f dob\u0159e reaguje na triptany za v\u00fdrazn\u011b ni\u017e\u0161\u00ed cenu.<\/p>\n<h3 class=\"wp-block-heading\">Where can I buy Leemigran online?<\/h3>\n<p>You can buy Leemigran (sumatriptan 50 mg \/ 100 mg oral tablet, 30-180 tablet packs) from MedsBase with discreet packaging and worldwide shipping.<\/p>\n<h2 class=\"wp-block-heading\">Souvisej\u00edc\u00ed l\u00e9\u010dba migr\u00e9ny na MedsBase<\/h2>\n<ul>\n<li><a href=\"https:\/\/medsbase.com\/cs\/zolmist-nasal-spray\/\">Zolmist nosn\u00ed sprej \u2014 Zolmitriptan 5 mg (rychlej\u0161\u00ed n\u00e1stup \u00fa\u010dinku)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/zolitas-ods\/\">Zolitas ODS \u2014 Zolmitriptan 2,5\/5 mg orodispergovateln\u00e9 tablety<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/maxtan\/\">Maxtan \u2014 Rizatriptan 5\/10 mg<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/rizatop\/\">Rizatop \u2014 Rizatriptan 10 mg<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/rizact\/\">Rizact \u2014 Rizatriptan (Cipla)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/sumitop\/\">Sumitop \u2014 Sumatriptan 25\/50\/100 mg<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/anti-migraine\/\"><strong>Prohl\u00e9dnout v\u0161echny l\u00e9ky proti migr\u00e9n\u011b<\/strong><\/a><\/li>\n<\/ul>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:16px 20px;margin:24px 0;border-radius:4px;\"><strong>\u2695 L\u00e9ka\u0159sk\u00e9 upozorn\u011bn\u00ed.<\/strong> Tato str\u00e1nka slou\u017e\u00ed pouze pro informa\u010dn\u00ed \u00fa\u010dely a nenahrazuje odbornou l\u00e9ka\u0159skou pomoc. P\u0159ed zah\u00e1jen\u00edm, zm\u011bnou nebo ukon\u010den\u00edm jak\u00e9hokoli l\u00e9\u010den\u00ed migr\u00e9ny se v\u017edy pora\u010fte se sv\u00fdm l\u00e9ka\u0159em.<\/div>\n<h3>Pro\u010d objedn\u00e1vat z MedsBase<\/h3>\n<p class=\"medsbase-reship-line\" style=\"font-size:14px;color:#444;margin:8px 0 18px;\">\ud83d\udce6 Ka\u017ed\u00e1 objedn\u00e1vka je pokryta na\u0161\u00ed <a href=\"https:\/\/medsbase.com\/cs\/medsbase-re-shipment-assurance-policy\/\"><strong>Z\u00e1rukou op\u011btovn\u00e9ho odesl\u00e1n\u00ed<\/strong><\/a> \u2014 pokud va\u0161e z\u00e1silka nedoraz\u00ed do 20 pracovn\u00edch dn\u016f, p\u0159epos\u00edl\u00e1me ji.<\/p>\n<p><!-- medsbase-related-alts-v1 --><\/p>\n<h3 class=\"wp-block-heading\">Souvisej\u00edc\u00ed alternativy<\/h3>\n<p>Dal\u0161\u00ed produkty v <strong>Chronick\u00e1 onemocn\u011bn\u00ed<\/strong> kter\u00e9 z\u00e1kazn\u00edci tak\u00e9 prohl\u00ed\u017eej\u00ed:<\/p>\n<ul>\n<li><a href=\"https:\/\/medsbase.com\/cs\/anaridex\/\">Anaridex<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/trinex\/\">Trinex<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/asthalin-inhaler\/\">Asthalin Inhaler<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/desowen\/\">Desowen<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/ketanov-injection\/\">Injekce Ketanov<\/a><\/li>\n<\/ul>","protected":false},"excerpt":{"rendered":"<p>Leemigran is sumatriptan 50 mg \/ 100 mg oral tablets from Leeford Healthcare \u2014 the classic first-generation triptan for acute migraine with or without aura in adults. Take at first sign of migraine pain; onset 30-60 minutes. Maximum 200 mg per 24 hours. Standard triptan contraindications apply.<\/p>","protected":false},"featured_media":59364,"comment_status":"open","ping_status":"open","template":"","meta":[],"product_brand":[],"product_cat":[3553,3141,3223,3342,3554],"product_tag":[4684,3556],"class_list":{"0":"post-59363","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-anti-migraine","7":"product_cat-category-overview","8":"product_cat-chronic-conditions","9":"product_cat-general-health","10":"product_cat-migraine-treatment","11":"product_tag-leemigran","12":"product_tag-sumatriptan","14":"first","15":"instock","16":"shipping-taxable","17":"purchasable","18":"product-type-variable","19":"has-default-attributes"},"acf":[],"_links":{"self":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product\/59363","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/comments?post=59363"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/media\/59364"}],"wp:attachment":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/media?parent=59363"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product_brand?post=59363"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product_cat?post=59363"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product_tag?post=59363"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}