{"id":59456,"date":"2024-02-28T05:59:00","date_gmt":"2024-02-28T05:59:00","guid":{"rendered":"https:\/\/medsname.com\/nimodip\/"},"modified":"2026-05-01T10:49:15","modified_gmt":"2026-05-01T10:49:15","slug":"nimodip","status":"publish","type":"product","link":"https:\/\/medsbase.com\/cs\/product\/nimodip\/","title":{"rendered":"Nimodip"},"content":{"rendered":"<p><!-- medsbase-tldr-answer --><\/p>\n<div style=\"background:#fff8e1;border-left:4px solid #f5a623;padding:18px 22px;margin:0 0 24px 0;border-radius:4px;\">\n<h3 class=\"wp-block-heading\" style=\"margin:0 0 8px 0;font-size:16px;font-weight:700;\">\u26a1 Rychl\u00e1 odpov\u011b\u010f \u2014 Co je Nimodip?<\/h3>\n<p style=\"margin:0;\"><strong>Nimodip<\/strong> je peror\u00e1ln\u00ed <strong>nimodipine<\/strong> (30 mg) tablet \u2014 a <strong>cerebral-selective dihydropyridine calcium channel blocker<\/strong> specifically used to prevent and reduce the severity of <strong>cerebral vasospasm<\/strong> a <strong>delayed cerebral ischaemia (DCI)<\/strong> following <strong>aneurysmal subarachnoid haemorrhage (aSAH)<\/strong>. Dosing: <strong>60 mg every 4 hours (360 mg\/day) for 21 consecutive days<\/strong>, started within 96 hours of the bleed. Nimodipine preferentially dilates cerebral arteries over peripheral ones, reducing the incidence of vasospasm-related neurological deficits without causing significant systemic hypotension at standard doses. Common side effects: hypotension, headache, nausea, flushing.<\/p>\n<\/div>\n<div class=\"medsbase-trust-strip\" style=\"background:#f4f8fb;border:1px solid #d8e3eb;padding:12px 16px;margin:16px 0;border-radius:4px;font-size:14px;\">\n<strong>Co z\u00edsk\u00e1te s MedsBase:<\/strong> V\u00fdrobce certifikovan\u00fd WHO-GMP \u00b7 Diskr\u00e9tn\u00ed balen\u00ed \u00b7 Celosv\u011btov\u00e1 doprava \u00b7 V\u00edce ne\u017e 1 400 ov\u011b\u0159en\u00fdch <a href=\"https:\/\/medsbase.com\/cs\/reviews\/\">recenz\u00ed z\u00e1kazn\u00edk\u016f<\/a>\n<\/div>\n<p class=\"medsbase-reship-line\" style=\"font-size:14px;color:#444;margin:8px 0 18px;\">\ud83d\udce6 Ka\u017ed\u00e1 objedn\u00e1vka je pokryta na\u0161\u00ed <a href=\"https:\/\/medsbase.com\/cs\/medsbase-re-shipment-assurance-policy\/\"><strong>Z\u00e1rukou op\u011btovn\u00e9ho odesl\u00e1n\u00ed<\/strong><\/a> \u2014 pokud va\u0161e z\u00e1silka nedoraz\u00ed do 20 pracovn\u00edch dn\u016f, p\u0159epos\u00edl\u00e1me ji.<\/p>\n<h3>Pro\u010d objedn\u00e1vat z MedsBase<\/h3>\n<p>Na\u0161e generick\u00e9 l\u00e9ky poch\u00e1zej\u00ed od v\u00fdrobc\u016f certifikovan\u00fdch WHO-GMP a jsou expedov\u00e1ny po cel\u00e9m sv\u011bt\u011b v diskr\u00e9tn\u00edm, nen\u00e1padn\u00e9m balen\u00ed \u2013 na vn\u011bj\u0161\u00ed stran\u011b bal\u00edku nen\u00ed uveden n\u00e1zev l\u00e9ku. Platby kartou jsou sm\u011brov\u00e1ny prost\u0159ednictv\u00edm regulovan\u00e9ho procesoru (popisky na v\u00fdpisu zahrnuj\u00ed regulovan\u00e9ho procesora plateb kartou \u2013 nikdy \u201cMedsBase\u201d nebo n\u00e1zev l\u00e9ku). P\u0159ij\u00edm\u00e1me tak\u00e9 kryptom\u011bny a bankovn\u00ed p\u0159evody SEPA. Ka\u017ed\u00e1 objedn\u00e1vka je zaji\u0161t\u011bna na\u0161\u00ed politikou p\u0159eposl\u00e1n\u00ed.<\/p>\n<h2 class=\"wp-block-heading\">Co je Nimodip?<\/h2>\n<p>Nimodip is an oral tablet containing <strong>nimodipine 30 mg<\/strong>. Nimodipine is a <strong>cerebral-selective dihydropyridine calcium channel blocker<\/strong> &mdash; unlike other CCBs (amlodipine, nifedipine), it preferentially dilates cerebral arteries with minimal effect on peripheral blood pressure.