{"id":60007,"date":"2024-02-28T06:28:42","date_gmt":"2024-02-28T06:28:42","guid":{"rendered":"https:\/\/medsname.com\/xepar\/"},"modified":"2026-05-01T10:49:15","modified_gmt":"2026-05-01T10:49:15","slug":"xepar","status":"publish","type":"product","link":"https:\/\/medsbase.com\/cs\/product\/xepar\/","title":{"rendered":"Xepar"},"content":{"rendered":"

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\u26a1 Rychl\u00e1 odpov\u011b\u010f \u2014 Co je Xepar?<\/h3>\n
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Xepar<\/strong> obsahuje paroxetine 20 mg<\/strong> od v\u00fdrobce certifikovan\u00e9ho WHO-GMP (Sun Pharma) \u2014 SSRI s nej\u0161ir\u0161\u00edm spektrem indikac\u00ed \u00fazkosti schv\u00e1len\u00fdch FDA<\/strong> (MDD, GAD, soci\u00e1ln\u00ed \u00fazkost, panick\u00e1 porucha, OCD, PTSD, PMDD). Standardn\u00ed d\u00e1vka pro dosp\u011bl\u00e9: 20 mg jednou denn\u011b r\u00e1no<\/strong> s j\u00eddlem (rozmez\u00ed 10\u201350 mg\/den). Ze v\u0161ech SSRI m\u00e1 paroxetin nejsiln\u011bj\u0161\u00ed abstinen\u010dn\u00ed syndrom<\/strong> (velmi kr\u00e1tk\u00fd polo\u010das, \u017e\u00e1dn\u00fd aktivn\u00ed metabolit) \u2014 postupn\u00e9 vysazov\u00e1n\u00ed je povinn\u00e9; pacienti by nikdy nem\u011bli p\u0159estat n\u00e1hle. T\u011bhotensk\u00e1 kategorie D<\/strong> \u2014 nepou\u017e\u00edv\u00e1 se v t\u011bhotenstv\u00ed kv\u016fli sign\u00e1lu srde\u010dn\u00edch vad v prvn\u00edm trimestru. Nejv\u011bt\u0161\u00ed p\u0159\u00edr\u016fstek hmotnosti a sexu\u00e1ln\u00ed dysfunkce mezi b\u011b\u017en\u00fdmi SSRI. Siln\u00fd inhibitor CYP2D6 \u2014 v\u00fdznamn\u00e9 interakce s metoprololem, kodeinem, tamoxifenem.<\/p>\n<\/div>\n

\nCo z\u00edsk\u00e1te s MedsBase:<\/strong> V\u00fdrobce certifikovan\u00fd WHO-GMP \u00b7 Diskr\u00e9tn\u00ed balen\u00ed \u00b7 Celosv\u011btov\u00e1 doprava \u00b7 V\u00edce ne\u017e 1 400 ov\u011b\u0159en\u00fdch recenz\u00ed z\u00e1kazn\u00edk\u016f<\/a>\n<\/div>\n

\ud83d\udce6 Ka\u017ed\u00e1 objedn\u00e1vka je pokryta na\u0161\u00ed Z\u00e1rukou op\u011btovn\u00e9ho odesl\u00e1n\u00ed<\/strong><\/a> \u2014 pokud va\u0161e z\u00e1silka nedoraz\u00ed do 20 pracovn\u00edch dn\u016f, p\u0159epos\u00edl\u00e1me ji.<\/p>\n

Pro\u010d objedn\u00e1vat z MedsBase<\/h3>\n

Na\u0161e generick\u00e9 l\u00e9ky poch\u00e1zej\u00ed od v\u00fdrobc\u016f certifikovan\u00fdch WHO-GMP a jsou expedov\u00e1ny po cel\u00e9m sv\u011bt\u011b v diskr\u00e9tn\u00edm, nen\u00e1padn\u00e9m balen\u00ed \u2013 na vn\u011bj\u0161\u00ed stran\u011b bal\u00edku nen\u00ed uveden n\u00e1zev l\u00e9ku. Platby kartou jsou sm\u011brov\u00e1ny prost\u0159ednictv\u00edm regulovan\u00e9ho procesoru (popisky na v\u00fdpisu zahrnuj\u00ed regulovan\u00e9ho procesora plateb kartou \u2013 nikdy \u201cMedsBase\u201d nebo n\u00e1zev l\u00e9ku). P\u0159ij\u00edm\u00e1me tak\u00e9 kryptom\u011bny a bankovn\u00ed p\u0159evody SEPA. Ka\u017ed\u00e1 objedn\u00e1vka je zaji\u0161t\u011bna na\u0161\u00ed politikou p\u0159eposl\u00e1n\u00ed.<\/p>\n<\/div>\n

