{"id":59425,"date":"2024-02-28T05:57:23","date_gmt":"2024-02-28T05:57:23","guid":{"rendered":"https:\/\/medsname.com\/nicip\/"},"modified":"2026-05-01T10:49:15","modified_gmt":"2026-05-01T10:49:15","slug":"nicip","status":"publish","type":"product","link":"https:\/\/medsbase.com\/cs\/product\/nicip\/","title":{"rendered":"Nicip"},"content":{"rendered":"<p><!-- medsbase-tldr-answer --><\/p>\n<div style=\"background:#fff8e1;border-left:4px solid #f5a623;padding:18px 22px;margin:0 0 24px 0;border-radius:4px;\">\n<h3 class=\"wp-block-heading\" style=\"margin:0 0 8px 0;font-size:16px;font-weight:700;\">\u26a1 Rychl\u00e1 odpov\u011b\u010f \u2014 Co je Nicip?<\/h3>\n<p style=\"margin:0;\"><strong>Nicip<\/strong> je peror\u00e1ln\u00ed tableta od spole\u010dnosti Cipla obsahuj\u00edc\u00ed <strong>nimesulid 100 mg<\/strong> \u2014 preferen\u010dn\u00ed <strong>COX-2 inhibitor NSAID<\/strong> pou\u017e\u00edvan\u00fd ke kr\u00e1tkodob\u00e9 symptomatick\u00e9 l\u00e9\u010db\u011b akutn\u00ed muskuloskelet\u00e1ln\u00ed bolesti, prim\u00e1rn\u00ed dysmenorey a vzplanut\u00ed osteoartr\u00f3zy. Standardn\u00ed d\u00e1vka pro dosp\u011bl\u00e9: <strong>100 mg dvakr\u00e1t denn\u011b, u\u017e\u00edvan\u00e9 s j\u00eddlem<\/strong>, pro <strong>nejkrat\u0161\u00ed nezbytnou dobu a maxim\u00e1ln\u011b 15 dn\u00ed<\/strong>. <strong>D\u016fle\u017eit\u00fd regula\u010dn\u00ed kontext<\/strong>: nimesulid byl <strong>sta\u017een z trhu ve Spojen\u00fdch st\u00e1tech, Spojen\u00e9m kr\u00e1lovstv\u00ed, \u0160pan\u011blsku, Finsku, Izraeli, Singapuru<\/strong> a nikdy nebyl schv\u00e1len v <strong>Austr\u00e1lii nebo Kanad\u011b<\/strong> kv\u016fli p\u0159\u00edpad\u016fm <strong>fulminantn\u00ed (n\u011bkdy fat\u00e1ln\u00ed) hepatotoxicity<\/strong>. Z\u016fst\u00e1v\u00e1 registrovan\u00fd v n\u011bkolika evropsk\u00fdch zem\u00edch a \u010d\u00e1stech Asie a Latinsk\u00e9 Ameriky s p\u0159\u00edsn\u00fdmi omezen\u00edmi pou\u017eit\u00ed: <strong>vstupn\u00ed testy jatern\u00edch funkc\u00ed p\u0159ed jakoukoli l\u00e9\u010dbou<\/strong>, <strong>maxim\u00e1ln\u011b 15denn\u00ed l\u00e9\u010dba<\/strong>, <strong>kontraindikov\u00e1no u pacient\u016f mlad\u0161\u00edch 12 let<\/strong>, v t\u011bhotenstv\u00ed (zejm\u00e9na ve t\u0159et\u00edm trimestru), p\u0159i v\u00fdznamn\u00e9m po\u0161kozen\u00ed jater, p\u0159i aktivn\u00ed poru\u0161e u\u017e\u00edv\u00e1n\u00ed alkoholu a u pacient\u016f s anamn\u00e9zou hepatotoxicity souvisej\u00edc\u00ed s nimesulidem. Stejn\u011b jako u v\u0161ech NSAID zahrnuj\u00ed dal\u0161\u00ed rizika gastrointestin\u00e1ln\u00ed krv\u00e1cen\u00ed a v\u0159edy, po\u0161kozen\u00ed ledvin, hypertenzi a zv\u00fd\u0161en\u00e9 riziko kardiovaskul\u00e1rn\u00edch p\u0159\u00edhod. <strong>Paracetamol a ibuprofen jsou obvykle bezpe\u010dn\u011bj\u0161\u00ed l\u00e9ky prvn\u00ed volby<\/strong>; nimesulid by m\u011bl b\u00fdt vyhrazen pro kr\u00e1tkodob\u00e9 u\u017e\u00edv\u00e1n\u00ed, kdy\u017e jin\u00e1 NSAID sel\u017eou nebo nejsou tolerov\u00e1na.<\/p>\n<\/div>\n<div class=\"medsbase-trust-strip\" style=\"background:#f4f8fb;border:1px solid #d8e3eb;padding:12px 16px;margin:16px 0;border-radius:4px;font-size:14px;\">\n<strong>Co z\u00edsk\u00e1te s MedsBase:<\/strong> V\u00fdrobce certifikovan\u00fd WHO-GMP \u00b7 Diskr\u00e9tn\u00ed balen\u00ed \u00b7 Celosv\u011btov\u00e1 doprava \u00b7 V\u00edce ne\u017e 1 400 ov\u011b\u0159en\u00fdch <a href=\"https:\/\/medsbase.com\/cs\/reviews\/\">recenz\u00ed z\u00e1kazn\u00edk\u016f<\/a>\n<\/div>\n<p class=\"medsbase-reship-line\" style=\"font-size:14px;color:#444;margin:8px 0 18px;\">\ud83d\udce6 Ka\u017ed\u00e1 objedn\u00e1vka je pokryta na\u0161\u00ed <a href=\"https:\/\/medsbase.com\/cs\/medsbase-re-shipment-assurance-policy\/\"><strong>Z\u00e1rukou op\u011btovn\u00e9ho odesl\u00e1n\u00ed<\/strong><\/a> \u2014 pokud va\u0161e z\u00e1silka nedoraz\u00ed do 20 pracovn\u00edch dn\u016f, p\u0159epos\u00edl\u00e1me ji.<\/p>\n<h3>Pro\u010d objedn\u00e1vat z MedsBase<\/h3>\n<p>Na\u0161e generick\u00e9 l\u00e9ky poch\u00e1zej\u00ed od v\u00fdrobc\u016f certifikovan\u00fdch WHO-GMP a jsou expedov\u00e1ny po cel\u00e9m sv\u011bt\u011b v diskr\u00e9tn\u00edm, nen\u00e1padn\u00e9m balen\u00ed \u2013 na vn\u011bj\u0161\u00ed stran\u011b bal\u00edku nen\u00ed uveden n\u00e1zev l\u00e9ku. Platby kartou jsou sm\u011brov\u00e1ny prost\u0159ednictv\u00edm regulovan\u00e9ho procesoru (popisky na v\u00fdpisu zahrnuj\u00ed regulovan\u00e9ho procesora plateb kartou \u2013 nikdy \u201cMedsBase\u201d nebo n\u00e1zev l\u00e9ku). P\u0159ij\u00edm\u00e1me tak\u00e9 kryptom\u011bny a bankovn\u00ed p\u0159evody SEPA. Ka\u017ed\u00e1 objedn\u00e1vka je zaji\u0161t\u011bna na\u0161\u00ed politikou p\u0159eposl\u00e1n\u00ed.<\/p>\n<p><!-- medsbase-specialist-strip --><\/p>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:16px 20px;margin:0 0 24px 0;border-radius:4px;font-size:14px;\"><strong>\u26a0 Varov\u00e1n\u00ed p\u0159ed hepatotoxicitou \u2013 pouze kr\u00e1tkodob\u00e9 u\u017e\u00edv\u00e1n\u00ed.<\/strong> Nimesulid nese zdokumentovan\u00e9 riziko z\u00e1va\u017en\u00e9ho, ob\u010das fat\u00e1ln\u00edho po\u0161kozen\u00ed jater a byl z tohoto d\u016fvodu sta\u017een z n\u011bkolika trh\u016f v\u010detn\u011b USA a UK. Pou\u017e\u00edvejte pouze tehdy, kdy\u017e jin\u00e1 NSAID nejsou vhodn\u00e1, v nejni\u017e\u0161\u00ed \u00fa\u010dinn\u00e9 d\u00e1vce, po <strong>nejkrat\u0161\u00ed mo\u017enou dobu (maxim\u00e1ln\u011b 15 dn\u00ed na jeden l\u00e9\u010debn\u00fd cyklus)<\/strong>. Vyhn\u011bte se u\u017e\u00edv\u00e1n\u00ed p\u0159i aktivn\u00edm onemocn\u011bn\u00ed jater, poru\u0161e u\u017e\u00edv\u00e1n\u00ed alkoholu a v t\u011bhotenstv\u00ed. Okam\u017eit\u011b p\u0159esta\u0148te u\u017e\u00edvat a vyhledejte l\u00e9ka\u0159skou pomoc, pokud se u v\u00e1s objev\u00ed \u017eloutenka, tmav\u00e1 mo\u010d, sv\u011btl\u00e1 stolice, p\u0159etrv\u00e1vaj\u00edc\u00ed nevolnost, bolest v prav\u00e9m horn\u00edm kvadrantu b\u0159icha nebo neobvykl\u00e1 \u00fanava. P\u0159ed zah\u00e1jen\u00edm l\u00e9\u010dby proberte s o\u0161et\u0159uj\u00edc\u00edm l\u00e9ka\u0159em jak\u00e9koli p\u0159edchoz\u00ed probl\u00e9my s j\u00e1try.