{"id":59484,"date":"2024-02-28T06:00:08","date_gmt":"2024-02-28T06:00:08","guid":{"rendered":"https:\/\/medsname.com\/angiplat\/"},"modified":"2026-05-01T10:49:15","modified_gmt":"2026-05-01T10:49:15","slug":"angiplat","status":"publish","type":"product","link":"https:\/\/medsbase.com\/cs\/product\/angiplat\/","title":{"rendered":"Angiplat"},"content":{"rendered":"

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⚡ Quick Answer — What is Angiplat?<\/h3>\n

Angiplat<\/strong> je nitroglycerin (glyceryl trinitrate) 2.5 mg sustained-release capsule<\/strong>, used for the profylaxi<\/em> (prevention) of chronic stable angina pectoris. A usual starting dose is one capsule two to three times a day<\/strong> with an 8–12 hour nitrate-free interval<\/strong> overnight. Angiplat is ne<\/strong> suitable for aborting an acute angina attack — use sublingual nitroglycerin or isosorbide dinitrate for that purpose.<\/p>\n<\/div>\n

\nCo z\u00edsk\u00e1te s MedsBase:<\/strong> V\u00fdrobce certifikovan\u00fd WHO-GMP \u00b7 Diskr\u00e9tn\u00ed balen\u00ed \u00b7 Celosv\u011btov\u00e1 doprava \u00b7 V\u00edce ne\u017e 1 400 ov\u011b\u0159en\u00fdch recenz\u00ed z\u00e1kazn\u00edk\u016f<\/a>\n<\/div>\n

\ud83d\udce6 Ka\u017ed\u00e1 objedn\u00e1vka je pokryta na\u0161\u00ed Z\u00e1rukou op\u011btovn\u00e9ho odesl\u00e1n\u00ed<\/strong><\/a> \u2014 pokud va\u0161e z\u00e1silka nedoraz\u00ed do 20 pracovn\u00edch dn\u016f, p\u0159epos\u00edl\u00e1me ji.<\/p>\n

Pro\u010d objedn\u00e1vat z MedsBase<\/h3>\n

Na\u0161e generick\u00e9 l\u00e9ky poch\u00e1zej\u00ed od v\u00fdrobc\u016f certifikovan\u00fdch WHO-GMP a jsou expedov\u00e1ny po cel\u00e9m sv\u011bt\u011b v diskr\u00e9tn\u00edm, nen\u00e1padn\u00e9m balen\u00ed \u2013 na vn\u011bj\u0161\u00ed stran\u011b bal\u00edku nen\u00ed uveden n\u00e1zev l\u00e9ku. Platby kartou jsou sm\u011brov\u00e1ny prost\u0159ednictv\u00edm regulovan\u00e9ho procesoru (popisky na v\u00fdpisu zahrnuj\u00ed regulovan\u00e9ho procesora plateb kartou \u2013 nikdy \u201cMedsBase\u201d nebo n\u00e1zev l\u00e9ku). P\u0159ij\u00edm\u00e1me tak\u00e9 kryptom\u011bny a bankovn\u00ed p\u0159evody SEPA. Ka\u017ed\u00e1 objedn\u00e1vka je zaji\u0161t\u011bna na\u0161\u00ed politikou p\u0159eposl\u00e1n\u00ed.<\/p>\n

Angiplat 2.5 mg<\/strong> is an oral, sustained-release (SR) nitroglycerin capsule manufactured for daily use in patients with chronic stable angina pectoris. Each capsule contains 2.5 mg of glyceryl trinitrate (nitroglycerin)<\/strong> in a controlled-release matrix that slowly releases the active drug over 6–8 hours. This extended release profile allows twice- or thrice-daily dosing rather than the very short action of sublingual nitroglycerin.<\/p>\n

Angiplat is widely prescribed in cardiology practice as part of a long-term anti-anginal regimen — usually alongside a beta-blocker (atenolol, metoprolol, bisoprolol) or a calcium channel blocker (amlodipine, diltiazem), plus aspirin and a statin for secondary prevention of coronary events. It reduces the number and severity of angina episodes, improves exercise tolerance, and can reduce the need for short-acting rescue medication during the day.<\/p>\n

