{"id":59393,"date":"2024-02-28T05:56:08","date_gmt":"2024-02-28T05:56:08","guid":{"rendered":"https:\/\/medsname.com\/nicerbium\/"},"modified":"2026-05-01T10:49:15","modified_gmt":"2026-05-01T10:49:15","slug":"nicerbium","status":"publish","type":"product","link":"https:\/\/medsbase.com\/cs\/product\/nicerbium\/","title":{"rendered":"Nicerbium"},"content":{"rendered":"<p><!-- medsbase-tldr-answer --><\/p>\n<div style=\"background:#fff8e1;border-left:4px solid #f5a623;padding:18px 22px;margin:0 0 24px 0;border-radius:4px;\">\n<h3 class=\"wp-block-heading\" style=\"margin:0 0 8px 0;font-size:16px;font-weight:700;\">&#9889; Quick Answer &mdash; What is Nicerbium?<\/h3>\n<p style=\"margin:0;\"><strong>Nicerbium<\/strong> je peror\u00e1ln\u00ed <strong>nicergoline<\/strong> (30 mg) tablet \u2014 an <strong>ergot-derivative nootropic and cerebral vasodilator<\/strong> pou\u017e\u00edvan\u00e1 k l\u00e9\u010db\u011b <strong>cognitive impairment<\/strong> and symptoms of <strong>cerebrovascular insufficiency<\/strong>, including <strong>vascular dementia<\/strong>, <strong>age-related cognitive decline<\/strong>, a <strong>peripheral vascular disorders<\/strong>. It works through multiple mechanisms: &alpha;-adrenergic blockade (improving cerebral blood flow), enhancement of cholinergic and dopaminergic neurotransmission, and neuroprotective effects. Usual dose: <strong>30 mg twice daily<\/strong> (or 60 mg once daily). Generally well tolerated \u2014 common side effects: mild GI upset, dizziness, flushing.<\/p>\n<\/div>\n<div class=\"medsbase-trust-strip\" style=\"background:#f4f8fb;border:1px solid #d8e3eb;padding:12px 16px;margin:16px 0;border-radius:4px;font-size:14px;\">\n<strong>Co z\u00edsk\u00e1te s MedsBase:<\/strong> V\u00fdrobce certifikovan\u00fd WHO-GMP \u00b7 Diskr\u00e9tn\u00ed balen\u00ed \u00b7 Celosv\u011btov\u00e1 doprava \u00b7 V\u00edce ne\u017e 1 400 ov\u011b\u0159en\u00fdch <a href=\"https:\/\/medsbase.com\/cs\/reviews\/\">recenz\u00ed z\u00e1kazn\u00edk\u016f<\/a>\n<\/div>\n<p class=\"medsbase-reship-line\" style=\"font-size:14px;color:#444;margin:8px 0 18px;\">\ud83d\udce6 Ka\u017ed\u00e1 objedn\u00e1vka je pokryta na\u0161\u00ed <a href=\"https:\/\/medsbase.com\/cs\/medsbase-re-shipment-assurance-policy\/\"><strong>Z\u00e1rukou op\u011btovn\u00e9ho odesl\u00e1n\u00ed<\/strong><\/a> \u2014 pokud va\u0161e z\u00e1silka nedoraz\u00ed do 20 pracovn\u00edch dn\u016f, p\u0159epos\u00edl\u00e1me ji.<\/p>\n<h3>Pro\u010d objedn\u00e1vat z MedsBase<\/h3>\n<p>Na\u0161e generick\u00e9 l\u00e9ky poch\u00e1zej\u00ed od v\u00fdrobc\u016f certifikovan\u00fdch WHO-GMP a jsou expedov\u00e1ny po cel\u00e9m sv\u011bt\u011b v diskr\u00e9tn\u00edm, nen\u00e1padn\u00e9m balen\u00ed \u2013 na vn\u011bj\u0161\u00ed stran\u011b bal\u00edku nen\u00ed uveden n\u00e1zev l\u00e9ku. Platby kartou jsou sm\u011brov\u00e1ny prost\u0159ednictv\u00edm regulovan\u00e9ho procesoru (popisky na v\u00fdpisu zahrnuj\u00ed regulovan\u00e9ho procesora plateb kartou \u2013 nikdy \u201cMedsBase\u201d nebo n\u00e1zev l\u00e9ku). P\u0159ij\u00edm\u00e1me tak\u00e9 kryptom\u011bny a bankovn\u00ed p\u0159evody SEPA. Ka\u017ed\u00e1 objedn\u00e1vka je zaji\u0161t\u011bna na\u0161\u00ed politikou p\u0159eposl\u00e1n\u00ed.<\/p>\n<h2 class=\"wp-block-heading\">What Is Nicerbium?<\/h2>\n<p>Nicerbium is an oral tablet containing <strong>nicergoline 30 mg<\/strong>. Nicergoline is an <strong>ergot-derived cerebral vasodilator and nootropic<\/strong> that has been in clinical use since the 1970s, primarily in Europe and Asia. It improves cerebral blood flow, enhances cholinergic and catecholaminergic neurotransmission, and has neuroprotective properties via antioxidant mechanisms.