<\/p>\n<p>Nimodipine is the <strong>only calcium channel blocker with a neurology indication<\/strong>: prevention of ischaemic neurological deficits (vasospasm) following aneurysmal <strong>subarachnoid haemorrhage (SAH)<\/strong>. The landmark BIDA trial (1983) demonstrated a ~40% reduction in cerebral infarction and improved neurological outcomes with the standard 21-day oral protocol. Nimodip is manufactured by a WHO-GMP certified facility and is bioequivalent to the originator brand <strong>Nimotop<\/strong> (Bayer).<\/p>\n<h2 class=\"wp-block-heading\">How Does Nimodip (Nimodipine) Work?<\/h2>\n<p>Nimodipine blocks <strong>L-type voltage-gated calcium channels<\/strong>, but unlike other calcium channel blockers (amlodipine, nifedipine), it has <strong>preferential affinity for cerebral vascular smooth muscle<\/strong>. This cerebral selectivity means it dilates brain arteries more than peripheral ones, making it uniquely suited for preventing vasospasm after subarachnoid haemorrhage.<\/p>\n<p>Beyond vasodilation, nimodipine may have <strong>neuroprotective effects<\/strong> \u2014 it reduces calcium influx into neurons during ischaemia, which attenuates excitotoxic cell death. Clinical trials (the landmark British Aneurysm Nimodipine Trial) demonstrated a significant reduction in poor outcomes, even though angiographic vasospasm rates were not dramatically different \u2014 suggesting the benefit is partly neuroprotective.<\/p>\n<h2 class=\"wp-block-heading\">Indikace<\/h2>\n<ul>\n<li><strong>Prevention of cerebral vasospasm<\/strong> and delayed cerebral ischaemia after aneurysmal subarachnoid haemorrhage \u2014 the <strong>only approved indication<\/strong><\/li>\n<li><strong>Off-label uses:<\/strong> migraine prophylaxis, vascular dementia (limited evidence), traumatic subarachnoid haemorrhage<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Dosing \u2014 The 21-Day Protocol<\/h2>\n<table style=\"width:100%;border-collapse:collapse;margin:0 0 24px 0;\">\n<thead>\n<tr style=\"background:#2c7cb0;color:#fff;\">\n<th style=\"padding:10px 14px;\">Parametr<\/th>\n<th style=\"padding:10px 14px;\">Standard Protocol<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td style=\"padding:10px 14px;\">D\u00e1vka<\/td>\n<td style=\"padding:10px 14px;\">60 mg (two 30 mg tablets)<\/td>\n<\/tr>\n<tr style=\"background:#f9f9f9;\">\n<td style=\"padding:10px 14px;\">Frekvence<\/td>\n<td style=\"padding:10px 14px;\">Every 4 hours<\/td>\n<\/tr>\n<tr>\n<td style=\"padding:10px 14px;\">Total daily dose<\/td>\n<td style=\"padding:10px 14px;\">360 mg\/day<\/td>\n<\/tr>\n<tr style=\"background:#f9f9f9;\">\n<td style=\"padding:10px 14px;\">D\u00e9lka<\/td>\n<td style=\"padding:10px 14px;\">21 consecutive days<\/td>\n<\/tr>\n<tr>\n<td style=\"padding:10px 14px;\">Start<\/td>\n<td style=\"padding:10px 14px;\">Within 96 hours of haemorrhage<\/td>\n<\/tr>\n<tr style=\"background:#f9f9f9;\">\n<td style=\"padding:10px 14px;\">Porucha funkce jater<\/td>\n<td style=\"padding:10px 14px;\">30 mg every 4 hours (halved dose)<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p><strong>Kritick\u00e9:<\/strong> Nimodipine tablets must be <strong>swallowed whole<\/strong>, not crushed. For patients unable to swallow, the contents can be extracted via syringe and administered through a nasogastric tube \u2014 but <strong>never inject the oral solution intravenously<\/strong> (fatal cases of inadvertent IV administration of oral nimodipine have occurred). Take at least 1 hour before or 2 hours after meals for optimal absorption.<\/p>\n<h2 class=\"wp-block-heading\">Vedlej\u0161\u00ed \u00fa\u010dinky<\/h2>\n<p><strong>\u010cast\u00e9:<\/strong> hypotension (dose-related, usually mild), headache, nausea, flushing, peripheral oedema.