{"id":59771,"date":"2024-02-28T06:15:46","date_gmt":"2024-02-28T06:15:46","guid":{"rendered":"https:\/\/medsname.com\/waf-5\/"},"modified":"2026-05-01T10:49:15","modified_gmt":"2026-05-01T10:49:15","slug":"waf-5","status":"publish","type":"product","link":"https:\/\/medsbase.com\/cs\/product\/waf-5\/","title":{"rendered":"Waf-5"},"content":{"rendered":"<p><!-- medsbase-tldr-answer --><\/p>\n<div style=\"background:#fff8e1;border-left:4px solid #f5a623;padding:18px 22px;margin:0 0 24px 0;border-radius:4px;\">\n<h3 class=\"wp-block-heading\" style=\"margin:0 0 8px 0;font-size:16px;font-weight:700;\">\u26a1 Rychl\u00e1 odpov\u011b\u010f \u2014 Co je Waf-5?<\/h3>\n<p style=\"margin:0;\"><strong>Waf-5<\/strong> jsou tablety warfarinu 5 mg od v\u00fdrobce certifikovan\u00e9ho WHO-GMP \u2014 antagonista vitaminu K (VKA) \u2014 peror\u00e1ln\u00ed antikoagulans. Warfarin byl zaveden v roce 1954 po synt\u00e9ze z dikumarolu (l\u00e1tky pou\u017e\u00edvan\u00e9 jako jed na krysy, kter\u00e1 zp\u016fsobovala krv\u00e1cen\u00ed u skotu po konzumaci zka\u017een\u00e9ho sladk\u00e9ho jetele ve Wisconsinu ve 20. letech 20. stolet\u00ed). Pojmenov\u00e1n podle Wisconsin Alumni Research Foundation (WARF), kter\u00e1 financovala jeho v\u00fdvoj. Z\u016fst\u00e1v\u00e1 nezbytn\u00fd pro mechanick\u00e9 srde\u010dn\u00ed chlopn\u011b, st\u0159edn\u011b t\u011b\u017ekou a\u017e t\u011b\u017ekou mitr\u00e1ln\u00ed sten\u00f3zu a pacienty, u kter\u00fdch jsou DOAC kontraindikov\u00e1ny. Blokuje vitamin K-epoxid-redukt\u00e1zu (VKORC1), \u010d\u00edm\u017e br\u00e1n\u00ed regeneraci redukovan\u00e9ho vitaminu K pot\u0159ebn\u00e9ho pro karboxylaci koagula\u010dn\u00edch faktor\u016f II, VII, IX, X a protein\u016f C a S. \u00dapln\u00fd \u00fa\u010dinek nast\u00e1v\u00e1 za 3\u20135 dn\u00ed (polo\u010das faktoru II ~60 hodin). D\u00e1vkov\u00e1n\u00ed: <strong>Individualizov\u00e1no podle c\u00edlov\u00e9ho INR<\/strong> (2,0\u20133,0 u v\u011bt\u0161iny indikac\u00ed; 2,5\u20133,5 u mechanick\u00fdch chlopn\u00ed). Po\u010d\u00e1te\u010dn\u00ed d\u00e1vka 5 mg denn\u011b po dobu 2\u20133 dn\u016f, pot\u00e9 upraveno podle INR; typick\u00e1 udr\u017eovac\u00ed d\u00e1vka 2\u20134 mg denn\u011b; velk\u00e9 meziosobn\u00ed rozd\u00edly zp\u016fsoben\u00e9 genotypem CYP2C9 a VKORC1 plus stravou. <strong>Riziko krv\u00e1cen\u00ed:<\/strong> z\u00e1va\u017en\u00e9 krv\u00e1cen\u00ed ~3\u20135 %\/rok p\u0159i terapeutick\u00e9m INR; prudce stoup\u00e1 p\u0159i supraterapeutick\u00e9m INR, akutn\u00edm onemocn\u011bn\u00ed a interakc\u00edch s l\u00e9ky. Reverze vitaminem K (pomal\u00e1, hodiny), 4faktorov\u00fdm PCC nebo \u010derstv\u011b zmra\u017eenou plazmou (nouzov\u00e9 situace). V\u00fdb\u011br antikoagulancia a antiagregancia se individualizuje podle diagn\u00f3zy, rizika krv\u00e1cen\u00ed, funkce ledvin a l\u00e9kov\u00fdch interakc\u00ed. Standardem je dohled specialisty nebo praktick\u00e9ho l\u00e9ka\u0159e.