<\/p>\n<p>Nicergoline is prescribed for <strong>age-related cognitive decline<\/strong>, <strong>vascular dementia<\/strong>, <strong>chronic cerebrovascular insufficiency<\/strong>, a <strong>peripheral vascular disorders<\/strong>. It is not approved by the FDA (US) but is widely used internationally. Nicerbium is manufactured by a WHO-GMP certified facility and is bioequivalent to the originator brand <strong>Sermion<\/strong> (Pfizer).<\/p>\n<h2 class=\"wp-block-heading\">How Does Nicerbium (Nicergoline) Work?<\/h2>\n<p>Nicergoline has a <strong>multimodal mechanism<\/strong> that distinguishes it from simple vasodilators:<\/p>\n<ul>\n<li><strong>&alpha;<sub>1<\/sub>-Adrenergic receptor blockade:<\/strong> Relaxes cerebral and peripheral vascular smooth muscle, improving blood flow to the brain and extremities<\/li>\n<li><strong>Cholinergic enhancement:<\/strong> Increases acetylcholine release and inhibits acetylcholinesterase \u2014 supporting memory and cognitive function<\/li>\n<li><strong>Dopaminergic facilitation:<\/strong> Enhances dopamine turnover in the frontal cortex<\/li>\n<li><strong>Neuroprotection:<\/strong> Reduces oxidative stress, inhibits platelet aggregation, and promotes nerve growth factor (NGF) production<\/li>\n<\/ul>\n<p>These combined effects make nicergoline more than a vasodilator \u2014 it acts as a <strong>multimodal nootropic<\/strong> addressing both vascular and neurodegenerative components of cognitive decline.<\/p>\n<h2 class=\"wp-block-heading\">Indikace<\/h2>\n<ul>\n<li><strong>Mild-to-moderate vascular dementia<\/strong> a <strong>multi-infarct dementia<\/strong><\/li>\n<li><strong>Chronic cerebrovascular insufficiency<\/strong> \u2014 dizziness, tinnitus, headache, and memory problems related to reduced cerebral blood flow<\/li>\n<li><strong>Age-related cognitive decline<\/strong> (not meeting criteria for dementia)<\/li>\n<li><strong>Peripheral vascular disorders<\/strong> \u2014 Raynaud phenomenon, intermittent claudication<\/li>\n<li><strong>Profylaxe migr\u00e9ny<\/strong> (adjunct, off-label in some markets)<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Dosing and Administration<\/h2>\n<table style=\"width:100%;border-collapse:collapse;margin:0 0 24px 0;\">\n<thead>\n<tr style=\"background:#2c7cb0;color:#fff;\">\n<th style=\"padding:10px 14px;\">Indikace<\/th>\n<th style=\"padding:10px 14px;\">D\u00e1vka<\/th>\n<th style=\"padding:10px 14px;\">D\u00e9lka<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td style=\"padding:10px 14px;\">Cognitive impairment \/ vascular dementia<\/td>\n<td style=\"padding:10px 14px;\">30 mg twice daily<\/td>\n<td style=\"padding:10px 14px;\">\u22653&ndash;6 months (assess benefit at 3 months)<\/td>\n<\/tr>\n<tr style=\"background:#f9f9f9;\">\n<td style=\"padding:10px 14px;\">Cerebrovascular insufficiency<\/td>\n<td style=\"padding:10px 14px;\">30 mg twice or three times daily<\/td>\n<td style=\"padding:10px 14px;\">Ongoing as directed<\/td>\n<\/tr>\n<tr>\n<td style=\"padding:10px 14px;\">Onemocn\u011bn\u00ed perifern\u00edch c\u00e9v<\/td>\n<td style=\"padding:10px 14px;\">30 mg three times daily<\/td>\n<td style=\"padding:10px 14px;\">Ongoing as directed<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>Take between meals for optimal absorption (food reduces bioavailability by ~15&ndash;20%). Treatment response for cognitive symptoms typically requires <strong>at least 2&ndash;3 months<\/strong>.