D\u016fle\u017eit\u00e9 \u2014 nejedn\u00e1 se o l\u00e9k na situa\u010dn\u00ed \u00fazkost.<\/strong> Xepar je selektivn\u00ed inhibitor zp\u011btn\u00e9ho vychyt\u00e1v\u00e1n\u00ed serotoninu (SSRI)<\/strong>, p\u0159edepisov\u00e1n a titrov\u00e1n po t\u00fddny pro z\u00e1va\u017en\u00e1 depresivn\u00ed porucha (MDD), generalizovan\u00e1 \u00fazkostn\u00e1 porucha (GAD), soci\u00e1ln\u00ed \u00fazkost, panick\u00e1 porucha, OCD, PTSD a PMDD<\/strong>. Nen\u00ed ne<\/strong> spr\u00e1vn\u00fdm l\u00e9kem pro akutn\u00ed, v\u00fdkonov\u011b souvisej\u00edc\u00ed \u00fazkost (l\u00e9t\u00e1n\u00ed, ve\u0159ejn\u00e9 vystupov\u00e1n\u00ed, zkou\u0161ky) \u2014 pro tyto p\u0159\u00edpady jsou klinicky vhodn\u011bj\u0161\u00ed betablok\u00e1tory (propranolol), benzodiazepiny nebo hydroxyzin. Pokud nem\u00e1te diagnostikovanou poruchu n\u00e1lady, \u00fazkostnou nebo psychiatrickou poruchu, neza\u010d\u00ednejte s u\u017e\u00edv\u00e1n\u00edm tohoto l\u00e9ku.<\/div>\n
FDA \u010dern\u00e9 varov\u00e1n\u00ed \u2014 sebevra\u017eednost.<\/strong> V\u0161echna antidepresiva nesou \u010dern\u00e9 varov\u00e1n\u00ed FDA pro zv\u00fd\u0161en\u00e9 riziko sebevra\u017eedn\u00e9ho my\u0161len\u00ed a chov\u00e1n\u00ed u d\u011bt\u00ed, dosp\u00edvaj\u00edc\u00edch a mlad\u00fdch dosp\u011bl\u00fdch do 25 let, zejm\u00e9na b\u011bhem prvn\u00edch t\u00fddn\u016f l\u00e9\u010dby nebo po zm\u011bn\u00e1ch d\u00e1vkov\u00e1n\u00ed. \u010clenov\u00e9 rodiny a p\u0159edepisuj\u00edc\u00ed l\u00e9ka\u0159i by m\u011bli pe\u010dliv\u011b sledovat zhor\u0161en\u00ed n\u00e1lady, agitovanost nebo sebevra\u017eedn\u00e9 my\u0161lenky v t\u00e9to v\u011bkov\u00e9 skupin\u011b.<\/div>\n

Co je Xepar?<\/h2>\n

Xepar je peror\u00e1ln\u00ed tableta paroxetinhydrochloridu 20 mg<\/strong> vyr\u00e1b\u011bn\u00e1 spole\u010dnost\u00ed Sun Pharma. Paroxetin (americk\u00e1 zna\u010dka Paxil<\/strong>; britsk\u00e1 zna\u010dka Seroxat<\/strong>) je SSRI antidepresivum uveden\u00e9 na trh spole\u010dnost\u00ed SmithKline Beecham v roce 1992 a jedno z nej\u010dast\u011bji p\u0159edepisovan\u00fdch antidepresiv v 90. letech a na po\u010d\u00e1tku 21. stolet\u00ed. Siln\u011b a selektivn\u011b blokuje serotoninov\u00fd transport\u00e9r (SERT) a m\u00e1 nej\u0161ir\u0161\u00ed spektrum indikac\u00ed schv\u00e1len\u00fdch FDA<\/strong> mezi SSRI.<\/p>\n