<\/div>\n<h2 class=\"wp-block-heading\">Co je Nicip?<\/h2>\n<p>Nicip je peror\u00e1ln\u00ed tableta vyr\u00e1b\u011bn\u00e1 spole\u010dnost\u00ed Cipla obsahuj\u00edc\u00ed <strong>nimesulid<\/strong>, preferen\u010dn\u00ed inhibitor cyklooxygen\u00e1zy-2 (COX-2) ze <strong>t\u0159\u00eddy sulfonanilid\u016f<\/strong> nesteroidn\u00edch protiz\u00e1n\u011btliv\u00fdch l\u00e9k\u016f. Nimesulid byl poprv\u00e9 uveden na trh koncem 80. let 20. stolet\u00ed; m\u00e1 analgetick\u00e9, protiz\u00e1n\u011btliv\u00e9 a antipyretick\u00e9 \u00fa\u010dinky obecn\u011b podobn\u00e9 jin\u00fdm NSAID, s relativn\u011b rychl\u00fdm n\u00e1stupem \u00falevy od bolesti.<\/p>\n<p>Nicip je zna\u010dkov\u00e1 tableta nimesulidu od spole\u010dnosti Cipla, kter\u00e1 je dlouhodob\u011b skladem \u2013 jedno z nejzn\u00e1m\u011bj\u0161\u00edch jmen v region\u00e1ln\u00edm prostoru NSAID. S\u00edla 100 mg je standardn\u00ed d\u00e1vka pro dosp\u011bl\u00e9, u\u017e\u00edvan\u00e1 dvakr\u00e1t denn\u011b pro kr\u00e1tkodobou symptomatickou l\u00e9\u010dbu (maxim\u00e1ln\u011b 15denn\u00ed k\u00fara) akutn\u00ed muskuloskelet\u00e1ln\u00ed bolesti, bolestiv\u00e9ho vzplanut\u00ed osteoartr\u00f3zy a prim\u00e1rn\u00ed dysmenorey.<\/p>\n<p><strong>Up\u0159\u00edmn\u00e9 regula\u010dn\u00ed a bezpe\u010dnostn\u00ed zar\u00e1mov\u00e1n\u00ed.<\/strong> Nimesulid m\u00e1 komplikovanou regula\u010dn\u00ed historii. Po v\u00fdskytu skupin z\u00e1va\u017en\u00e9 a n\u011bkdy smrteln\u00e9 hepatotoxicity na po\u010d\u00e1tku 2000 let n\u011bkolik n\u00e1rodn\u00edch regul\u00e1tor\u016f st\u00e1hlo l\u00e9k z trhu: Spojen\u00e9 st\u00e1ty a Austr\u00e1lie jej nikdy neschv\u00e1lily; Spojen\u00e9 kr\u00e1lovstv\u00ed jej st\u00e1hlo v roce 1999; \u0160pan\u011blsko v roce 2002; Finsko v roce 2002; Izrael v roce 2007; a Singapur v roce 2007. Evropsk\u00e1 agentura pro l\u00e9\u010div\u00e9 p\u0159\u00edpravky p\u0159ezkoumala nimesulid v letech 2007 a 2011 a potvrdila, \u017ee z\u016fst\u00e1v\u00e1 schv\u00e1len v n\u011bkter\u00fdch evropsk\u00fdch zem\u00edch s omezen\u00edmi: maxim\u00e1ln\u011b 100 mg dvakr\u00e1t denn\u011b, maxim\u00e1ln\u011b 15denn\u00ed k\u00fara, z\u00e1kladn\u00ed testy jatern\u00edch funkc\u00ed, kontraindikov\u00e1n u d\u011bt\u00ed mlad\u0161\u00edch 12 let, u v\u00fdznamn\u00e9ho po\u0161kozen\u00ed jater a v t\u011bhotenstv\u00ed. Indie si nimesulid ponechala na sv\u00e9m trhu s obecn\u011b podobn\u00fdmi (i kdy\u017e r\u016fzn\u011b vynucovan\u00fdmi) omezen\u00edmi. Tento l\u00e9k by m\u011bl b\u00fdt v\u017edy pova\u017eov\u00e1n za <strong>analgetikum druh\u00e9 volby<\/strong> \u2013 vyhrazen\u00e9 pro pacienty, kte\u0159\u00ed nem\u011bli adekv\u00e1tn\u00ed odpov\u011b\u010f na paracetamol, ibuprofen, naproxen nebo diklofenak nebo je nesn\u00e1\u0161ej\u00ed.<\/p>\n<h2 class=\"wp-block-heading\">Jak Nicip funguje?<\/h2>\n<p>Nimesulid preferen\u010dn\u011b inhibuje <strong>indukovateln\u00fd enzym cyklooxygen\u00e1za-2 (COX-2)<\/strong> m\u00edsto konstitutivn\u00ed COX-1, \u010d\u00edm\u017e blokuje p\u0159em\u011bnu kyseliny arachidonov\u00e9 na prostaglandin H2 a n\u00e1sledn\u00e9 prostaglandiny (PGE2, PGI2). V\u00fdsledkem je sn\u00ed\u017een\u00ed z\u00e1n\u011btu, sn\u00ed\u017een\u00ed perifern\u00ed senzibilizace na bolest a sn\u00ed\u017een\u00ed hore\u010dky.<\/p>\n<p>Dal\u0161\u00ed mechanismy mimo inhibici COX-2, kter\u00e9 mohou p\u0159isp\u00edvat ke klinick\u00e9mu \u00fa\u010dinku:<\/p>\n<ul>\n<li>Inhibice fosfodiester\u00e1zy IV, zv\u00fd\u0161en\u00ed intracelul\u00e1rn\u00edho cAMP a sn\u00ed\u017een\u00ed uvol\u0148ov\u00e1n\u00ed z\u00e1n\u011btliv\u00fdch medi\u00e1tor\u016f<\/li>\n<li>P\u0159\u00edm\u00e9 pohlcov\u00e1n\u00ed kyseliny chlorn\u00e9 produkovan\u00e9 aktivovan\u00fdmi neutrofily<\/li>\n<li>Inhibice uvol\u0148ov\u00e1n\u00ed histaminu ze \u017e\u00edrn\u00fdch bun\u011bk<\/li>\n<\/ul>\n<p>N\u00e1stup analgetick\u00e9ho \u00fa\u010dinku: <strong>30\u201360 minut<\/strong> po jedn\u00e9 peror\u00e1ln\u00ed d\u00e1vce; vrcholov\u00fd \u00fa\u010dinek za 2\u20133 hodiny. Polo\u010das v plazm\u011b: 2\u20135 hodin. Dvakr\u00e1t denn\u00ed d\u00e1vkov\u00e1n\u00ed udr\u017euje stabiln\u00ed hladiny analgetika. Metabolizov\u00e1n v j\u00e1trech, p\u0159edev\u0161\u00edm pomoc\u00ed CYP2C9.<\/p>\n<h2 class=\"wp-block-heading\">Pou\u017eit\u00ed a indikace<\/h2>\n<p>V r\u00e1mci sou\u010dasn\u00fdch regula\u010dn\u00edch omezen\u00ed je p\u0159\u00edpravek Nicip schv\u00e1len pro <strong>kr\u00e1tkodobou symptomatickou l\u00e9\u010dbu<\/strong> of:<\/p>\n<ul>\n<li><strong>Akutn\u00ed bolest pohybov\u00e9ho apar\u00e1tu<\/strong> \u2014 v\u00fdrony, nata\u017een\u00ed, poran\u011bn\u00ed m\u011bkk\u00fdch tk\u00e1n\u00ed, bolesti zad<\/li>\n<li><strong>Akutn\u00ed vzplanut\u00ed bolestiv\u00e9 osteoartr\u00f3zy<\/strong> \u2014 kr\u00e1tkodob\u00e1 \u00faleva b\u011bhem p\u016fsoben\u00ed dlouhodob\u011bj\u0161\u00edch opat\u0159en\u00ed<\/li>\n<li><strong>Prim\u00e1rn\u00ed dysmenorea<\/strong> \u2014 menstrua\u010dn\u00ed bolesti nereaguj\u00edc\u00ed na prvn\u00ed linii analgezie<\/li>\n<li><strong>Akutn\u00ed poopera\u010dn\u00ed nebo po v\u00fdkonov\u00e9 bolesti<\/strong> \u2014 kr\u00e1tkodob\u00e9 k\u00fary<\/li>\n<li><strong>Bolesti zub\u016f<\/strong> \u2014 kr\u00e1tkodob\u00e9 k\u00fary<\/li>\n<\/ul>\n<p>Nicip je <strong>ne<\/strong> vhodn\u00e9 pro: b\u011b\u017enou analgezii, dlouhodobou l\u00e9\u010dbu bolesti (maxim\u00e1ln\u011b 15denn\u00ed k\u00fara), sni\u017eov\u00e1n\u00ed hore\u010dky (paracetamol je bezpe\u010dn\u011bj\u0161\u00ed), bolest u d\u011bt\u00ed mlad\u0161\u00edch 12 let (kontraindikov\u00e1no), bolest v t\u011bhotenstv\u00ed (kontraindikov\u00e1no) nebo chronick\u00e9 z\u00e1n\u011btliv\u00e9 onemocn\u011bn\u00ed (preferuj\u00ed se jin\u00e9 DMARDs a dlouhodob\u011b p\u016fsob\u00edc\u00ed NSAIDs).