{"id":59908,"date":"2024-02-28T06:23:19","date_gmt":"2024-02-28T06:23:19","guid":{"rendered":"https:\/\/medsname.com\/ondem-injection\/"},"modified":"2026-04-30T10:23:53","modified_gmt":"2026-04-30T10:23:53","slug":"ondem-injection","status":"publish","type":"product","link":"https:\/\/medsbase.com\/cs\/product\/ondem-injection\/","title":{"rendered":"Ondem Injection"},"content":{"rendered":"

<\/p>\n

\n

\u26a1 Rychl\u00e1 odpov\u011b\u010f \u2014 Co je injekce Ondem?<\/h3>\n

Ondem Injection<\/strong> obsahuje ondansetron 2 mg\/ml<\/strong> v ampul\u00edch po 2 ml (celkem 4 mg) \u2014 selektivn\u00ed serotoninov\u00fd antagonista 5-HT3 receptor\u016f<\/strong> pou\u017e\u00edv\u00e1 se v nemocnic\u00edch k prevenci a l\u00e9\u010db\u011b chemoterapi\u00ed vyvolan\u00e9<\/strong>, radiac\u00ed vyvolan\u00e9<\/strong>, a poopera\u010dn\u00ed nevolnosti a zvracen\u00ed (PONV)<\/strong>. Pod\u00e1v\u00e1 se zdravotnick\u00fdm pracovn\u00edkem intraven\u00f3zn\u011b (pomal\u00fd vpich nebo kr\u00e1tk\u00e1 infuze) nebo intramuskul\u00e1rn\u011b. N\u00e1stup \u00fa\u010dinku do 5\u201310 minut p\u0159i IV pod\u00e1n\u00ed. V\u00fdrobce: Alkem Laboratories \u2014 generick\u00fd ekvivalent injek\u010dn\u00edho p\u0159\u00edpravku Zofran. FDA omezen\u00ed d\u00e1vky na 16 mg IV v jedn\u00e9 d\u00e1vce<\/strong> kv\u016fli riziku QT prodlou\u017een\u00ed p\u0159i vy\u0161\u0161\u00edch d\u00e1vk\u00e1ch.<\/p>\n<\/div>\n

Pro\u010d objedn\u00e1vat z MedsBase:<\/strong> \u2714 v\u00fdrobce certifikovan\u00e9ho WHO-GMP<\/strong> \u2714 Diskr\u00e9tn\u00ed balen\u00ed \u2714 Celosv\u011btov\u00e1 doprava \u2714 Ov\u011b\u0159en\u00e9 recenze z\u00e1kazn\u00edk\u016f (1 400+ z\u00e1kazn\u00edk\u016f)<\/a><\/div>\n

\ud83d\udce6 Ka\u017ed\u00e1 objedn\u00e1vka je pokryta na\u0161\u00ed Z\u00e1rukou op\u011btovn\u00e9ho odesl\u00e1n\u00ed<\/strong><\/a> \u2014 pokud va\u0161e z\u00e1silka nedoraz\u00ed do 20 pracovn\u00edch dn\u016f, p\u0159epos\u00edl\u00e1me ji.<\/p>\n

Pro\u010d objedn\u00e1vat z MedsBase<\/h3>\n

Na\u0161e generick\u00e9 l\u00e9ky poch\u00e1zej\u00ed od v\u00fdrobc\u016f certifikovan\u00fdch WHO-GMP a jsou expedov\u00e1ny po cel\u00e9m sv\u011bt\u011b v diskr\u00e9tn\u00edm, nen\u00e1padn\u00e9m balen\u00ed \u2013 na vn\u011bj\u0161\u00ed stran\u011b bal\u00edku nen\u00ed uveden n\u00e1zev l\u00e9ku. Platby kartou jsou sm\u011brov\u00e1ny prost\u0159ednictv\u00edm regulovan\u00e9ho procesoru (popisky na v\u00fdpisu zahrnuj\u00ed regulovan\u00e9ho procesora plateb kartou \u2013 nikdy \u201cMedsBase\u201d nebo n\u00e1zev l\u00e9ku). P\u0159ij\u00edm\u00e1me tak\u00e9 kryptom\u011bny a bankovn\u00ed p\u0159evody SEPA. Ka\u017ed\u00e1 objedn\u00e1vka je zaji\u0161t\u011bna na\u0161\u00ed politikou p\u0159eposl\u00e1n\u00ed.<\/p>\n

