{"id":60357,"date":"2024-02-28T06:45:27","date_gmt":"2024-02-28T06:45:27","guid":{"rendered":"https:\/\/medsname.com\/rcifax\/"},"modified":"2026-04-30T10:23:48","modified_gmt":"2026-04-30T10:23:48","slug":"rcifax","status":"publish","type":"product","link":"https:\/\/medsbase.com\/cs\/product\/rcifax\/","title":{"rendered":"Rcifax"},"content":{"rendered":"<p><!-- medsbase-tldr-answer --><\/p>\n<div style=\"background:#fff8e1;border-left:4px solid #f5a623;padding:18px 22px;margin:0 0 24px 0;border-radius:4px;\">\n<h3 class=\"wp-block-heading\" style=\"margin:0 0 8px 0;font-size:16px;font-weight:700;\">&#9889; Quick Answer &mdash; What is Rcifax?<\/h3>\n<p style=\"margin:0;\"><strong>Rcifax<\/strong> je <strong>rifaximin 400 mg or 550 mg<\/strong> &mdash; a non-absorbable rifamycin antibiotic that acts almost entirely within the gut lumen. Three validated indications: <strong>traveller&#8217;s diarrhoea (non-invasive E. coli), prevention of overt hepatic encephalopathy in cirrhosis, and IBS-D (diarrhoea-predominant irritable bowel)<\/strong>. Less than 0.4 percent of an oral dose is absorbed systemically, so off-target side effects, drug interactions, and resistance pressure on commensal bacteria are minimal. WHO-GMP certified manufacturer.<\/p>\n<\/div>\n<div class=\"medsbase-trust-strip\" style=\"background:#f5f6f8;border:1px solid #e1e4e8;border-radius:6px;padding:14px 18px;margin:24px 0;font-size:14px;\"><strong>Pro\u010d objedn\u00e1vat z MedsBase:<\/strong> \u2714 <strong>v\u00fdrobce certifikovan\u00e9ho WHO-GMP<\/strong> \u2714 Diskr\u00e9tn\u00ed balen\u00ed \u2714 Celosv\u011btov\u00e1 doprava \u2714 <a href=\"https:\/\/medsbase.com\/cs\/reviews\/\">Ov\u011b\u0159en\u00e9 recenze z\u00e1kazn\u00edk\u016f (1 400+ z\u00e1kazn\u00edk\u016f)<\/a><\/div>\n<p class=\"medsbase-reship-line\" style=\"font-size:14px;color:#444;margin:8px 0 18px;\">\ud83d\udce6 Ka\u017ed\u00e1 objedn\u00e1vka je pokryta na\u0161\u00ed <a href=\"https:\/\/medsbase.com\/cs\/medsbase-re-shipment-assurance-policy\/\"><strong>Z\u00e1rukou op\u011btovn\u00e9ho odesl\u00e1n\u00ed<\/strong><\/a> \u2014 pokud va\u0161e z\u00e1silka nedoraz\u00ed do 20 pracovn\u00edch dn\u016f, p\u0159epos\u00edl\u00e1me ji.<\/p>\n<h3>Pro\u010d objedn\u00e1vat z MedsBase<\/h3>\n<p>Na\u0161e generick\u00e9 l\u00e9ky poch\u00e1zej\u00ed od v\u00fdrobc\u016f certifikovan\u00fdch WHO-GMP a jsou expedov\u00e1ny po cel\u00e9m sv\u011bt\u011b v diskr\u00e9tn\u00edm, nen\u00e1padn\u00e9m balen\u00ed \u2013 na vn\u011bj\u0161\u00ed stran\u011b bal\u00edku nen\u00ed uveden n\u00e1zev l\u00e9ku. Platby kartou jsou sm\u011brov\u00e1ny prost\u0159ednictv\u00edm regulovan\u00e9ho procesoru (popisky na v\u00fdpisu zahrnuj\u00ed regulovan\u00e9ho procesora plateb kartou \u2013 nikdy \u201cMedsBase\u201d nebo n\u00e1zev l\u00e9ku). P\u0159ij\u00edm\u00e1me tak\u00e9 kryptom\u011bny a bankovn\u00ed p\u0159evody SEPA. Ka\u017ed\u00e1 objedn\u00e1vka je zaji\u0161t\u011bna na\u0161\u00ed politikou p\u0159eposl\u00e1n\u00ed.<\/p>\n<div style=\"background:#f4f8fb;border-left:4px solid #2c7cb0;padding:14px 18px;margin:18px 0;border-radius:4px;\"><strong>&#128161; Why &#8220;gut-selective&#8221;?