<\/p>\n<\/div>\n<div class=\"medsbase-trust-strip\" style=\"background:#f4f8fb;border:1px solid #d8e3eb;padding:12px 16px;margin:16px 0;border-radius:4px;font-size:14px;\">\n<strong>Co z\u00edsk\u00e1te s MedsBase:<\/strong> V\u00fdrobce certifikovan\u00fd WHO-GMP \u00b7 Diskr\u00e9tn\u00ed balen\u00ed \u00b7 Celosv\u011btov\u00e1 doprava \u00b7 V\u00edce ne\u017e 1 400 ov\u011b\u0159en\u00fdch <a href=\"https:\/\/medsbase.com\/cs\/reviews\/\">recenz\u00ed z\u00e1kazn\u00edk\u016f<\/a>\n<\/div>\n<p class=\"medsbase-reship-line\" style=\"font-size:14px;color:#444;margin:8px 0 18px;\">\ud83d\udce6 Ka\u017ed\u00e1 objedn\u00e1vka je pokryta na\u0161\u00ed <a href=\"https:\/\/medsbase.com\/cs\/medsbase-re-shipment-assurance-policy\/\"><strong>Z\u00e1rukou op\u011btovn\u00e9ho odesl\u00e1n\u00ed<\/strong><\/a> \u2014 pokud va\u0161e z\u00e1silka nedoraz\u00ed do 20 pracovn\u00edch dn\u016f, p\u0159epos\u00edl\u00e1me ji.<\/p>\n<h3>Pro\u010d objedn\u00e1vat z MedsBase<\/h3>\n<p>Na\u0161e generick\u00e9 l\u00e9ky poch\u00e1zej\u00ed od v\u00fdrobc\u016f certifikovan\u00fdch WHO-GMP a jsou expedov\u00e1ny po cel\u00e9m sv\u011bt\u011b v diskr\u00e9tn\u00edm, nen\u00e1padn\u00e9m balen\u00ed \u2013 na vn\u011bj\u0161\u00ed stran\u011b bal\u00edku nen\u00ed uveden n\u00e1zev l\u00e9ku. Platby kartou jsou sm\u011brov\u00e1ny prost\u0159ednictv\u00edm regulovan\u00e9ho procesoru (popisky na v\u00fdpisu zahrnuj\u00ed regulovan\u00e9ho procesora plateb kartou \u2013 nikdy \u201cMedsBase\u201d nebo n\u00e1zev l\u00e9ku). P\u0159ij\u00edm\u00e1me tak\u00e9 kryptom\u011bny a bankovn\u00ed p\u0159evody SEPA. Ka\u017ed\u00e1 objedn\u00e1vka je zaji\u0161t\u011bna na\u0161\u00ed politikou p\u0159eposl\u00e1n\u00ed.<\/p>\n<h2 class=\"wp-block-heading\">Co je Waf-5?<\/h2>\n<p>Waf-5 jsou tablety warfarinu 5 mg od v\u00fdrobce certifikovan\u00e9ho WHO-GMP, dod\u00e1van\u00e9 v balen\u00ed po 30\u2013180 tablet\u00e1ch. Warfarin byl zaveden v roce 1954 po synt\u00e9ze z dikumarolu (l\u00e1tky pou\u017e\u00edvan\u00e9 jako jed na krysy, kter\u00e1 zp\u016fsobovala krv\u00e1cen\u00ed u skotu po konzumaci zka\u017een\u00e9ho sladk\u00e9ho jetele ve Wisconsinu ve 20. letech 20. stolet\u00ed). Pojmenov\u00e1n podle Wisconsin Alumni Research Foundation (WARF), kter\u00e1 financovala jeho v\u00fdvoj. Z\u016fst\u00e1v\u00e1 nezbytn\u00fd pro mechanick\u00e9 srde\u010dn\u00ed chlopn\u011b, st\u0159edn\u011b t\u011b\u017ekou a\u017e t\u011b\u017ekou mitr\u00e1ln\u00ed sten\u00f3zu a pacienty, u kter\u00fdch jsou DOAC kontraindikov\u00e1ny.<\/p>\n<h2 class=\"wp-block-heading\">Jak warfarin funguje<\/h2>\n<p>Warfarin blokuje vitamin K-epoxid-redukt\u00e1zu (VKORC1), \u010d\u00edm\u017e br\u00e1n\u00ed regeneraci redukovan\u00e9ho vitaminu K pot\u0159ebn\u00e9ho pro karboxylaci koagula\u010dn\u00edch faktor\u016f II, VII, IX, X a protein\u016f C a S. \u00dapln\u00fd \u00fa\u010dinek nast\u00e1v\u00e1 za 3\u20135 dn\u00ed (polo\u010das faktoru II ~60 hodin).