{"id":59701,"date":"2024-02-28T06:11:20","date_gmt":"2024-02-28T06:11:20","guid":{"rendered":"https:\/\/medsname.com\/diovan-160\/"},"modified":"2026-05-01T10:49:15","modified_gmt":"2026-05-01T10:49:15","slug":"diovan-160","status":"publish","type":"product","link":"https:\/\/medsbase.com\/cs\/product\/diovan-160\/","title":{"rendered":"Diovan 160"},"content":{"rendered":"<p><!-- medsbase-tldr-answer --><\/p>\n<div style=\"background:#fff8e1;border-left:4px solid #f5a623;padding:18px 22px;margin:0 0 24px 0;border-radius:4px;\">\n<h3 class=\"wp-block-heading\" style=\"margin:0 0 8px 0;font-size:16px;font-weight:700;\">&#9889; Quick Answer &mdash; What is Diovan 160?<\/h3>\n<p style=\"margin:0;\"><strong>Diovan 160<\/strong> je <strong>160 mg valsartan tablet<\/strong> from Novartis &mdash; an <strong>blok\u00e1tor receptoru pro angiotensin II (ARB)<\/strong>. ARB jsou <strong>l\u00e9\u010dba hypertenze prvn\u00ed volby<\/strong> vedle ACE inhibitor\u016f, CCB a thiazid\u016f dle doporu\u010den\u00ed NICE, AHA\/ACC a ESC\/ESH \u2014 a jsou <strong>preferovanou alternativou, kdy\u017e ACE inhibitor nen\u00ed tolerov\u00e1n<\/strong> (obvykle kv\u016fli such\u00e9mu ka\u0161li, kter\u00fd postihuje a\u017e 20 % u\u017eivatel\u016f ACE inhibitor\u016f). Zaveden 1996 (Novartis jako <strong>Diovan<\/strong>ARB s nejv\u00edce d\u016fkazy pro srde\u010dn\u00ed selh\u00e1n\u00ed po losartanu; sou\u010d\u00e1st kombinace sacubitril\/valsartan (Entresto), kter\u00e1 nahradila ACE inhibitory jako prvn\u00ed linii terapie HF-REF podle doporu\u010den\u00ed ESC z roku 2021. Aktivn\u00ed l\u00e1tka (nikoli prol\u00e9\u010divo); nevy\u017eaduje metabolickou aktivaci. Polo\u010das 6 hodin, ale \u00fa\u010dinek trv\u00e1 24 hodin d\u00edky pevn\u00e9 vazb\u011b na receptor AT1. Typick\u00e1 d\u00e1vka pro hypertenzi: <strong>za\u010dn\u011bte s 80 mg jednou denn\u011b (40 mg u star\u0161\u00edch pacient\u016f, p\u0159i hypovolemii nebo poru\u0161e funkce jater), c\u00edlovou d\u00e1vkou je 160 mg jednou denn\u011b<\/strong>. Sou\u010d\u00e1st <strong>sacubitril\/valsartan (Entresto)<\/strong> \u2014 t\u0159\u00edda inhibitor\u016f angiotensinov\u00e9ho receptoru a neprilysinu (ARNI). Studie PARADIGM-HF (2014) prok\u00e1zala, \u017ee sacubitril\/valsartan sn\u00ed\u017eil kardiovaskul\u00e1rn\u00ed mortalitu o 20 % ve srovn\u00e1n\u00ed s enalaprilem u HF-REF, co\u017e zm\u011bnilo prvn\u00ed linii terapie HF-REF. Monoterapie standardn\u00edm valsartanem z\u016fst\u00e1v\u00e1 mo\u017enost\u00ed u pacient\u016f, kte\u0159\u00ed si nemohou dovolit nebo nesn\u00e1\u0161ej\u00ed sacubitril\/valsartan. <strong>Absolutn\u011b kontraindikov\u00e1n v t\u011bhotenstv\u00ed<\/strong> (v\u0161echna trimestra \u2014 stejn\u00fd teratogenn\u00ed profil jako ACE inhibitory: ren\u00e1ln\u00ed ageneze plodu, oligohydramnion, plicn\u00ed hypoplazie), <strong>bilater\u00e1ln\u00ed sten\u00f3za ren\u00e1ln\u00ed arterie<\/strong>, a <strong>sou\u010dasn\u00e9 pod\u00e1v\u00e1n\u00ed sacubitrilu\/valsartanu nebo aliskirenu<\/strong>. Monitorujte hladinu drasl\u00edku a kreatininu.<\/p>\n<\/div>\n<div class=\"medsbase-trust-strip\" style=\"background:#f4f8fb;border:1px solid #d8e3eb;padding:12px 16px;margin:16px 0;border-radius:4px;font-size:14px;\">\n<strong>Co z\u00edsk\u00e1te s MedsBase:<\/strong> V\u00fdrobce certifikovan\u00fd WHO-GMP \u00b7 Diskr\u00e9tn\u00ed balen\u00ed \u00b7 Celosv\u011btov\u00e1 doprava \u00b7 V\u00edce ne\u017e 1 400 ov\u011b\u0159en\u00fdch <a href=\"https:\/\/medsbase.com\/cs\/reviews\/\">recenz\u00ed z\u00e1kazn\u00edk\u016f<\/a>\n<\/div>\n<p class=\"medsbase-reship-line\" style=\"font-size:14px;color:#444;margin:8px 0 18px;\">\ud83d\udce6 Ka\u017ed\u00e1 objedn\u00e1vka je pokryta na\u0161\u00ed <a href=\"https:\/\/medsbase.com\/cs\/medsbase-re-shipment-assurance-policy\/\"><strong>Z\u00e1rukou op\u011btovn\u00e9ho odesl\u00e1n\u00ed<\/strong><\/a> \u2014 pokud va\u0161e z\u00e1silka nedoraz\u00ed do 20 pracovn\u00edch dn\u016f, p\u0159epos\u00edl\u00e1me ji.