<\/strong> Rifaximin is a structural analogue of rifamycin SV with an additional pyridoimidazole ring that prevents intestinal absorption. The compound therefore reaches very high concentrations in the gut lumen but does not enter the systemic circulation in significant amounts. This explains its safety profile and its preferential effect on enteric bacteria.<\/div>\n<h3 class=\"wp-block-heading\">Pro\u010d objedn\u00e1vat z MedsBase<\/h3>\n<p>Rcifax is supplied from a <strong>v\u00fdrobce certifikovan\u00e9ho WHO-GMP<\/strong>. Ka\u017ed\u00e1 objedn\u00e1vka je diskr\u00e9tn\u011b zas\u00edl\u00e1na po cel\u00e9m sv\u011bt\u011b a je pokryta na\u0161\u00ed <a href=\"https:\/\/medsbase.com\/cs\/medsbase-re-shipment-assurance-policy\/\">Z\u00e1rukou op\u011btovn\u00e9ho odesl\u00e1n\u00ed<\/a> &mdash; if it does not arrive within 20 business days, we reship at no cost. Rifaximin is endorsed by AASLD 2021 for hepatic encephalopathy prevention and by ACG 2021 for traveller&#8217;s diarrhoea and IBS-D &mdash; one of the few antibiotics with strong evidence in functional GI disorders.<\/p>\n<h2 class=\"wp-block-heading\">Mechanismus \u00fa\u010dinku<\/h2>\n<p>Rifaximin binds the &beta;-subunit of bacterial DNA-dependent RNA polymerase (rpoB), inhibiting bacterial RNA synthesis. Spectrum covers Gram-positive and Gram-negative aerobes and anaerobes including E. coli, Shigella, Salmonella, Campylobacter, and many enteric anaerobes. Because absorption is &lt; 0.4 percent of the oral dose, the drug acts effectively only on intra-luminal organisms.<\/p>\n<h2 class=\"wp-block-heading\">Indications &amp; doses<\/h2>\n<table border=\"1\" cellpadding=\"6\" style=\"border-collapse:collapse;width:100%;\">\n<thead>\n<tr style=\"background:#2c7cb0;color:#fff;\">\n<th>Indikace<\/th>\n<th>D\u00e1vka<\/th>\n<th>D\u00e9lka<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td>Traveller&#8217;s diarrhoea (non-invasive)<\/td>\n<td>200&ndash;400 mg three times daily<\/td>\n<td>3 dny<\/td>\n<\/tr>\n<tr style=\"background:#f9f9f9;\">\n<td>Hepatic encephalopathy &mdash; prevention<\/td>\n<td>550 mg twice daily<\/td>\n<td>Long-term, with lactulose<\/td>\n<\/tr>\n<tr>\n<td>IBS-D<\/td>\n<td>550 mg three times daily<\/td>\n<td>14 days; can be re-dosed up to 2 more times if symptoms recur<\/td>\n<\/tr>\n<tr style=\"background:#f9f9f9;\">\n<td>Small-intestinal bacterial overgrowth (SIBO)<\/td>\n<td>550 mg three times daily<\/td>\n<td>14 days (off-label)<\/td>\n<\/tr>\n<tr>\n<td>Diverticulitis (mild)<\/td>\n<td>400 mg dvakr\u00e1t denn\u011b<\/td>\n<td>7 days (off-label, with diet)<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2 class=\"wp-block-heading\">When it is NOT the right drug<\/h2>\n<ul>\n<li>Invasive enteric infection (fever, bloody stool, severe systemic illness) &mdash; needs ciprofloxacin or azithromycin systemically.<\/li>\n<li>Pseudomembranous colitis (C. difficile) &mdash; oral vancomycin or fidaxomicin is first-line; rifaximin has limited evidence as a relapse-prevention adjunct.<\/li>\n<li>Suspected typhoid &mdash; needs systemic antibiotic.<\/li>\n<li>Suspected appendicitis \/ cholangitis \/ pyelonephritis &mdash; needs systemic.