{"id":59919,"date":"2024-02-28T06:23:55","date_gmt":"2024-02-28T06:23:55","guid":{"rendered":"https:\/\/medsname.com\/ondem-md\/"},"modified":"2026-04-30T10:23:53","modified_gmt":"2026-04-30T10:23:53","slug":"ondem-md","status":"publish","type":"product","link":"https:\/\/medsbase.com\/cs\/product\/ondem-md\/","title":{"rendered":"Ondem MD"},"content":{"rendered":"

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\u26a1 Rychl\u00e1 odpov\u011b\u010f \u2013 Co je Ondem MD?<\/h3>\n

Ondem MD<\/strong> je peror\u00e1ln\u00ed tableta rozpustn\u00e1 v \u00fastech (ODT\/MD)<\/strong> z ondansetron 4 mg \/ 8 mg<\/strong>, selektivn\u00ed serotoninov\u00fd antagonista 5-HT3 receptor\u016f<\/strong>. Je to celosv\u011btov\u011b nejpou\u017e\u00edvan\u011bj\u0161\u00ed antiemetikum, kter\u00e9 p\u016fsob\u00ed proti siln\u00e9mu serotoninergn\u00edmu emetick\u00e9mu podn\u011btu vyvolan\u00e9mu chemoterapi\u00ed, radiac\u00ed, chirurgick\u00fdm z\u00e1krokem, gastroenteritidou a migr\u00e9nou. Vyr\u00e1b\u00ed spole\u010dnost Alkem podle standard\u016f WHO-GMP. N\u00e1stup \u00fa\u010dinku do 30 minut p\u0159i peror\u00e1ln\u00edm pod\u00e1n\u00ed a d\u00e9lka \u00fa\u010dinku 8\u201312 hodin; obvykle se pod\u00e1v\u00e1 30\u201360 minut p\u0159ed chemoterapi\u00ed nebo podle pot\u0159eby p\u0159i pr\u016flomov\u00e9 nevolnosti.<\/p>\n<\/div>\n

Pro\u010d objedn\u00e1vat z MedsBase:<\/strong> \u2714 v\u00fdrobce certifikovan\u00e9ho WHO-GMP<\/strong> \u2714 Diskr\u00e9tn\u00ed balen\u00ed \u2714 Celosv\u011btov\u00e1 doprava \u2714 Ov\u011b\u0159en\u00e9 recenze z\u00e1kazn\u00edk\u016f (1 400+ z\u00e1kazn\u00edk\u016f)<\/a><\/div>\n

\ud83d\udce6 Ka\u017ed\u00e1 objedn\u00e1vka je pokryta na\u0161\u00ed Z\u00e1rukou op\u011btovn\u00e9ho odesl\u00e1n\u00ed<\/strong><\/a> \u2014 pokud va\u0161e z\u00e1silka nedoraz\u00ed do 20 pracovn\u00edch dn\u016f, p\u0159epos\u00edl\u00e1me ji.<\/p>\n

Pro\u010d objedn\u00e1vat z MedsBase<\/h3>\n

Na\u0161e generick\u00e9 l\u00e9ky poch\u00e1zej\u00ed od v\u00fdrobc\u016f certifikovan\u00fdch WHO-GMP a jsou expedov\u00e1ny po cel\u00e9m sv\u011bt\u011b v diskr\u00e9tn\u00edm, nen\u00e1padn\u00e9m balen\u00ed \u2013 na vn\u011bj\u0161\u00ed stran\u011b bal\u00edku nen\u00ed uveden n\u00e1zev l\u00e9ku. Platby kartou jsou sm\u011brov\u00e1ny prost\u0159ednictv\u00edm regulovan\u00e9ho procesoru (popisky na v\u00fdpisu zahrnuj\u00ed regulovan\u00e9ho procesora plateb kartou \u2013 nikdy \u201cMedsBase\u201d nebo n\u00e1zev l\u00e9ku). P\u0159ij\u00edm\u00e1me tak\u00e9 kryptom\u011bny a bankovn\u00ed p\u0159evody SEPA. Ka\u017ed\u00e1 objedn\u00e1vka je zaji\u0161t\u011bna na\u0161\u00ed politikou p\u0159eposl\u00e1n\u00ed.<\/p>\n

\u26a0\ufe0f Ondansetron \u2013 omezen\u00ed d\u00e1vky FDA kv\u016fli prodlou\u017een\u00ed QT intervalu.<\/strong> Jednor\u00e1zov\u00e1 intraven\u00f3zn\u00ed d\u00e1vka > 16 mg byla spojov\u00e1na s prodlou\u017een\u00edm QT intervalu a torsades-de-pointes. Maxim\u00e1ln\u00ed jednor\u00e1zov\u00e1 d\u00e1vka je 16 mg IV (peror\u00e1ln\u00ed jednor\u00e1zov\u00e1 d\u00e1vka 24 mg m\u00e1 m\u00edrn\u011b odli\u0161n\u00e9 omezen\u00ed). Vyvarujte se pod\u00e1v\u00e1n\u00ed u vrozen\u00e9ho dlouh\u00e9ho QT intervalu<\/strong>, hypokal\u00e9mie, hypomagnez\u00e9mie nebo p\u0159i sou\u010dasn\u00e9m u\u017e\u00edv\u00e1n\u00ed jin\u00fdch l\u00e9k\u016f prodlu\u017euj\u00edc\u00edch QT interval (azithromycin, citalopram, methadon, hydroxychlorochin, amiodaron, fluorochinolony, antipsychotika). Apomorfin je absolutn\u00ed kontraindikac\u00ed (t\u011b\u017ek\u00e1 hypotenze).<\/div>\n