What Is Angiplat Used For?<\/h2>\n

Angiplat is indicated for:<\/p>\n

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  • Dlouhodob\u00e1 profylaxe chronick\u00e9 stabiln\u00ed anginy pectoris<\/strong> — reducing the frequency of chest pain episodes<\/li>\n
  • Effort-induced angina<\/strong> — pre-medication before predictable strain (walking uphill, climbing stairs)<\/li>\n
  • Mixed angina<\/strong> (combination of effort and spasm) — as add-on therapy<\/li>\n
  • Left ventricular failure with angina<\/strong> — reducing preload and ischaemia<\/li>\n<\/ul>\n

    Angiplat is ne<\/em> indicated for acute angina attacks. Sustained-release oral nitroglycerin has an onset of 30–45 minutes — too slow to abort a live ischaemic episode. For that indication, use a sublingual nitroglycerin tablet or spray, or a sublingual isosorbide dinitrate 5 mg tablet.<\/p>\n

    Jak funguj\u00ed nitr\u00e1ty?<\/h2>\n

    V\u0161echna nitr\u00e1tov\u00e1 l\u00e9\u010diva maj\u00ed stejn\u00fd z\u00e1kladn\u00ed mechanismus \u00fa\u010dinku. Po vst\u0159eb\u00e1n\u00ed jsou enzymaticky p\u0159em\u011bn\u011bny na oxid dusnat\u00fd (NO)<\/strong> uvnit\u0159 bun\u011bk hladk\u00e9ho svalstva c\u00e9v. NO aktivuje guanyl\u00e1tcykl\u00e1zu, \u010d\u00edm\u017e zvy\u0161uje intracelul\u00e1rn\u00ed cGMP a uvol\u0148uje hladk\u00e9 svalstvo c\u00e9v. Klinick\u00e9 \u00fa\u010dinky jsou:<\/p>\n

      \n
    • \u017diln\u00ed dilatace<\/strong> (dominantn\u00ed p\u0159i n\u00edzk\u00fdch d\u00e1vk\u00e1ch) \u2014 sni\u017euje \u017eiln\u00ed n\u00e1vrat k srdci, \u010d\u00edm\u017e se sni\u017euje p\u0159edt\u00ed\u017een\u00ed<\/em>. Takto nitr\u00e1ty sni\u017euj\u00ed spot\u0159ebu kysl\u00edku myokardem.<\/li>\n
    • Arteri\u00e1ln\u00ed dilatace<\/strong> (vy\u0161\u0161\u00ed d\u00e1vky) \u2014 sni\u017euje syst\u00e9movou c\u00e9vn\u00ed rezistenci a dot\u00ed\u017een\u00ed<\/em>, co\u017e d\u00e1le sni\u017euje srde\u010dn\u00ed pr\u00e1ci.<\/li>\n
    • Dilatace koron\u00e1rn\u00edch tepen<\/strong> \u2014 zlep\u0161uje pr\u016ftok krve do ischemick\u00fdch oblast\u00ed srde\u010dn\u00edho svalu, zejm\u00e9na p\u0159i koron\u00e1rn\u00edm spasmu.<\/li>\n<\/ul>\n

      V\u00fdsledn\u00fdm efektem je m\u00e9n\u011b bolest\u00ed na hrudi, m\u00e9n\u011b angin\u00f3zn\u00edch epizod a lep\u0161\u00ed tolerance z\u00e1t\u011b\u017ee u pacient\u016f se stabiln\u00ed ischemickou chorobou srde\u010dn\u00ed.<\/p>\n

      Nitr\u00e1tov\u00e1 tolerance \u2014 kritick\u00e9 d\u00e1vkovac\u00ed pravidlo<\/h2>\n