Schv\u00e1len\u00e9 indikace<\/h2>\n
    \n
  • Hlavn\u00ed depresivn\u00ed porucha (MDD)<\/strong><\/li>\n
  • Generalizovan\u00e1 \u00fazkostn\u00e1 porucha (GAD)<\/strong><\/li>\n
  • Soci\u00e1ln\u00ed \u00fazkostn\u00e1 porucha (chronick\u00e1\/generalizovan\u00e1)<\/strong><\/li>\n
  • panick\u00e1 porucha<\/strong> \u2014 s agorafobi\u00ed i bez n\u00ed<\/li>\n
  • obsedantn\u011b-kompulzivn\u00ed porucha (OCD)<\/strong><\/li>\n
  • Posttraumatick\u00e1 stresov\u00e1 porucha (PTSD)<\/strong><\/li>\n
  • Premenstrua\u010dn\u00ed dysforick\u00e1 porucha (PMDD)<\/strong><\/li>\n
  • Mimo schv\u00e1len\u00e9 indikace: n\u00e1valy horka (n\u00edzk\u00e1 d\u00e1vka 7,5 mg paroxetin mesyl\u00e1tu je pro tento \u00fa\u010del schv\u00e1lena FDA; mimo schv\u00e1len\u00e9 indikace pro vazomotorick\u00e9 p\u0159\u00edznaky menopauzy u \u017een, kter\u00e9 nemohou u\u017e\u00edvat HRT)<\/li>\n<\/ul>\n

    D\u00e1vkov\u00e1n\u00ed<\/h2>\n\n\n\n\n\n\n\n\n\n
    Indikace<\/th>\nStart<\/th>\nC\u00edlov\u00e1 d\u00e1vka<\/th>\nPozn\u00e1mky<\/th>\n<\/tr>\n<\/thead>\n
    MDD, GAD, soci\u00e1ln\u00ed \u00fazkost, PTSD<\/td>\n20 mg\/den r\u00e1no s j\u00eddlem<\/td>\n20\u201350 mg\/den<\/td>\nZvy\u0161ovat o 10 mg\/den v intervalech minim\u00e1ln\u011b 1 t\u00fdden<\/td>\n<\/tr>\n
    panick\u00e1 porucha<\/td>\n10 mg\/den \u00d7 1 t\u00fdden<\/td>\n40\u201360 mg\/den<\/td>\nPomal\u00e9 zvy\u0161ov\u00e1n\u00ed d\u00e1vky, aby se p\u0159ede\u0161lo \u010dasn\u00e9mu zhor\u0161en\u00ed paniky<\/td>\n<\/tr>\n
    OCD<\/td>\n20 mg\/den<\/td>\n40\u201360 mg\/den<\/td>\n\u010casto vy\u017eaduje horn\u00ed hranici rozmez\u00ed; 8\u201312 t\u00fddn\u016f pro vyhodnocen\u00ed<\/td>\n<\/tr>\n
    PMDD<\/td>\n12,5\u201325 mg\/den<\/td>\n25\u201350 mg\/den<\/td>\nNep\u0159etr\u017eit\u00e9 nebo pouze lute\u00e1ln\u00ed f\u00e1ze pod\u00e1v\u00e1n\u00ed<\/td>\n<\/tr>\n
    Star\u0161\u00ed pacienti \/ porucha funkce jater<\/td>\n10 mg\/den<\/td>\nMaxim\u00e1ln\u011b 40 mg\/den<\/td>\nSn\u00ed\u017eit po\u010d\u00e1te\u010dn\u00ed d\u00e1vku; titrovat pomalu<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