<\/p>\n<h3>Pro\u010d objedn\u00e1vat z MedsBase<\/h3>\n<p>Na\u0161e generick\u00e9 l\u00e9ky poch\u00e1zej\u00ed od v\u00fdrobc\u016f certifikovan\u00fdch WHO-GMP a jsou expedov\u00e1ny po cel\u00e9m sv\u011bt\u011b v diskr\u00e9tn\u00edm, nen\u00e1padn\u00e9m balen\u00ed \u2013 na vn\u011bj\u0161\u00ed stran\u011b bal\u00edku nen\u00ed uveden n\u00e1zev l\u00e9ku. Platby kartou jsou sm\u011brov\u00e1ny prost\u0159ednictv\u00edm regulovan\u00e9ho procesoru (popisky na v\u00fdpisu zahrnuj\u00ed regulovan\u00e9ho procesora plateb kartou \u2013 nikdy \u201cMedsBase\u201d nebo n\u00e1zev l\u00e9ku). P\u0159ij\u00edm\u00e1me tak\u00e9 kryptom\u011bny a bankovn\u00ed p\u0159evody SEPA. Ka\u017ed\u00e1 objedn\u00e1vka je zaji\u0161t\u011bna na\u0161\u00ed politikou p\u0159eposl\u00e1n\u00ed.<\/p>\n<h2 class=\"wp-block-heading\">What Is Diovan 160?<\/h2>\n<p>Diovan 160 is an oral 160 mg valsartan tablet from Novartis, supplied in 30-180 tablets. Introduced 1996 (Novartis as <strong>Diovan<\/strong>). ARB s nejv\u00edce d\u016fkazy pro srde\u010dn\u00ed selh\u00e1n\u00ed po losartanu; sou\u010d\u00e1st kombinace sacubitril\/valsartan (Entresto), kter\u00e1 nahradila ACE inhibitory jako prvn\u00ed linii terapie HF-REF podle doporu\u010den\u00ed ESC z roku 2021. Aktivn\u00ed l\u00e1tka (nikoli prol\u00e9\u010divo); nevy\u017eaduje metabolickou aktivaci. Polo\u010das 6 hodin, ale \u00fa\u010dinek trv\u00e1 24 hodin d\u00edky pevn\u00e9 vazb\u011b na receptor AT1.<\/p>\n<h2 class=\"wp-block-heading\">Jak Valsartan Sni\u017euje Krevn\u00ed Tlak<\/h2>\n<p>ARB blokuj\u00ed <strong>receptor angiotenzinu II typu 1 (AT<sub>1<\/sub>),<\/strong> p\u0159\u00edmo zabra\u0148uj\u00ed vazb\u011b angiotenzinu II a jeho vazokonstrik\u010dn\u00edm a aldosteron-uvol\u0148uj\u00edc\u00edm \u00fa\u010dink\u016fm. Tento receptor se nach\u00e1z\u00ed o jeden krok d\u00e1le v kask\u00e1d\u011b ne\u017e m\u00edsto p\u016fsoben\u00ed ACE inhibitor\u016f (kter\u00e9 blokuj\u00ed tvorbu angiotenzinu II) a vyvol\u00e1v\u00e1 srovnateln\u00e9 klinick\u00e9 \u00fa\u010dinky:<\/p>\n<ul>\n<li><strong>P\u0159\u00edmou vazodilataci tepen<\/strong> \u2014 sn\u00ed\u017een\u00ed syst\u00e9mov\u00e9 vaskul\u00e1rn\u00ed rezistence = sn\u00ed\u017een\u00ed krevn\u00edho tlaku<\/li>\n<li><strong>Sn\u00ed\u017eenou sekreci aldosteronu<\/strong> \u2014 men\u0161\u00ed retence sod\u00edku a vody<\/li>\n<li><strong>Sn\u00ed\u017eenou aktivaci sympatick\u00e9ho nervov\u00e9ho syst\u00e9mu<\/strong><\/li>\n<li><strong>Zlep\u0161en\u00e1 endoteli\u00e1ln\u00ed funkce a sn\u00ed\u017een\u00e9 ventrikul\u00e1rn\u00ed remodelov\u00e1n\u00ed<\/strong> \u2014 vaskul\u00e1rn\u011b-protektivn\u00ed mechanismus p\u0159esahuj\u00edc\u00ed pouh\u00e9 sn\u00ed\u017een\u00ed krevn\u00edho tlaku<\/li>\n<li><strong>\u017d\u00e1dn\u00e1 akumulace bradykininu<\/strong> \u2014 to je kl\u00ed\u010dov\u00fd klinick\u00fd rozd\u00edl oproti ACE inhibitor\u016fm. ARB NEzp\u016fsobuj\u00ed such\u00fd ka\u0161el, kter\u00fd postihuje a\u017e 20 % u\u017eivatel\u016f ACE inhibitor\u016f, proto\u017ee neovliv\u0148uj\u00ed metabolismus bradykininu.<\/li>\n<\/ul>\n<p>Klinick\u00fd d\u016fsledek tohoto mechanismu: ARB dosahuj\u00ed srovnateln\u00e9 kontroly krevn\u00edho tlaku jako ACE inhibitory, ale s ni\u017e\u0161\u00ed incidenc\u00ed ka\u0161le (0\u20133 % vs. 20 % u ACE inhibitor\u016f) a angioed\u00e9mu (p\u0159ibli\u017en\u011b o 30\u201350 % ni\u017e\u0161\u00ed ne\u017e u ACE inhibitor\u016f, i kdy\u017e ne nulov\u00fd).