<\/p>\n<h2 class=\"wp-block-heading\">Schv\u00e1len\u00e9 indikace<\/h2>\n<ul>\n<li><strong>Mechanick\u00e9 srde\u010dn\u00ed chlopn\u011b<\/strong> \u2014 pouze warfarin je schv\u00e1len (DOAC jsou kontraindikov\u00e1ny)<\/li>\n<li><strong>St\u0159edn\u011b t\u011b\u017ek\u00e1 a\u017e t\u011b\u017ek\u00e1 mitr\u00e1ln\u00ed sten\u00f3za s fibrilac\u00ed s\u00edn\u00ed<\/strong> \u2014 warfarin je preferov\u00e1n<\/li>\n<li><strong>Fibrilace s\u00edn\u00ed<\/strong> \u2014 DOAC jsou nyn\u00ed prvn\u00ed volbou na v\u011bt\u0161in\u011b trh\u016f; warfarin z\u016fst\u00e1v\u00e1 tam, kde jsou DOAC kontraindikov\u00e1ny (t\u011b\u017ek\u00e9 CKD, sou\u010dasn\u00e9 u\u017e\u00edv\u00e1n\u00ed siln\u00fdch inhibitor\u016f)<\/li>\n<li><strong>L\u00e9\u010dba a sekund\u00e1rn\u00ed prevence VTE<\/strong> \u2014 v\u011bt\u0161inou nahrazeny DOAC<\/li>\n<li><strong>Antifosfolipidov\u00fd syndrom<\/strong> \u2014 warfarin st\u00e1le preferov\u00e1n (RCT nazna\u010duj\u00ed hor\u0161\u00ed \u00fa\u010dinnost DOAC)<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">D\u00e1vkov\u00e1n\u00ed<\/h2>\n<p><strong>Individualizov\u00e1no podle c\u00edlov\u00e9ho INR<\/strong> (2,0\u20133,0 u v\u011bt\u0161iny indikac\u00ed; 2,5\u20133,5 u mechanick\u00fdch chlopn\u00ed). Po\u010d\u00e1te\u010dn\u00ed d\u00e1vka 5 mg denn\u011b po dobu 2\u20133 dn\u016f, pot\u00e9 upraveno podle INR; typick\u00e1 udr\u017eovac\u00ed d\u00e1vka 2\u20134 mg denn\u011b; velk\u00e9 meziosobn\u00ed rozd\u00edly zp\u016fsoben\u00e9 genotypem CYP2C9 a VKORC1 plus stravou.<\/p>\n<h2 class=\"wp-block-heading\">Riziko krv\u00e1cen\u00ed a monitorov\u00e1n\u00ed<\/h2>\n<p><strong>Riziko krv\u00e1cen\u00ed:<\/strong> v\u011bt\u0161\u00ed krv\u00e1cen\u00ed ~3-5 %\/rok p\u0159i terapeutick\u00e9m INR; prudce stoup\u00e1 p\u0159i supraterapeutick\u00e9m INR, akutn\u00edm onemocn\u011bn\u00ed a interakc\u00edch s l\u00e9ky. Reverze vitaminem K (pomal\u00e1, hodiny), 4-faktorov\u00fdm PCC nebo \u010derstv\u011b zmra\u017eenou plazmou (nouzov\u00e9 situace).<\/p>\n<p><strong>Monitorov\u00e1n\u00ed INR je nezbytn\u00e9.<\/strong> Kontrolujte ka\u017ed\u00e9 3-4 dny p\u0159i zah\u00e1jen\u00ed l\u00e9\u010dby, dokud nen\u00ed stabiln\u00ed; pot\u00e9 t\u00fddn\u011b a\u017e \u010dtrn\u00e1ctidenn\u011b po m\u011bs\u00edc; n\u00e1sledn\u011b m\u011bs\u00ed\u010dn\u011b p\u0159i stabiln\u00edm stavu (nebo d\u00e9le u zku\u0161en\u00fdch pacient\u016f). Akutn\u00ed onemocn\u011bn\u00ed, antibiotika, zm\u011bny stravy a nov\u00e9 l\u00e9ky vy\u017eaduj\u00ed \u010dast\u011bj\u0161\u00ed kontroly.<\/p>\n<h2 class=\"wp-block-heading\">Vedlej\u0161\u00ed \u00fa\u010dinky<\/h2>\n<ul>\n<li>Krv\u00e1cen\u00ed \u2014 v\u011bt\u0161\u00ed 3-5 %\/rok p\u0159i terapeutick\u00e9m INR<\/li>\n<li>Warfarinov\u00e1 ko\u017en\u00ed nekr\u00f3za (vz\u00e1cn\u00e1; 3-10 dn\u00ed po zah\u00e1jen\u00ed l\u00e9\u010dby, zejm\u00e9na p\u0159i deficitu proteinu C\/S)<\/li>\n<li>Syndrom fialov\u00e9ho prstu (vz\u00e1cn\u00e9 cholesterolov\u00e9 embolizace)<\/li>\n<li>Vypad\u00e1v\u00e1n\u00ed vlas\u016f<\/li>\n<li>Hepatotoxicita (vz\u00e1cn\u011b)<\/li>\n<li>Nestabilita INR \u2014 zm\u011bny stravy, akutn\u00ed onemocn\u011bn\u00ed, interaguj\u00edc\u00ed l\u00e9ky v\u0161e destabilizuje<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Kontraindikace<\/h2>\n<ul>\n<li>Aktivn\u00ed krv\u00e1cen\u00ed<\/li>\n<li>T\u011b\u017ek\u00e1 nekontrolovan\u00e1 hypertenze<\/li>\n<li>Ned\u00e1vn\u00e1 velk\u00e1 operace nebo trauma<\/li>\n<li>Aktivn\u00ed peptick\u00fd v\u0159ed<\/li>\n<li>T\u011b\u017ek\u00e9 jatern\u00ed po\u0161kozen\u00ed<\/li>\n<li>T\u011bhotenstv\u00ed \u2014 warfarin je teratogenn\u00ed (prvn\u00ed trimestr) a zp\u016fsobuje fet\u00e1ln\u00ed krv\u00e1cen\u00ed (t\u0159et\u00ed trimestr); pou\u017eijte LMWH<\/li>\n<li>Pl\u00e1novan\u00e9 t\u011bhotenstv\u00ed (pou\u017eijte LMWH)<\/li>\n<li>Neschopnost doch\u00e1zet na monitorov\u00e1n\u00ed INR<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Interakce s l\u00e9\u010divy<\/h2>\n<ul>\n<li><strong>Mnoho l\u00e9k\u016f m\u011bn\u00ed INR \u2014 rozs\u00e1hl\u00fd seznam interakc\u00ed.<\/strong> Pozoruhodn\u00e9: <strong>antibiotika<\/strong> (ciprofloxacin, metronidazol, trimethoprim-sulfamethoxazol, erytromycin, klarithromycin zvy\u0161uj\u00ed INR; rifampicin jej sni\u017euje), <strong>amiodaron<\/strong> (p\u0159ibli\u017en\u011b zdvojn\u00e1sobuje INR), <strong>flukonazol, mikonazol<\/strong> (v\u00fdrazn\u011b zvy\u0161uj\u00ed INR), <strong>fenytoin, karbamazepin, rifampicin<\/strong> (ni\u017e\u0161\u00ed INR).<\/li>\n<li><strong>Vitamin K v potrav\u011b<\/strong> \u2014 v\u00fdrazn\u00e9 zm\u011bny v p\u0159\u00edjmu vitaminu K (listov\u00e1 zelenina) destabilizuj\u00ed INR. Udr\u017eujte p\u0159\u00edjem konzistentn\u00ed sp\u00ed\u0161e ne\u017e se vitaminu K zcela vyh\u00fdbat.<\/li>\n<li><strong>Alkohol<\/strong> \u2014 akutn\u00ed vysok\u00fd p\u0159\u00edjem zvy\u0161uje INR; chronick\u00fd vysok\u00fd p\u0159\u00edjem jej m\u016f\u017ee sn\u00ed\u017eit. M\u00edrn\u00fd, konzistentn\u00ed p\u0159\u00edjem je v po\u0159\u00e1dku.<\/li>\n<li><strong>NSAID, SSRI, antiagregancia<\/strong> \u2014 aditivn\u00ed krv\u00e1cen\u00ed bez zm\u011bny INR.<\/li>\n<li><strong>Citlivost na warfarin je z\u00e1visl\u00e1 na genotypu<\/strong> \u2014 varianty CYP2C9 a VKORC1 ovliv\u0148uj\u00ed pot\u0159ebnou d\u00e1vku 2-3kr\u00e1t.<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Skladov\u00e1n\u00ed<\/h2>\n<p>Skladujte Waf-5 p\u0159i teplot\u011b pod 25\u00b0C. Uchov\u00e1vejte mimo dosah d\u011bt\u00ed.<\/p>\n<h2 id=\"faqs\">\u010casto kladen\u00e9 dotazy<\/h2>\n<h3 class=\"wp-block-heading\">Pot\u0159ebuji na Waf-5 krevn\u00ed testy?<\/h3>\n<p>Ano \u2014 monitorov\u00e1n\u00ed INR je nezbytn\u00e9 (zpo\u010d\u00e1tku ka\u017ed\u00e9 3-4 dny, stabilizuje se na ka\u017ed\u00fdch 1-4 t\u00fddn\u016f). Toto je hlavn\u00ed praktick\u00e1 z\u00e1t\u011b\u017e warfarinu.<\/p>\n<h3 class=\"wp-block-heading\">Co m\u00e1m d\u011blat, kdy\u017e se \u0159\u00edznu p\u0159i u\u017e\u00edv\u00e1n\u00ed Waf-5?