    Vedlej\u0161\u00ed \u00fa\u010dinky<\/h2>\n

    Profil ne\u017e\u00e1douc\u00edch \u00fa\u010dink\u016f<\/h2>\n\n\n\n\n\n\n\n\n\n\n\n\n\n
    Frekvence<\/th>\n\u00da\u010dinek<\/th>\nPozn\u00e1mky<\/th>\n<\/tr>\n<\/thead>\n
    B\u011b\u017en\u00e9<\/td>\nNevolnost, sucho v \u00fastech, z\u00e1cpa, pocen\u00ed<\/td>\nAnticholinergn\u00ed z\u00e1t\u011b\u017e je m\u00edrn\u00e1, ale vy\u0161\u0161\u00ed ne\u017e u jin\u00fdch SSRI<\/td>\n<\/tr>\n
    B\u011b\u017en\u00e9<\/td>\nSedace<\/td>\nU\u017e\u00edvat p\u0159ed span\u00edm, pokud zp\u016fsobuje ospalost; m\u016f\u017ee pomoci, pokud je nespavost p\u0159\u00edznakem deprese<\/td>\n<\/tr>\n
    B\u011b\u017en\u00e9<\/td>\nSexu\u00e1ln\u00ed dysfunkce (opo\u017ed\u011bn\u00fd orgasmus, n\u00edzk\u00e9 libido, pot\u00ed\u017ee s erekc\u00ed)<\/td>\nNejvy\u0161\u0161\u00ed ze skupiny SSRI \u2014 a\u017e 60 % dlouhodob\u00fdch u\u017eivatel\u016f<\/td>\n<\/tr>\n
    B\u011b\u017en\u00e9<\/td>\nP\u0159ib\u00fdv\u00e1n\u00ed na v\u00e1ze (3\u20137+ kg za 6\u201312 m\u011bs\u00edc\u016f)<\/td>\nNejvy\u0161\u0161\u00ed ze skupiny SSRI<\/td>\n<\/tr>\n
    B\u011b\u017en\u00e9<\/td>\nZ\u00e1vrat\u011b, rozmazan\u00e9 vid\u011bn\u00ed<\/td>\nAnticholinergn\u00ed<\/td>\n<\/tr>\n
    M\u00e9n\u011b \u010dast\u00e9<\/td>\nMod\u0159iny, krv\u00e1cen\u00ed do GI traktu<\/td>\nOpatrnost s NSAID \/ antikoagulancii<\/td>\n<\/tr>\n
    M\u00e9n\u011b \u010dast\u00e9<\/td>\nHyponatr\u00e9mie (SIADH)<\/td>\nStar\u0161\u00ed dosp\u011bl\u00ed v riziku<\/td>\n<\/tr>\n
    Vz\u00e1cn\u00e9<\/td>\nSerotoninov\u00fd syndrom<\/td>\nInterakce<\/td>\n<\/tr>\n
    Vz\u00e1cn\u00e9<\/td>\nAkathisie (neklidn\u00e9 rozru\u0161en\u00ed), sebevra\u017eedn\u00e9 my\u0161lenky<\/td>\nPrvn\u00ed t\u00fddny l\u00e9\u010dby; monitorov\u00e1n\u00ed s \u010dernou v\u00fdstrahou<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

    Discontinua\u010dn\u00ed syndrom \u2014 probl\u00e9m paroxetinu<\/h2>\n

    Paroxetin m\u00e1 nejkrat\u0161\u00ed polo\u010das ze v\u0161ech SSRI (~21 h)<\/strong> a \u017e\u00e1dn\u00fd aktivn\u00ed metabolit<\/strong>. Tato kombinace zp\u016fsobuje nejhor\u0161\u00ed discontinua\u010dn\u00ed syndrom<\/strong> ve t\u0159\u00edd\u011b antidepresiv: z\u00e1vrat\u011b, mozkov\u00e9 v\u00fdboje, parestezie, \u00fazkost, podr\u00e1\u017ed\u011bnost, nespavost, nevolnost a bolest hlavy \u2014 \u010dasto za\u010d\u00ednaj\u00edc\u00ed do 24\u201348 hodin po vynech\u00e1n\u00ed d\u00e1vky. P\u0159\u00edznaky mohou p\u0159etrv\u00e1vat t\u00fddny p\u0159i n\u00e1hl\u00e9m vysazen\u00ed.<\/p>\n