<\/p>\n<h2 class=\"wp-block-heading\">Schv\u00e1len\u00e9 a v\u011bdecky podlo\u017een\u00e9 indikace<\/h2>\n<ul>\n<li><strong>Hypertenze<\/strong> \u2014 prim\u00e1rn\u00ed indikace; prvn\u00ed volba dle mezin\u00e1rodn\u00edch doporu\u010den\u00ed<\/li>\n<li><strong>Srde\u010dn\u00ed selh\u00e1n\u00ed se sn\u00ed\u017eenou ejek\u010dn\u00ed frakc\u00ed (HF-REF)<\/strong> \u2014 d\u016fkazy z Val-HeFT; p\u0159edch\u016fdce ARNI<\/li>\n<li><strong>Dysfunkce lev\u00e9 komory po infarktu myokardu<\/strong> \u2014 VALIANT<\/li>\n<li><strong>Hypertenze<\/strong> (\u0161irok\u00e9 d\u00e1vkovac\u00ed rozmez\u00ed umo\u017e\u0148uje titraci od 40 mg do 320 mg)<\/li>\n<li><strong>Nesn\u00e1\u0161enlivost ACE inhibitor\u016f<\/strong> (ka\u0161el, m\u00e9n\u011b \u010dasto angioed\u00e9m) \u2014 standardn\u00ed c\u00edl pro zm\u011bnu<\/li>\n<\/ul>\n<p><strong>Kl\u00ed\u010dov\u00e9 d\u016fkazy z klinick\u00fdch studi\u00ed:<\/strong> <strong>Val-HeFT (2001)<\/strong> \u2014 valsartan u HF-REF sn\u00ed\u017eil hospitalizaci. <strong>VALIANT (2003)<\/strong> \u2014 valsartan nebyl hor\u0161\u00ed ne\u017e kaptopril u dysfunkce lev\u00e9 komory po infarktu myokardu. <strong>VALUE (2004)<\/strong> \u2014 valsartan vs amlodipin u vysokorizikov\u00e9 hypertenze; m\u00edrn\u00e1 v\u00fdhoda amlodipinu u koncov\u00fdch bod\u016f mrtvice + infarktu myokardu, zp\u016fsoben\u00e1 zejm\u00e9na rychlej\u0161\u00ed kontrolou TK s amlodipinem.<\/p>\n<h2 class=\"wp-block-heading\">Diovan 160 Dosage<\/h2>\n<p><strong>Hypertenze:<\/strong><\/p>\n<ul>\n<li><strong>Po\u010d\u00e1te\u010dn\u00ed d\u00e1vka:<\/strong> 80 mg jednou denn\u011b (40 mg u star\u0161\u00edch pacient\u016f, pacient\u016f s hypovol\u00e9mi\u00ed nebo po\u0161kozen\u00edm jater)<\/li>\n<li><strong>C\u00edlov\u00e1 d\u00e1vka:<\/strong> 160 mg jednou denn\u011b<\/li>\n<li><strong>Maxim\u00e1ln\u00ed d\u00e1vka:<\/strong> 320 mg jednou denn\u011b<\/li>\n<li>Titrujte ka\u017ed\u00e9 2-4 t\u00fddny; pln\u00fd antihypertenzn\u00ed \u00fa\u010dinek za 3-6 t\u00fddn\u016f<\/li>\n<\/ul>\n<p><strong>Srde\u010dn\u00ed selh\u00e1n\u00ed:<\/strong> 40 mg dvakr\u00e1t denn\u011b, titrovat na 160 mg dvakr\u00e1t denn\u011b (c\u00edlov\u00e9 d\u00e1vkov\u00e1n\u00ed ve studii Val-HeFT)<\/p>\n<p><strong>Pod\u00e1v\u00e1n\u00ed:<\/strong> jednou denn\u011b, s j\u00eddlem nebo bez. U\u017e\u00edvejte ve stejnou dobu ka\u017ed\u00fd den pro stabiln\u00ed kontrolu krevn\u00edho tlaku.<\/p>\n<p><strong>Monitorov\u00e1n\u00ed:<\/strong><\/p>\n<ul>\n<li>V\u00fdchoz\u00ed vy\u0161et\u0159en\u00ed: mo\u010dovina, elektrolyty (zejm\u00e9na drasl\u00edk), kreatinin, eGFR. Dom\u00e1c\u00ed m\u011b\u0159en\u00ed krevn\u00edho tlaku jako v\u00fdchoz\u00ed hodnota.<\/li>\n<li>Po 1-2 t\u00fddnech: opakovat U&amp;E. M\u00edrn\u00fd vzestup kreatininu (a\u017e o 30 %) je o\u010dek\u00e1van\u00fd a p\u0159ijateln\u00fd. M\u00edrn\u00fd vzestup drasl\u00edku je b\u011b\u017en\u00fd.<\/li>\n<li>Po zv\u00fd\u0161en\u00ed d\u00e1vky: opakujte U&amp;E za 1\u20132 t\u00fddny.<\/li>\n<li>Pr\u016fb\u011b\u017en\u011b: ro\u010dn\u00ed kontrola U&amp;E po stabilizaci.<\/li>\n<li><strong>P\u0159eru\u0161te a vy\u0161et\u0159ete:<\/strong> vzestup kreatininu &gt;30 %, pokles eGFR &gt;25 %, drasl\u00edk &gt;5,5, symptomatick\u00e1 hypotenze.<\/li>\n<\/ul>\n<p><strong>Ukon\u010den\u00ed l\u00e9\u010dby:<\/strong> neexistuje abstinen\u010dn\u00ed syndrom; av\u0161ak n\u00e1hl\u00e9 vysazen\u00ed zp\u016fsob\u00ed rebound hypertenzi b\u011bhem n\u011bkolika dn\u00ed. Sni\u017eujte d\u00e1vky postupn\u011b po dobu 1-2 t\u00fddn\u016f p\u0159i vysazov\u00e1n\u00ed.