      Nitr\u00e1tov\u00e1 tolerance je nejd\u016fle\u017eit\u011bj\u0161\u00edm konceptem pro ka\u017ed\u00e9ho pacienta u\u017e\u00edvaj\u00edc\u00edho nitr\u00e1ty. Pokud se nitr\u00e1t pod\u00e1v\u00e1 nep\u0159etr\u017eit\u011b \u2013 s konstantn\u00ed hladinou v krvi 24 hodin denn\u011b \u2013 antiangin\u00f3zn\u00ed \u00fa\u010dinek se vytr\u00e1c\u00ed b\u011bhem 48 a\u017e 72 hodin. Jedn\u00e1 se o dob\u0159e zdokumentovan\u00fd, reprodukovateln\u00fd farmakologick\u00fd jev, nikoli o domn\u011bl\u00fd efekt.<\/p>\n

      \u0158e\u0161en\u00ed je jednoduch\u00e9 a nezpochybniteln\u00e9: ka\u017ed\u00fd 24hodinov\u00fd cyklus mus\u00ed zahrnovat nitr\u00e1tov\u00fd interval alespo\u0148 8\u201312 hodin<\/strong>, obvykle p\u0159es noc. Standardn\u00ed strategie jsou:<\/p>\n

        \n
      • Asymetrick\u00e9 d\u00e1vkov\u00e1n\u00ed dvakr\u00e1t denn\u011b (nap\u0159. v 7 hodin r\u00e1no a ve 3 hodiny odpoledne, pot\u00e9 nic a\u017e do n\u00e1sleduj\u00edc\u00edho r\u00e1na)<\/li>\n
      • Jednou denn\u011b pod\u00e1van\u00e9 tablety s prodlou\u017een\u00fdm uvol\u0148ov\u00e1n\u00edm navr\u017een\u00e9 tak, aby udr\u017eovaly n\u00edzkou hladinu<\/li>\n
      • Odstran\u011bn\u00ed transderm\u00e1ln\u00ed n\u00e1plasti po 12\u201314 hodin\u00e1ch no\u0161en\u00ed<\/li>\n<\/ul>\n

        Nep\u0159est\u00e1vejte ne<\/em> nep\u0159id\u00e1vejte dal\u0161\u00ed d\u00e1vky \u201cp\u0159ed span\u00edm\u201d nebo b\u011bhem noci, pokud v\u00e1m l\u00e9ka\u0159 v\u00fdslovn\u011b nep\u0159edep\u00ed\u0161e nep\u0159etr\u017eitou terapii z konkr\u00e9tn\u00edho d\u016fvodu.<\/p>\n

        Angiplat Dosing<\/h2>\n

        Pro chronickou stabiln\u00ed anginu pectoris u dosp\u011bl\u00fdch:<\/p>\n

          \n
        • Po\u010d\u00e1te\u010dn\u00ed d\u00e1vka:<\/strong> 2.5 mg (one capsule) two to three times daily, with meals<\/li>\n
        • Titrace:<\/strong> If angina remains uncontrolled after 1–2 weeks, doctors may increase to 5 mg (two capsules) twice or three times daily, or switch to Angispan-TR 6.5 mg<\/li>\n
        • Nitrate-free interval:<\/strong> Leave at least 8–12 hours between the last dose of one day and the first dose of the next. The easiest way: take at 7 a.m. and 3 p.m., then nothing until the following morning<\/li>\n
        • Maxim\u00e1ln\u00ed d\u00e1vka:<\/strong> 26 mg\/day in divided doses (rarely needed)<\/li>\n<\/ul>\n

          Capsules should be swallowed whole with water; do not crush, chew, or open them — this destroys the sustained-release matrix and causes a rapid burst of nitroglycerin with a bad headache and hypotension.<\/p>\n

          Missed dose: take it as soon as you remember, unless it is within 3 hours of the next scheduled dose — in that case skip the missed dose. Never double up.<\/p>\n

          Who Should Not Take Angiplat?<\/h2>\n

          Existuje jedna absolutn\u00ed kontraindikace, kterou mus\u00ed ka\u017ed\u00fd pacient pochopit p\u0159ed prvn\u00ed d\u00e1vkou:<\/p>\n

