{"id":59954,"date":"2024-02-28T06:25:37","date_gmt":"2024-02-28T06:25:37","guid":{"rendered":"https:\/\/medsname.com\/palip-xr\/"},"modified":"2026-04-30T10:23:52","modified_gmt":"2026-04-30T10:23:52","slug":"palip-xr","status":"publish","type":"product","link":"https:\/\/medsbase.com\/cs\/product\/palip-xr\/","title":{"rendered":"Palip XR"},"content":{"rendered":"

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\u26a1 Rychl\u00e1 odpov\u011b\u010f<\/h3>\n

Palip XR (Paliperidon 3 \/ 6 \/ 9 mg XR, s prodlou\u017een\u00fdm uvol\u0148ov\u00e1n\u00edm) je atypick\u00e9 antipsychotikum pro schizofrenii a schizoafektivn\u00ed poruchu. Aktivn\u00ed metabolit risperidonu, pod\u00e1van\u00fd jednou denn\u011b ve form\u011b OROS osmotick\u00e9 tablety. P\u0159ev\u00e1\u017en\u011b vylu\u010dov\u00e1n ledvinami \u2014 upravte d\u00e1vkov\u00e1n\u00ed p\u0159i ren\u00e1ln\u00ed insuficienci.<\/p>\n<\/div>\n

\nCo z\u00edsk\u00e1te s MedsBase:<\/strong> V\u00fdrobce certifikovan\u00fd WHO-GMP \u00b7 Diskr\u00e9tn\u00ed balen\u00ed \u00b7 Celosv\u011btov\u00e1 doprava \u00b7 V\u00edce ne\u017e 1 400 ov\u011b\u0159en\u00fdch recenz\u00ed z\u00e1kazn\u00edk\u016f<\/a>\n<\/div>\n

\ud83d\udce6 Ka\u017ed\u00e1 objedn\u00e1vka je pokryta na\u0161\u00ed Z\u00e1rukou op\u011btovn\u00e9ho odesl\u00e1n\u00ed<\/strong><\/a> \u2014 pokud va\u0161e z\u00e1silka nedoraz\u00ed do 20 pracovn\u00edch dn\u016f, p\u0159epos\u00edl\u00e1me ji.<\/p>\n

Pro\u010d objedn\u00e1vat z MedsBase<\/h3>\n

Palip XR na MedsBase je dod\u00e1v\u00e1n p\u0159\u00edmo od v\u00fdrobce certifikovan\u00e9ho WHO-GMP v jednoduch\u00e9m, diskr\u00e9tn\u00edm balen\u00ed. Ka\u017ed\u00e1 objedn\u00e1vka je pokryta na\u0161\u00edm Z\u00e1rukou op\u011btovn\u00e9ho odesl\u00e1n\u00ed<\/a> \u2014 20pracovn\u00edchdenn\u00ed lh\u016fta pro doru\u010den\u00ed, nebo v\u00e1m z\u00e1silku zdarma p\u0159epo\u0161leme \u2014 a oprav\u0148uje v\u00e1s k \u00fa\u010dasti v na\u0161em v\u011brnostn\u00edm programu<\/a>. Dod\u00e1v\u00e1me do v\u011bt\u0161iny zem\u00ed po cel\u00e9m sv\u011bt\u011b.<\/p>\n

Co je Palip XR a jak funguje<\/h2>\n

Palip XR je tableta s prodlou\u017een\u00fdm uvol\u0148ov\u00e1n\u00edm paliperidonu dod\u00e1van\u00e1 spole\u010dnost\u00ed Sun Pharma. Dostupn\u00e9 s\u00edly: 3 \/ 6 \/ 9 mg XR<\/strong>. Paliperidon je hlavn\u00edm aktivn\u00edm metabolitem risperidonu (9-hydroxyrisperidon). Farmakologicky velmi podobn\u00fd \u2014 siln\u00e1 antagonizace D2 a 5-HT2A receptor\u016f, elevace prolaktinu, EPS p\u0159i vy\u0161\u0161\u00edch d\u00e1vk\u00e1ch \u2014 ale s dv\u011bma praktick\u00fdmi rozd\u00edly: (1) OROS forma s prodlou\u017een\u00fdm uvol\u0148ov\u00e1n\u00edm vytv\u00e1\u0159\u00ed plochou 24hodinovou k\u0159ivku plazmatick\u00e9 koncentrace (lep\u0161\u00ed sn\u00e1\u0161enlivost ne\u017e risperidon IR) a (2) paliperidon je z v\u011bt\u0161\u00ed \u010d\u00e1sti vylu\u010dov\u00e1n ledvinami (75%) sp\u00ed\u0161e ne\u017e metabolizov\u00e1n j\u00e1try, tak\u017ee nen\u00ed ovlivn\u011bn l\u00e9ky m\u011bn\u00edc\u00edmi CYP, ale vy\u017eaduje \u00fapravu d\u00e1vkov\u00e1n\u00ed p\u0159i ren\u00e1ln\u00ed insuficienci.<\/p>\n

