{"id":60357,"date":"2024-02-28T06:45:27","date_gmt":"2024-02-28T06:45:27","guid":{"rendered":"https:\/\/medsname.com\/rcifax\/"},"modified":"2026-04-30T10:23:48","modified_gmt":"2026-04-30T10:23:48","slug":"rcifax","status":"publish","type":"product","link":"https:\/\/medsbase.com\/cs\/product\/rcifax\/","title":{"rendered":"Rcifax"},"content":{"rendered":"

<\/p>\n

\n

\u26a1 Rychl\u00e1 odpov\u011b\u010f \u2014 Co je Rcifax?<\/h3>\n

Rcifax<\/strong> je rifaximin 400 mg nebo 550 mg<\/strong> \u2014 neabsorbovateln\u00e9 rifamycinov\u00e9 antibiotikum p\u016fsob\u00edc\u00ed t\u00e9m\u011b\u0159 v\u00fdhradn\u011b v lumen st\u0159eva. T\u0159i schv\u00e1len\u00e9 indikace: cestovatelsk\u00fd pr\u016fjem (neinvazivn\u00ed E. coli), prevence manifestn\u00ed hepatick\u00e9 encefalopatie p\u0159i cirh\u00f3ze a IBS-D (dr\u00e1\u017ediv\u00fd tra\u010dn\u00edk s p\u0159evahou pr\u016fjm\u016f)<\/strong>. M\u00e9n\u011b ne\u017e 0,4 % peror\u00e1ln\u00ed d\u00e1vky je syst\u00e9mov\u011b absorbov\u00e1no, tak\u017ee ne\u017e\u00e1douc\u00ed \u00fa\u010dinky mimo st\u0159evo, l\u00e9kov\u00e9 interakce a tlak na rezistenci komenz\u00e1ln\u00edch bakteri\u00ed jsou minim\u00e1ln\u00ed. V\u00fdrobce certifikovan\u00fd WHO-GMP.<\/p>\n<\/div>\n

Pro\u010d objedn\u00e1vat z MedsBase:<\/strong> \u2714 v\u00fdrobce certifikovan\u00e9ho WHO-GMP<\/strong> \u2714 Diskr\u00e9tn\u00ed balen\u00ed \u2714 Celosv\u011btov\u00e1 doprava \u2714 Ov\u011b\u0159en\u00e9 recenze z\u00e1kazn\u00edk\u016f (1 400+ z\u00e1kazn\u00edk\u016f)<\/a><\/div>\n

\ud83d\udce6 Ka\u017ed\u00e1 objedn\u00e1vka je pokryta na\u0161\u00ed Z\u00e1rukou op\u011btovn\u00e9ho odesl\u00e1n\u00ed<\/strong><\/a> \u2014 pokud va\u0161e z\u00e1silka nedoraz\u00ed do 20 pracovn\u00edch dn\u016f, p\u0159epos\u00edl\u00e1me ji.<\/p>\n

Pro\u010d objedn\u00e1vat z MedsBase<\/h3>\n

Na\u0161e generick\u00e9 l\u00e9ky poch\u00e1zej\u00ed od v\u00fdrobc\u016f certifikovan\u00fdch WHO-GMP a jsou expedov\u00e1ny po cel\u00e9m sv\u011bt\u011b v diskr\u00e9tn\u00edm, nen\u00e1padn\u00e9m balen\u00ed \u2013 na vn\u011bj\u0161\u00ed stran\u011b bal\u00edku nen\u00ed uveden n\u00e1zev l\u00e9ku. Platby kartou jsou sm\u011brov\u00e1ny prost\u0159ednictv\u00edm regulovan\u00e9ho procesoru (popisky na v\u00fdpisu zahrnuj\u00ed regulovan\u00e9ho procesora plateb kartou \u2013 nikdy \u201cMedsBase\u201d nebo n\u00e1zev l\u00e9ku). P\u0159ij\u00edm\u00e1me tak\u00e9 kryptom\u011bny a bankovn\u00ed p\u0159evody SEPA. Ka\u017ed\u00e1 objedn\u00e1vka je zaji\u0161t\u011bna na\u0161\u00ed politikou p\u0159eposl\u00e1n\u00ed.<\/p>\n