<\/p>\n<p><strong>M\u00e9n\u011b \u010dast\u00e9:<\/strong> dizziness, tachycardia, rash, GI upset, bradycardia.<\/p>\n<p><strong>Z\u00e1va\u017en\u00e9:<\/strong> severe hypotension (especially in patients with pre-existing low blood pressure or on other antihypertensives), ileus (in critically ill SAH patients), hepatotoxicity (rare \u2014 elevated transaminases).<\/p>\n<h2 class=\"wp-block-heading\">Varov\u00e1n\u00ed a opat\u0159en\u00ed<\/h2>\n<ul>\n<li><strong>Hypotension.<\/strong> Nimodipine can cause significant blood pressure drops, particularly in hypovolaemic SAH patients or those on other antihypertensives. Monitor BP every 1&ndash;2 hours during the initial 48 hours. Reduce dose to 30 mg every 4 hours (from every 2 hours) if systolic drops below 90 mmHg.<\/li>\n<li><strong>Jatern\u00ed porucha.<\/strong> Nimodipine undergoes extensive first-pass hepatic metabolism. In cirrhosis, bioavailability increases markedly &mdash; halve the dose and monitor for hypotension and bradycardia.<\/li>\n<li><strong>Cerebral oedema \/ raised ICP.<\/strong> Use with caution in patients with cerebral oedema or severely elevated intracranial pressure.<\/li>\n<li><strong>Grapefruit juice.<\/strong> Inhibits CYP3A4 metabolism of nimodipine, doubling plasma levels. Avoid grapefruit products during the 21-day protocol.<\/li>\n<li><strong>Epilepsie.<\/strong> Use nimodipine cautiously in patients with epilepsy &mdash; although it is not epileptogenic, seizures are a common SAH complication and drug interactions with anticonvulsants (especially enzyme inducers like phenytoin and carbamazepine) are clinically significant.<\/li>\n<li><strong>Pregnancy category C.<\/strong> Teratogenic in animals at high doses. Use only if benefit outweighs risk.<\/li>\n<li><strong>Kojen\u00ed.<\/strong> Nimodipine is excreted in breast milk. The clinical significance is uncertain &mdash; use with caution.<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Contraindications &mdash; Who Should NOT Take Nimodip<\/h2>\n<ul>\n<li>Known hypersensitivity to nimodipine, other dihydropyridines or any excipient<\/li>\n<li>Concurrent use with <strong>rifampicin<\/strong> (reduces nimodipine to subtherapeutic levels via CYP3A4 induction)<\/li>\n<li>Concurrent use with <strong>strong CYP3A4 inhibitors<\/strong> (ketoconazole, itraconazole, ritonavir) without dose reduction<\/li>\n<li>Unstable angina or recent MI (within 4 weeks)<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Interakce s l\u00e9\u010divy<\/h2>\n<ul>\n<li><strong>Other antihypertensives &amp; calcium channel blockers:<\/strong> Aditivn\u00ed hypotenze<\/li>\n<li><strong>Inhibitory CYP3A4<\/strong> (ketoconazole, fluconazole, macrolide antibiotics, grapefruit juice): Increase nimodipine levels significantly<\/li>\n<li><strong>Induktory CYP3A4<\/strong> (rifampicin, phenytoin, carbamazepine, phenobarbital): Reduce nimodipine levels, potentially to sub-therapeutic<\/li>\n<li><strong>Beta-blockers:<\/strong> Additive negative chronotropic effect \u2014 monitor heart rate<\/li>\n<li><strong>Nephrotoxic drugs:<\/strong> Nimodipine may worsen renal function in SAH patients receiving concurrent nephrotoxics<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Pokyny k uchov\u00e1v\u00e1n\u00ed<\/h2>\n<ul>\n<li>Skladujte p\u0159i pokojov\u00e9 teplot\u011b, <strong>15\u201325\u00b0C<\/strong>. <strong>Chra\u0148te p\u0159ed sv\u011btlem<\/strong> &mdash; nimodipine is light-sensitive.<\/li>\n<li>Keep in original amber blister packaging until use.<\/li>\n<li>Neskladujte v koupeln\u011b.<\/li>\n<li>Uchov\u00e1vejte mimo dosah d\u011bt\u00ed.<\/li>\n<li>Nepou\u017e\u00edvejte po uplynut\u00ed data expirace.