<\/h3>\n<p>P\u0159ilo\u017ete pevn\u00fd p\u0159\u00edm\u00fd tlak po dobu 15-20 minut bez kontroly. V\u011bt\u0161ina drobn\u00fdch \u0159ez\u016f se norm\u00e1ln\u011b zastav\u00ed; krv\u00e1cen\u00ed trvaj\u00edc\u00ed d\u00e9le ne\u017e 20 minut nebo prosakuj\u00edc\u00ed p\u0159es v\u00edce obvaz\u016f vy\u017eaduje neodkladn\u00e9 l\u00e9ka\u0159sk\u00e9 vy\u0161et\u0159en\u00ed. Nahlaste jakoukoli \u010dernou nebo krvavou stolici, jasn\u011b \u010derven\u00e9 rekt\u00e1ln\u00ed krv\u00e1cen\u00ed, hematurii, nevysv\u011btliteln\u00e9 mod\u0159iny, krv\u00e1cen\u00ed z nosu trvaj\u00edc\u00ed d\u00e9le ne\u017e 15 minut nebo menstrua\u010dn\u00ed krv\u00e1cen\u00ed v\u00fdrazn\u011b siln\u011bj\u0161\u00ed ne\u017e obvykle.<\/p>\n<h3 class=\"wp-block-heading\">Mohu u\u017e\u00edvat Waf-5 v t\u011bhotenstv\u00ed?<\/h3>\n<p>Ne \u2014 warfarin je teratogenn\u00ed v prvn\u00edm trimestru a zp\u016fsobuje fet\u00e1ln\u00ed krv\u00e1cen\u00ed ve t\u0159et\u00edm. P\u0159ed po\u010det\u00edm p\u0159ejd\u011bte na LMWH.<\/p>\n<h3 class=\"wp-block-heading\">Co kdy\u017e pot\u0159ebuji operaci?<\/h3>\n<p>Informujte opera\u010dn\u00ed t\u00fdm s dostate\u010dn\u00fdm p\u0159edstihem. Warfarin se obvykle vysazuje 5 dn\u00ed p\u0159ed v\u011bt\u0161\u00edm chirurgick\u00fdm z\u00e1krokem; u pacient\u016f s vysok\u00fdm rizikem tromb\u00f3zy m\u016f\u017ee b\u00fdt nutn\u00e1 p\u0159echodn\u00e1 l\u00e9\u010dba LMWH.<\/p>\n<h3 class=\"wp-block-heading\">Kde lze koupit Waf-5 online?<\/h3>\n<p>Waf-5 (warfarin 5 mg, 30-180 tablet) m\u016f\u017eete zakoupit na MedsBase s diskr\u00e9tn\u00edm balen\u00edm a celosv\u011btovou dopravou.<\/p>\n<h2 class=\"wp-block-heading\">Souvisej\u00edc\u00ed kardiovaskul\u00e1rn\u00ed l\u00e9ky<\/h2>\n<ul>\n<li><a href=\"https:\/\/medsbase.com\/cs\/aldactone\/\">Aldactone \u2014 Spironolakton<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/cordarone\/\">Cordarone \u2014 Amiodarone 100\/200 mg<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/ecopril\/\">Ecopril \u2014 Clopidogrel 75 mg (antiagregancium)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/lonitab\/\">Lonitab \u2014 Minoxidil 5 mg (or\u00e1ln\u00ed vazodilat\u00e1tor)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/rioci-1\/\">Rioci 1 \u2014 Riociguat 1 mg (stimul\u00e1tor sGC pro PAH)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/vymada\/\">Vymada \u2014 Sacubitril\/Valsartan ARNI<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/high-blood-pressure-medication\/\"><strong>Prohl\u00e9dnout v\u0161echny l\u00e9ky na vysok\u00fd krevn\u00ed tlak<\/strong><\/a><\/li>\n<\/ul>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:16px 20px;margin:24px 0;border-radius:4px;\"><strong>\u2695 L\u00e9ka\u0159sk\u00e9 upozorn\u011bn\u00ed.