<\/p>\n<h2 class=\"wp-block-heading\">Vedlej\u0161\u00ed \u00fa\u010dinky<\/h2>\n<p><strong>\u010cast\u00e9 (&gt;1 %, obvykle m\u00edrn\u00e9):<\/strong><\/p>\n<ul>\n<li>Z\u00e1vrat\u011b, ortostatick\u00e1 hypotenze (obvykle m\u00edrn\u00e1; \u010dast\u011bj\u0161\u00ed na za\u010d\u00e1tku l\u00e9\u010dby)<\/li>\n<li>M\u00edrn\u00e1 hyperkal\u00e9mie<\/li>\n<li>O\u010dek\u00e1van\u00fd m\u00edrn\u00fd vzestup kreatininu (a\u017e ~30 % je p\u0159ijateln\u00e9; intraren\u00e1ln\u00ed hemodynamick\u00e1 zm\u011bna, nikoli nefrotoxicita)<\/li>\n<li>\u00danava, bolest hlavy<\/li>\n<li>P\u0159\u00edznaky horn\u00edch cest d\u00fdchac\u00edch, nazofaryngitida<\/li>\n<li>Bolest zad, svalov\u00e9 k\u0159e\u010de<\/li>\n<\/ul>\n<p><strong>M\u00e9n\u011b \u010dast\u00e9, ale d\u016fle\u017eit\u00e9:<\/strong><\/p>\n<ul>\n<li><strong>Angioed\u00e9m<\/strong> \u2014 ni\u017e\u0161\u00ed v\u00fdskyt ne\u017e u ACE inhibitor\u016f, ale st\u00e1le mo\u017en\u00fd. Incidence ~0,1 %. NEPOU\u017d\u00cdVEJTE ARB, pokud m\u00e1 pacient v anamn\u00e9ze dokumentovan\u00fd angioed\u00e9m po ACE inhibitoru v prvn\u00edch 4 t\u00fddnech; opatrn\u00e9 dlouhodob\u00e9 u\u017e\u00edv\u00e1n\u00ed je \u010dasto p\u0159ijateln\u00e9.<\/li>\n<li><strong>T\u011b\u017ek\u00e1 hyperkal\u00e9mie<\/strong> \u2014 zejm\u00e9na s kalium \u0161et\u0159\u00edc\u00edmi diuretiky (spironolakton), drasl\u00edkov\u00fdmi dopl\u0148ky, NSAID nebo CKD<\/li>\n<li><strong>Akutn\u00ed po\u0161kozen\u00ed ledvin p\u0159i oboustrann\u00e9 sten\u00f3ze ren\u00e1ln\u00ed arterie<\/strong> \u2014 stejn\u00fd mechanismus jako ACE inhibitory<\/li>\n<li><strong>Hypotenze po prvn\u00ed d\u00e1vce<\/strong> u pacient\u016f s deplec\u00ed objemu (nap\u0159. p\u0159i vysok\u00fdch d\u00e1vk\u00e1ch diuretik, t\u011b\u017ek\u00e9m srde\u010dn\u00edm selh\u00e1n\u00ed)<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Kontraindikace<\/h2>\n<ul>\n<li><strong>T\u011bhotenstv\u00ed \u2014 ABSOLUTN\u00cd kontraindikace ve v\u0161ech trimestrech<\/strong>. Stejn\u00fd teratogenn\u00ed profil jako ACE inhibitory. Okam\u017eit\u011b vysadit p\u0159i zji\u0161t\u011bn\u00ed t\u011bhotenstv\u00ed; p\u0159ej\u00edt na <a href=\"https:\/\/medsbase.com\/cs\/labebet\/\">labetalol<\/a>, methyldopu, nifedipin nebo hydralazin.<\/li>\n<li>Anamn\u00e9za angioed\u00e9mu s jak\u00fdmkoli ACE inhibitorem nebo ARB (do 4 t\u00fddn\u016f)<\/li>\n<li>Oboustrann\u00e1 sten\u00f3za ren\u00e1ln\u00ed arterie nebo sten\u00f3za u jedn\u00e9 funk\u010dn\u00ed ledviny<\/li>\n<li>T\u011b\u017ek\u00e9 po\u0161kozen\u00ed jater (Child-Pugh C) \u2014 zejm\u00e9na u prol\u00e9\u010div ARB<\/li>\n<li>Hyperkal\u00e9mie &gt;5,5 mmol\/l v\u00fdchoz\u00ed<\/li>\n<li>Sou\u010dasn\u00e9 u\u017e\u00edv\u00e1n\u00ed sacubitrilu\/valsartanu (Entresto) \u2014 p\u0159i p\u0159echodu je nutn\u00e1 36hodinov\u00e1 p\u0159est\u00e1vka<\/li>\n<li>Sou\u010dasn\u00e9 u\u017e\u00edv\u00e1n\u00ed aliskirenu u diabetu nebo CKD (po\u0161kozen\u00ed dle studie ALTITUDE)<\/li>\n<li>Sou\u010dasn\u00e9 u\u017e\u00edv\u00e1n\u00ed ACE inhibitoru \u2014 po\u0161kozen\u00ed bez benefit\u016f dle studie ONTARGET<\/li>\n<li>P\u0159ecitliv\u011blost na valsartan<\/li>\n<\/ul>\n<p><strong>Kojen\u00ed:<\/strong> vyhn\u011bte se u\u017e\u00edv\u00e1n\u00ed v prvn\u00edch t\u00fddnech po porodu p\u0159ed\u010dasn\u011b narozen\u00e9ho d\u00edt\u011bte. Dlouhodob\u00e9 u\u017e\u00edv\u00e1n\u00ed p\u0159i zaveden\u00e9m kojen\u00ed je obecn\u011b pova\u017eov\u00e1no za p\u0159ijateln\u00e9 vzhledem k n\u00edzk\u00e9mu p\u0159enosu do ml\u00e9ka, ale pokud mo\u017eno jsou preferov\u00e1ny alternativn\u00ed antihypertenziva (propranolol, nifedipin).