<\/p>\n<h2 class=\"wp-block-heading\">D\u00e1vkov\u00e1n\u00ed p\u0159\u00edpravku Nicip a zp\u016fsob u\u017e\u00edv\u00e1n\u00ed<\/h2>\n<p>Nicip je dod\u00e1v\u00e1n v <strong>100 mg<\/strong>. Standardn\u00ed d\u00e1vka pro dosp\u011bl\u00e9 je <strong>100 mg dvakr\u00e1t denn\u011b<\/strong>, u\u017e\u00edvejte s j\u00eddlem.<\/p>\n<h3 class=\"wp-block-heading\">Pravidla d\u00e1vkov\u00e1n\u00ed<\/h3>\n<table style=\"border-collapse:collapse;width:100%;margin:12px 0;\">\n<thead>\n<tr style=\"background:#2c7cb0;color:#fff;\">\n<th style=\"padding:10px;border:1px solid #ddd;text-align:left;\">Parametr<\/th>\n<th style=\"padding:10px;border:1px solid #ddd;text-align:left;\">Doporu\u010den\u00ed<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td style=\"padding:10px;border:1px solid #ddd;\">Standardn\u00ed d\u00e1vka pro dosp\u011bl\u00e9<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">100 mg dvakr\u00e1t denn\u011b<\/td>\n<\/tr>\n<tr>\n<td style=\"padding:10px;border:1px solid #ddd;\">Maxim\u00e1ln\u00ed denn\u00ed d\u00e1vka<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">200 mg\/den<\/td>\n<\/tr>\n<tr>\n<td style=\"padding:10px;border:1px solid #ddd;\">Maxim\u00e1ln\u00ed d\u00e9lka k\u00fary<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\"><strong>15 dn\u00ed<\/strong><\/td>\n<\/tr>\n<tr>\n<td style=\"padding:10px;border:1px solid #ddd;\">D\u011bti do 12 let<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\"><strong>Kontraindikov\u00e1no<\/strong><\/td>\n<\/tr>\n<tr>\n<td style=\"padding:10px;border:1px solid #ddd;\">Dosp\u00edvaj\u00edc\u00ed 12\u201317 let<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">U\u017e\u00edvat opatrn\u011b; ni\u017e\u0161\u00ed d\u00e1vky; preferov\u00e1n odborn\u00fd dohled<\/td>\n<\/tr>\n<tr>\n<td style=\"padding:10px;border:1px solid #ddd;\">Star\u0161\u00ed pacienti<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Nejni\u017e\u0161\u00ed \u00fa\u010dinn\u00e1 d\u00e1vka, nejkrat\u0161\u00ed mo\u017en\u00e1 doba l\u00e9\u010dby; \u010dast\u011bj\u0161\u00ed kontrola ren\u00e1ln\u00edch a jatern\u00edch funkc\u00ed<\/td>\n<\/tr>\n<tr>\n<td style=\"padding:10px;border:1px solid #ddd;\">M\u00edrn\u00e9 ren\u00e1ln\u00ed po\u0161kozen\u00ed (eGFR 50\u201380)<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">U\u017e\u00edvat opatrn\u011b; vyvarovat se p\u0159i st\u0159edn\u011b t\u011b\u017ek\u00e9m a\u017e t\u011b\u017ek\u00e9m posti\u017een\u00ed<\/td>\n<\/tr>\n<tr>\n<td style=\"padding:10px;border:1px solid #ddd;\">Porucha funkce jater<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\"><strong>Kontraindikov\u00e1no<\/strong><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h3 class=\"wp-block-heading\">Jak spr\u00e1vn\u011b u\u017e\u00edvat Nicip<\/h3>\n<ol>\n<li><strong>Prov\u00e9st vstupn\u00ed jatern\u00ed testy<\/strong> p\u0159ed zah\u00e1jen\u00edm jak\u00e9koli k\u00fary p\u0159\u00edpravkem Nicip, zejm\u00e9na pokud m\u00e1te v anamn\u00e9ze jatern\u00ed probl\u00e9my, pravideln\u011b konzumujete alkohol nebo u\u017e\u00edv\u00e1te jin\u00e9 potenci\u00e1ln\u011b hepatotoxick\u00e9 l\u00e9ky (vysok\u00e9 d\u00e1vky paracetamolu, isoniazid, methotrex\u00e1t, statiny).<\/li>\n<li><strong>U\u017e\u00edvejte s j\u00eddlem<\/strong> \u2014 sni\u017euje \u017ealude\u010dn\u00ed podr\u00e1\u017ed\u011bn\u00ed a riziko gastrointestin\u00e1ln\u00edho krv\u00e1cen\u00ed.<\/li>\n<li><strong>Polykejte tablety cel\u00e9 s plnou sklenic\u00ed vody.<\/strong><\/li>\n<li><strong>U\u017e\u00edvejte 100 mg dvakr\u00e1t denn\u011b, ne v\u00edce.<\/strong> Nep\u0159ekra\u010dujte maxim\u00e1ln\u00ed denn\u00ed d\u00e1vku. Pokud vynech\u00e1te d\u00e1vku, nedvojte ji.<\/li>\n<li><strong>P\u0159esta\u0148te u\u017e\u00edvat p\u0159i prvn\u00edm p\u0159\u00edznaku jatern\u00edch pot\u00ed\u017e\u00ed<\/strong> \u2014 ze\u017eloutnut\u00ed k\u016f\u017ee nebo b\u011blma o\u010d\u00ed (\u017eloutenka), tmav\u00e1 mo\u010d, sv\u011btl\u00e1 stolice, p\u0159etrv\u00e1vaj\u00edc\u00ed bolest v prav\u00e9m pod\u017eeb\u0159\u00ed, v\u00fdrazn\u00fd nechutenstv\u00ed, siln\u00e1 nevolnost, extr\u00e9mn\u00ed \u00fanava. Okam\u017eit\u011b vyhledejte l\u00e9ka\u0159skou pomoc a po\u017eadujte urgentn\u00ed jatern\u00ed testy.<\/li>\n<li><strong>P\u0159esta\u0148te u\u017e\u00edvat po 15 dnech bez ohledu na stav bolesti.<\/strong> Pokud bolest p\u0159etrv\u00e1v\u00e1, p\u0159ejd\u011bte na alternativn\u00ed analgetikum nebo zajist\u011bte odborn\u00e9 vy\u0161et\u0159en\u00ed z\u00e1kladn\u00edho onemocn\u011bn\u00ed.<\/li>\n<li><strong>Vyhn\u011bte se alkoholu<\/strong> b\u011bhem l\u00e9\u010dby \u2014 alkohol v\u00fdrazn\u011b zvy\u0161uje riziko hepatotoxicity.<\/li>\n<li><strong>Nekombinujte s jin\u00fdmi NSAID<\/strong> (ibuprofen, diklofenak, naproxen, mefenamov\u00e1 kyselina, aspirin) \u2014 kombinace zvy\u0161uje riziko gastrointestin\u00e1ln\u00edho krv\u00e1cen\u00ed a nefrotoxicity bez dal\u0161\u00edho analgetick\u00e9ho \u00fa\u010dinku.<\/li>\n<li><strong>Dostate\u010dn\u011b pijte<\/strong> \u2014 dehydratace v\u00fdrazn\u011b zhor\u0161uje nefrotoxicitu NSAID, zejm\u00e9na u star\u0161\u00edch pacient\u016f nebo t\u011bch na diuretik\u00e1ch \u010di ACEi\/ARB.<\/li>\n<li><strong>Informujte ka\u017ed\u00e9ho p\u0159edepisuj\u00edc\u00edho l\u00e9ka\u0159e a l\u00e9k\u00e1rn\u00edka, \u017ee u\u017e\u00edv\u00e1te Nicip<\/strong>, i kdy\u017e je v n\u011bkter\u00fdch zem\u00edch voln\u011b prodejn\u00fd \u2014 interak\u010dn\u00ed potenci\u00e1l je v\u00fdznamn\u00fd.<\/li>\n<\/ol>\n<h2 class=\"wp-block-heading\">Vedlej\u0161\u00ed \u00fa\u010dinky Nicipu<\/h2>\n<p>Nimesulid nese standardn\u00ed vedlej\u0161\u00ed \u00fa\u010dinky NSAID plus specifick\u00e9 riziko hepatotoxicity. Vedlej\u0161\u00ed \u00fa\u010dinky jsou z\u00e1visl\u00e9 na d\u00e1vce a d\u00e9lce u\u017e\u00edv\u00e1n\u00ed.