\ud83d\udca1 Pro\u010d \u201cst\u0159evn\u011b selektivn\u00ed\u201d?<\/strong> Rifaximin je strukturn\u00ed analog rifamycinu SV s p\u0159\u00eddavn\u00fdm pyridoimidazolov\u00fdm kruhem, kter\u00fd zabra\u0148uje st\u0159evn\u00ed absorpci. L\u00e1tka tedy dosahuje velmi vysok\u00fdch koncentrac\u00ed v lumen st\u0159eva, ale nevstupuje do syst\u00e9mov\u00e9ho ob\u011bhu ve v\u00fdznamn\u00e9m mno\u017estv\u00ed. To vysv\u011btluje jej\u00ed bezpe\u010dnostn\u00ed profil a preferen\u010dn\u00ed \u00fa\u010dinek na enterick\u00e9 bakterie.<\/div>\n

Pro\u010d objedn\u00e1vat z MedsBase<\/h3>\n

Rcifax je dod\u00e1v\u00e1n od v\u00fdrobce certifikovan\u00e9ho WHO-GMP<\/strong>. Ka\u017ed\u00e1 objedn\u00e1vka je diskr\u00e9tn\u011b zas\u00edl\u00e1na po cel\u00e9m sv\u011bt\u011b a je pokryta na\u0161\u00ed Z\u00e1rukou op\u011btovn\u00e9ho odesl\u00e1n\u00ed<\/a> \u2014 pokud nedoraz\u00ed do 20 pracovn\u00edch dn\u016f, p\u0159epos\u00edl\u00e1me zdarma. Rifaximin je doporu\u010den AASLD 2021 pro prevenci hepatick\u00e9 encefalopatie a ACG 2021 pro cestovatelsk\u00fd pr\u016fjem a IBS-D \u2014 jedno z m\u00e1la antibiotik s pevnou evidenc\u00ed u funk\u010dn\u00edch GI poruch.<\/p>\n

Mechanismus \u00fa\u010dinku<\/h2>\n

Rifaximin se v\u00e1\u017ee na \u03b2-podjednotku bakteri\u00e1ln\u00ed DNA-dependentn\u00ed RNA polymer\u00e1zy (rpoB), \u010d\u00edm\u017e inhibuje synt\u00e9zu bakteri\u00e1ln\u00ed RNA. Spektrum pokr\u00fdv\u00e1 grampozitivn\u00ed a gramnegativn\u00ed aeroby i anaeroby v\u010detn\u011b E. coli, Shigella, Salmonella, Campylobacter a mnoha enterick\u00fdch anaerob\u016f. Proto\u017ee absorpce je < 0,4 % peror\u00e1ln\u00ed d\u00e1vky, l\u00e9k \u00fa\u010dinkuje efektivn\u011b pouze na intralumin\u00e1ln\u00ed organismy.<\/p>\n

Indikace & d\u00e1vkov\u00e1n\u00ed<\/h2>\n\n\n\n\n\n\n\n\n\n
Indikace<\/th>\nD\u00e1vka<\/th>\nD\u00e9lka<\/th>\n<\/tr>\n<\/thead>\n
Cestovatelsk\u00fd pr\u016fjem (neinvazivn\u00ed)<\/td>\n200\u2013400 mg t\u0159ikr\u00e1t denn\u011b<\/td>\n3 dny<\/td>\n<\/tr>\n
Hepatick\u00e1 encefalopatie \u2014 prevence<\/td>\n550 mg dvakr\u00e1t denn\u011b<\/td>\nDlouhodob\u011b, s laktul\u00f3zou<\/td>\n<\/tr>\n
IBS-D<\/td>\n550 mg t\u0159ikr\u00e1t denn\u011b<\/td>\n14 dn\u00ed; lze opakovat a\u017e 2\u00d7 p\u0159i recidiv\u011b p\u0159\u00edznak\u016f<\/td>\n<\/tr>\n
Bakteri\u00e1ln\u00ed p\u0159er\u016fst\u00e1n\u00ed v tenk\u00e9m st\u0159ev\u011b (SIBO)<\/td>\n550 mg t\u0159ikr\u00e1t denn\u011b<\/td>\n14 dn\u00ed (mimo schv\u00e1len\u00e9 indikace)<\/td>\n<\/tr>\n
Divertikulitida (m\u00edrn\u00e1)<\/td>\n400 mg dvakr\u00e1t denn\u011b<\/td>\n7 dn\u00ed (mimo schv\u00e1len\u00e9 indikace, s dietou)<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Kdy NEN\u00cd vhodn\u00fd l\u00e9k<\/h2>\n