<\/p>\n<h2 class=\"wp-block-heading\">Interakce s l\u00e9\u010divy<\/h2>\n<ul>\n<li><strong>\u0160et\u0159\u00edc\u00ed drasl\u00edk diuretika<\/strong> (spironolakton, eplerenon, amilorid, triamteren) \u2014 aditivn\u00ed hyperkalemie; pe\u010dliv\u011b monitorujte<\/li>\n<li><strong>Dopl\u0148ky drasl\u00edku a n\u00e1hrady soli<\/strong> \u2014 riziko hyperkalemie<\/li>\n<li><strong>NSAID<\/strong> \u2014 sni\u017euj\u00ed antihypertenzn\u00ed \u00fa\u010dinek a zvy\u0161uj\u00ed riziko AKI (zejm\u00e9na \u201ctrojit\u00fd \u00fader\u201d: ARB + diuretikum + NSAID)<\/li>\n<li><strong>Lithium<\/strong> \u2014 ARB sni\u017euj\u00ed clearance lithia; monitorujte hladiny<\/li>\n<li><strong>ACE inhibitory<\/strong> \u2014 NEKOMBINOVAT (po\u0161kozen\u00ed dle ONTARGET)<\/li>\n<li><strong>Sacubitril\/valsartan (Entresto)<\/strong> \u2014 nekombinovat; 36hodinov\u00e1 p\u0159est\u00e1vka<\/li>\n<li><strong>Aliskiren<\/strong> \u2014 vyhn\u011bte se u diabetu nebo CKD (po\u0161kozen\u00ed dle ALTITUDE)<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">P\u0159ehled t\u0159\u00eddy ARB<\/h2>\n<table style=\"width:100%;border-collapse:collapse;margin:14px 0;\">\n<thead>\n<tr style=\"background:#2c7cb0;color:#fff;\">\n<th style=\"padding:10px;border:1px solid #ddd;text-align:left;\">ARB<\/th>\n<th style=\"padding:10px;border:1px solid #ddd;text-align:left;\">Polo\u010das<\/th>\n<th style=\"padding:10px;border:1px solid #ddd;text-align:left;\">Specializovan\u00e1 oblast<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td style=\"padding:10px;border:1px solid #ddd;\"><a href=\"https:\/\/medsbase.com\/cs\/losar\/\">Losartan (Losar, Cosart)<\/a><\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">2 h \/ 6-9 h (metabolit)<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Urikosurikum (u\u017eite\u010dn\u00e9 p\u0159i dn\u011b); sn\u00ed\u017een\u00ed rizika mrtvice ve studii LIFE<\/td>\n<\/tr>\n<tr style=\"background:#f9f9f9;\">\n<td style=\"padding:10px;border:1px solid #ddd;\"><a href=\"https:\/\/medsbase.com\/cs\/olmin\/\">Olmesartan (Olmin, Olmeheal, Olmesar)<\/a><\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">13 h<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Siln\u00fd \u00fa\u010dinek na mg; FDA varov\u00e1n\u00ed p\u0159ed sprue-like enteropati\u00ed<\/td>\n<\/tr>\n<tr>\n<td style=\"padding:10px;border:1px solid #ddd;\"><a href=\"https:\/\/medsbase.com\/cs\/telmaheal\/\">Telmisartan (Telmaheal, Cresar, Targit)<\/a><\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">24 h (nejdel\u0161\u00ed)<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Metabolick\u00fd benefit (PPAR-\u03b3); kardiovaskul\u00e1rn\u00ed ochrana v ONTARGET<\/td>\n<\/tr>\n<tr style=\"background:#fff3cd;\">\n<td style=\"padding:10px;border:1px solid #ddd;\"><a href=\"https:\/\/medsbase.com\/cs\/diovan-160\/\">Valsartan (Diovan 160, Valent)<\/a><\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">6 h (24h \u00fa\u010dinek)<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">D\u016fkazy pro srde\u010dn\u00ed selh\u00e1n\u00ed (Val-HeFT, VALIANT); prekurzor ARNI (Entresto)<\/td>\n<\/tr>\n<tr>\n<td style=\"padding:10px;border:1px solid #ddd;\"><a href=\"https:\/\/medsbase.com\/cs\/irovel\/\">Irbesartan (Irovel)<\/a><\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">11-15 h<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Diabetick\u00e1 nefropatie (IRMA-2, IDNT)<\/td>\n<\/tr>\n<tr style=\"background:#f9f9f9;\">\n<td style=\"padding:10px;border:1px solid #ddd;\">Kandesartan<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">9 h<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Srde\u010dn\u00ed selh\u00e1n\u00ed (d\u016fkaz CHARM); nedostupn\u00e9 na MedsBase<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2 class=\"wp-block-heading\">ARB vs ACE inhibitory \u2014 kdy zvolit ARB<\/h2>\n<p>ACE inhibitory (<a href=\"https:\/\/medsbase.com\/cs\/ramcor\/\">ramipril<\/a>, <a href=\"https:\/\/medsbase.com\/cs\/enapril\/\">enalapril<\/a>, <a href=\"https:\/\/medsbase.com\/cs\/lispro\/\">lisinoprilem<\/a>, <a