<\/p>\n<p><strong>B\u011b\u017en\u00e9 (1\u201310 %):<\/strong><\/p>\n<ul>\n<li>P\u00e1len\u00ed \u017e\u00e1hy, nevolnost, dyspepsie<\/li>\n<li>Bolesti b\u0159icha<\/li>\n<li>Pr\u016fjem nebo z\u00e1cpa<\/li>\n<li>M\u00edrn\u00e9 zv\u00fd\u0161en\u00ed ALT\/AST \u2014 obvykle p\u0159echodn\u00e9 a bezp\u0159\u00edznakov\u00e9<\/li>\n<li>Z\u00e1vrat\u011b, bolesti hlavy<\/li>\n<li>Ko\u017en\u00ed vyr\u00e1\u017eka, sv\u011bd\u011bn\u00ed<\/li>\n<li>M\u00edrn\u00e1 retence tekutin, zv\u00fd\u0161en\u00ed krevn\u00edho tlaku<\/li>\n<\/ul>\n<p><strong>M\u00e9n\u011b \u010dast\u00e9 (0,1\u20131 %):<\/strong><\/p>\n<ul>\n<li>\u017dalude\u010dn\u00ed nebo dvan\u00e1ctn\u00edkov\u00e9 v\u0159edy<\/li>\n<li>Gastrointestin\u00e1ln\u00ed krv\u00e1cen\u00ed<\/li>\n<li>Zhor\u0161en\u00ed ren\u00e1ln\u00edch funkc\u00ed (zv\u00fd\u0161en\u00ed kreatininu)<\/li>\n<li>Hyperkal\u00e9mie<\/li>\n<li>Zhor\u0161en\u00ed hypertenze nebo srde\u010dn\u00edho selh\u00e1n\u00ed<\/li>\n<li>Bronchospazmus u astmatik\u016f citliv\u00fdch na aspirin\/NSAID<\/li>\n<li>V\u00fdznamn\u00e9 zv\u00fd\u0161en\u00ed jatern\u00edch transamin\u00e1z (&gt; 3\u00d7 horn\u00ed hranice normy)<\/li>\n<\/ul>\n<p><strong>Vz\u00e1cn\u00e9, ale potenci\u00e1ln\u011b fat\u00e1ln\u00ed \u2014 d\u016fvod regula\u010dn\u00edch omezen\u00ed:<\/strong><\/p>\n<ul>\n<li><strong>Akutn\u00ed hepatitida \u2014 v\u010detn\u011b fulminantn\u00edho selh\u00e1n\u00ed jater vy\u017eaduj\u00edc\u00edho transplantaci nebo vedouc\u00edho k \u00famrt\u00ed.<\/strong> Odhadovan\u00e1 incidence v klinick\u00fdch studi\u00edch: p\u0159ibli\u017en\u011b 1 z 10 000 a\u017e 1 ze 100 000 p\u0159edepsan\u00fdch d\u00e1vek, av\u0161ak postmarketingov\u00fd monitoring uv\u00e1d\u00ed vy\u0161\u0161\u00ed v\u00fdskyt. Rizikov\u00e9 faktory: preexistuj\u00edc\u00ed jatern\u00ed onemocn\u011bn\u00ed, konzumace alkoholu, \u017eensk\u00e9 pohlav\u00ed, v\u011bk &gt; 60 let, del\u0161\u00ed l\u00e9\u010debn\u00e9 k\u00fary, kombinace s dal\u0161\u00edmi hepatotoxick\u00fdmi l\u00e9ky.<\/li>\n<li><strong>Z\u00e1va\u017en\u00e9 ko\u017en\u00ed reakce<\/strong> \u2014 Stevens-Johnson\u016fv syndrom, toxick\u00e1 epiderm\u00e1ln\u00ed nekrol\u00fdza, DRESS<\/li>\n<li><strong>Z\u00e1va\u017en\u00e9 gastrointestin\u00e1ln\u00ed krv\u00e1cen\u00ed nebo perforace<\/strong><\/li>\n<li><strong>Akutn\u00ed selh\u00e1n\u00ed ledvin<\/strong>, zejm\u00e9na u dehydratovan\u00fdch pacient\u016f, senior\u016f nebo p\u0159i kombinaci ACEi\/ARB + diuretika<\/li>\n<li><strong>Z\u00e1va\u017en\u00e9 exacerbace astmatu<\/strong> u astmatik\u016f citliv\u00fdch na NSAID<\/li>\n<li><strong>Anafylaxe<\/strong><\/li>\n<li><strong>Akutn\u00ed hemolytick\u00e1 an\u00e9mie<\/strong> p\u0159i deficitu G6PD<\/li>\n<li><strong>Exacerbace srde\u010dn\u00edho selh\u00e1n\u00ed, IM, CMP<\/strong> \u2014 m\u00edrn\u011b zv\u00fd\u0161en\u00e9 riziko spole\u010dn\u00e9 pro v\u0161echna neselektivn\u00ed NSAID, zvl\u00e1\u0161t\u011b p\u0159i dlouhodob\u00e9m u\u017e\u00edv\u00e1n\u00ed<\/li>\n<\/ul>\n<p><strong>Varovn\u00e9 p\u0159\u00edznaky vy\u017eaduj\u00edc\u00ed OKAM\u017dIT\u00c9 U\u017dIT\u00cd Nicip:<\/strong><\/p>\n<ul>\n<li>\u017dlut\u00e9 zabarven\u00ed k\u016f\u017ee nebo o\u010dn\u00edho b\u011blma (\u017eloutenka)<\/li>\n<li>Tmav\u00e1 (barvy \u010daje) mo\u010d<\/li>\n<li>Bled\u00e9, hn\u011bdo\u0161ed\u00e9 stolice<\/li>\n<li>Siln\u00e1 bolest v prav\u00e9m horn\u00edm kvadrantu b\u0159icha<\/li>\n<li>Siln\u00e1 nevolnost nebo ztr\u00e1ta chuti k j\u00eddlu<\/li>\n<li>Zvracen\u00ed \u010derstv\u00e9 nebo k\u00e1vov\u00e9 sedliny<\/li>\n<li>\u010cern\u00e1 dehtovit\u00e1 stolice (mel\u00e9na)<\/li>\n<li>Siln\u00e1 roz\u0161\u00ed\u0159en\u00e1 ko\u017en\u00ed vyr\u00e1\u017eka, puch\u00fd\u0159e nebo olupov\u00e1n\u00ed k\u016f\u017ee<\/li>\n<li>Siln\u00e9 s\u00edp\u00e1n\u00ed nebo du\u0161nost<\/li>\n<li>V\u00fdrazn\u00e9 sn\u00ed\u017een\u00ed mno\u017estv\u00ed mo\u010di<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Varov\u00e1n\u00ed a opat\u0159en\u00ed<\/h2>\n<ul>\n<li><strong>Onemocn\u011bn\u00ed jater<\/strong> \u2014 absolutn\u00ed kontraindikace u st\u0159edn\u011b t\u011b\u017ek\u00e9ho a\u017e t\u011b\u017ek\u00e9ho onemocn\u011bn\u00ed. Vyhn\u011bte se i u m\u00edrn\u00fdch onemocn\u011bn\u00ed, pokud neexistuje bezpe\u010dn\u011bj\u0161\u00ed alternativa. P\u0159ed zah\u00e1jen\u00edm l\u00e9\u010dby prove\u010fte z\u00e1kladn\u00ed jatern\u00ed testy.<\/li>\n<li><strong>Aktivn\u00ed porucha u\u017e\u00edv\u00e1n\u00ed alkoholu, pravideln\u011b vysok\u00fd p\u0159\u00edjem alkoholu<\/strong> \u2014 v\u00fdrazn\u011b zvy\u0161uje riziko hepatotoxicity; kombinaci se vyhn\u011bte.<\/li>\n<li><strong>Ned\u00e1vn\u00e9 nebo pl\u00e1novan\u00e9 u\u017e\u00edv\u00e1n\u00ed jin\u00fdch hepatotoxick\u00fdch l\u00e9k\u016f<\/strong> (paracetamol ve vysok\u00fdch d\u00e1vk\u00e1ch, isoniazid, methotrex\u00e1t, statiny, antiepileptika) \u2014 kumulativn\u00ed riziko; zva\u017ete alternativn\u00ed analgetikum.<\/li>\n<li><strong>Aktivn\u00ed nebo ned\u00e1vno prod\u011blan\u00e9 peptick\u00e9 v\u0159edy, anamn\u00e9za gastrointestin\u00e1ln\u00edho krv\u00e1cen\u00ed<\/strong> \u2014 relativn\u00ed kontraindikace; pokud je nezbytn\u00e1, p\u0159edepi\u0161te sou\u010dasn\u011b PPI; zva\u017ete alternativu selektivn\u00edho COX-2 inhibitoru (celecoxib).<\/li>\n<li><strong>Porucha funkce ledvin<\/strong> \u2014 vyvarujte se u st\u0159edn\u011b t\u011b\u017ek\u00e9ho a\u017e t\u011b\u017ek\u00e9ho po\u0161kozen\u00ed; p\u0159i m\u00edrn\u00e9m po\u0161kozen\u00ed pou\u017e\u00edvejte s opatrnost\u00ed a pe\u010dliv\u00fdm monitorov\u00e1n\u00edm. Udr\u017eujte hydrataci.<\/li>\n<li><strong>Hypertenze, srde\u010dn\u00ed selh\u00e1n\u00ed, ischemick\u00e1 choroba srde\u010dn\u00ed<\/strong> \u2014 vyvarujte se dlouhodob\u00e9ho u\u017e\u00edv\u00e1n\u00ed; pokud mo\u017eno zvolte alternativn\u00ed analgetikum.<\/li>\n<li><strong>Astma, zejm\u00e9na aspirin-senzitivn\u00ed astma<\/strong> \u2014 vyvarujte se; k\u0159\u00ed\u017eov\u00e1 reaktivita s jin\u00fdmi NSAID je dob\u0159e zdokumentov\u00e1na.<\/li>\n<li><strong>T\u011bhotenstv\u00ed<\/strong> \u2014 <strong>kontraindikov\u00e1no<\/strong>, zejm\u00e9na ve t\u0159et\u00edm trimestru (p\u0159ed\u010dasn\u00e9 uzav\u0159en\u00ed ductus arteriosus, oligohydramnion, perzistuj\u00edc\u00ed plicn\u00ed hypertenze novorozence). Vyvarujte se tak\u00e9 v prvn\u00edm a druh\u00e9m trimestru.