{"id":60074,"date":"2024-02-28T06:32:14","date_gmt":"2024-02-28T06:32:14","guid":{"rendered":"https:\/\/medsname.com\/mozep\/"},"modified":"2026-04-30T10:23:51","modified_gmt":"2026-04-30T10:23:51","slug":"mozep","status":"publish","type":"product","link":"https:\/\/medsbase.com\/cs\/product\/mozep\/","title":{"rendered":"Mozep"},"content":{"rendered":"

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\u26a1 Rychl\u00e1 odpov\u011b\u010f<\/h3>\n

Mozep (Pimozid 2 mg) je butyrofenonov\u00e9 antipsychotikum prvn\u00ed generace. Modern\u00ed pou\u017eit\u00ed je omezeno na refraktern\u00ed Tourett\u016fv syndrom (s motorick\u00fdmi a vok\u00e1ln\u00edmi tiky) a l\u00e9\u010debn\u011b rezistentn\u00ed bludnou poruchu. Siln\u00e9 d\u00e1vkov\u011b z\u00e1visl\u00e9 prodlou\u017een\u00ed QT intervalu a riziko torsades de pointes \u2014 p\u0159ed l\u00e9\u010dbou je nutn\u00e9 EKG.<\/p>\n<\/div>\n

\nCo z\u00edsk\u00e1te s MedsBase:<\/strong> V\u00fdrobce certifikovan\u00fd WHO-GMP \u00b7 Diskr\u00e9tn\u00ed balen\u00ed \u00b7 Celosv\u011btov\u00e1 doprava \u00b7 V\u00edce ne\u017e 1 400 ov\u011b\u0159en\u00fdch recenz\u00ed z\u00e1kazn\u00edk\u016f<\/a>\n<\/div>\n

\ud83d\udce6 Ka\u017ed\u00e1 objedn\u00e1vka je pokryta na\u0161\u00ed Z\u00e1rukou op\u011btovn\u00e9ho odesl\u00e1n\u00ed<\/strong><\/a> \u2014 pokud va\u0161e z\u00e1silka nedoraz\u00ed do 20 pracovn\u00edch dn\u016f, p\u0159epos\u00edl\u00e1me ji.<\/p>\n

Pro\u010d objedn\u00e1vat z MedsBase<\/h3>\n

Mozep na MedsBase je dod\u00e1v\u00e1n p\u0159\u00edmo od v\u00fdrobce certifikovan\u00e9ho WHO-GMP v prost\u00e9m, diskr\u00e9tn\u00edm balen\u00ed. Ka\u017ed\u00e1 objedn\u00e1vka je pokryta na\u0161\u00edm Z\u00e1rukou op\u011btovn\u00e9ho odesl\u00e1n\u00ed<\/a> \u2014 20pracovn\u00edchdenn\u00ed lh\u016fta pro doru\u010den\u00ed, nebo v\u00e1m z\u00e1silku zdarma p\u0159epo\u0161leme \u2014 a oprav\u0148uje v\u00e1s k \u00fa\u010dasti v na\u0161em v\u011brnostn\u00edm programu<\/a>. Dod\u00e1v\u00e1me do v\u011bt\u0161iny zem\u00ed po cel\u00e9m sv\u011bt\u011b.<\/p>\n

Co je Mozep a jak funguje<\/h2>\n

Mozep je tableta pimozidu dod\u00e1van\u00e1 spole\u010dnost\u00ed Sun Pharma. Dostupn\u00e9 s\u00edly: 2 mg<\/strong>. Pimozid je butyrofenon (p\u0159\u00edbuzn\u00fd haloperidolu) se selektivn\u00ed D2 antagonizac\u00ed, m\u00edrnou 5-HT2A antagonizac\u00ed a v\u00fdznamnou blok\u00e1dou kalciov\u00fdch kan\u00e1l\u016f \u2014 posledn\u00ed zm\u00edn\u011bn\u00fd mechanismus je z\u00e1kladem pro \u00fa\u010dinek prodlu\u017euj\u00edc\u00ed QT interval, kter\u00fd omezuje jeho pou\u017eit\u00ed.<\/p>\n

Modern\u00ed indikace: refraktern\u00ed Tourett\u016fv syndrom (schv\u00e1leno FDA), monosymptomatick\u00e1 porucha s bludy (nap\u0159. bludy parazit\u00f3zy, somatick\u00e9 bludy) a vz\u00e1cn\u00e9 p\u0159\u00edpady schizofrenie nereaguj\u00edc\u00ed na jin\u00e9 l\u00e9ky.<\/p>\n