          \n

          Nikdy nekombinujte \u017e\u00e1dn\u00fd nitr\u00e1t s inhibitorem PDE5.<\/strong> Sildenafil (Viagra), tadalafil (Cialis), vardenafil (Levitra) a avanafil (Stendra) zesiluj\u00ed vazodilata\u010dn\u00ed \u00fa\u010dinek nitr\u00e1t\u016f a mohou zp\u016fsobit \u017eivot ohro\u017euj\u00edc\u00ed hypotenzi, kolaps, c\u00e9vn\u00ed mozkovou p\u0159\u00edhodu nebo infarkt myokardu. Po\u010dkejte alespo\u0148 24 hodiny po pod\u00e1n\u00ed sildenafilu\/vardenafilu<\/strong> a 48 hodin po pod\u00e1n\u00ed tadalafilu<\/strong> ne\u017e u\u017eijete jakoukoli d\u00e1vku nitr\u00e1tu. Toto plat\u00ed pro v\u0161echny formy \u2013 peror\u00e1ln\u00ed, sublingv\u00e1ln\u00ed, transderm\u00e1ln\u00ed a sprej.<\/p>\n<\/div>\n

          Dal\u0161\u00ed d\u016fle\u017eit\u00e9 kontraindikace:<\/p>\n

            \n
          • T\u011b\u017ek\u00e1 hypotenze nebo hypovol\u00e9mie (systolick\u00fd TK < 90 mmHg)<\/li>\n
          • T\u011b\u017ek\u00e1 an\u00e9mie (nitr\u00e1ty mohou zhor\u0161it dod\u00e1vku kysl\u00edku do tk\u00e1n\u00ed)<\/li>\n
          • Hypertrofick\u00e1 obstruk\u010dn\u00ed kardiomyopatie (HOCM) \u2013 nitr\u00e1ty mohou zhor\u0161it v\u00fdtokovou obstrukci<\/li>\n
          • T\u011b\u017ek\u00e1 aort\u00e1ln\u00ed sten\u00f3za \u2013 riziko synkopy<\/li>\n
          • Zv\u00fd\u0161en\u00fd nitrolebn\u00ed tlak nebo ned\u00e1vn\u00e9 poran\u011bn\u00ed hlavy<\/li>\n
          • Infarkt prav\u00e9 komory \u2013 preload je z\u00e1sadn\u00ed, nitr\u00e1ty jej sni\u017euj\u00ed<\/li>\n
          • Konstriktivn\u00ed perikarditida nebo srde\u010dn\u00ed tampon\u00e1da<\/li>\n
          • Zn\u00e1m\u00e1 p\u0159ecitliv\u011blost na organick\u00e9 nitr\u00e1ty<\/li>\n
          • Sou\u010dasn\u00e9 u\u017e\u00edv\u00e1n\u00ed stimul\u00e1tor\u016f solubiln\u00ed guanyl\u00e1tcykl\u00e1zy (riociguat)<\/li>\n<\/ul>\n

            Pou\u017e\u00edvejte opatrn\u011b v t\u011bhotenstv\u00ed (kategorie C) a konzultujte s odborn\u00edkem. P\u0159i kojen\u00ed je ob\u010dasn\u00e9 u\u017e\u00edv\u00e1n\u00ed obecn\u011b p\u0159ijateln\u00e9, ale rutinn\u00ed terapii by m\u011bl posoudit kardiolog.<\/p>\n

            Common Side Effects of Angiplat<\/h2>\n

            V\u011bt\u0161ina ne\u017e\u00e1douc\u00edch \u00fa\u010dink\u016f nitr\u00e1t\u016f je p\u0159\u00edm\u00fdm d\u016fsledkem jejich vazodilata\u010dn\u00edho \u00fa\u010dinku a obvykle ustupuje b\u011bhem prvn\u00edch 1\u20132 t\u00fddn\u016f l\u00e9\u010dby.<\/p>\n

            Velmi \u010dast\u00e9 (>10 % pacient\u016f):<\/strong><\/p>\n