{"id":59789,"date":"2024-02-28T06:16:21","date_gmt":"2024-02-28T06:16:21","guid":{"rendered":"https:\/\/medsname.com\/onoff-400\/"},"modified":"2026-04-30T11:50:31","modified_gmt":"2026-04-30T11:50:31","slug":"onoff-400","status":"publish","type":"product","link":"https:\/\/medsbase.com\/cs\/product\/onoff-400\/","title":{"rendered":"ONOFF-400"},"content":{"rendered":"

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\u26a1 Quick Answer \u2014 What is ONOFF-400?<\/h3>\n

ONOFF-400 is a fixed-dose combination for mixed aerobic-anaerobic GI infections. Take with food. Manufactured under WHO-GMP standards.<\/p>\n<\/div>\n

Pro\u010d objedn\u00e1vat z MedsBase?<\/strong> Dod\u00e1v\u00e1no od v\u00fdrobce certifikovan\u00e9ho WHO-GMP \u00b7 Diskr\u00e9tn\u00ed balen\u00ed \u00b7 Doprava po cel\u00e9m sv\u011bt\u011b \u00b7 1 400+ ov\u011b\u0159en\u00fdch recenz\u00ed z\u00e1kazn\u00edk\u016f<\/a><\/div>\n

\ud83d\udce6 Ka\u017ed\u00e1 objedn\u00e1vka je pokryta na\u0161\u00ed Z\u00e1rukou op\u011btovn\u00e9ho odesl\u00e1n\u00ed<\/strong><\/a> \u2014 pokud va\u0161e z\u00e1silka nedoraz\u00ed do 20 pracovn\u00edch dn\u016f, p\u0159epos\u00edl\u00e1me ji.<\/p>\n

Pro\u010d objedn\u00e1vat z MedsBase<\/h3>\n

Na\u0161e generick\u00e9 l\u00e9ky poch\u00e1zej\u00ed od v\u00fdrobc\u016f certifikovan\u00fdch WHO-GMP a jsou expedov\u00e1ny po cel\u00e9m sv\u011bt\u011b v diskr\u00e9tn\u00edm, nen\u00e1padn\u00e9m balen\u00ed \u2013 na vn\u011bj\u0161\u00ed stran\u011b bal\u00edku nen\u00ed uveden n\u00e1zev l\u00e9ku. Platby kartou jsou sm\u011brov\u00e1ny prost\u0159ednictv\u00edm regulovan\u00e9ho procesoru (popisky na v\u00fdpisu zahrnuj\u00ed regulovan\u00e9ho procesora plateb kartou \u2013 nikdy \u201cMedsBase\u201d nebo n\u00e1zev l\u00e9ku). P\u0159ij\u00edm\u00e1me tak\u00e9 kryptom\u011bny a bankovn\u00ed p\u0159evody SEPA. Ka\u017ed\u00e1 objedn\u00e1vka je zaji\u0161t\u011bna na\u0161\u00ed politikou p\u0159eposl\u00e1n\u00ed.<\/p>\n

P\u0159ehled produktu<\/strong><\/p>\n

ONOFF-400 is a medication containing the active ingredient Ofloxacin. It belongs to the class of antibiotics known as fluoroquinolones, which are effective against a wide range of bacterial infections. ONOFF-400 works by inhibiting the enzymes necessary for bacterial DNA replication, thus preventing the growth and spread of bacteria in the body. It is available in tablet form and is typically prescribed by healthcare professionals for the treatment of various bacterial infections.<\/p>\n

Pou\u017eit\u00ed<\/strong><\/p>\n

ONOFF-400 is prescribed for the treatment of bacterial infections such as urinary tract infections, respiratory tract infections, skin infections, and certain sexually transmitted diseases like gonorrhea. It is also used in the prevention of anthrax infection after exposure. Your healthcare provider will determine the appropriate use of ONOFF-400 based on the specific type and severity of the bacterial infection.<\/p>\n

Jak pou\u017e\u00edvat<\/strong><\/p>\n

ONOFF-400 tablets are taken orally with a full glass of water, usually with or without food, as directed by your doctor. It is important to follow the dosage instructions provided by your healthcare provider. Do not crush or chew the tablets, swallow them whole. If you have difficulty swallowing the tablets, consult your doctor for alternative options.<\/p>\n

Jak p\u016fsob\u00ed<\/strong><\/p>\n

ONOFF-400 works by inhibiting the activity of bacterial DNA gyrase and topoisomerase IV enzymes, which are essential for bacterial DNA replication, transcription, repair, and recombination. By interfering with these processes, ONOFF-400 prevents the growth and spread of bacteria, ultimately leading to their death.<\/p>\n

D\u00e1vkov\u00e1n\u00ed a pod\u00e1n\u00ed<\/strong><\/p>\n

The dosage of ONOFF-400 varies depending on the type and severity of the infection being treated, as well as the patient’s age, weight, and overall health condition. It is typically taken twice daily, with or without food. Follow your doctor’s instructions carefully and complete the full course of treatment even if you start to feel better.<\/p>\n