Indikace a d\u00e1vkov\u00e1n\u00ed<\/h2>\n\n\n\n\n\n\n\n\n\n
Indikace<\/th>\nPo\u010d\u00e1te\u010dn\u00ed d\u00e1vka<\/th>\nC\u00edlov\u00e1 d\u00e1vka<\/th>\nMaxim\u00e1ln\u00ed d\u00e1vka<\/th>\n<\/tr>\n<\/thead>\n
Tourett\u016fv syndrom (dosp\u011bl\u00ed)<\/td>\n1 mg na noc<\/td>\n1\u201310 mg\/den<\/td>\n0,2 mg\/kg nebo 10 mg<\/td>\n<\/tr>\n
Tourett\u016fv syndrom (d\u011bti \u2265 12 let)<\/td>\n0,05 mg\/kg na noc<\/td>\n0,2 mg\/kg\/den<\/td>\n0,2 mg\/kg nebo 10 mg<\/td>\n<\/tr>\n
Monosymptomatick\u00e1 porucha s bludy<\/td>\n2 mg 1\u00d7 denn\u011b<\/td>\n2\u20134 mg\/den<\/td>\n\u2014<\/td>\n<\/tr>\n
Schizofrenie (refraktern\u00ed)<\/td>\n1 mg 2\u00d7 denn\u011b<\/td>\n2\u201310 mg\/den<\/td>\n20 mg<\/td>\n<\/tr>\n
\u0160patn\u00fd metaboliz\u00e9r CYP2D6 \/ inhibitor<\/td>\npolovi\u010dn\u00ed d\u00e1vka<\/td>\n\u2014<\/td>\n\u2014<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

D\u016fle\u017eit\u00e9 bezpe\u010dnostn\u00ed aspekty<\/h2>\n
\nFDA black-box \u2014 psych\u00f3za spojen\u00e1 s demenc\u00ed<\/strong><\/p>\n

V\u0161echna atypick\u00e1 antipsychotika nesou varov\u00e1n\u00ed FDA black-box pro zv\u00fd\u0161enou mortalitu (p\u0159edev\u0161\u00edm kardiovaskul\u00e1rn\u00ed a infek\u010dn\u00ed) p\u0159i pou\u017eit\u00ed k l\u00e9\u010db\u011b behavior\u00e1ln\u00edch poruch u star\u0161\u00edch dosp\u011bl\u00fdch s demenc\u00ed. Atypick\u00e1 antipsychotika nejsou schv\u00e1lena pro psych\u00f3zu nebo agitovanost spojenou s demenc\u00ed<\/strong>. Pou\u017eit\u00ed u t\u00e9to populace je off-label, posledn\u00ed mo\u017enost\u00ed, \u010dasov\u011b omezen\u00e9 a vy\u017eaduje explicitn\u00ed rozhovor o rizic\u00edch a p\u0159\u00ednosech.<\/p>\n<\/div>\n

\nPovinn\u00e9 p\u0159edl\u00e9\u010debn\u00e9 EKG a absolutn\u00ed kontraindikace<\/strong><\/p>\n

Pimozid m\u00e1 siln\u00fd d\u00e1vkov\u011b z\u00e1visl\u00fd sign\u00e1l prodlou\u017een\u00ed QT intervalu. P\u0159ed zah\u00e1jen\u00edm l\u00e9\u010dby je nutn\u00e9 EKG; kontrolovat QTc p\u0159i ka\u017ed\u00e9m zv\u00fd\u0161en\u00ed d\u00e1vky; p\u0159eru\u0161it l\u00e9\u010dbu, pokud QTc > 500 ms nebo vzroste o > 60 ms od v\u00fdchoz\u00ed hodnoty.<\/strong> Absolutn\u00ed kontraindikace: zn\u00e1m\u00e9 prodlou\u017een\u00ed QT intervalu, vrozen\u00e9 arytmick\u00e9 syndromy, ned\u00e1vn\u00fd IM, dekompenzovan\u00e9 srde\u010dn\u00ed selh\u00e1n\u00ed, hypokal\u00e9mie\/hypomagnez\u00e9mie (nutno korigovat p\u0159ed zah\u00e1jen\u00edm l\u00e9\u010dby), sou\u010dasn\u00e9 pod\u00e1v\u00e1n\u00ed l\u00e9k\u016f prodlu\u017euj\u00edc\u00edch QT interval a siln\u00fdch inhibitor\u016f CYP3A4 (azoly, klarithromycin, ritonavir, grapefruitov\u00e1 \u0161\u0165\u00e1va \u2014 v\u0161echny v\u00fdznamn\u011b zvy\u0161uj\u00ed hladinu pimozidu a riziko prodlou\u017een\u00ed QT intervalu).<\/p>\n<\/div>\n

\nDualn\u00ed substr\u00e1t CYP3A4 + CYP2D6<\/strong><\/p>\n

Pimozid je metabolizov\u00e1n jak CYP3A4, tak CYP2D6. Siln\u00ed inhibitory kter\u00e9hokoli z t\u011bchto enzym\u016f zvy\u0161uj\u00ed hladinu a zesiluj\u00ed riziko prodlou\u017een\u00ed QT intervalu. Siln\u00e9 inhibitory CYP2D6 (paroxetin, fluoxetin, bupropion, chinidin) a siln\u00e9 inhibitory CYP3A4 jsou absolutn\u00ed kontraindikace.<\/p>\n<\/div>\n

\nEPS, TD a akutn\u00ed dystonie<\/strong><\/p>\n

Jako butyrofenon pimozid zp\u016fsobuje v\u00fdznamn\u00e9 EPS, akatizii, akutn\u00ed dystonii (zejm\u00e9na u mlad\u00fdch mu\u017e\u016f) a kumulativn\u00ed tardivn\u00ed dyskinezi. Anticholinergn\u00ed adjuvantn\u00ed l\u00e9\u010dba (procyklidin, benztropin) je n\u011bkdy pou\u017eita akutn\u011b.<\/p>\n<\/div>\n

\u010cast\u00e9 ne\u017e\u00e1douc\u00ed \u00fa\u010dinky<\/h2>\n