{"id":60195,"date":"2024-02-28T06:37:55","date_gmt":"2024-02-28T06:37:55","guid":{"rendered":"https:\/\/medsname.com\/prazinec\/"},"modified":"2026-05-09T11:38:18","modified_gmt":"2026-05-09T11:38:18","slug":"prazinec","status":"publish","type":"product","link":"https:\/\/medsbase.com\/cs\/product\/prazinec\/","title":{"rendered":"Prazinec"},"content":{"rendered":"

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Rychl\u00e1 odpov\u011b\u010f \u2014 Co je Prazinec?<\/h3>\n
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Prazinec<\/strong> je praziquantel 600 mg<\/strong> od Sun Pharma<\/strong>. Praziquantel je z\u00e1kladn\u00ed l\u00e9k WHO pro schistosom\u00f3zu, st\u0159evn\u00ed motolice, jatern\u00ed motolice a v\u011bt\u0161inu tasemnic v\u010detn\u011b neurocysticerk\u00f3zy<\/strong>. Standardn\u00ed d\u00e1vka pro dosp\u011bl\u00e9 u schistosom\u00f3zy: 40 mg\/kg jednor\u00e1zov\u011b<\/strong>; u tasemnice: 5\u201310 mg\/kg jednor\u00e1zov\u011b; u neurocysticerk\u00f3zy: 50 mg\/kg\/den ve 3 rozd\u011blen\u00fdch d\u00e1vk\u00e1ch po dobu 14\u201330 dn\u016f pod odborn\u00fdm dohledem.<\/p>\n<\/div>\n<\/div>\n

\ud83d\udcd6 Kompletn\u00ed pr\u016fvodce:<\/strong> Kupte si Ivermectin pro lidi online \u2014 d\u00e1vkov\u00e1n\u00ed, bezpe\u010dnost a co pot\u0159ebujete v\u011bd\u011bt<\/a><\/p>\n

Pro\u010d objedn\u00e1vat z MedsBase:<\/strong> \u2713 Zdrojeno od WHO-GMP certifikovan\u00fdch v\u00fdrobc\u016f<\/strong> \u00b7 \u2713 Diskr\u00e9tn\u00ed balen\u00ed \u00b7 \u2713 Doprava do cel\u00e9ho sv\u011bta \u00b7 \u2713 1,400+ recenz\u00ed z\u00e1kazn\u00edk\u016f<\/strong> na medsbase.com\/reviews<\/a><\/div>\n

\ud83d\udce6 Ka\u017ed\u00e1 objedn\u00e1vka je pokryta na\u0161\u00ed Z\u00e1rukou op\u011btovn\u00e9ho odesl\u00e1n\u00ed<\/strong><\/a> \u2014 pokud va\u0161e z\u00e1silka nedoraz\u00ed do 20 pracovn\u00edch dn\u016f, p\u0159epos\u00edl\u00e1me ji.<\/p>\n

Pro\u010d objedn\u00e1vat z MedsBase<\/h3>\n

Na\u0161e generick\u00e9 l\u00e9ky poch\u00e1zej\u00ed od v\u00fdrobc\u016f certifikovan\u00fdch WHO-GMP a jsou expedov\u00e1ny po cel\u00e9m sv\u011bt\u011b v diskr\u00e9tn\u00edm, nen\u00e1padn\u00e9m balen\u00ed \u2013 na vn\u011bj\u0161\u00ed stran\u011b bal\u00edku nen\u00ed uveden n\u00e1zev l\u00e9ku. Platby kartou jsou sm\u011brov\u00e1ny prost\u0159ednictv\u00edm regulovan\u00e9ho procesoru (popisky na v\u00fdpisu zahrnuj\u00ed regulovan\u00e9ho procesora plateb kartou \u2013 nikdy \u201cMedsBase\u201d nebo n\u00e1zev l\u00e9ku). P\u0159ij\u00edm\u00e1me tak\u00e9 kryptom\u011bny a bankovn\u00ed p\u0159evody SEPA. Ka\u017ed\u00e1 objedn\u00e1vka je zaji\u0161t\u011bna na\u0161\u00ed politikou p\u0159eposl\u00e1n\u00ed.<\/p>\n

Co je Prazinec?<\/h2>\n

Prazinec<\/strong> je praziquantel 600 mg od Sun Pharma<\/strong>. Praziquantel je jedn\u00edm z nejd\u016fle\u017eit\u011bj\u0161\u00edch l\u00e9k\u016f v tropick\u00e9 medic\u00edn\u011b \u2014 celosv\u011btov\u00fd standard pro schistosom\u00f3zu (kter\u00e1 postihuje p\u0159ibli\u017en\u011b 240 milion\u016f lid\u00ed na cel\u00e9m sv\u011bt\u011b) a l\u00e9k volby pro v\u011bt\u0161inu infekc\u00ed zp\u016fsoben\u00fdch tasemnicemi a motolicemi. Programy hromadn\u00e9ho pod\u00e1v\u00e1n\u00ed l\u00e9k\u016f WHO pou\u017eily praziquantel k l\u00e9\u010db\u011b p\u0159es miliardu lid\u00ed od 90. let 20. stolet\u00ed.<\/p>\n