<\/li>\n<li><strong>Kojen\u00ed<\/strong> \u2014 kontraindikov\u00e1no; existuj\u00ed bezpe\u010dn\u011bj\u0161\u00ed alternativy NSAID (ibuprofen).<\/li>\n<li><strong>D\u011bti do 12 let<\/strong> \u2014 <strong>kontraindikov\u00e1no<\/strong>. U d\u011btsk\u00e9 bolesti nebo hore\u010dky jsou paracetamol nebo ibuprofen v standardn\u00edch pediatrick\u00fdch d\u00e1vk\u00e1ch prvn\u00ed volbou.<\/li>\n<li><strong>Star\u0161\u00ed pacienti<\/strong> \u2014 v\u00fdrazn\u011b vy\u0161\u0161\u00ed riziko gastrointestin\u00e1ln\u00edho krv\u00e1cen\u00ed, ren\u00e1ln\u00ed toxicity, kardiovaskul\u00e1rn\u00edch p\u0159\u00edhod a hepatotoxicity. Pou\u017e\u00edvejte nejni\u017e\u0161\u00ed d\u00e1vku po nejkrat\u0161\u00ed mo\u017enou dobu; up\u0159ednost\u0148ujte paracetamol nebo topick\u00e1 NSAID.<\/li>\n<li><strong>Sou\u010dasn\u00e9 u\u017e\u00edv\u00e1n\u00ed antikoagulanci\u00ed nebo antiagreganci\u00ed<\/strong> \u2014 v\u00fdrazn\u00e9 zv\u00fd\u0161en\u00ed rizika gastrointestin\u00e1ln\u00edho krv\u00e1cen\u00ed; p\u0159edepi\u0161te sou\u010dasn\u011b PPI; zva\u017ete bezpe\u010dn\u011bj\u0161\u00ed alternativu.<\/li>\n<li><strong>deficit G6PD<\/strong> \u2014 relativn\u00ed kontraindikace (riziko hemol\u00fdzy).<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Kontraindikace \u2014 Kdo by NEM\u011aL u\u017e\u00edvat Nicip<\/h2>\n<ul>\n<li>Zn\u00e1m\u00e1 p\u0159ecitliv\u011blost na nimesulid nebo kteroukoli pomocnou l\u00e1tku tablety<\/li>\n<li>P\u0159edchoz\u00ed ne\u017e\u00e1douc\u00ed jatern\u00ed reakce na nimesulid<\/li>\n<li>V\u00fdznamn\u00e9 po\u0161kozen\u00ed jater (aktivn\u00ed hepatitida, cirh\u00f3za, zv\u00fd\u0161en\u00e9 baz\u00e1ln\u00ed hodnoty transamin\u00e1z)<\/li>\n<li>T\u011b\u017ek\u00e9 ren\u00e1ln\u00ed posti\u017een\u00ed (eGFR &lt; 30)<\/li>\n<li>T\u011b\u017ek\u00e9 srde\u010dn\u00ed selh\u00e1n\u00ed<\/li>\n<li>Aktivn\u00ed nebo ned\u00e1vn\u00e9 peptick\u00e9 v\u0159edov\u00e9 onemocn\u011bn\u00ed, anamn\u00e9za recidivuj\u00edc\u00edch peptick\u00fdch v\u0159ed\u016f nebo gastrointestin\u00e1ln\u00edho krv\u00e1cen\u00ed<\/li>\n<li>Anamn\u00e9za gastrointestin\u00e1ln\u00edho krv\u00e1cen\u00ed nebo perforace spojen\u00e9 s p\u0159edchoz\u00edm u\u017e\u00edv\u00e1n\u00edm NSAID<\/li>\n<li>Poruchy sr\u00e1\u017elivosti krve (hemofilie, t\u011b\u017ek\u00e1 trombocytopenie, antikoagula\u010dn\u00ed l\u00e9\u010dba s \u0161patn\u011b kontrolovan\u00fdm INR)<\/li>\n<li>NSAID\/aspirinem indukovan\u00e9 astma, t\u011b\u017ek\u00e1 rinitida nebo angioed\u00e9m po NSAID<\/li>\n<li>T\u011bhotenstv\u00ed (zejm\u00e9na t\u0159et\u00ed trimestr)<\/li>\n<li>Kojen\u00ed<\/li>\n<li>D\u011bti do 12 let<\/li>\n<li>Aktivn\u00ed porucha u\u017e\u00edv\u00e1n\u00ed alkoholu nebo chronick\u00e1 vysok\u00e1 konzumace alkoholu<\/li>\n<li>Sou\u010dasn\u00e9 u\u017e\u00edv\u00e1n\u00ed jin\u00fdch hepatotoxick\u00fdch l\u00e9k\u016f bez odborn\u00e9ho dohledu<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Interakce s l\u00e9\u010divy<\/h2>\n<table style=\"border-collapse:collapse;width:100%;margin:12px 0;\">\n<thead>\n<tr style=\"background:#2c7cb0;color:#fff;\">\n<th style=\"padding:10px;border:1px solid #ddd;text-align:left;\">Kombinujte s<\/th>\n<th style=\"padding:10px;border:1px solid #ddd;text-align:left;\">\u00da\u010dinek<\/th>\n<th style=\"padding:10px;border:1px solid #ddd;text-align:left;\">Co d\u011blat<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td style=\"padding:10px;border:1px solid #ddd;\"><strong>Jin\u00e1 NSAID a aspirin (analgetick\u00e1 d\u00e1vka)<\/strong><\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Aditivn\u00ed riziko gastrointestin\u00e1ln\u00edho krv\u00e1cen\u00ed a nefrotoxicity; \u017e\u00e1dn\u00fd analgetick\u00fd p\u0159\u00ednos<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Vyhn\u011bte se kombinaci. Kardioprotektivn\u00ed aspirin v n\u00edzk\u00e9 d\u00e1vce se obvykle ponech\u00e1v\u00e1, ale sou\u010dasn\u011b p\u0159edepi\u0161te PPI.<\/td>\n<\/tr>\n<tr>\n<td style=\"padding:10px;border:1px solid #ddd;\"><strong>Antikoagulancia (warfarin, DOAC) a antiagregancia (klopidogrel)<\/strong><\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Vysok\u00e9 riziko gastrointestin\u00e1ln\u00edho krv\u00e1cen\u00ed; INR warfarinu m\u016f\u017ee stoupnout<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Vyhn\u011bte se kombinaci; pokud je nezbytn\u00e1, sou\u010dasn\u011b p\u0159edepi\u0161te PPI a pe\u010dliv\u011b monitorujte INR.<\/td>\n<\/tr>\n<tr>\n<td style=\"padding:10px;border:1px solid #ddd;\"><strong>ACE inhibitory, ARB, diuretika (\u201ctrojit\u00e1 r\u00e1na\u201d)<\/strong><\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Riziko akutn\u00edho po\u0161kozen\u00ed ledvin \u2013 zejm\u00e9na u dehydratovan\u00fdch nebo star\u0161\u00edch pacient\u016f<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Udr\u017eujte dobrou hydrataci; vyhn\u011bte se u pacient\u016f na kombinaci \u201ctrojit\u00e9 r\u00e1ny\u201d.<\/td>\n<\/tr>\n<tr>\n<td style=\"padding:10px;border:1px solid #ddd;\"><strong>Lithium<\/strong><\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Zvy\u0161uje hladinu lithia \u2013 riziko toxicity<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Zkontrolujte hladinu lithia do 1 t\u00fddne; v p\u0159\u00edpad\u011b pot\u0159eby upravte d\u00e1vku.<\/td>\n<\/tr>\n<tr>\n<td style=\"padding:10px;border:1px solid #ddd;\"><strong>Metotrex\u00e1t (vysok\u00e1 d\u00e1vka, t\u00fddenn\u00ed)<\/strong><\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Sn\u00ed\u017een\u00e1 clearance metotrex\u00e1tu \u2013 toxicita kostn\u00ed d\u0159en\u011b a jater<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Vyhn\u011bte se kombinaci. N\u00edzk\u00e1 t\u00fddenn\u00ed d\u00e1vka metotrex\u00e1tu (\u2264 15 mg\/t\u00fdden) je obvykle bezpe\u010dn\u00e1 p\u0159i kr\u00e1tkodob\u00e9m u\u017e\u00edv\u00e1n\u00ed NSAID, ale monitorujte.