    Povinn\u00e9 postupn\u00e9 vysazov\u00e1n\u00ed<\/strong>: sni\u017eovat d\u00e1vku o 10 mg ka\u017ed\u00e9 2\u20134 t\u00fddny u kr\u00e1tkodob\u00fdch u\u017eivatel\u016f; u dlouhodob\u00fdch u\u017eivatel\u016f (> 1 rok) pou\u017e\u00edt mnohem pomalej\u0161\u00ed hyperbolick\u00e9 sni\u017eov\u00e1n\u00ed d\u00e1vek (nap\u0159. postupn\u00fd p\u0159echod na tekutou formu s redukc\u00ed 1\u20132 mg ka\u017ed\u00e9 2\u20134 t\u00fddny pod 10 mg). Nikdy nep\u0159est\u00e1vejte s paroxetinem n\u00e1hle<\/strong> mimo nemocni\u010dn\u00ed prost\u0159ed\u00ed.<\/p>\n

    Interakce s l\u00e9\u010divy<\/h2>\n

    Absolutn\u00ed kontraindikace<\/strong>: MAOI, linezolid, methylenov\u00e1 mod\u0159, thioridazin, pimozid. 14denn\u00ed vyplachovac\u00ed obdob\u00ed.<\/p>\n

    CYP2D6 (siln\u00fd inhibitor)<\/strong> \u2014 klinicky v\u00fdznamn\u00e9: tamoxifen<\/em> (sni\u017euje p\u0159em\u011bnu na endoxifen \u2014 vyvarovat se u pacientek po l\u00e9\u010db\u011b rakoviny prsu), kodein a tramadol<\/em> (sni\u017euje analgetickou aktivaci), metoprolol a dal\u0161\u00ed beta-blok\u00e1tory 2D6<\/em> (zvy\u0161uje hladiny v plazm\u011b), atomoxetin, risperidon, aripiprazol<\/em> (zvy\u0161uje hladiny).<\/p>\n

    Serotonergn\u00ed interakce<\/strong>: triptany, tramadol, dextromethorfan, t\u0159ezalka te\u010dkovan\u00e1, lithium \u2014 riziko serotoninov\u00e9ho syndromu.<\/p>\n

    Antikoagulancia a NSAID<\/strong>: zv\u00fd\u0161en\u00e9 riziko krv\u00e1cen\u00ed (zejm\u00e9na v horn\u00ed \u010d\u00e1sti GI traktu).<\/p>\n

    T\u011bhotenstv\u00ed a kojen\u00ed<\/h2>\n

    T\u011bhotensk\u00e1 kategorie D<\/strong> \u2014 expozice paroxetinu v prvn\u00edm trimestru byla spojena s mal\u00fdm, ale reprodukovateln\u00fdm sign\u00e1lem pro srde\u010dn\u00ed malformace plodu, zejm\u00e9na Ebsteinovu anom\u00e1lii. Paroxetin se nepou\u017e\u00edv\u00e1 v t\u011bhotenstv\u00ed<\/strong> pokud jsou k dispozici alternativy (sertralin, citalopram, escitalopram). \u017deny pl\u00e1nuj\u00edc\u00ed t\u011bhotenstv\u00ed by m\u011bly zm\u011bnit antidepresiva s p\u0159edstihem.<\/p>\n

    Kojen\u00ed: n\u00edzk\u00fd p\u0159enos; sertralin je preferov\u00e1n, ale paroxetin je p\u0159ijateln\u00fd, pokud pokra\u010duje v tom, co fungovalo v t\u011bhotenstv\u00ed.<\/p>\n

    \u010casto kladen\u00e9 dotazy<\/h2>\n

    Jak dlouho trv\u00e1, ne\u017e Xepar za\u010dne \u00fa\u010dinkovat?<\/h3>\n

    \u00dazkostn\u00e9 a panick\u00e9 p\u0159\u00edznaky \u010dasto reaguj\u00ed do 2\u20133 t\u00fddn\u016f; \u00fa\u010dinek na n\u00e1ladu u MDD se obvykle objevuje za 4\u20136 t\u00fddn\u016f. OCD m\u016f\u017ee vy\u017eadovat 8\u201312 t\u00fddn\u016f p\u0159i vy\u0161\u0161\u00edch d\u00e1vk\u00e1ch.<\/p>\n