<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Souvisej\u00edc\u00ed kategorie na MedsBase<\/h2>\n<ul>\n<li><a href=\"https:\/\/medsbase.com\/cs\/neurological-conditions-and-epilepsy\/\">Prohl\u00e9dn\u011bte si v\u0161echny neurologick\u00e9 a antiepileptick\u00e9 l\u00e9ky<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/heart-and-blood-pressure\/\">Browse heart &amp; blood pressure medications<\/a><\/li>\n<\/ul>\n<h2 id=\"faqs\">\u010casto kladen\u00e9 dotazy<\/h2>\n<h3 class=\"wp-block-heading\">What is Nimodip used for?<\/h3>\n<p>Nimodip contains <strong>nimodipine 30 mg<\/strong> and is used to prevent <strong>cerebral vasospasm<\/strong> a <strong>delayed cerebral ischaemia<\/strong> following aneurysmal subarachnoid haemorrhage (aSAH). It is the only drug proven to improve neurological outcomes after SAH.<\/p>\n<h3 class=\"wp-block-heading\">Why is nimodipine given every 4 hours and not twice daily?<\/h3>\n<p>Nimodipine has a short half-life (<strong>1&ndash;2 hours<\/strong> orally). The every-4-hour dosing ensures continuous therapeutic levels throughout the 21-day critical vasospasm period (days 3&ndash;14 are highest risk). Missing doses creates gaps in protection.<\/p>\n<h3 class=\"wp-block-heading\">Is nimodipine the same as nifedipine or amlodipine?<\/h3>\n<p>All three are dihydropyridine calcium channel blockers, but nimodipine is <strong>uniquely cerebral-selective<\/strong>. Nifedipine and amlodipine primarily target peripheral and coronary arteries and are used for hypertension\/angina. They are <strong>not interchangeable<\/strong> \u2014 only nimodipine has evidence for SAH outcomes.<\/p>\n<h3 class=\"wp-block-heading\">Why must nimodipine never be given intravenously?<\/h3>\n<p>Oral nimodipine formulations contain excipients not suitable for IV injection. Inadvertent IV administration has caused <strong>cardiovascular collapse and death<\/strong>. When oral dosing is impossible (unconscious patients), nimodipine should be given via nasogastric tube, not injected.<\/p>\n<h3 class=\"wp-block-heading\">Does nimodipine actually prevent vasospasm?<\/h3>\n<p>Interestingly, nimodipine does <strong>not significantly reduce angiographic vasospasm<\/strong>. Its benefit appears to be primarily <strong>neuroprotective<\/strong> \u2014 reducing ischaemic neuronal damage from vasospasm rather than preventing the spasm itself. The clinical result is fewer patients with permanent neurological deficits.<\/p>\n<h3 class=\"wp-block-heading\">Can I take nimodipine with grapefruit juice?<\/h3>\n<p><strong>Ne.<\/strong> Grapefruit juice inhibits CYP3A4, significantly increasing nimodipine levels and the risk of hypotension. Avoid grapefruit throughout treatment.<\/p>\n<h3 class=\"wp-block-heading\">What happens if a dose is missed?<\/h3>\n<p>Take the missed dose as soon as possible. If it is nearly time for the next dose, skip the missed one and continue the schedule. Given the short half-life, any gap reduces protection during the critical vasospasm window.<\/p>\n<h3 class=\"wp-block-heading\">Is nimodipine used for migraine?<\/h3>\n<p>Nimodipine has been studied for <strong>profylaxe migr\u00e9ny<\/strong> with mixed results. Some patients benefit, but it is not a first-line migraine preventive \u2014 propranolol, topiramate, and valproate have stronger evidence. It is used off-label when other options have failed or are contraindicated.<\/p>\n<h3 class=\"wp-block-heading\">Can nimodipine lower blood pressure too much?<\/h3>\n<p>Yes \u2014 hypotension is the main clinical concern. In SAH patients, maintaining adequate cerebral perfusion pressure is critical. Blood pressure should be monitored regularly, and the dose may need to be halved (30 mg every 4 hours) in patients with hepatic impairment or significant hypotension.