Kdy je ondansetron spr\u00e1vn\u00fdm antiemetikem<\/h2>\n

Ondansetron je l\u00e9k prvn\u00ed volby p\u0159i nevolnosti zp\u016fsoben\u00e9 serotoninem<\/strong> \u2013 chemoterapi\u00ed vyvolan\u00e1 nevolnost a zvracen\u00ed (CINV), poopera\u010dn\u00ed nevolnost a zvracen\u00ed (PONV), radiac\u00ed vyvolan\u00e1 nevolnost a t\u011b\u017ek\u00e1 gastroenteritida. Je m\u00e9n\u011b \u00fa\u010dinn\u00fd p\u0159i kinet\u00f3z\u00e1ch a vestibul\u00e1rn\u00ed nevolnosti<\/strong> (kde dominantn\u00ed dr\u00e1ha je histaminergn\u00ed a cholinergn\u00ed \u2013 promethazin\/Avomine, cinnarizin a meklozin funguj\u00ed l\u00e9pe) a nen\u00ed l\u00e9kem prvn\u00ed volby p\u0159i nevolnosti a zvracen\u00ed v t\u011bhotenstv\u00ed<\/strong> (l\u00e9kem prvn\u00ed volby u NVP je doxylamin + B6; ondansetron je vyhrazen pro refraktern\u00ed hyperemesis gravidarum po zv\u00e1\u017een\u00ed mal\u00e9ho sign\u00e1lu srde\u010dn\u00edch\/roz\u0161t\u011bpov\u00fdch vad v prvn\u00edm trimestru v observa\u010dn\u00edch studi\u00edch).<\/p>\n

Pro\u010d objedn\u00e1vat z MedsBase<\/h3>\n

Ondem MD je dod\u00e1v\u00e1n z v\u00fdrobce certifikovan\u00e9ho WHO-GMP<\/strong>. Ka\u017ed\u00e1 objedn\u00e1vka je diskr\u00e9tn\u011b zas\u00edl\u00e1na po cel\u00e9m sv\u011bt\u011b a je pokryta na\u0161\u00ed Z\u00e1rukou op\u011btovn\u00e9ho odesl\u00e1n\u00ed<\/a> \u2013 pokud nedoraz\u00ed do 20 pracovn\u00edch dn\u016f, p\u0159epos\u00edl\u00e1me zdarma. Ondansetron je celosv\u011btov\u00fd standard pro serotoninem \u0159\u00edzen\u00e9 zvracen\u00ed s miliony bezpe\u010dn\u011b podan\u00fdch d\u00e1vek ro\u010dn\u011b. Formulace peror\u00e1ln\u00edch tablet rozpustn\u00fdch v \u00fastech (ODT\/MD) je v\u00fdhodn\u00e1, kdy\u017e aktivn\u00ed zvracen\u00ed znemo\u017e\u0148uje spolehliv\u00e9 polyk\u00e1n\u00ed.<\/p>\n

Mechanismus \u00fa\u010dinku<\/h2>\n

Chemoterapie, oza\u0159ov\u00e1n\u00ed a chirurgick\u00fd z\u00e1krok po\u0161kozuj\u00ed st\u0159evn\u00ed enterochromafinn\u00ed bu\u0148ky, kter\u00e9 uvol\u0148uj\u00ed velk\u00e9 mno\u017estv\u00ed serotoninu (5-HT)<\/strong>. Serotonin se v\u00e1\u017ee na receptory 5-HT3 na vag\u00e1ln\u00edch aferentn\u00edch vl\u00e1knech a na spou\u0161t\u011bc\u00ed z\u00f3n\u011b chemoreceptor\u016f (area postrema), kter\u00e9 vys\u00edlaj\u00ed sign\u00e1ly do zvraciv\u00e9ho centra v prodlou\u017een\u00e9 m\u00ed\u0161e. Ondansetron je vysoce selektivn\u00ed antagonista receptoru 5-HT3 \u2014 blokuje tento sign\u00e1l jak na perifern\u00ed, tak na centr\u00e1ln\u00ed \u00farovni, ani\u017e by ovliv\u0148oval receptory D2, H1, muskarinov\u00e9 nebo alfa-adrenergn\u00ed. Tato selektivita vysv\u011btluje jeho \u010dist\u00fd profil ne\u017e\u00e1douc\u00edch \u00fa\u010dink\u016f: minim\u00e1ln\u00ed sedace, \u017e\u00e1dn\u00e9 extrapyramidov\u00e9 reakce, \u017e\u00e1dn\u00e1 anticholinergn\u00ed z\u00e1t\u011b\u017e.<\/p>\n

Indikace<\/h2>\n