href=\"https:\/\/medsbase.com\/cs\/coversyl\/\">perindopril<\/a>) a ARB p\u016fsob\u00ed na stejn\u00e9 renin-angiotenzinov\u00e9 dr\u00e1ze a poskytuj\u00ed srovnateln\u00e9 sn\u00ed\u017een\u00ed TK a kardiovaskul\u00e1rn\u00ed ochranu. Zvolte ARB kdy\u017e:<\/p>\n<ul>\n<li><strong>Ka\u0161el p\u0159i u\u017e\u00edv\u00e1n\u00ed ACE inhibitor\u016f<\/strong> se objev\u00ed (a\u017e u 20 % u\u017eivatel\u016f; nej\u010dast\u011bj\u0161\u00ed d\u016fvod pro zm\u011bnu l\u00e9\u010dby)<\/li>\n<li>Angioed\u00e9m po ACE inhibitory (pou\u017e\u00edvejte ARB opatrn\u011b, ne d\u0159\u00edve ne\u017e 4 t\u00fddny po epizod\u011b angioed\u00e9mu)<\/li>\n<li>N\u011bkte\u0159\u00ed pacienti preferuj\u00ed dlouhodob\u011b p\u016fsob\u00edc\u00ed ARB jako je telmisartan pro rovnom\u011brnou 24hodinovou kontrolu krevn\u00edho tlaku<\/li>\n<li>Specifick\u00e9 indikace molekul \u2014 losartan u hypertenze a dny, irbesartan u diabetick\u00e9 nefropatie 2. typu, valsartan jako prekurzor ARNI u srde\u010dn\u00edho selh\u00e1n\u00ed<\/li>\n<\/ul>\n<p><strong>NEKOMBINUJTE ARB + ACE inhibitor.<\/strong> Studie ONTARGET (2008) prok\u00e1zala, \u017ee tato kombinace zvy\u0161uje v\u00fdskyt ne\u017e\u00e1douc\u00edch \u00fa\u010dink\u016f (hyperkal\u00e9mie, AKI, hypotenze) bez dal\u0161\u00edho kardiovaskul\u00e1rn\u00edho benefitu. Pokud pacient u\u017e\u00edv\u00e1 oba, jeden vysa\u010fte.<\/p>\n<h2 class=\"wp-block-heading\">Skladov\u00e1n\u00ed<\/h2>\n<p>Store Diovan 160 below 25&deg;C in the original blister pack. Keep out of reach of children.<\/p>\n<h2 id=\"faqs\">\u010casto kladen\u00e9 dotazy<\/h2>\n<h3 class=\"wp-block-heading\">How long does Diovan 160 take to lower blood pressure?<\/h3>\n<p>Po\u010d\u00e1te\u010dn\u00ed pokles TK do 1-2 hodin; pln\u00fd antihypertenzn\u00ed \u00fa\u010dinek nast\u00e1v\u00e1 za <strong>3-6 t\u00fddn\u016f<\/strong>. M\u011b\u0159te dom\u00e1c\u00ed TK ve stejnou denn\u00ed dobu pro sledov\u00e1n\u00ed \u00fa\u010dinku. Pokud TK nedos\u00e1hne c\u00edlov\u00fdch hodnot za 6 t\u00fddn\u016f, zvy\u0161te d\u00e1vku nebo p\u0159idejte l\u00e9k druh\u00e9 volby (CCB nebo thiazid jsou standardn\u00ed kombinac\u00ed s ARB).<\/p>\n<h3 class=\"wp-block-heading\">P\u0159estal\/a jsem u\u017e\u00edvat ACE inhibitor kv\u016fli ka\u0161li \u2014 zmiz\u00ed m\u016fj ka\u0161el?<\/h3>\n<p>Ano. Ka\u0161el po ACE inhibitory je zp\u016fsoben akumulac\u00ed bradykininu; ARB bradykinin nezvy\u0161uj\u00ed. Ka\u0161el obvykle vymiz\u00ed do <strong>1-4 t\u00fddn\u016f<\/strong> of stopping the ACE inhibitor. If your cough persists beyond 6 weeks after switching to Diovan 160, investigate an alternative cause (reflux, postnasal drip, asthma).<\/p>\n<h3 class=\"wp-block-heading\">Can I take Diovan 160 in pregnancy?<\/h3>\n<p><strong>Ne \u2014 blok\u00e1tory receptor\u016f pro angiotensin II (ARB) jsou v t\u011bhotenstv\u00ed absolutn\u011b kontraindikov\u00e1ny<\/strong>, stejn\u011b jako ACE inhibitory. Zp\u016fsobuj\u00ed ren\u00e1ln\u00ed agenezi plodu, oligohydramnion, plicn\u00ed hypopl\u00e1zii a defekty lebky. Okam\u017eit\u011b p\u0159eru\u0161te l\u00e9\u010dbu, pokud dojde k ot\u011bhotn\u011bn\u00ed. \u017deny v reproduk\u010dn\u00edm v\u011bku by m\u011bly pou\u017e\u00edvat spolehlivou antikoncepci; u t\u011bch, kter\u00e9 pl\u00e1nuj\u00ed t\u011bhotenstv\u00ed, p\u0159ejd\u011bte p\u0159ed po\u010det\u00edm na <a href=\"https:\/\/medsbase.com\/cs\/labebet\/\">labetalol<\/a>, methyldopu nebo nifedipin.<\/p>\n<h3 class=\"wp-block-heading\">My creatinine went up a bit after starting Diovan 160 &mdash; should I stop?