    Pro\u010d je paroxetin obt\u00ed\u017en\u011bj\u0161\u00ed vysadit ne\u017e jin\u00e1 SSRI?<\/h3>\n

    Paroxetin m\u00e1 velmi kr\u00e1tk\u00fd polo\u010das (asi 21 hodin) a \u017e\u00e1dn\u00fd aktivn\u00ed metabolit, tak\u017ee hladiny v plazm\u011b rychle klesaj\u00ed p\u0159i vynech\u00e1n\u00ed d\u00e1vek. To zp\u016fsobuje v\u00fdrazn\u011bj\u0161\u00ed abstinen\u010dn\u00ed p\u0159\u00edznaky ne\u017e SSRI s del\u0161\u00edm polo\u010dasem (sertralin, citalopram) nebo ty s aktivn\u00edmi metabolity (fluoxetin).<\/p>\n

    Mohu p\u0159ej\u00edt z p\u0159\u00edpravku Xepar na jin\u00e9 SSRI?<\/h3>\n

    Ano \u2014 b\u011b\u017en\u00fdmi alternativami jsou sertralin (\u010dist\u0161\u00ed profil) nebo escitalopram (l\u00e9pe sn\u00e1\u0161en). P\u0159echod obvykle zahrnuje k\u0159\u00ed\u017eov\u00e9 sni\u017eov\u00e1n\u00ed d\u00e1vek nebo postupn\u00e9 vysazen\u00ed paroxetinu n\u00e1sledovan\u00e9 kr\u00e1tkou p\u0159est\u00e1vkou. V\u017edy pod dohledem l\u00e9ka\u0159e.<\/p>\n

    Je Xepar bezpe\u010dn\u00fd v t\u011bhotenstv\u00ed?<\/h3>\n

    Paroxetin se v t\u011bhotenstv\u00ed obecn\u011b nedoporu\u010duje kv\u016fli m\u00edrn\u011b zv\u00fd\u0161en\u00e9mu riziku srde\u010dn\u00edch vad v prvn\u00edm trimestru. \u017deny pl\u00e1nuj\u00edc\u00ed t\u011bhotenstv\u00ed by m\u011bly p\u0159edem p\u0159ej\u00edt na sertralin nebo escitalopram.<\/p>\n

    Zp\u016fsobuje Xepar p\u0159ib\u00fdv\u00e1n\u00ed na v\u00e1ze?<\/h3>\n

    Ano \u2014 paroxetin zp\u016fsobuje ze v\u0161ech SSRI nejv\u011bt\u0161\u00ed n\u00e1r\u016fst hmotnosti (obvykle 3\u20137 kg za 6\u201312 m\u011bs\u00edc\u016f). To je \u010dast\u00fd d\u016fvod, pro\u010d pacienti p\u0159ech\u00e1zej\u00ed na sertralin, escitalopram nebo bupropion.<\/p>\n

    Pom\u00e1h\u00e1 paroxetin proti n\u00e1val\u016fm horka v menopauze?<\/h3>\n

    N\u00edzk\u00e1 d\u00e1vka paroxetinu (7,5 mg paroxetin mesyl\u00e1tu, v USA prod\u00e1van\u00fd jako Brisdelle) je schv\u00e1lena FDA pro l\u00e9\u010dbu n\u00e1val\u016f horka v menopauze \u2014 vhodn\u00e9 pro \u017eeny, kter\u00e9 nemohou nebo necht\u011bj\u00ed u\u017e\u00edvat hormon\u00e1ln\u00ed substituci.<\/p>\n

    Co se stane, kdy\u017e vynech\u00e1m d\u00e1vku?<\/h3>\n

    Vezm\u011bte si ho, jakmile si vzpomenete; pokud si vzpomenete bl\u00edzko k dal\u0161\u00ed d\u00e1vce, vynechejte tu vynechanou. Nezdvojujte d\u00e1vku. Vynech\u00e1n\u00ed v\u00edce ne\u017e jedn\u00e9 d\u00e1vky m\u016f\u017ee do 24\u201348 hodin zp\u016fsobit v\u00fdrazn\u00e9 abstinen\u010dn\u00ed p\u0159\u00edznaky.<\/p>\n