<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Vedlej\u0161\u00ed \u00fa\u010dinky<\/h2>\n<ul>\n<li>Gastrointestinal: nausea, abdominal pain, flatulence (mostly mild)<\/li>\n<li>Bolest hlavy, z\u00e1vrat\u011b<\/li>\n<li>Peripheral oedema (with HE-prevention long courses)<\/li>\n<li>C. difficile-associated diarrhoea (rare; the gut-selective profile reduces but does not eliminate this risk)<\/li>\n<li>Hypersensitivity reactions (rare): rash, urticaria, anaphylaxis<\/li>\n<li>Cross-reactivity with rifampicin\/rifabutin in patients with rifamycin allergy<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Interakce l\u00e9k\u016f<\/h2>\n<p>Rifaximin&#8217;s very low systemic absorption means clinically significant interactions are unusual. However:<\/p>\n<ul>\n<li><strong>P-gp inhibitors<\/strong> (cyclosporin) raise the small absorbed fraction.<\/li>\n<li><strong>Warfarin:<\/strong> isolated reports of INR change &mdash; check INR if used concurrently.<\/li>\n<li><strong>Kombinovan\u00e1 hormon\u00e1ln\u00ed antikoncepce:<\/strong> oral contraceptive efficacy is theoretically reduced if rifaximin causes severe diarrhoea (transit time effect).<\/li>\n<\/ul>\n<h2 id=\"faqs\">\u010casto kladen\u00e9 dotazy<\/h2>\n<h3 class=\"wp-block-heading\">How quickly does it work in traveller&#8217;s diarrhoea?<\/h3>\n<p>Symptom improvement is usually within 24&ndash;48 hours. The 3-day course is sufficient for non-invasive E. coli, the most common cause. If symptoms are severe (fever, bloody stool) or do not improve in 48 hours, change to systemic antibiotic.<\/p>\n<h3 class=\"wp-block-heading\">Does it cure IBS?<\/h3>\n<p>No. Rifaximin reduces IBS-D symptoms in about 40 percent of patients; benefit lasts 10&ndash;12 weeks. It can be repeated if symptoms recur. It is not a cure but a useful symptomatic intervention.<\/p>\n<h3 class=\"wp-block-heading\">Why do I need lactulose with it for hepatic encephalopathy?<\/h3>\n<p>Lactulose acidifies the colon and ion-traps ammonia. Rifaximin reduces ammonia-producing bacteria. The two work synergistically; combination therapy reduces HE recurrence by ~60 percent versus lactulose alone.<\/p>\n<h3 class=\"wp-block-heading\">M\u016f\u017eu p\u0159i u\u017e\u00edv\u00e1n\u00ed p\u00edt alkohol?<\/h3>\n<p>There is no disulfiram-like interaction. However, traveller&#8217;s diarrhoea recovery and HE prevention both benefit from minimal alcohol intake.<\/p>\n<h3 class=\"wp-block-heading\">Je bezpe\u010dn\u00fd v t\u011bhotenstv\u00ed?<\/h3>\n<p>Category C. Used in pregnancy when the indication justifies it (HE in pregnant cirrhotic) under specialist advice. Discuss with obstetric prescriber.<\/p>\n<h3 class=\"wp-block-heading\">How is it different from rifampicin?<\/h3>\n<p>Same drug-class binding target but rifampicin is highly absorbed (oral bioavailability ~90 percent) and used systemically for tuberculosis, leprosy, and meningococcal prophylaxis &mdash; with significant CYP3A4\/2C19 induction and CYP-driven interactions. Rifaximin is gut-restricted with negligible systemic effect.<\/p>\n<h3 class=\"wp-block-heading\">Will it disrupt my normal gut bacteria?<\/h3>\n<p>Yes, but transiently. The gut microbiome typically recovers within 2&ndash;4 weeks. Probiotics during and after the course may shorten recovery (modest evidence).<\/p>\n<h3 class=\"wp-block-heading\">Is resistance a concern?<\/h3>\n<p>Rifaximin resistance can develop in enteric bacteria with repeated courses but the impact on systemic rifamycin use (rifampicin for TB, rifabutin for HIV) is limited because rifaximin is not used systemically. Still, avoid casual repeat courses.