<\/p>\n<h2 class=\"wp-block-heading\">Vedlej\u0161\u00ed \u00fa\u010dinky<\/h2>\n<p><strong>Common (generally mild):<\/strong> gastric discomfort, nausea, flushing, dizziness, drowsiness, hypotension (usually postural).<\/p>\n<p><strong>M\u00e9n\u011b \u010dast\u00e9:<\/strong> skin rash, insomnia, agitation, uric acid elevation (due to purine metabolite).<\/p>\n<p><strong>Rare\/serious:<\/strong> ergotism symptoms (extremely rare at therapeutic doses \u2014 nicergoline has minimal vasoconstrictive activity unlike other ergot derivatives), fibrotic reactions (very rare, class warning for ergot derivatives with prolonged use).<\/p>\n<h2 class=\"wp-block-heading\">Varov\u00e1n\u00ed a opat\u0159en\u00ed<\/h2>\n<ul>\n<li><strong>Ergot derivative.<\/strong> Nicergoline retains weak ergot-receptor activity. Prolonged use at supratherapeutic doses carries a theoretical risk of retroperitoneal, pleural or cardiac-valve fibrosis (class effect of ergots). Standard 30 mg\/day doses have not shown clinically significant fibrosis risk in 50+ years of post-marketing surveillance.<\/li>\n<li><strong>Hypotension.<\/strong> Nicergoline is an &alpha;1-adrenoceptor antagonist &mdash; orthostatic hypotension can occur, particularly in older adults or patients on antihypertensives. Rise slowly from sitting\/lying.<\/li>\n<li><strong>Hyperuricaemia.<\/strong> Nicergoline is metabolised to nicotinic acid, which raises uric acid levels. Monitor in gout-prone patients.<\/li>\n<li><strong>Jatern\u00ed porucha.<\/strong> Nicergoline undergoes extensive first-pass hepatic metabolism. Use caution in severe liver disease.<\/li>\n<li><strong>Bleeding risk.<\/strong> Nicergoline has mild antiplatelet activity. Use caution with anticoagulants (warfarin, DOACs) and dual antiplatelet therapy.<\/li>\n<li><strong>T\u011bhotenstv\u00ed &amp; kojen\u00ed.<\/strong> Insufficient data. Avoid unless clearly necessary.<\/li>\n<li><strong>Driving.<\/strong> Dizziness and hypotension may impair driving ability in the first 1&ndash;2 weeks.<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Contraindications &mdash; Who Should NOT Take Nicerbium<\/h2>\n<ul>\n<li>Known hypersensitivity to nicergoline, other ergot derivatives or any excipient<\/li>\n<li>Recent myocardial infarction (acute phase)<\/li>\n<li>Acute haemorrhage or active bleeding<\/li>\n<li>Severe hypotension (systolic &lt;90 mmHg)<\/li>\n<li>Severe bradycardia<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Interakce s l\u00e9\u010divy<\/h2>\n<ul>\n<li><strong>Antihypertensives:<\/strong> Additive blood-pressure lowering \u2014 monitor for hypotension<\/li>\n<li><strong>Anticoagulants\/antiplatelets:<\/strong> Nicergoline inhibits platelet aggregation \u2014 theoretical additive bleeding risk<\/li>\n<li><strong>Other ergot derivatives:<\/strong> Avoid concurrent use (cumulative ergot effects)<\/li>\n<li><strong>CYP2D6 substrates:<\/strong> Nicergoline weakly inhibits CYP2D6 \u2014 clinical significance is low at standard doses<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Pokyny k uchov\u00e1v\u00e1n\u00ed<\/h2>\n<ul>\n<li>Skladujte p\u0159i pokojov\u00e9 teplot\u011b, <strong>15\u201325\u00b0C<\/strong>. Chra\u0148te p\u0159ed sv\u011btlem a vlhkost\u00ed.<\/li>\n<li>Keep in original packaging until use.<\/li>\n<li>Do not store in the bathroom.<\/li>\n<li>Uchov\u00e1vejte mimo dosah d\u011bt\u00ed.<\/li>\n<li>Nepou\u017e\u00edvejte po uplynut\u00ed data expirace.