<\/p>\n<h3 class=\"wp-block-heading\">How long is the treatment course?<\/h3>\n<p>The standard protocol is <strong>21 consecutive days<\/strong>, regardless of whether vasospasm occurs. The highest-risk period is days 3&ndash;14, but treatment extends to day 21 to cover late vasospasm events.<\/p>\n<h3 class=\"wp-block-heading\">Is Nimodip the same as Nimotop?<\/h3>\n<p>Both contain nimodipine 30 mg. Nimotop is the original Bayer brand. Nimodip is a bioequivalent generic at a lower cost.<\/p>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:16px 20px;margin:24px 0;border-radius:4px;font-size:13px;\"><strong>Zdravotn\u00ed upozorn\u011bn\u00ed:<\/strong> Tato str\u00e1nka slou\u017e\u00ed pouze pro informa\u010dn\u00ed \u00fa\u010dely a nenahrazuje odbornou l\u00e9ka\u0159skou pomoc. P\u0159ed zah\u00e1jen\u00edm, zm\u011bnou nebo ukon\u010den\u00edm jak\u00e9hokoli l\u00e9ku se v\u017edy pora\u010fte s kvalifikovan\u00fdm zdravotnick\u00fdm pracovn\u00edkem. D\u00e1vkov\u00e1n\u00ed odpov\u00edd\u00e1 \u00fadaj\u016fm v\u00fdrobce a publikovan\u00fdm klinick\u00fdm doporu\u010den\u00edm \u2014 individu\u00e1ln\u00ed pot\u0159eby se mohou li\u0161it.<\/div>\n<p><!-- medsbase-related-alts-v1 --><\/p>\n<h3 class=\"wp-block-heading\">Souvisej\u00edc\u00ed alternativy<\/h3>\n<p>Dal\u0161\u00ed produkty v <strong>Chronick\u00e1 onemocn\u011bn\u00ed<\/strong> kter\u00e9 z\u00e1kazn\u00edci tak\u00e9 prohl\u00ed\u017eej\u00ed:<\/p>\n<ul>\n<li><a href=\"https:\/\/medsbase.com\/cs\/glinil-m\/\">Glinil M<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/trinicalm-plus\/\">Objednejte si Glynase XL (5 mg nebo 10 mg (XL)) od spole\u010dnosti MedsBase v balen\u00edch po 30, 60, 90 nebo 180 tablet\u00e1ch. Dod\u00e1v\u00e1me po cel\u00e9m sv\u011bt\u011b, s diskr\u00e9tn\u00edm balen\u00edm a certifikovan\u00fdm v\u00fdrobcem WHO-GMP.<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/opiprol\/\">Opiprol<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/atrest\/\">Atrest<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/ramgee\/\">Ramgee<\/a><\/li>\n<\/ul>","protected":false},"excerpt":{"rendered":"<p>\u2705 Manages hypertension<br \/>\n\u2705 Prevents stroke<br \/>\n\u2705 Enhances blood flow<br \/>\n\u2705 Reduces migraine frequency<br \/>\n\u2705 Alleviates brain-related issues<\/p>\n<p>Nimodip contains Nimodipine.<\/p>","protected":false},"featured_media":59457,"comment_status":"open","ping_status":"open","template":"","meta":[],"product_brand":[],"product_cat":[3141,3223,3468],"product_tag":[3892,3893],"class_list":{"0":"post-59456","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-category-overview","7":"product_cat-chronic-conditions","8":"product_cat-neurological-conditions-and-epilepsy","9":"product_tag-nimodip","10":"product_tag-nimodipine","12":"first","13":"instock","14":"shipping-taxable","15":"purchasable","16":"product-type-variable","17":"has-default-attributes"},"acf":[],"_links":{"self":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product\/59456","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/comments?post=59456"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/media\/59457"}],"wp:attachment":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/media?parent=59456"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product_brand?post=59456"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product_cat?post=59456"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product_tag?post=59456"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}