{"id":60195,"date":"2024-02-28T06:37:55","date_gmt":"2024-02-28T06:37:55","guid":{"rendered":"https:\/\/medsname.com\/prazinec\/"},"modified":"2026-05-09T11:38:18","modified_gmt":"2026-05-09T11:38:18","slug":"prazinec","status":"publish","type":"product","link":"https:\/\/medsbase.com\/cs\/product\/prazinec\/","title":{"rendered":"Prazinec"},"content":{"rendered":"

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Quick Answer — What is Prazinec?<\/h3>\n
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Prazinec<\/strong> je praziquantel 600 mg<\/strong> od Sun Pharma<\/strong>. Praziquantel is the WHO Essential Medicine for schistosomiasis, intestinal flukes, liver flukes, and most cestodes including neurocysticercosis<\/strong>. Standard adult dose for schistosomiasis: 40 mg\/kg as a single dose<\/strong>; for tapeworm: 5–10 mg\/kg single dose; for neurocysticercosis: 50 mg\/kg\/day in 3 divided doses for 14–30 days under specialist supervision.<\/p>\n<\/div>\n<\/div>\n

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What is Prazinec?<\/h2>\n

Prazinec<\/strong> is praziquantel 600 mg from Sun Pharma<\/strong>. Praziquantel is one of the most important drugs in tropical medicine — the global standard for schistosomiasis (which affects roughly 240 million people worldwide), and the agent of choice for most cestode and trematode infections. WHO mass-drug-administration programmes have used praziquantel to treat over a billion people since the 1990s.<\/p>\n

Mechanismus \u00fa\u010dinku<\/h2>\n

Praziquantel increases calcium permeability<\/strong> across the parasite tegument (outer covering), causing rapid sustained muscle contraction. This paralyses the worm and exposes its surface antigens to host immune attack — a one-two punch of pharmacological paralysis followed by immune-mediated killing. The mechanism explains why praziquantel works so well in immunocompetent patients and is somewhat less effective in heavily immunosuppressed hosts.<\/p>\n

Oral bioavailability is good (~80%) but first-pass hepatic metabolism is heavy — only about 25% reaches systemic circulation as active drug. Plasma half-life is 1–1.5 hours.<\/p>\n

Prazinec indications and dose<\/h2>\n\n\n\n\n\n\n\n\n\n\n
Indikace<\/th>\nD\u00e1vka<\/th>\nD\u00e1vkovac\u00ed sch\u00e9ma<\/th>\n<\/tr>\n<\/thead>\n
Schistosomiasis (S. mansoni, S. haematobium, S. japonicum)<\/td>\n40 mg\/kg<\/td>\nSingle dose (S. japonicum: 60 mg\/kg)<\/td>\n<\/tr>\n
Intestinal tapeworm (Taenia saginata, T. solium)<\/td>\n5–10 mg\/kg<\/td>\nJednor\u00e1zov\u00e1 d\u00e1vka<\/td>\n<\/tr>\n
(trpasli\u010d\u00ed tasemnice),<\/td>\n25 mg\/kg<\/td>\nSingle dose, repeat at 1 week<\/td>\n<\/tr>\n
Liver flukes (Clonorchis, Opisthorchis)<\/td>\n25 mg\/kg TID<\/td>\nFor 1 day (75 mg\/kg total)<\/td>\n<\/tr>\n
Lung fluke (Paragonimus)<\/td>\n25 mg\/kg TID<\/td>\nFor 2 days<\/td>\n<\/tr>\n
Neurocysticercosis (specialist)<\/td>\n50 mg\/kg\/day in 3 doses<\/td>\nFor 14–30 days WITH steroid cover<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Take with water or a soft drink during or shortly after a meal. Tablets have a bitter taste — do not chew. Children > 4 years: same weight-based dosing applies.<\/p>\n

Neurocysticercosis is a specialist diagnosis.<\/strong> Praziquantel for CNS cysticercosis must be given with concurrent corticosteroid (typically dexamethasone) to suppress the inflammatory response to dying cysts — otherwise raised intracranial pressure can be catastrophic. Imaging (MRI brain) is mandatory before treatment. Do not self-treat suspected neurocysticercosis.<\/div>\n

Vedlej\u0161\u00ed \u00fa\u010dinky<\/h2>\n