    Lze Xepar kombinovat s l\u00e9ky proti \u00fazkosti?<\/h3>\n

    U t\u011b\u017ek\u00e9 panick\u00e9 poruchy l\u00e9ka\u0159i n\u011bkdy na prvn\u00ed 2\u20134 t\u00fddny p\u0159ekr\u00fdvaj\u00ed benzodiazepin, dokud SS nezabere, pot\u00e9 benzodiazepin vysazuj\u00ed. Jde o kr\u00e1tkodobou p\u0159emos\u0165ovac\u00ed strategii, nikoli o dlouhodobou kombinovanou terapii.<\/p>\n

    \u010c\u00edm se Xepar li\u0161\u00ed od sertralinu?<\/h3>\n

    Oba jsou SSRI s podobn\u00fdm mechanismem \u00fa\u010dinku. Paroxetin zp\u016fsobuje v\u00edce \u00fanavy, v\u011bt\u0161\u00ed n\u00e1r\u016fst hmotnosti, \u010dast\u011bj\u0161\u00ed sexu\u00e1ln\u00ed dysfunkci, hor\u0161\u00ed abstinen\u010dn\u00ed p\u0159\u00edznaky a siln\u011bj\u0161\u00ed interakce s CYP2D6 \u2014 ale historicky o n\u011bco rychlej\u0161\u00ed \u00falevu od \u00fazkosti. Sertralin je pro v\u011bt\u0161inu pacient\u016f \u010dist\u0161\u00ed volbou.<\/p>\n

    Jak se m\u00e1 Xepar skladovat?<\/h3>\n

    Skladujte p\u0159i teplot\u011b 15\u201330 \u00b0C v p\u016fvodn\u00edm blistrov\u00e9m obalu, mimo dosah vlhkosti a slune\u010dn\u00edho sv\u011btla. Uchov\u00e1vejte mimo dosah d\u011bt\u00ed.<\/p>\n

    Zdravotn\u00ed upozorn\u011bn\u00ed:<\/strong> Informace na t\u00e9to str\u00e1nce jsou ur\u010deny dosp\u011bl\u00fdm u\u017e\u00edvaj\u00edc\u00edm p\u0159edepsan\u00e9 psychiatrick\u00e9 l\u00e9ky a nenahrazuj\u00ed individu\u00e1ln\u00ed l\u00e9ka\u0159skou p\u00e9\u010di. Antidepresiva, antipsychotika a p\u0159\u00edbuzn\u00e9 l\u00e9ky mohou interagovat s jin\u00fdmi l\u00e9ky, alkoholem a st\u00e1vaj\u00edc\u00edmi zdravotn\u00edmi stavy. Jak\u00e9koli nov\u00e9 l\u00e9ky, zm\u011bnu d\u00e1vkov\u00e1n\u00ed nebo pl\u00e1novan\u00e9 vysazen\u00ed konzultujte s kvalifikovan\u00fdm l\u00e9ka\u0159em. Pokud se u v\u00e1s objev\u00ed sebevra\u017eedn\u00e9 my\u0161lenky, m\u00e1nie, t\u011b\u017ek\u00e1 akathisie, p\u0159\u00edznaky serotoninov\u00e9ho syndromu (vysok\u00e1 hore\u010dka, zmatenost, svalov\u00e1 ztuhlost, zrychlen\u00fd srde\u010dn\u00ed tep) nebo neuroleptick\u00fd malign\u00ed syndrom, vyhledejte okam\u017eit\u011b l\u00e9ka\u0159skou pomoc.<\/div>\n

    <\/p>\n

    Souvisej\u00edc\u00ed alternativy<\/h3>\n

    Dal\u0161\u00ed produkty v Chronick\u00e1 onemocn\u011bn\u00ed<\/strong> kter\u00e9 z\u00e1kazn\u00edci tak\u00e9 prohl\u00ed\u017eej\u00ed:<\/p>\n