<\/p>\n<h3 class=\"wp-block-heading\">Skladov\u00e1n\u00ed<\/h3>\n<p>Below 30&deg;C, dry place. Keep blister sealed until use.<\/p>\n<h3 class=\"wp-block-heading\">Co kdy\u017e vynech\u00e1m d\u00e1vku?<\/h3>\n<p>Take it as soon as you remember unless close to the next dose. Do not double up. Try to keep the schedule consistent.<\/p>\n<p><!-- medsbase-related-alts-v1 --><\/p>\n<h3 class=\"wp-block-heading\">Dal\u0161\u00ed l\u00e9ky na za\u017e\u00edvac\u00ed pot\u00ed\u017ee<\/h3>\n<ul>\n<li><a href=\"https:\/\/medsbase.com\/cs\/rifagut\/\">Rifagut &mdash; Rifaximin (alternate brand)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/ciplox\/\">Ciplox &mdash; Ciprofloxacin (systemic option for invasive enteric infection)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/synclar\/\">Synclar \u2014 Clarithromycin (H. pylori)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/cendox\/\">Cendox \u2014 Doxycycline<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/colospa\/\">Colospa \u2014 Mebeverin (antispasmodikum pro IBS)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/gastro-health\/\"><strong>Prohl\u00e9dnout v\u0161echny l\u00e9ky na za\u017e\u00edvac\u00ed pot\u00ed\u017ee<\/strong><\/a><\/li>\n<\/ul>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:16px 20px;margin:24px 0;border-radius:4px;\"><strong>\u2695 L\u00e9ka\u0159sk\u00e9 upozorn\u011bn\u00ed.<\/strong> This page is for informational purposes only and does not replace medical advice from a qualified healthcare professional. Bloody stool, high fever, severe abdominal pain, dehydration, or no improvement in 48 hours needs urgent assessment. Hepatic encephalopathy is a medical emergency.<\/div>","protected":false},"excerpt":{"rendered":"<p>Rcifax (Rifaximin 400 mg or 550 mg) \u2014 non-absorbable rifamycin for traveller&#8217;s diarrhoea, hepatic encephalopathy prevention, and IBS-D. Less than 0.4 percent systemic absorption. WHO-GMP certified manufacturer. Worldwide shipping from MedsBase.<\/p>","protected":false},"featured_media":60358,"comment_status":"open","ping_status":"open","template":"","meta":[],"product_brand":[],"product_cat":[3141,3542,3342],"product_tag":[4850,3585],"class_list":{"0":"post-60357","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-category-overview","7":"product_cat-gastro-health","8":"product_cat-general-health","9":"product_tag-rcifax","10":"product_tag-rifaximin","12":"first","13":"instock","14":"shipping-taxable","15":"purchasable","16":"product-type-variable","17":"has-default-attributes"},"acf":[],"_links":{"self":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product\/60357","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/comments?post=60357"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/media\/60358"}],"wp:attachment":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/media?parent=60357"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product_brand?post=60357"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product_cat?post=60357"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product_tag?post=60357"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}