{"id":59803,"date":"2024-02-28T06:16:55","date_gmt":"2024-02-28T06:16:55","guid":{"rendered":"https:\/\/medsname.com\/olanzap\/"},"modified":"2026-04-30T10:23:54","modified_gmt":"2026-04-30T10:23:54","slug":"olanzap","status":"publish","type":"product","link":"https:\/\/medsbase.com\/cs\/product\/olanzap\/","title":{"rendered":"Olanzap"},"content":{"rendered":"

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\u26a1 Rychl\u00e1 odpov\u011b\u010f<\/h3>\n

Olanzap (Olanzapine 2,5 \/ 5 \/ 7,5 \/ 10 \/ 15 \/ 20 mg) je atypick\u00e9 antipsychotikum pro l\u00e9\u010dbu schizofrenie, bipol\u00e1rn\u00ed m\u00e1nie a udr\u017eovac\u00ed terapii, l\u00e9\u010debn\u011b rezistentn\u00ed deprese (v kombinaci s fluoxetinem) a akutn\u00ed agitace. Nejsiln\u011bj\u0161\u00ed antipsychotick\u00fd \u00fa\u010dinek mezi atypick\u00fdmi antipsychotiky \u2014 ale tak\u00e9 nejvy\u0161\u0161\u00ed metabolick\u00e1 z\u00e1t\u011b\u017e.<\/p>\n<\/div>\n

\nCo z\u00edsk\u00e1te s MedsBase:<\/strong> V\u00fdrobce certifikovan\u00fd WHO-GMP \u00b7 Diskr\u00e9tn\u00ed balen\u00ed \u00b7 Celosv\u011btov\u00e1 doprava \u00b7 V\u00edce ne\u017e 1 400 ov\u011b\u0159en\u00fdch recenz\u00ed z\u00e1kazn\u00edk\u016f<\/a>\n<\/div>\n

\ud83d\udce6 Ka\u017ed\u00e1 objedn\u00e1vka je pokryta na\u0161\u00ed Z\u00e1rukou op\u011btovn\u00e9ho odesl\u00e1n\u00ed<\/strong><\/a> \u2014 pokud va\u0161e z\u00e1silka nedoraz\u00ed do 20 pracovn\u00edch dn\u016f, p\u0159epos\u00edl\u00e1me ji.<\/p>\n

Pro\u010d objedn\u00e1vat z MedsBase<\/h3>\n

Olanzap na MedsBase je dod\u00e1v\u00e1n p\u0159\u00edmo od v\u00fdrobce certifikovan\u00e9ho WHO-GMP v jednoduch\u00e9m, diskr\u00e9tn\u00edm balen\u00ed. Ka\u017ed\u00e1 objedn\u00e1vka je pokryta na\u0161\u00edm Z\u00e1rukou op\u011btovn\u00e9ho odesl\u00e1n\u00ed<\/a> \u2014 20pracovn\u00edchdenn\u00ed lh\u016fta pro doru\u010den\u00ed, nebo v\u00e1m z\u00e1silku zdarma p\u0159epo\u0161leme \u2014 a oprav\u0148uje v\u00e1s k \u00fa\u010dasti v na\u0161em v\u011brnostn\u00edm programu<\/a>. Dod\u00e1v\u00e1me do v\u011bt\u0161iny zem\u00ed po cel\u00e9m sv\u011bt\u011b.<\/p>\n

Co je Olanzap a jak funguje<\/h2>\n

Olanzap je tableta olanzapinu dod\u00e1van\u00e1 spole\u010dnost\u00ed Sun Pharma. Dostupn\u00e9 s\u00edly: 2,5 \/ 5 \/ 7,5 \/ 10 \/ 15 \/ 20 mg<\/strong>. Olanzapin je thienobenzodiazepinov\u00fd atypick\u00fd antipsychotikum se silnou D2 antagonizac\u00ed, silnou 5-HT2A antagonizac\u00ed a v\u00fdraznou blok\u00e1dou H1 (sedace, p\u0159\u00edr\u016fstek hmotnosti), M1 (anticholinergn\u00ed \u00fa\u010dinky) a \u03b11 (ortostatick\u00e1 hypotenze). Profil receptor\u016f H1+M1 je zodpov\u011bdn\u00fd jak za jeho uklid\u0148uj\u00edc\u00ed\/sedativn\u00ed \u00fa\u010dinek (u\u017eite\u010dn\u00fd p\u0159i akutn\u00ed agitaci), tak za jeho metabolickou z\u00e1t\u011b\u017e.<\/p>\n