<\/td>\n<\/tr>\n<tr>\n<td style=\"padding:10px;border:1px solid #ddd;\"><strong>SSRI, SNRI (sertralin, fluoxetin, venlafaxin, duloxetin)<\/strong><\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Riziko aditivn\u00edho GI krv\u00e1cen\u00ed<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">P\u0159edepi\u0161te sou\u010dasn\u011b PPI; vyhn\u011bte se dlouhodob\u00e9 kombinaci.<\/td>\n<\/tr>\n<tr>\n<td style=\"padding:10px;border:1px solid #ddd;\"><strong>Jin\u00e9 hepatotoxick\u00e9 l\u00e9ky<\/strong> (paracetamol vysok\u00e1 d\u00e1vka, isoniazid, methotrex\u00e1t, statiny, antiepileptika)<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Kumulativn\u00ed hepatotoxicita<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Vyhn\u011bte se kombinaci; zvolte alternativn\u00ed analgetikum.<\/td>\n<\/tr>\n<tr>\n<td style=\"padding:10px;border:1px solid #ddd;\"><strong>Cyklosporin, takrolimus<\/strong><\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Aditivn\u00ed nefrotoxicita<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Vyhn\u011bte se kombinaci; pou\u017eijte paracetamol nebo lok\u00e1ln\u00ed NSAID.<\/td>\n<\/tr>\n<tr>\n<td style=\"padding:10px;border:1px solid #ddd;\"><strong>Antihypertenziva (v\u0161echny t\u0159\u00eddy)<\/strong><\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Sn\u00ed\u017een\u00fd antihypertenzn\u00ed \u00fa\u010dinek; zv\u00fd\u0161en\u00fd TK<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Monitorujte TK b\u011bhem l\u00e9\u010dby; v p\u0159\u00edpad\u011b pot\u0159eby upravte d\u00e1vkov\u00e1n\u00ed antihypertenziv.<\/td>\n<\/tr>\n<tr>\n<td style=\"padding:10px;border:1px solid #ddd;\"><strong>Sulfonylurea (glimepirid, gliclazid)<\/strong><\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Riziko hypoglyk\u00e9mie v d\u016fsledku vyt\u011bsn\u011bn\u00ed z vazby na b\u00edlkoviny<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Monitorujte hladinu gluk\u00f3zy v kapil\u00e1rn\u00ed krvi \u010dast\u011bji; v p\u0159\u00edpad\u011b hypoglyk\u00e9mie sni\u017ete d\u00e1vku sulfonylurey.<\/td>\n<\/tr>\n<tr>\n<td style=\"padding:10px;border:1px solid #ddd;\"><strong>Alkohol<\/strong><\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">V\u00fdznamn\u00e9 dodate\u010dn\u00e9 riziko hepatotoxicity<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">B\u011bhem l\u00e9\u010dby se vyhn\u011bte konzumaci alkoholu.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2 class=\"wp-block-heading\">Pokyny k uchov\u00e1v\u00e1n\u00ed<\/h2>\n<ul>\n<li>Skladujte p\u0159i pokojov\u00e9 teplot\u011b, <strong>pod 25\u00b0C<\/strong>, chr\u00e1n\u011bno p\u0159ed sv\u011btlem a vlhkost\u00ed.<\/li>\n<li>Tablety uchov\u00e1vejte v p\u016fvodn\u00edm blistru a\u017e do pou\u017eit\u00ed.<\/li>\n<li>Neskladujte v koupeln\u011b.<\/li>\n<li>Uchov\u00e1vejte mimo dosah d\u011bt\u00ed \u2014 nimesulid je kontraindikov\u00e1n u d\u011bt\u00ed mlad\u0161\u00edch 12 let a n\u00e1hodn\u00e9 po\u017eit\u00ed m\u016f\u017ee b\u00fdt velmi \u0161kodliv\u00e9.<\/li>\n<li>Nepou\u017e\u00edvejte po uplynut\u00ed data expirace uveden\u00e9ho na obalu.<\/li>\n<li>Nepou\u017eit\u00e9 tablety vra\u0165te do l\u00e9k\u00e1rny k likvidaci.<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Souvisej\u00edc\u00ed alternativy na MedsBase<\/h2>\n<p>Dal\u0161\u00ed l\u00e9ky pou\u017e\u00edvan\u00e9 v protiz\u00e1n\u011btliv\u00e9 a autoimunitn\u00ed p\u00e9\u010di skladem vedle tohoto produktu:<\/p>\n<ul>\n<li><a href=\"https:\/\/medsbase.com\/cs\/barinat\/\"><strong>Barinat (baricitinib 2 \/ 4 mg) \u2014 inhibitor JAK1\/2 pro RA<\/strong><\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/tofe\/\"><strong>Tofe (tofacitinib 5 mg) \u2014 inhibitor JAK1\/3 pro RA, UC, PsA<\/strong><\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/azoran\/\"><strong>Azoran (azathioprin 50 mg) \u2014 klasick\u00e9 imunosupresivum DMARD<\/strong><\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/lefuheal\/\"><strong>Lefuheal (leflunomid) \u2014 peror\u00e1ln\u00ed DMARD pro revmatoidn\u00ed artritidu<\/strong><\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/conimune-me\/\"><strong>Conimune ME (cyklosporin) \u2014 inhibitor kalcineurinu<\/strong><\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/wysolone\/\"><strong>Wysolone (prednisolon 5 \/ 10 \/ 20 mg) \u2014 peror\u00e1ln\u00ed kortikosteroid<\/strong><\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/medrol\/\"><strong>Medrol (methylprednisolon 4 \/ 8 \/ 16 mg) \u2014 peror\u00e1ln\u00ed kortikosteroid<\/strong><\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/predniheal\/\"><strong>Predniheal (prednisolon) \u2014 peror\u00e1ln\u00ed kortikosteroid<\/strong><\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/hisone\/\"><strong>Hisone (hydrokortizon) \u2014 fyziologick\u00e1 n\u00e1hradn\u00ed terapie steroidy<\/strong><\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/budez-cr\/\"><strong>Budez CR (budesonid) \u2014 st\u0159evn\u011b p\u016fsob\u00edc\u00ed kortikosteroid pro Crohnovu chorobu<\/strong><\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/kenacort\/\"><strong>Kenacort (triamcinolon) \u2014 syst\u00e9mov\u00fd kortikosteroid<\/strong><\/a><\/li>\n<\/ul>\n<p>Prozkoumejte celou <a href=\"https:\/\/medsbase.com\/cs\/anti-inflammatory-autoimmune-care\/\">Protiz\u00e1n\u011btliv\u00e1 a autoimunitn\u00ed p\u00e9\u010de<\/a> kategorie.<\/p>\n<h2 id=\"faqs\">\u010casto kladen\u00e9 dotazy<\/h2>\n<h3 class=\"wp-block-heading\">Pro\u010d je Nicip omezen na 15denn\u00ed l\u00e9\u010dbu?