<\/strong> Tato str\u00e1nka slou\u017e\u00ed pouze pro informa\u010dn\u00ed \u00fa\u010dely a nenahrazuje l\u00e9ka\u0159skou p\u00e9\u010di kvalifikovan\u00e9ho zdravotnick\u00e9ho pracovn\u00edka. Hypertenze, srde\u010dn\u00ed selh\u00e1n\u00ed a arytmie vy\u017eaduj\u00ed diagn\u00f3zu, monitorov\u00e1n\u00ed a individu\u00e1ln\u00ed d\u00e1vkov\u00e1n\u00ed l\u00e9ka\u0159em \u2014 v\u017edy u\u017e\u00edvejte betablok\u00e1tory pod l\u00e9ka\u0159sk\u00fdm dohledem.<\/div>\n<p><!-- medsbase-related-alts-v1 --><\/p>\n<h3 class=\"wp-block-heading\">Souvisej\u00edc\u00ed alternativy<\/h3>\n<p>Dal\u0161\u00ed produkty v <strong>Chronick\u00e1 onemocn\u011bn\u00ed<\/strong> kter\u00e9 z\u00e1kazn\u00edci tak\u00e9 prohl\u00ed\u017eej\u00ed:<\/p>\n<ul>\n<li><a href=\"https:\/\/medsbase.com\/cs\/p-nolol-sr\/\">P-Nolol SR<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/choltran-sachet\/\">Ezedoc<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/admenta\/\">Admenta<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/omnacortil\/\">Omnacortil<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/veenat\/\">Veenat<\/a><\/li>\n<\/ul>","protected":false},"excerpt":{"rendered":"<p>Waf-5 jsou tablety warfarinu 5 mg \u2014 referen\u010dn\u00ed antagonista vitaminu K. Zaveden 1954; st\u00e1le nezbytn\u00fd pro mechanick\u00e9 srde\u010dn\u00ed chlopn\u011b, st\u0159edn\u011b t\u011b\u017ekou a\u017e t\u011b\u017ekou mitr\u00e1ln\u00ed sten\u00f3zu a antifosfolipidov\u00fd syndrom, kde jsou DOAC kontraindikov\u00e1ny. D\u00e1vkov\u00e1n\u00ed se individualizuje podle INR (2,0\u20133,0 u v\u011bt\u0161iny indikac\u00ed, 2,5\u20133,5 u mechanick\u00fdch chlopn\u00ed). Rozs\u00e1hl\u00e9 interakce s l\u00e9ky a stravou; citlivost z\u00e1visl\u00e1 na genu CYP2C9\/VKORC1. Pravideln\u00e9 monitorov\u00e1n\u00ed INR je povinn\u00e9. Lze zvr\u00e1tit vitaminem K nebo 4faktorov\u00fdm PCC.<\/p>","protected":false},"featured_media":59772,"comment_status":"open","ping_status":"open","template":"","meta":[],"product_brand":[],"product_cat":[3635,3141,3223,3342,3260,3356],"product_tag":[4741,4742],"class_list":{"0":"post-59771","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-anti-coagulants","7":"product_cat-category-overview","8":"product_cat-chronic-conditions","9":"product_cat-general-health","10":"product_cat-heart-blood-pressure","11":"product_cat-high-blood-pressure-medication","12":"product_tag-waf-5","13":"product_tag-warfarin","15":"first","16":"instock","17":"shipping-taxable","18":"purchasable","19":"product-type-variable","20":"has-default-attributes"},"acf":[],"_links":{"self":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product\/59771","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/comments?post=59771"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/media\/59772"}],"wp:attachment":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/media?parent=59771"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product_brand?post=59771"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product_cat?post=59771"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product_tag?post=59771"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}