Indikace a d\u00e1vkov\u00e1n\u00ed<\/h2>\n\n\n\n\n\n\n\n\n\n\n
Indikace<\/th>\nPo\u010d\u00e1te\u010dn\u00ed d\u00e1vka<\/th>\nC\u00edlov\u00e1 d\u00e1vka<\/th>\nMaxim\u00e1ln\u00ed d\u00e1vka<\/th>\n<\/tr>\n<\/thead>\n
Schizofrenie (dosp\u011bl\u00ed)<\/td>\n5\u201310 mg 1\u00d7 denn\u011b<\/td>\n10\u201320 mg 1\u00d7 denn\u011b<\/td>\n20 mg<\/td>\n<\/tr>\n
Schizofrenie (dosp\u00edvaj\u00edc\u00ed \u2265 13 let)<\/td>\n2,5\u20135 mg 1\u00d7 denn\u011b<\/td>\n10 mg 1\u00d7 denn\u011b<\/td>\n20 mg<\/td>\n<\/tr>\n
Bipol\u00e1rn\u00ed m\u00e1nie (dosp\u011bl\u00ed)<\/td>\n10\u201315 mg 1\u00d7 denn\u011b<\/td>\n10\u201320 mg 1\u00d7 denn\u011b<\/td>\n20 mg<\/td>\n<\/tr>\n
Akutn\u00ed agitace (i.m.)<\/td>\n10 mg i.m.<\/td>\n\u2014<\/td>\n3 d\u00e1vky\/24h<\/td>\n<\/tr>\n
L\u00e9\u010dba rezistentn\u00ed deprese (s fluoxetinem)<\/td>\n5 mg + 20 mg fluoxetinu<\/td>\n5\u201318 mg<\/td>\n18 mg<\/td>\n<\/tr>\n
Star\u0161\u00ed dosp\u011bl\u00ed<\/td>\n2,5\u20135 mg 1\u00d7 denn\u011b<\/td>\n5\u201310 mg 1\u00d7 denn\u011b<\/td>\ndle sn\u00e1\u0161enlivosti<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

D\u016fle\u017eit\u00e9 bezpe\u010dnostn\u00ed aspekty<\/h2>\n
\nFDA black-box \u2014 psych\u00f3za spojen\u00e1 s demenc\u00ed<\/strong><\/p>\n

V\u0161echna atypick\u00e1 antipsychotika nesou varov\u00e1n\u00ed FDA black-box pro zv\u00fd\u0161enou mortalitu (p\u0159edev\u0161\u00edm kardiovaskul\u00e1rn\u00ed a infek\u010dn\u00ed) p\u0159i pou\u017eit\u00ed k l\u00e9\u010db\u011b behavior\u00e1ln\u00edch poruch u star\u0161\u00edch dosp\u011bl\u00fdch s demenc\u00ed. Atypick\u00e1 antipsychotika nejsou schv\u00e1lena pro psych\u00f3zu nebo agitovanost spojenou s demenc\u00ed<\/strong>. Pou\u017eit\u00ed u t\u00e9to populace je off-label, posledn\u00ed mo\u017enost\u00ed, \u010dasov\u011b omezen\u00e9 a vy\u017eaduje explicitn\u00ed rozhovor o rizic\u00edch a p\u0159\u00ednosech.<\/p>\n<\/div>\n

\nNejv\u011bt\u0161\u00ed metabolick\u00e1 z\u00e1t\u011b\u017e mezi atypick\u00fdmi antipsychotiky<\/strong><\/p>\n

Olanzapin zp\u016fsobuje nejv\u011bt\u0161\u00ed p\u0159\u00edr\u016fstek hmotnosti (obvykle 4\u201310 kg v prvn\u00edch 6 m\u011bs\u00edc\u00edch, n\u011bkdy v\u00fdrazn\u011b v\u00edce), nejv\u011bt\u0161\u00ed inzulinovou rezistenci a nejv\u011bt\u0161\u00ed poruchy lipid\u016f ze v\u0161ech b\u011b\u017en\u011b pou\u017e\u00edvan\u00fdch antipsychotik. U pacient\u016f se m\u016f\u017ee b\u011bhem m\u011bs\u00edc\u016f od zah\u00e1jen\u00ed l\u00e9\u010dby rozvinout diabetes 2. typu. Povinn\u00e9 monitorov\u00e1n\u00ed: hmotnost p\u0159i ka\u017ed\u00e9 n\u00e1v\u0161t\u011bv\u011b; glyk\u00e9mie nala\u010dno\/HbA1c a lipidy nala\u010dno na za\u010d\u00e1tku, po 12 t\u00fddnech a pot\u00e9 ka\u017ed\u00fdch 6 m\u011bs\u00edc\u016f.<\/strong> Od za\u010d\u00e1tku l\u00e9\u010dby pacienty pou\u010dte o diet\u011b a cvi\u010den\u00ed.<\/p>\n<\/div>\n

\nSedace a anticholinergn\u00ed z\u00e1t\u011b\u017e<\/strong><\/p>\n

Siln\u00e1 sedace v prvn\u00edch 1\u20132 t\u00fddnech. Anticholinergn\u00ed \u00fa\u010dinky (sucho v \u00fastech, z\u00e1cpa, obt\u00ed\u017en\u00e9 mo\u010den\u00ed) jsou b\u011b\u017en\u00e9. Ob\u011b skupiny \u00fa\u010dink\u016f se zm\u00edr\u0148uj\u00ed, ale nezmiz\u00ed \u00fapln\u011b.<\/p>\n<\/div>\n

\nOlanzapin i.m. + benzodiazepin \u2013 opatrn\u011b<\/strong><\/p>\n

Kombinace i.m. olanzapinu s parenter\u00e1ln\u00edmi benzodiazepiny vedla k p\u0159\u00edpad\u016fm t\u011b\u017ek\u00e9 hypotenze, respira\u010dn\u00ed deprese a \u00famrt\u00ed. Pokud jsou oba l\u00e9ky klinicky nutn\u00e9 p\u0159i akutn\u00ed agitaci, pod\u00e1vejte je s odstupem \u2265 1 hodiny a pacienta pe\u010dliv\u011b monitorujte.<\/p>\n<\/div>\n

\u010cast\u00e9 ne\u017e\u00e1douc\u00ed \u00fa\u010dinky<\/h2>\n