<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Related Categories on MedsBase<\/h2>\n<ul>\n<li><a href=\"https:\/\/medsbase.com\/cs\/neurological-conditions-and-epilepsy\/\">Prohl\u00e9dn\u011bte si v\u0161echny neurologick\u00e9 a antiepileptick\u00e9 l\u00e9ky<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/heart-and-blood-pressure\/\">Browse heart &amp; blood pressure medications<\/a><\/li>\n<\/ul>\n<h2 id=\"faqs\">\u010casto kladen\u00e9 dotazy<\/h2>\n<h3 class=\"wp-block-heading\">What is Nicerbium used for?<\/h3>\n<p>Nicerbium contains <strong>nicergoline 30 mg<\/strong> and is used to improve cognitive function and cerebral blood flow in patients with <strong>vascular dementia, chronic cerebrovascular insufficiency, and age-related cognitive decline<\/strong>.<\/p>\n<h3 class=\"wp-block-heading\">How long does nicergoline take to show benefit?<\/h3>\n<p>Cognitive improvement is gradual. Most clinical trials assessed outcomes at <strong>3\u20136 m\u011bs\u00edc\u00edch<\/strong>. Some patients notice improvements in alertness and concentration within 4&ndash;6 weeks, but meaningful cognitive changes require longer treatment.<\/p>\n<h3 class=\"wp-block-heading\">Is nicergoline effective for Alzheimer disease?<\/h3>\n<p>Nicergoline has shown modest benefit in <strong>vascular dementia<\/strong> a <strong>mixed dementia<\/strong> (vascular + Alzheimer) in Cochrane-reviewed trials. It is <strong>not a first-line treatment for pure Alzheimer disease<\/strong> \u2014 cholinesterase inhibitors (donepezil, rivastigmine) are standard of care. However, its cholinergic-enhancing and neuroprotective properties may provide adjunctive benefit in mixed-aetiology cognitive decline.<\/p>\n<h3 class=\"wp-block-heading\">Is Nicerbium the same as Sermion?<\/h3>\n<p>Both contain nicergoline. Sermion is the original brand by Pfizer (formerly Farmitalia). Nicerbium is a bioequivalent generic.<\/p>\n<h3 class=\"wp-block-heading\">Can I take nicergoline with blood pressure medications?<\/h3>\n<p>Yes, but with monitoring. Nicergoline has mild blood-pressure-lowering effects via &alpha;-blockade. Combined with antihypertensives, <strong>orthostatic hypotension<\/strong> may occur \u2014 rise slowly from sitting\/lying positions.<\/p>\n<h3 class=\"wp-block-heading\">Does nicergoline cause ergotism?<\/h3>\n<p>Extremely unlikely at therapeutic doses. Unlike ergotamine (used for migraine), nicergoline has <strong>minimal vasoconstrictive activity<\/strong>. The ergot-class fibrosis warning is retained as a precaution but has not been reported at standard nicergoline doses in clinical practice.<\/p>\n<h3 class=\"wp-block-heading\">Is nicergoline a nootropic?<\/h3>\n<p>Yes \u2014 nicergoline is classified as a <strong>nootropic<\/strong> (cognitive enhancer) in many pharmacological references. Its combination of vascular, cholinergic, and neuroprotective mechanisms distinguishes it from single-mechanism nootropics like piracetam.<\/p>\n<h3 class=\"wp-block-heading\">Can nicergoline help with tinnitus?<\/h3>\n<p>Nicergoline is prescribed for <strong>tinnitus associated with cerebrovascular insufficiency<\/strong> in some markets. It may improve tinnitus when the underlying cause is reduced blood flow to the auditory system. It is unlikely to help tinnitus from other causes (noise damage, M\u00e9ni\u00e8re disease).<\/p>\n<h3 class=\"wp-block-heading\">What are the long-term safety considerations?