Indikace a d\u00e1vkov\u00e1n\u00ed<\/h2>\n\n\n\n\n\n\n\n\n\n\n
Indikace<\/th>\nPo\u010d\u00e1te\u010dn\u00ed d\u00e1vka<\/th>\nC\u00edlov\u00e1 d\u00e1vka<\/th>\nMaxim\u00e1ln\u00ed d\u00e1vka<\/th>\n<\/tr>\n<\/thead>\n
Schizofrenie (dosp\u011bl\u00ed)<\/td>\n6 mg 1\u00d7 denn\u011b r\u00e1no<\/td>\n3\u201312 mg 1\u00d7 denn\u011b<\/td>\n12 mg<\/td>\n<\/tr>\n
Schizofrenie (dosp\u00edvaj\u00edc\u00ed \u2265 12 let, \u2265 51 kg)<\/td>\n3 mg 1\u00d7 denn\u011b<\/td>\n3\u201312 mg 1\u00d7 denn\u011b<\/td>\n12 mg<\/td>\n<\/tr>\n
Schizoafektivn\u00ed porucha<\/td>\n6 mg 1\u00d7 denn\u011b<\/td>\n3\u201312 mg 1\u00d7 denn\u011b<\/td>\n12 mg<\/td>\n<\/tr>\n
Ren\u00e1ln\u00ed insuficience (CrCl 50\u201380)<\/td>\n3 mg 1\u00d7 denn\u011b<\/td>\na\u017e 6 mg<\/td>\n6 mg<\/td>\n<\/tr>\n
Ren\u00e1ln\u00ed insuficience (CrCl 10\u201350)<\/td>\n1,5 mg 1\u00d7 denn\u011b<\/td>\na\u017e 3 mg<\/td>\n3 mg<\/td>\n<\/tr>\n
Ren\u00e1ln\u00ed insuficience (CrCl < 10)<\/td>\nnedoporu\u010duje se<\/td>\n\u2014<\/td>\n\u2014<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Polykat cel\u00e9 \u2014 nedrtit, ne\u017ev\u00fdkat ani ned\u011blit. OROS osmotick\u00e1 pumpov\u00e1 ob\u00e1lka bude vylou\u010dena neporu\u0161en\u00e1 ve stolici \u2014 to je norm\u00e1ln\u00ed a o\u010dek\u00e1van\u00e9.<\/p>\n

D\u016fle\u017eit\u00e9 bezpe\u010dnostn\u00ed aspekty<\/h2>\n
\nFDA black-box \u2014 psych\u00f3za spojen\u00e1 s demenc\u00ed<\/strong><\/p>\n

V\u0161echna atypick\u00e1 antipsychotika nesou varov\u00e1n\u00ed FDA black-box pro zv\u00fd\u0161enou mortalitu (p\u0159edev\u0161\u00edm kardiovaskul\u00e1rn\u00ed a infek\u010dn\u00ed) p\u0159i pou\u017eit\u00ed k l\u00e9\u010db\u011b behavior\u00e1ln\u00edch poruch u star\u0161\u00edch dosp\u011bl\u00fdch s demenc\u00ed. Atypick\u00e1 antipsychotika nejsou schv\u00e1lena pro psych\u00f3zu nebo agitovanost spojenou s demenc\u00ed<\/strong>. Pou\u017eit\u00ed u t\u00e9to populace je off-label, posledn\u00ed mo\u017enost\u00ed, \u010dasov\u011b omezen\u00e9 a vy\u017eaduje explicitn\u00ed rozhovor o rizic\u00edch a p\u0159\u00ednosech.<\/p>\n<\/div>\n

\nHyperprolaktinemie (podobn\u011b jako risperidon)<\/strong><\/p>\n

Jako aktivn\u00ed metabolit risperidonu zp\u016fsobuje paliperidon stejn\u00e9 zv\u00fd\u0161en\u00ed prolaktinu: amenorea, galaktorea, sexu\u00e1ln\u00ed dysfunkce a dlouhodob\u00fd \u00fabytek kostn\u00ed denzity. Monitorujte jako u risperidonu; p\u0159i p\u0159\u00edznac\u00edch p\u0159ejd\u011bte na atypikum \u0161et\u0159\u00edc\u00ed prolaktin (aripiprazol, kvetiapin).<\/p>\n<\/div>\n

\nEPS \/ d\u00e1vkov\u011b z\u00e1visl\u00e9<\/strong><\/p>\n

P\u0159i d\u00e1vk\u00e1ch nad 6 mg\/den se zvy\u0161uje frekvence EPS a akathisie. Z\u00e1visl\u00e9 na d\u00e1vce.<\/p>\n<\/div>\n

\nUpozorn\u011bn\u00ed na gastrointestin\u00e1ln\u00ed obstrukci<\/strong><\/p>\n

Nedeformovateln\u00e1 OROS tableta je teoreticky problematick\u00e1 u p\u0159edem existuj\u00edc\u00edch z\u00e1va\u017en\u00fdch z\u00fa\u017een\u00ed GI traktu (t\u011b\u017ek\u00e9 striktury u Crohnovy choroby, striktury j\u00edcnu, p\u0159edchoz\u00ed resekce st\u0159eva). Klinicky vz\u00e1cn\u00e9, ale stoj\u00ed za zm\u00ednku.<\/p>\n<\/div>\n

\u010cast\u00e9 ne\u017e\u00e1douc\u00ed \u00fa\u010dinky<\/h2>\n