V\u00fdhody<\/strong><\/p>\n

The benefits of ONOFF-400 include its effectiveness in treating a wide range of bacterial infections, its convenient oral tablet form, and its relatively low risk of serious side effects when used as directed by a healthcare professional. It provides rapid relief from symptoms and helps to eliminate bacterial infections from the body.<\/p>\n

B\u011b\u017en\u00e9 ne\u017e\u00e1douc\u00ed \u00fa\u010dinky<\/strong><\/p>\n

Common side effects of ONOFF-400 may include nausea, diarrhea, dizziness, headache, and abdominal pain. These side effects are usually mild and temporary, but if they persist or worsen, contact your doctor promptly. In rare cases, ONOFF-400 may cause serious side effects such as tendon rupture, allergic reactions, and nerve damage.<\/p>\n

Varov\u00e1n\u00ed<\/strong><\/p>\n

Before using ONOFF-400, inform your doctor about any medical conditions you have, especially kidney disease, liver disease, or myasthenia gravis. Avoid taking ONOFF-400 if you have a history of hypersensitivity to fluoroquinolones or any of its components. Use caution when driving or operating machinery, as ONOFF-400 may cause dizziness or drowsiness.<\/p>\n

Informace o skladov\u00e1n\u00ed<\/strong><\/p>\n

Store ONOFF-400 tablets at room temperature away from moisture and heat. Keep the medication out of reach of children and pets. Do not use ONOFF-400 after the expiration date printed on the packaging. Properly discard any unused medication.<\/p>\n

Odm\u00edtnut\u00ed odpov\u011bdnosti:<\/strong><\/p>\n

Na\u0161\u00edm jedin\u00fdm z\u00e1m\u011brem je zajistit, aby spot\u0159ebitel\u00e9 z\u00edskali informace, kter\u00e9 jsou odborn\u011b ov\u011b\u0159en\u00e9, p\u0159esn\u00e9 a d\u016fv\u011bryhodn\u00e9. Informace zde uveden\u00e9 by v\u0161ak NEM\u011aLY b\u00fdt pou\u017e\u00edv\u00e1ny jako n\u00e1hrada za rady kvalifikovan\u00e9ho l\u00e9ka\u0159e. Informace poskytovan\u00e9 zde slou\u017e\u00ed pouze pro informa\u010dn\u00ed \u00fa\u010dely. Nemus\u00ed zahrnovat v\u0161echny mo\u017en\u00e9 vedlej\u0161\u00ed \u00fa\u010dinky, interakce l\u00e9k\u016f, varov\u00e1n\u00ed nebo upozorn\u011bn\u00ed. Pros\u00edm, pora\u010fte se se sv\u00fdm l\u00e9ka\u0159em a proberte v\u0161echny sv\u00e9 dotazy t\u00fdkaj\u00edc\u00ed se jak\u00e9hokoli onemocn\u011bn\u00ed nebo l\u00e9ku. Na\u0161\u00edm c\u00edlem je podporovat, nikoli nahrazovat vztah mezi l\u00e9ka\u0159em a pacientem.<\/p>\n

\u010casto kladen\u00e9 dotazy<\/h2>\n

Why is ONOFF-400 a fixed-dose combination?<\/h3>\n

ONOFF-400 combines a fluoroquinolone (broad gram-negative + atypical cover) with a nitroimidazole (anaerobic cover) to treat mixed aerobic\/anaerobic infections in a single tablet \u2014 most commonly intra-abdominal, pelvic, gynaecological, dental, and infected diabetic-foot infections.<\/p>\n

Can I drink alcohol while taking ONOFF-400?<\/h3>\n

No. The nitroimidazole component (ornidazole or metronidazole) can produce a disulfiram-like reaction with alcohol \u2014 flushing, nausea, vomiting, palpitations, and headache. Avoid all alcohol during the course AND for 48 hours after the last dose, including mouthwash and cough syrup.<\/p>\n

Should I separate ONOFF-400 from antacids and supplements?<\/h3>\n

Yes. The fluoroquinolone fraction binds aluminium\/magnesium antacids, sucralfate, iron, zinc, calcium, and dairy. Take ONOFF-400 at least 2 hours before or 6 hours after any of these.<\/p>\n

Is ONOFF-400 safe in pregnancy?<\/h3>\n

ONOFF-400 is generally avoided in pregnancy. The fluoroquinolone fraction has a theoretical arthropathy signal in the foetus, and metronidazole is avoided in the first trimester. Specialist supervision required for any pregnancy use.<\/p>\n

Jak\u00e9 jsou nej\u010dast\u011bj\u0161\u00ed vedlej\u0161\u00ed \u00fa\u010dinky?<\/h3>\n

Nausea, metallic taste (from the nitroimidazole), abdominal discomfort, dizziness, and a transient skin rash. Rarer but serious: tendon pain (stop and seek review), seizures, peripheral neuropathy with prolonged use of either component, and Clostridioides difficile colitis.<\/p>\n

How long is a typical course of ONOFF-400?<\/h3>\n

5\u20137 days is typical for routine intra-abdominal or gynaecological infection. Severe, complicated, or specialist-managed infections may run longer. Complete the prescribed course even if symptoms resolve early.<\/p>\n

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Other Anti-Infective Medications<\/h2>\n