Mechanismus \u00fa\u010dinku<\/h2>\n

Praziquantel zvy\u0161uje propustnost pro v\u00e1pn\u00edk<\/strong> skrz povrch parazita (vn\u011bj\u0161\u00ed obal), co\u017e zp\u016fsobuje rychlou a trvalou svalovou kontrakci. To ochrom\u00ed \u010derva a vystav\u00ed jeho povrchov\u00e9 antigeny \u00fatoku hostitelsk\u00e9ho imunitn\u00edho syst\u00e9mu \u2014 kombinace farmakologick\u00e9 paral\u00fdzy n\u00e1sledovan\u00e9 imunitn\u011b zprost\u0159edkovan\u00fdm usmrcen\u00edm. Tento mechanismus vysv\u011btluje, pro\u010d praziquantel tak dob\u0159e funguje u imunokompetentn\u00edch pacient\u016f a je pon\u011bkud m\u00e9n\u011b \u00fa\u010dinn\u00fd u siln\u011b imunosuprimovan\u00fdch hostitel\u016f.<\/p>\n

Or\u00e1ln\u00ed biologick\u00e1 dostupnost je dobr\u00e1 (~80 %), ale jatern\u00ed metabolismus prvn\u00edho pr\u016fchodu je v\u00fdrazn\u00fd \u2014 pouze asi 25 % se dostane do syst\u00e9mov\u00e9ho ob\u011bhu jako aktivn\u00ed l\u00e9\u010divo. Polo\u010das v plazm\u011b je 1\u20131,5 hodiny.<\/p>\n

Indikace a d\u00e1vkov\u00e1n\u00ed Prazinec<\/h2>\n\n\n\n\n\n\n\n\n\n\n
Indikace<\/th>\nD\u00e1vka<\/th>\nD\u00e1vkovac\u00ed sch\u00e9ma<\/th>\n<\/tr>\n<\/thead>\n
Schistosom\u00f3za (S. mansoni, S. haematobium, S. japonicum)<\/td>\n40 mg\/kg<\/td>\nJednor\u00e1zov\u00e1 d\u00e1vka (S. japonicum: 60 mg\/kg)<\/td>\n<\/tr>\n
St\u0159evn\u00ed tasemnice (Taenia saginata, T. solium)<\/td>\n5\u201310 mg\/kg<\/td>\nJednor\u00e1zov\u00e1 d\u00e1vka<\/td>\n<\/tr>\n
(trpasli\u010d\u00ed tasemnice),<\/td>\n25 mg\/kg<\/td>\nJednor\u00e1zov\u00e1 d\u00e1vka, opakovat po 1 t\u00fddnu<\/td>\n<\/tr>\n
Motolice jatern\u00ed (Clonorchis, Opisthorchis)<\/td>\n25 mg\/kg 3\u00d7 denn\u011b<\/td>\nPo dobu 1 dne (celkem 75 mg\/kg)<\/td>\n<\/tr>\n
Motolice plicn\u00ed (Paragonimus)<\/td>\n25 mg\/kg 3\u00d7 denn\u011b<\/td>\nPo dobu 2 dn\u016f<\/td>\n<\/tr>\n
Neurocysticerk\u00f3za (specializovan\u00e9 vy\u0161et\u0159en\u00ed)<\/td>\n50 mg\/kg\/den ve 3 d\u00e1vk\u00e1ch<\/td>\nPo dobu 14\u201330 dn\u016f SOU\u010cASN\u011a s kortikosteroidy<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

U\u017e\u00edvejte s vodou nebo nealkoholick\u00fdm n\u00e1pojem b\u011bhem j\u00eddla nebo kr\u00e1tce po n\u011bm. Tablety maj\u00ed ho\u0159kou chu\u0165 \u2013 nerozkous\u00e1vejte. D\u011bti nad 4 roky: stejn\u00e9 d\u00e1vkov\u00e1n\u00ed podle hmotnosti.<\/p>\n

Neurocysticerk\u00f3za vy\u017eaduje specializovanou diagnostiku.<\/strong> Praziquantel pro l\u00e9\u010dbu CNS cysticer\u00f3zy mus\u00ed b\u00fdt pod\u00e1v\u00e1n sou\u010dasn\u011b s kortikosteroidem (obvykle dexamethasonem) k potla\u010den\u00ed z\u00e1n\u011btliv\u00e9 reakce na odum\u00edraj\u00edc\u00ed cysty \u2013 jinak m\u016f\u017ee zv\u00fd\u0161en\u00fd nitrolebn\u00ed tlak v\u00e9st k z\u00e1va\u017en\u00fdm komplikac\u00edm. P\u0159ed l\u00e9\u010dbou je nutn\u00e9 zobrazovac\u00ed vy\u0161et\u0159en\u00ed (MRI mozku). Neu\u017e\u00edvejte praziquantel p\u0159i podez\u0159en\u00ed na neurocysticerk\u00f3zu bez odborn\u00e9ho dohledu.<\/div>\n

Vedlej\u0161\u00ed \u00fa\u010dinky<\/h2>\n