<\/h3>\n<p>Nicergoline has been used for <strong>decades<\/strong> with a good long-term safety profile. The main consideration is periodic monitoring of uric acid levels (nicergoline is metabolised to a purine derivative) and blood pressure.<\/p>\n<h3 class=\"wp-block-heading\">Can I drive while taking Nicerbium?<\/h3>\n<p>Nicergoline can cause mild dizziness and drowsiness, especially initially. Use caution when driving until you know how it affects you. At stable doses, most patients have no driving impairment.<\/p>\n<h3 class=\"wp-block-heading\">Does nicergoline interact with warfarin?<\/h3>\n<p>Nicergoline mildly inhibits platelet aggregation. While it does not directly affect warfarin metabolism, the additive antiplatelet effect warrants monitoring of INR if used together, particularly when starting or stopping nicergoline.<\/p>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:16px 20px;margin:24px 0;border-radius:4px;font-size:13px;\"><strong>Zdravotn\u00ed upozorn\u011bn\u00ed:<\/strong> This page is for informational purposes only and does not replace professional medical advice. Always consult a qualified healthcare provider before starting, changing or stopping any medication. Dosing information reflects manufacturer labelling and published clinical guidance \u2014 individual requirements may differ.<\/div>\n<p><!-- medsbase-related-alts-v1 --><\/p>\n<h3 class=\"wp-block-heading\">Souvisej\u00edc\u00ed alternativy<\/h3>\n<p>Dal\u0161\u00ed produkty v <strong>Chronick\u00e1 onemocn\u011bn\u00ed<\/strong> kter\u00e9 z\u00e1kazn\u00edci tak\u00e9 prohl\u00ed\u017eej\u00ed:<\/p>\n<ul>\n<li><a href=\"https:\/\/medsbase.com\/cs\/neurobion-forte-rf-injection\/\">Neurobion Forte RF Injekce (Methylkobalamin + B6 + B3) \u2014 Oprava nerv\u016f<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/aerocort-inhaler\/\">Aerocort Inhaler<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/arkamin\/\">Arkamin<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/meftal\/\">Meftal<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/temozol-20\/\">Temozol 20<\/a><\/li>\n<\/ul>","protected":false},"excerpt":{"rendered":"<p>\u2705 Zlep\u0161uje pr\u016ftok krve<br \/>\n\u2705 Zlep\u0161uje kognitivn\u00ed funkce<br \/>\n\u2705 Sni\u017euje p\u0159\u00edznaky vertiga<br \/>\n\u2705 Manages migraines<br \/>\n\u2705 Podporuje zdrav\u00ed mozku<\/p>\n<p>Nicerbium contains Nicergoline.<\/p>","protected":false},"featured_media":59394,"comment_status":"open","ping_status":"open","template":"","meta":[],"product_brand":[],"product_cat":[3141,3223,3468],"product_tag":[4689,4690],"class_list":{"0":"post-59393","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-category-overview","7":"product_cat-chronic-conditions","8":"product_cat-neurological-conditions-and-epilepsy","9":"product_tag-nicerbium","10":"product_tag-nicergoline","12":"first","13":"instock","14":"shipping-taxable","15":"purchasable","16":"product-type-variable","17":"has-default-attributes"},"acf":[],"_links":{"self":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product\/59393","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/comments?post=59393"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/media\/59394"}],"wp:attachment":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/media?parent=59393"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product_brand?post=59393"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product_cat?post=59393"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product_tag?post=59393"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}