<\/h3>\n<p>N\u00e1r\u016fst kreatininu a\u017e o <strong>30%<\/strong> b\u011bhem prvn\u00edch 1\u20132 t\u00fddn\u016f je <strong>je o\u010dek\u00e1van\u00fd a p\u0159ijateln\u00fd<\/strong>. Odr\u00e1\u017e\u00ed norm\u00e1ln\u00ed intraren\u00e1ln\u00ed hemodynamickou adaptaci, kdy\u017e je odstran\u011bn tonus eferentn\u00edch arteriol zprost\u0159edkovan\u00fd angiotensinem II. Vzestup &gt;30% nazna\u010duje bilater\u00e1ln\u00ed sten\u00f3zu ren\u00e1ln\u00ed arterie, hypovol\u00e9mii nebo interakci s NSAID a vy\u017eaduje vy\u0161et\u0159en\u00ed (p\u0159eru\u0161te pod\u00e1v\u00e1n\u00ed l\u00e9ku, prove\u010fte zobrazovac\u00ed vy\u0161et\u0159en\u00ed ledvin, zhodno\u0165te sou\u010dasnou medikaci).<\/p>\n<h3 class=\"wp-block-heading\">Should I avoid potassium-rich foods on Diovan 160?<\/h3>\n<p>M\u00edrn\u00fd p\u0159\u00edjem potravin bohat\u00fdch na drasl\u00edk (ban\u00e1ny, pomeran\u010de, \u0161pen\u00e1t, avok\u00e1do, brambory) je pro v\u011bt\u0161inu u\u017eivatel\u016f v po\u0159\u00e1dku. Vyhn\u011bte se dopl\u0148k\u016fm drasl\u00edku (slow-K) a n\u00e1hrad\u00e1m soli obsahuj\u00edc\u00edm drasl\u00edk, pokud nejsou v\u00fdslovn\u011b p\u0159edeps\u00e1ny \u2014 tyto v kombinaci s ARB, zejm\u00e9na u chronick\u00e9ho onemocn\u011bn\u00ed ledvin nebo s drasl\u00edk \u0161et\u0159\u00edc\u00edmi diuretiky, mohou zp\u016fsobit nebezpe\u010dnou hyperkal\u00e9mii.<\/p>\n<h3 class=\"wp-block-heading\">Can I combine Diovan 160 with my other BP medications?<\/h3>\n<p>Ano \u2014 ARB se dob\u0159e kombinuj\u00ed s <strong>blok\u00e1tory kalciov\u00fdch kan\u00e1l\u016f<\/strong> (<a href=\"https:\/\/medsbase.com\/cs\/amlode\/\">amlodipin<\/a>), <strong>thiazidov\u00fdmi diuretiky<\/strong> (<a href=\"https:\/\/medsbase.com\/cs\/aquazide\/\">HCTZ<\/a>), a <strong>beta-blok\u00e1tory<\/strong> (<a href=\"https:\/\/medsbase.com\/cs\/concor\/\">bisoprolol<\/a>, <a href=\"https:\/\/medsbase.com\/cs\/betablock-xl\/\">metoprolol sukcin\u00e1t<\/a>). <strong>NEkombinujte ARB s ACE inhibitorem<\/strong> (ramipril, lisinopril atd.) \u2014 studie ONTARGET prok\u00e1zala \u0161kodu bez p\u0159\u00ednosu.<\/p>\n<h3 class=\"wp-block-heading\">Can I take ibuprofen with Diovan 160?<\/h3>\n<p>Ob\u010dasn\u00e9 kr\u00e1tkodob\u00e9 u\u017e\u00edv\u00e1n\u00ed je obvykle p\u0159ijateln\u00e9; <strong>chronick\u00e9 denn\u00ed u\u017e\u00edv\u00e1n\u00ed NSAID<\/strong> (ibuprofen, diklofenak, naproxen) sni\u017euj\u00ed antihypertenzn\u00ed \u00fa\u010dinek ARB a v\u00fdrazn\u011b zvy\u0161uj\u00ed riziko akutn\u00edho po\u0161kozen\u00ed ledvin (AKI) \u2014 zejm\u00e9na v kombinaci s diuretikem (tzv. \u201ctrojit\u00e1 r\u00e1na\u201d). P\u0159i chronick\u00e9 bolesti je paracetamol bezpe\u010dn\u011bj\u0161\u00ed; u z\u00e1n\u011bt\u016f proberte alternativy.<\/p>\n<h3 class=\"wp-block-heading\">Is Diovan 160 lifelong?<\/h3>\n<p>For most patients with essential hypertension, yes &mdash; antihypertensive therapy is lifelong because stopping returns BP to pre-treatment levels within days to weeks. Some patients lose their hypertension through significant weight loss, reduced alcohol intake, or better sleep; their physician may then trial a careful taper under BP monitoring. Never stop Diovan 160 without medical advice.<\/p>\n<h3 class=\"wp-block-heading\">Co kdy\u017e vynech\u00e1m d\u00e1vku?<\/h3>\n<p>Vynechanou d\u00e1vku u\u017eijte co nejd\u0159\u00edve, jak si vzpomenete, pokud nen\u00ed t\u00e9m\u011b\u0159 \u010das na dal\u0161\u00ed d\u00e1vku \u2014 v tom p\u0159\u00edpad\u011b vynechanou d\u00e1vku p\u0159esko\u010dte a pokra\u010dujte v obvykl\u00e9m re\u017eimu. Nezdvojujte d\u00e1vky. Jedna vynechan\u00e1 d\u00e1vka v\u00fdznamn\u011b neovlivn\u00ed dlouhodobou kontrolu TK.<\/p>\n<h3 class=\"wp-block-heading\">Where can I buy Diovan 160 online?<\/h3>\n<p>You can buy Diovan 160 (valsartan 160 mg, 30-180 tablets) from MedsBase with discreet packaging and worldwide shipping.