{"id":59683,"date":"2024-02-28T06:10:41","date_gmt":"2024-02-28T06:10:41","guid":{"rendered":"https:\/\/medsname.com\/udimax-300\/"},"modified":"2026-04-30T10:23:56","modified_gmt":"2026-04-30T10:23:56","slug":"udimax-300","status":"publish","type":"product","link":"https:\/\/medsbase.com\/cs\/product\/udimax-300\/","title":{"rendered":"Udimax 300"},"content":{"rendered":"

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\u26a1 Rychl\u00e1 odpov\u011b\u010f \u2014 Co je Udimax 300?<\/h3>\n

Udimax 300<\/strong> je kyselina ursodeoxycholov\u00e1 (UDCA) 300 mg<\/strong> \u2014 hydrofiln\u00ed \u017elu\u010dov\u00e1 kyselina, kter\u00e1 je standardem l\u00e9\u010dby pro prim\u00e1rn\u00ed bili\u00e1rn\u00ed cholangitida (PBC), cholesterolov\u00e9 \u017elu\u010dov\u00e9 kameny u pacient\u016f nevhodn\u00fdch k operaci, intrahepat\u00e1ln\u00ed cholest\u00e1za v t\u011bhotenstv\u00ed (ICP), pr\u016fjem zp\u016fsoben\u00fd \u017elu\u010dov\u00fdmi kyselinami a pruritus p\u0159i cholestatick\u00e9m onemocn\u011bn\u00ed jater<\/strong>. UDCA sni\u017euje saturaci cholesterolu ve \u017elu\u010di, nahrazuje toxick\u00e9 hydrofobn\u00ed \u017elu\u010dov\u00e9 kyseliny v poolu \u017elu\u010dov\u00fdch kyselin, p\u016fsob\u00ed cytoprotektivn\u011b a antiapoptoticky na hepatocyty a cholangiocyty a stimuluje choler\u00e9zu bohatou na bikarbon\u00e1t. Standardn\u00ed d\u00e1vky pro dosp\u011bl\u00e9 se pohybuj\u00ed od 10\u201315 mg\/kg\/day for PBC and gallstones to 14\u201330 mg\/kg\/day for cholestasis of pregnancy<\/strong>. V\u00fdrobce certifikovan\u00fd WHO-GMP.<\/p>\n<\/div>\n

Pro\u010d objedn\u00e1vat z MedsBase:<\/strong> \u2714 v\u00fdrobce certifikovan\u00e9ho WHO-GMP<\/strong> \u2714 Diskr\u00e9tn\u00ed balen\u00ed \u2714 Celosv\u011btov\u00e1 doprava \u2714 Ov\u011b\u0159en\u00e9 recenze z\u00e1kazn\u00edk\u016f (1 400+ z\u00e1kazn\u00edk\u016f)<\/a><\/div>\n

\ud83d\udce6 Ka\u017ed\u00e1 objedn\u00e1vka je pokryta na\u0161\u00ed Z\u00e1rukou op\u011btovn\u00e9ho odesl\u00e1n\u00ed<\/strong><\/a> \u2014 pokud va\u0161e z\u00e1silka nedoraz\u00ed do 20 pracovn\u00edch dn\u016f, p\u0159epos\u00edl\u00e1me ji.<\/p>\n

Pro\u010d objedn\u00e1vat z MedsBase<\/h3>\n

Na\u0161e generick\u00e9 l\u00e9ky poch\u00e1zej\u00ed od v\u00fdrobc\u016f certifikovan\u00fdch WHO-GMP a jsou expedov\u00e1ny po cel\u00e9m sv\u011bt\u011b v diskr\u00e9tn\u00edm, nen\u00e1padn\u00e9m balen\u00ed \u2013 na vn\u011bj\u0161\u00ed stran\u011b bal\u00edku nen\u00ed uveden n\u00e1zev l\u00e9ku. Platby kartou jsou sm\u011brov\u00e1ny prost\u0159ednictv\u00edm regulovan\u00e9ho procesoru (popisky na v\u00fdpisu zahrnuj\u00ed regulovan\u00e9ho procesora plateb kartou \u2013 nikdy \u201cMedsBase\u201d nebo n\u00e1zev l\u00e9ku). P\u0159ij\u00edm\u00e1me tak\u00e9 kryptom\u011bny a bankovn\u00ed p\u0159evody SEPA. Ka\u017ed\u00e1 objedn\u00e1vka je zaji\u0161t\u011bna na\u0161\u00ed politikou p\u0159eposl\u00e1n\u00ed.<\/p>\n

\ud83d\udca1 Prvn\u00ed volba pro PBC od roku 1994.<\/strong> UDCA je jedinou terapi\u00ed, u kter\u00e9 bylo prok\u00e1z\u00e1no, \u017ee prodlu\u017euje transplant-free p\u0159e\u017eit\u00ed u prim\u00e1rn\u00ed bili\u00e1rn\u00ed cholangitidy. U 30\u201340 % pacient\u016f s PBC se ALP na samotn\u00e9 UDCA normalizuje a p\u0159id\u00e1v\u00e1 se obeticholov\u00e1 kyselina nebo fibr\u00e1t (rozhodnut\u00ed specialisty hepatologie).<\/div>\n