<\/h3>\n<p>Maxim\u00e1ln\u00ed 15denn\u00ed l\u00e9\u010dba je regula\u010dn\u00ed po\u017eadavek, kter\u00fd m\u00e1 omezit kumulativn\u00ed riziko hepatotoxicity. Na po\u010d\u00e1tku 2000 let byly hl\u00e1\u0161eny p\u0159\u00edpady z\u00e1va\u017en\u00e9ho a n\u011bkdy fat\u00e1ln\u00edho po\u0161kozen\u00ed jater, zejm\u00e9na p\u0159i del\u0161\u00edch l\u00e9\u010debn\u00fdch k\u00far\u00e1ch, u pacient\u016f se z\u00e1kladn\u00edm onemocn\u011bn\u00edm jater, u siln\u00fdch konzument\u016f alkoholu a u t\u011bch, kte\u0159\u00ed u\u017e\u00edvali dal\u0161\u00ed hepatotoxick\u00e9 l\u00e9ky. 15denn\u00ed limit v kombinaci se z\u00e1kladn\u00edm screeningem jatern\u00edch funkc\u00ed a kontraindikacemi u pacient\u016f s poruchou funkce jater sni\u017euje absolutn\u00ed riziko na \u00farove\u0148, kterou evrop\u0161t\u00ed a indi\u010dt\u00ed regul\u00e1to\u0159i pova\u017euj\u00ed za p\u0159ijatelnou pro kr\u00e1tkodob\u00e9 symptomatick\u00e9 u\u017eit\u00ed. <strong>Pokud bolest p\u0159etrv\u00e1v\u00e1 d\u00e9le ne\u017e 15 dn\u00ed, p\u0159ejd\u011bte na alternativn\u00ed analgetikum a vyhledejte diagn\u00f3zu z\u00e1kladn\u00edho onemocn\u011bn\u00ed.<\/strong><\/p>\n<h3 class=\"wp-block-heading\">Pro\u010d byl Nicip sta\u017een z trhu v USA\/Velk\u00e9 Brit\u00e1nii, ale jinde je st\u00e1le dostupn\u00fd?<\/h3>\n<p>N\u00e1rodn\u00ed regul\u00e1to\u0159i vyhodnotili stejn\u00e1 data o hepatotoxicit\u011b a dosp\u011bli k r\u016fzn\u00fdm z\u00e1v\u011br\u016fm, \u010d\u00e1ste\u010dn\u011b kv\u016fli rozd\u00edl\u016fm v dostupn\u00fdch alternativn\u00edch analgetik\u00e1ch, p\u0159edepisovac\u00edch vzorc\u00edch a syst\u00e9mech postmarketingov\u00e9ho sledov\u00e1n\u00ed. USA a Austr\u00e1lie nikdy nimesulid neschv\u00e1lily. Velk\u00e1 Brit\u00e1nie, \u0160pan\u011blsko, Finsko, Izrael a Singapur jej st\u00e1hly po v\u00fdskytu specifick\u00fdch p\u0159\u00edpadov\u00fdch shluk\u016f. Evropsk\u00e1 l\u00e9kov\u00e1 agentura jej p\u0159ezkoumala v letech 2007 a 2011 a rozhodla, \u017ee s omezen\u00edmi (maxim\u00e1ln\u011b 15denn\u00ed l\u00e9\u010dba, z\u00e1kladn\u00ed testy jatern\u00edch funkc\u00ed, \u010detn\u00e9 kontraindikace) p\u0159eva\u017euj\u00ed p\u0159\u00ednosy u vybran\u00fdch pacient\u016f nad riziky. Indick\u00fd, n\u011bkolik evropsk\u00fdch, asijsk\u00fdch a latinskoamerick\u00fdch trh\u016f n\u00e1sledovalo v z\u00e1sad\u011b podobn\u00e9 politiky omezen\u00e9ho u\u017eit\u00ed. <strong>Up\u0159\u00edmn\u00e9 stanovisko<\/strong>: nimesulid m\u016f\u017ee b\u00fdt u\u017eite\u010dn\u00fd pro kr\u00e1tkodobou l\u00e9\u010dbu bolesti, kdy\u017e jin\u00e1 NSAID sel\u017eou nebo nejsou tolerov\u00e1na, ale paracetamol, ibuprofen, naproxen a diklofenak jsou obvykle bezpe\u010dn\u011bj\u0161\u00ed volbou prvn\u00ed linie.<\/p>\n<h3 class=\"wp-block-heading\">M\u011bl bych si p\u0159ed u\u017eit\u00edm Nicipu nechat ud\u011blat krevn\u00ed testy?<\/h3>\n<p>Ano \u2014 z\u00e1kladn\u00ed testy jatern\u00edch funkc\u00ed (ALT, AST, ALP, bilirubin) jsou doporu\u010deny p\u0159ed jakoukoli l\u00e9\u010dbou nimesulidem, zejm\u00e9na pokud m\u00e1te v anamn\u00e9ze probl\u00e9my s j\u00e1try, pravideln\u011b konzumujete alkohol, u\u017e\u00edv\u00e1te jin\u00e9 hepatotoxick\u00e9 l\u00e9ky, jste star\u0161\u00ed 65 let nebo pl\u00e1nujete u\u017e\u00edvat v\u00edce ne\u017e n\u011bkolikadenn\u00ed d\u00e1vku. Pokud jsou va\u0161e z\u00e1kladn\u00ed testy jatern\u00edch funkc\u00ed norm\u00e1ln\u00ed a nem\u00e1te \u017e\u00e1dn\u00e9 rizikov\u00e9 faktory, kr\u00e1tkodob\u00e1 l\u00e9\u010dba (3\u20135 dn\u00ed) nimesulidem je obecn\u011b bezpe\u010dn\u00e1; pokud je jak\u00fdkoli test jatern\u00edch funkc\u00ed abnorm\u00e1ln\u00ed, zvolte alternativn\u00ed analgetikum. B\u011bhem l\u00e9\u010dby nejsou opakovan\u00e9 testy jatern\u00edch funkc\u00ed u kr\u00e1tkodob\u00fdch k\u00far rutinn\u011b vy\u017eadov\u00e1ny, ale m\u011bly by b\u00fdt neprodlen\u011b provedeny, pokud se objev\u00ed jak\u00fdkoli varovn\u00fd p\u0159\u00edznak souvisej\u00edc\u00ed s j\u00e1try.<\/p>\n<h3 class=\"wp-block-heading\">Mohu podat Nicip sv\u00e9mu d\u00edt\u011bti?<\/h3>\n<p><strong>Ne<\/strong> \u2014 nimesulid je kontraindikov\u00e1n u d\u011bt\u00ed mlad\u0161\u00edch 12 let. N\u011bkolik n\u00e1rodn\u00edch regul\u00e1tor\u016f v\u00fdslovn\u011b zak\u00e1zalo pou\u017eit\u00ed u d\u011bt\u00ed kv\u016fli p\u0159\u00edpad\u016fm z\u00e1va\u017en\u00e9 hepatotoxicity v t\u00e9to v\u011bkov\u00e9 skupin\u011b. Pro d\u011btskou bolest nebo hore\u010dku jsou, <strong>paracetamol<\/strong> (15 mg\/kg ka\u017ed\u00e9 4\u20136 hodin, max. 60 mg\/kg\/den) a <strong>ibuprofen<\/strong> (5\u201310 mg\/kg ka\u017ed\u00fdch 6\u20138 hodin, max. 40 mg\/kg\/den) v standardn\u00edch d\u011btsk\u00fdch d\u00e1vk\u00e1ch prvn\u00ed volbou analgetik.<\/p>\n<h3 class=\"wp-block-heading\">Mohu u\u017e\u00edvat Nicip v t\u011bhotenstv\u00ed?<\/h3>\n<p><strong>Ne<\/strong> \u2014 nimesulid je kontraindikov\u00e1n v t\u011bhotenstv\u00ed. U\u017e\u00edv\u00e1n\u00ed ve t\u0159et\u00edm trimestru nese riziko p\u0159ed\u010dasn\u00e9ho uzav\u0159en\u00ed ductus arteriosus plodu, oligohydramniu a perzistuj\u00edc\u00ed plicn\u00ed hypertenze novorozence, co\u017e je spole\u010dn\u00e9 pro v\u0161echna neselektivn\u00ed NSAID. U\u017e\u00edv\u00e1n\u00ed v prvn\u00edm a druh\u00e9m trimestru se tak\u00e9 nedoporu\u010duje kv\u016fli teoretick\u00e9 teratogenit\u011b a ren\u00e1ln\u00edm \u00fa\u010dink\u016fm. <strong>Paracetamol<\/strong> ve standardn\u00edch d\u00e1vk\u00e1ch pro dosp\u011bl\u00e9 je analgetikum volby v t\u011bhotenstv\u00ed.<\/p>\n<h3 class=\"wp-block-heading\">Mohu p\u00edt alkohol p\u0159i u\u017e\u00edv\u00e1n\u00ed Nicipu?<\/h3>\n<p>Ne. Alkohol v\u00fdznamn\u011b zvy\u0161uje riziko hepatotoxicity nimesulidu a p\u0159id\u00e1v\u00e1 se k riziku gastrointestin\u00e1ln\u00edho krv\u00e1cen\u00ed, kter\u00e9 je spole\u010dn\u00e9 pro v\u0161echna NSAID. Vyhn\u011bte se alkoholu b\u011bhem l\u00e9\u010dby a n\u011bkolik dn\u00ed po n\u00ed. <strong>Pacient\u016fm s aktivn\u00ed poruchou u\u017e\u00edv\u00e1n\u00ed alkoholu nebo chronick\u00fdm vysok\u00fdm p\u0159\u00edjmem alkoholu by nem\u011bl b\u00fdt nimesulid v\u016fbec p\u0159edepisov\u00e1n<\/strong> \u2014 absolutn\u00ed riziko hepatotoxicity je p\u0159\u00edli\u0161 vysok\u00e9.<\/p>\n<h3 class=\"wp-block-heading\">Co kdy\u017e vynech\u00e1m d\u00e1vku?