<\/p>\n<h2 class=\"wp-block-heading\">Souvisej\u00edc\u00ed antihypertenziva na MedsBase<\/h2>\n<ul>\n<li><a href=\"https:\/\/medsbase.com\/cs\/amlode\/\">Amlode \u2014 Amlodipin CCB<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/cresar\/\">Cresar \u2014 Telmisartan 20 mg<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/olmeheal\/\">Olmeheal &mdash; Olmesartan 20\/40 mg<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/ramcor\/\">Ramcor \u2014 Ramipril (alternativa ACE inhibitoru)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/targit\/\">Targit \u2014 Telmisartan 80 mg<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/valent\/\">Valent \u2014 Valsartan 80\/160 mg<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/high-blood-pressure-medication\/\"><strong>Prohl\u00e9dnout v\u0161echny l\u00e9ky na vysok\u00fd krevn\u00ed tlak<\/strong><\/a><\/li>\n<\/ul>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:16px 20px;margin:24px 0;border-radius:4px;\"><strong>\u2695 L\u00e9ka\u0159sk\u00e9 upozorn\u011bn\u00ed.<\/strong> Tato str\u00e1nka slou\u017e\u00ed pouze pro informa\u010dn\u00ed \u00fa\u010dely a nenahrazuje l\u00e9ka\u0159skou p\u00e9\u010di kvalifikovan\u00e9ho zdravotnick\u00e9ho pracovn\u00edka. Hypertenze, srde\u010dn\u00ed selh\u00e1n\u00ed a arytmie vy\u017eaduj\u00ed diagn\u00f3zu, monitorov\u00e1n\u00ed a individu\u00e1ln\u00ed d\u00e1vkov\u00e1n\u00ed l\u00e9ka\u0159em \u2014 v\u017edy u\u017e\u00edvejte betablok\u00e1tory pod l\u00e9ka\u0159sk\u00fdm dohledem.<\/div>\n<p><!-- medsbase-related-alts-v1 --><\/p>\n<h3 class=\"wp-block-heading\">Souvisej\u00edc\u00ed alternativy<\/h3>\n<p>Dal\u0161\u00ed produkty v <strong>Chronick\u00e1 onemocn\u011bn\u00ed<\/strong> kter\u00e9 z\u00e1kazn\u00edci tak\u00e9 prohl\u00ed\u017eej\u00ed:<\/p>\n<ul>\n<li><a href=\"https:\/\/medsbase.com\/cs\/ivabrad\/\">Ivabrad<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/lomoother\/\">Lomoother<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/rapacan\/\">Rapacan<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/goutnil\/\">Goutnil<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/floricot\/\">Floricot<\/a><\/li>\n<\/ul>","protected":false},"excerpt":{"rendered":"<p>Diovan 160 is Novartis&#8217; brand of valsartan 160 mg \u2014 target-dose ARB for hypertension (typical target 160 mg once daily; max 320). Val-HeFT + VALIANT trial evidence in heart failure and post-MI. Component of Entresto (sacubitril\/valsartan), the ARNI class that replaced ACE inhibitors as first-line HF-REF therapy (PARADIGM-HF trial).<\/p>","protected":false},"featured_media":59702,"comment_status":"open","ping_status":"open","template":"","meta":[],"product_brand":[],"product_cat":[3141,3223,3342,3260,3356],"product_tag":[4731,3438],"class_list":{"0":"post-59701","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-category-overview","7":"product_cat-chronic-conditions","8":"product_cat-general-health","9":"product_cat-heart-blood-pressure","10":"product_cat-high-blood-pressure-medication","11":"product_tag-diovan","12":"product_tag-valsartan","14":"first","15":"instock","16":"shipping-taxable","17":"purchasable","18":"product-type-variable","19":"has-default-attributes"},"acf":[],"_links":{"self":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product\/59701","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/comments?post=59701"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/media\/59702"}],"wp:attachment":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/media?parent=59701"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product_brand?post=59701"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product_cat?post=59701"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product_tag?post=59701"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}