Pro\u010d objedn\u00e1vat z MedsBase<\/h3>\n

Udimax 300 je dod\u00e1v\u00e1n z v\u00fdrobce certifikovan\u00e9ho WHO-GMP<\/strong>. Ka\u017ed\u00e1 objedn\u00e1vka je diskr\u00e9tn\u011b zas\u00edl\u00e1na po cel\u00e9m sv\u011bt\u011b a je pokryta na\u0161\u00ed Z\u00e1rukou op\u011btovn\u00e9ho odesl\u00e1n\u00ed<\/a> \u2014 pokud nedoraz\u00ed do 20 pracovn\u00edch dn\u016f, p\u0159epos\u00edl\u00e1me zdarma. UDCA je na seznamu z\u00e1kladn\u00edch l\u00e9k\u016f WHO ji\u017e des\u00edtky let a je z\u00e1kladem l\u00e9ka\u0159sk\u00e9 terapie cholestatick\u00e9ho onemocn\u011bn\u00ed jater.<\/p>\n

Mechanismus \u00fa\u010dinku<\/h2>\n

UDCA je p\u0159irozen\u011b se vyskytuj\u00edc\u00ed hydrofiln\u00ed 7\u03b2-hydroxy \u017elu\u010dov\u00e1 kyselina (\u201cmedv\u011bd\u00ed \u017elu\u010dov\u00e1 kyselina\u201d). P\u0159i peror\u00e1ln\u00edm pod\u00e1n\u00ed obohacuje pool \u017elu\u010dov\u00fdch kyselin a nahrazuje toxick\u00e9 hydrofobn\u00ed kyseliny (chenodeoxycholovou, lithocholovou), kter\u00e9 po\u0161kozuj\u00ed cholangiocyty a hepatocyty p\u0159i cholest\u00e1ze. Klinicky jsou d\u016fle\u017eit\u00e9 t\u0159i \u00fa\u010dinky: (1) sni\u017euje saturaci \u017elu\u010di cholesterolem, rozpou\u0161t\u00ed cholesterolov\u00e9 \u017elu\u010dov\u00e9 kameny b\u011bhem m\u011bs\u00edc\u016f; (2) m\u00e1 p\u0159\u00edm\u00fd cytoprotektivn\u00ed a anti-apoptotick\u00fd \u00fa\u010dinek na jatern\u00ed bu\u0148ky, sni\u017euje imunitn\u011b zprost\u0159edkovan\u00e9 po\u0161kozen\u00ed u PBC; (3) stimuluje bikarbon\u00e1tem bohatou \u201calkalickou vlnu\u201d cholerezi, kter\u00e1 chr\u00e1n\u00ed cholangiocyty p\u0159ed detergentn\u00edm \u00fa\u010dinkem hydrofobn\u00edch \u017elu\u010dov\u00fdch kyselin. Biochemick\u00e9 zlep\u0161en\u00ed u PBC obvykle nast\u00e1v\u00e1 za 2\u20136 m\u011bs\u00edc\u016f.<\/p>\n

Indikace & d\u00e1vkov\u00e1n\u00ed<\/h2>\n\n\n\n\n\n\n\n\n\n
Indikace<\/th>\nD\u00e1vka<\/th>\nPozn\u00e1mky<\/th>\n<\/tr>\n<\/thead>\n
Prim\u00e1rn\u00ed bili\u00e1rn\u00ed cholangitida (PBC)<\/td>\n13\u201315 mg\/kg\/den v 1\u20132 d\u00edl\u010d\u00edch d\u00e1vk\u00e1ch<\/td>\nDo\u017eivotn\u00ed<\/td>\n<\/tr>\n
Cholesterolov\u00e9 \u017elu\u010dov\u00e9 kameny (radiolucentn\u00ed, nekalcifikovan\u00e9, < 15 mm, funk\u010dn\u00ed \u017elu\u010dn\u00edk)<\/td>\n8\u201310 mg\/kg\/den<\/td>\n6\u201324 m\u011bs\u00edc\u016f; po vysazen\u00ed \u010dast\u00e9 recidivy<\/td>\n<\/tr>\n
Intrahepat\u00e1ln\u00ed cholest\u00e1za t\u011bhotn\u00fdch<\/td>\n10\u201315 mg\/kg\/den, m\u016f\u017ee se zv\u00fd\u0161it na 25 mg\/kg\/den<\/td>\nSni\u017euje pruritus, normalizuje \u017elu\u010dov\u00e9 kyseliny; studie PITCHES prok\u00e1zala sm\u00ed\u0161en\u00fd \u00fa\u010dinek na mrtv\u011b narozen\u00e9<\/td>\n<\/tr>\n
Pr\u016fjem zp\u016fsoben\u00fd \u017elu\u010dov\u00fdmi kyselinami<\/td>\n250\u2013500 mg dvakr\u00e1t denn\u011b (mimo schv\u00e1len\u00e9 indikace)<\/td>\nKombinovat s prysky\u0159i\u010dnat\u00fdmi l\u00e1tky v\u00e1zaj\u00edc\u00edmi \u017elu\u010dov\u00e9 kyseliny (cholestyramin)<\/td>\n<\/tr>\n
PSC, cystick\u00e1 fibr\u00f3za jater, d\u011btsk\u00e1 bili\u00e1rn\u00ed atr\u00e9zie<\/td>\n20\u201330 mg\/kg\/den<\/td>\nSpecialistick\u00fd dohled; vysok\u00e9 d\u00e1vky u PSC omezeny na 20 mg\/kg\/den po 30 mg\/kg zkou\u0161ce prok\u00e1zaly \u0161kodlivost<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Vedlej\u0161\u00ed \u00fa\u010dinky<\/h2>\n