\u26a0\ufe0f Injekce pouze pro nemocni\u010dn\u00ed pou\u017eit\u00ed \u2014 nen\u00ed ur\u010dena k samopod\u00e1n\u00ed.<\/strong> Parenter\u00e1ln\u00ed ondansetron pod\u00e1v\u00e1 zdravotnick\u00fd pracovn\u00edk v klinick\u00e9m prost\u0159ed\u00ed (chemoterapeutick\u00e1 jednotka, nemocni\u010dn\u00ed s\u00e1l, pohotovost), kde jsou k dispozici EKG a resuscita\u010dn\u00ed vybaven\u00ed. Samopod\u00e1n\u00ed nen\u00ed vhodn\u00e9. D\u00e1vky vy\u0161\u0161\u00ed ne\u017e 16 mg IV byly spojeny s prodlou\u017een\u00edm QT intervalu a torsades-de-pointes \u2014 FDA omezen\u00ed d\u00e1vky je 16 mg na jednu d\u00e1vku. Vyvarujte se pod\u00e1n\u00ed u vrozen\u00e9ho syndromu dlouh\u00e9ho QT intervalu<\/strong>, hypokal\u00e9mie, hypomagnez\u00e9mie a p\u0159i sou\u010dasn\u00e9m pod\u00e1v\u00e1n\u00ed l\u00e9k\u016f prodlu\u017euj\u00edc\u00edch QT interval (azithromycin, citalopram, methadon, amiodaron, fluorochinolony, antipsychotika, hydroxychlorochin). Apomorfin je absolutn\u00ed kontraindikac\u00ed.<\/div>\n

Pro\u010d objedn\u00e1vat z MedsBase<\/h3>\n

Ondem Injection je dod\u00e1v\u00e1n z v\u00fdrobce certifikovan\u00e9ho WHO-GMP<\/strong>. Ka\u017ed\u00e1 objedn\u00e1vka je diskr\u00e9tn\u011b zas\u00edl\u00e1na po cel\u00e9m sv\u011bt\u011b a je pokryta na\u0161\u00ed Z\u00e1rukou op\u011btovn\u00e9ho odesl\u00e1n\u00ed<\/a> \u2014 pokud nedoraz\u00ed do 20 pracovn\u00edch dn\u016f, za\u0161leme n\u00e1hradn\u00ed z\u00e1silku bez dal\u0161\u00edch n\u00e1klad\u016f. Ondem Injection je glob\u00e1ln\u00ed standard parenter\u00e1ln\u00edho antagonisty 5-HT3 pro nemocni\u010dn\u00ed antiemetickou l\u00e9\u010dbu. Alkem je jedn\u00edm z nejv\u011bt\u0161\u00edch indick\u00fdch v\u00fdrobc\u016f injek\u010dn\u00edch p\u0159\u00edpravk\u016f WHO-GMP a formulace je bioekvivalentn\u00ed s referen\u010dn\u00ed zna\u010dkou.<\/p>\n

Mechanismus \u00fa\u010dinku<\/h2>\n

Chemoterapie, oza\u0159ov\u00e1n\u00ed a chirurgick\u00fd stres po\u0161kozuj\u00ed st\u0159evn\u00ed enterochromafinn\u00ed bu\u0148ky, co\u017e vede k uvoln\u011bn\u00ed velk\u00e9ho mno\u017estv\u00ed serotoninu. Ten se v\u00e1\u017ee na receptory 5-HT3 na vag\u00e1ln\u00edch aferentn\u00edch vl\u00e1knech a v chemorecep\u010dn\u00ed spou\u0161t\u011bc\u00ed z\u00f3n\u011b (area postrema), \u010d\u00edm\u017e vytv\u00e1\u0159\u00ed nejsiln\u011bj\u0161\u00ed zn\u00e1m\u00fd or\u00e1ln\u00ed\/st\u0159evn\u00ed emetick\u00fd podn\u011bt. Ondansetron je vysoce selektivn\u00ed antagonista receptoru 5-HT3 \u2013 p\u0159eru\u0161uje tento sign\u00e1l jak na perifern\u00ed, tak centr\u00e1ln\u00ed \u00farovni, ani\u017e by ovliv\u0148oval receptory D2, H1, muskarinov\u00e9 nebo alfa-adrenergn\u00ed. \u010cist\u00fd receptorov\u00fd profil vysv\u011btluje absenci sedace, extrapyramidov\u00fdch reakc\u00ed a anticholinergn\u00edch vedlej\u0161\u00edch \u00fa\u010dink\u016f, kter\u00e9 omezuj\u00ed star\u0161\u00ed antiemetika jako prochlorperazin a metoklopramid. serotoninu (5-HT)<\/strong>. st\u0159edn\u011b nebo vysoce emetogenn\u00ed chemoterapie \u2013 obvykle s dexamethasonem \u00b1 aprepitantem u vysoce emetogenn\u00edch re\u017eim\u016f.<\/p>\n

Indikace<\/h2>\n