<\/h3>\n<p>Vezm\u011bte si ho, jakmile si vzpomenete, pokud nen\u00ed t\u00e9m\u011b\u0159 \u010das na dal\u0161\u00ed d\u00e1vku \u2014 v takov\u00e9m p\u0159\u00edpad\u011b vynechejte vynechanou d\u00e1vku a vezm\u011bte si dal\u0161\u00ed v obvyklou dobu. <strong>Nezdvojujte d\u00e1vku.<\/strong> Pokud jste vynechali v\u00edce d\u00e1vek, jednodu\u0161e pokra\u010dujte v obvykl\u00e9m dvakr\u00e1t denn\u00edm re\u017eimu.<\/p>\n<h3 class=\"wp-block-heading\">Jak\u00e9 jsou varovn\u00e9 p\u0159\u00edznaky probl\u00e9m\u016f s j\u00e1try p\u0159i u\u017e\u00edv\u00e1n\u00ed p\u0159\u00edpravku Nicip?<\/h3>\n<p><strong>Okam\u017eit\u011b p\u0159eru\u0161te u\u017e\u00edv\u00e1n\u00ed p\u0159\u00edpravku Nicip a vyhledejte t\u00e9ho\u017e dne l\u00e9ka\u0159sk\u00e9 vy\u0161et\u0159en\u00ed<\/strong> pokud se u v\u00e1s objev\u00ed n\u011bkter\u00fd z t\u011bchto p\u0159\u00edznak\u016f: ze\u017eloutnut\u00ed k\u016f\u017ee nebo b\u011blma o\u010d\u00ed (\u017eloutenka); tmav\u00e1, \u010dajov\u011b zbarven\u00e1 mo\u010d; sv\u011btl\u00e1, t\u011bstovit\u011b zbarven\u00e1 stolice; siln\u00e1 bolest v prav\u00e9 horn\u00ed \u010d\u00e1sti b\u0159icha; siln\u00e1 nevolnost nebo ztr\u00e1ta chuti k j\u00eddlu; siln\u00e1 \u00fanava; nebo neo\u010dek\u00e1van\u00e9 mod\u0159iny \u010di krv\u00e1cen\u00ed. Po\u017eadujte urgentn\u00ed jatern\u00ed testy a informujte p\u0159edepisuj\u00edc\u00edho l\u00e9ka\u0159e, \u017ee jste u\u017e\u00edval nimesulid.<\/p>\n<h3 class=\"wp-block-heading\">Existuj\u00ed bezpe\u010dn\u011bj\u0161\u00ed alternativy k p\u0159\u00edpravku Nicip?<\/h3>\n<p>Pro v\u011bt\u0161inu lid\u00ed ano. <strong>Paracetamol<\/strong> v b\u011b\u017en\u00fdch d\u00e1vk\u00e1ch pro dosp\u011bl\u00e9 je nejbezpe\u010dn\u011bj\u0161\u00edm analgetikem prvn\u00ed volby p\u0159i m\u00edrn\u00fdch a\u017e st\u0159edn\u011b siln\u00fdch bolestech. <strong>Ibuprofen<\/strong> 200\u2013400 mg t\u0159ikr\u00e1t denn\u011b, <strong>naproxen<\/strong> 250\u2013500 mg dvakr\u00e1t denn\u011b, nebo <strong>diklofenak<\/strong> 50 mg t\u0159ikr\u00e1t denn\u011b poskytuj\u00ed protiz\u00e1n\u011btliv\u00fd \u00fa\u010dinek na \u00farovni NSAID s l\u00e9pe prok\u00e1zan\u00fdm bezpe\u010dnostn\u00edm profilem. <strong>Topick\u00e9 NSAID<\/strong> (diklofenak gel, ibuprofen gel) maj\u00ed mnohem ni\u017e\u0161\u00ed syst\u00e9movou absorpci a jsou \u010dasto vhodn\u00e9 pro lokalizovanou muskuloskelet\u00e1ln\u00ed bolest. <strong>Celecoxib<\/strong> 100\u2013200 mg\/den je COX-2-selektivn\u00ed alternativa s prok\u00e1zanou bezpe\u010dnost\u00ed, zejm\u00e9na kdy\u017e je riziko GI krv\u00e1cen\u00ed limituj\u00edc\u00edm faktorem. Nimesulid by m\u011bl b\u00fdt vyhrazen pro kr\u00e1tkodob\u00e9 u\u017eit\u00ed, kdy\u017e tyto alternativy sel\u017eou nebo nejsou tolerov\u00e1ny.<\/p>\n<h3 class=\"wp-block-heading\">Pro\u010d objedn\u00e1vat z MedsBase<\/h3>\n<p>Nicip je dod\u00e1v\u00e1n v\u00fdrobcem certifikovan\u00fdm WHO-GMP s kompletn\u00ed dokumentac\u00ed COA. Dod\u00e1v\u00e1me po cel\u00e9m sv\u011bt\u011b v nen\u00e1padn\u00e9m obalu a ka\u017ed\u00e1 objedn\u00e1vka je pokryta na\u0161\u00edm <a href=\"\/cs\/medsbase-re-shipment-assurance-policy\/\">Z\u00e1rukou op\u011btovn\u00e9ho odesl\u00e1n\u00ed<\/a>. V\u00e1\u0161 popis transakce p\u0159i platb\u011b kartou zobrazuje regulovan\u00e9ho zpracovatele plateb (regulovan\u00e9ho zpracovatele plateb kartou), nikdy \u201cMedsBase\u201d nebo n\u00e1zev l\u00e9ku.<\/p>\n<p><!-- medsbase-related-alts-v1 --><\/p>\n<h3 class=\"wp-block-heading\">Dal\u0161\u00ed protiz\u00e1n\u011btliv\u00e9 a autoimunitn\u00ed l\u00e9ky<\/h3>\n<p>Pokud Nicip nevyhovuje va\u0161im pot\u0159eb\u00e1m, v t\u00e9to kategorii jsou k dispozici n\u00e1sleduj\u00edc\u00ed mo\u017enosti:<\/p>\n<ul>\n<li><a href=\"https:\/\/medsbase.com\/cs\/brufen\/\">Brufen (Ibuprofen 200\/400\/600 mg) \u2014 voln\u011b prodejn\u00e9 NSAID prvn\u00ed volby<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/voveran-sr\/\">Voveran SR (Diklofenak SR 75\/100 mg) \u2014 dlouhodob\u011b p\u016fsob\u00edc\u00ed NSAID na p\u0159edpis<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/celeheal\/\">Celeheal (Celekoxib 100\/200 mg) \u2014 COX-2 selektivn\u00ed, ni\u017e\u0161\u00ed GI riziko<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/meftal\/\">Meftal (Kyselina mefenamov\u00e1 250\/500 mg) \u2014 pro menstrua\u010dn\u00ed bolesti a bolesti hlavy<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/wysolone\/\">Wysolone (Prednisolon 5\/10\/20 mg) \u2014 kortikosteroid pro t\u011b\u017ek\u00e9 z\u00e1n\u011bty<\/a><\/li>\n<\/ul>","protected":false},"excerpt":{"rendered":"<p>\u2705 \u00da\u010dinn\u011b zm\u00edr\u0148uje bolest<br \/>\n\u2705 Sni\u017euje z\u00e1n\u011bt<br \/>\n\u2705 Zm\u00edr\u0148uje p\u0159\u00edznaky hore\u010dky<br \/>\n\u2705 Rychl\u00e1 \u00faleva<br \/>\n\u2705 Zlep\u0161uje pohyblivost<\/p>\n<p>Nicip obsahuje Nimesulid.<\/p>","protected":false},"featured_media":59426,"comment_status":"open","ping_status":"open","template":"","meta":[],"product_brand":[],"product_cat":[3897,3141,3223,3555],"product_tag":[4695,4696],"class_list":{"0":"post-59425","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-anti-inflammatory-autoimmune-care","7":"product_cat-category-overview","8":"product_cat-chronic-conditions","9":"product_cat-pain-relief-medication","10":"product_tag-nicip","11":"product_tag-nimesulide","13":"first","14":"instock","15":"shipping-taxable","16":"purchasable","17":"product-type-variable","18":"has-default-attributes"},"acf":[],"_links":{"self":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product\/59425","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/comments?post=59425"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/media\/59426"}],"wp:attachment":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/media?parent=59425"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product_brand?post=59425"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product_cat?post=59425"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product_tag?post=59425"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}