{"id":60451,"date":"2024-02-28T06:49:25","date_gmt":"2024-02-28T06:49:25","guid":{"rendered":"https:\/\/medsname.com\/xarelto-20\/"},"modified":"2026-05-01T10:49:16","modified_gmt":"2026-05-01T10:49:16","slug":"xarelto-20","status":"publish","type":"product","link":"https:\/\/medsbase.com\/cs\/product\/xarelto-20\/","title":{"rendered":"Sluch\u00e1tka"},"content":{"rendered":"<p><!-- medsbase-tldr-answer --><\/p>\n<div style=\"background:#fff8e1;border-left:4px solid #f5a623;padding:18px 22px;margin:0 0 24px 0;border-radius:4px;\">\n<h3 class=\"wp-block-heading\" style=\"margin:0 0 8px 0;font-size:16px;font-weight:700;\">&#9889; Quick Answer &mdash; What is Xarelto 20?<\/h3>\n<p style=\"margin:0;\"><strong>Sluch\u00e1tka<\/strong> is 20 mg rivaroxaban tablets from Bayer &mdash; direct oral anticoagulant (DOAC) &mdash; direct factor Xa inhibitor. Rivaroxaban was introduced by Bayer in 2008 as <strong>Xarelto<\/strong> &mdash; the first oral direct factor Xa inhibitor. ROCKET-AF (2011) and EINSTEIN-DVT\/PE (2010) established non-inferiority to warfarin in AF and VTE. directly inhibits factor Xa, the central convergence point of intrinsic and extrinsic coagulation cascades, reducing thrombin generation. 5-13 hour half-life; renally and hepatically cleared. Dosing: <strong>Non-valvular AF:<\/strong> 20 mg once daily with food (15 mg if CrCl 15-50 mL\/min). <strong>DVT\/PE treatment:<\/strong> 15 mg twice daily for 3 weeks then 20 mg once daily. <strong>COMPASS vascular prophylaxis:<\/strong> 2.5 mg twice daily with aspirin 75-100 mg daily. Major bleeding ~3-5%\/year in AF; GI bleeding somewhat higher than warfarin. No routine monitoring unlike warfarin &mdash; a major practical advantage. Reversal with andexanet alfa (specific antidote) where available, or 4-factor prothrombin complex concentrate. Anticoagulant and antiplatelet selection is individualised to diagnosis, bleeding risk, renal function, and drug interactions. Specialist or family-physician supervision is standard.<\/p>\n<\/div>\n<div class=\"medsbase-trust-strip\" style=\"background:#f4f8fb;border:1px solid #d8e3eb;padding:12px 16px;margin:16px 0;border-radius:4px;font-size:14px;\">\n<strong>Co z\u00edsk\u00e1te s MedsBase:<\/strong> V\u00fdrobce certifikovan\u00fd WHO-GMP \u00b7 Diskr\u00e9tn\u00ed balen\u00ed \u00b7 Celosv\u011btov\u00e1 doprava \u00b7 V\u00edce ne\u017e 1 400 ov\u011b\u0159en\u00fdch <a href=\"https:\/\/medsbase.com\/cs\/reviews\/\">recenz\u00ed z\u00e1kazn\u00edk\u016f<\/a>\n<\/div>\n<p class=\"medsbase-reship-line\" style=\"font-size:14px;color:#444;margin:8px 0 18px;\">\ud83d\udce6 Ka\u017ed\u00e1 objedn\u00e1vka je pokryta na\u0161\u00ed <a href=\"https:\/\/medsbase.com\/cs\/medsbase-re-shipment-assurance-policy\/\"><strong>Z\u00e1rukou op\u011btovn\u00e9ho odesl\u00e1n\u00ed<\/strong><\/a> \u2014 pokud va\u0161e z\u00e1silka nedoraz\u00ed do 20 pracovn\u00edch dn\u016f, p\u0159epos\u00edl\u00e1me ji.<\/p>\n<h3>Pro\u010d objedn\u00e1vat z MedsBase<\/h3>\n<p>Na\u0161e generick\u00e9 l\u00e9ky poch\u00e1zej\u00ed od v\u00fdrobc\u016f certifikovan\u00fdch WHO-GMP a jsou expedov\u00e1ny po cel\u00e9m sv\u011bt\u011b v diskr\u00e9tn\u00edm, nen\u00e1padn\u00e9m balen\u00ed \u2013 na vn\u011bj\u0161\u00ed stran\u011b bal\u00edku nen\u00ed uveden n\u00e1zev l\u00e9ku. Platby kartou jsou sm\u011brov\u00e1ny prost\u0159ednictv\u00edm regulovan\u00e9ho procesoru (popisky na v\u00fdpisu zahrnuj\u00ed regulovan\u00e9ho procesora plateb kartou \u2013 nikdy \u201cMedsBase\u201d nebo n\u00e1zev l\u00e9ku). P\u0159ij\u00edm\u00e1me tak\u00e9 kryptom\u011bny a bankovn\u00ed p\u0159evody SEPA. Ka\u017ed\u00e1 objedn\u00e1vka je zaji\u0161t\u011bna na\u0161\u00ed politikou p\u0159eposl\u00e1n\u00ed.<\/p>\n<h2 class=\"wp-block-heading\">What Is Xarelto 20?<\/h2>\n<p>Xarelto 20 is 20 mg rivaroxaban tablets from Bayer, supplied in 14-112 tablets. Rivaroxaban was introduced by Bayer in 2008 as <strong>Xarelto<\/strong> &mdash; the first oral direct factor Xa inhibitor. ROCKET-AF (2011) and EINSTEIN-DVT\/PE (2010) established non-inferiority to warfarin in AF and VTE.<\/p>\n<h2 class=\"wp-block-heading\">How Rivaroxaban Works<\/h2>\n<p>Rivaroxaban directly inhibits factor Xa, the central convergence point of intrinsic and extrinsic coagulation cascades, reducing thrombin generation. 5-13 hour half-life; renally and hepatically cleared.<\/p>\n<h2 class=\"wp-block-heading\">Schv\u00e1len\u00e9 indikace<\/h2>\n<ul>\n<li><strong>Nevalvul\u00e1rn\u00ed fibrilace s\u00edn\u00ed<\/strong> &mdash; stroke prevention (ROCKET-AF)<\/li>\n<li><strong>Deep vein thrombosis and pulmonary embolism<\/strong> &mdash; treatment (EINSTEIN trials) and extended prophylaxis<\/li>\n<li><strong>VTE prophylaxis<\/strong> after major orthopaedic surgery<\/li>\n<li><strong>Stable coronary or peripheral arterial disease<\/strong> &mdash; 2.5 mg twice daily + aspirin (COMPASS 2017) for atherothrombotic prevention in high-risk patients<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">D\u00e1vkov\u00e1n\u00ed<\/h2>\n<p><strong>Non-valvular AF:<\/strong> 20 mg once daily with food (15 mg if CrCl 15-50 mL\/min). <strong>DVT\/PE treatment:<\/strong> 15 mg twice daily for 3 weeks then 20 mg once daily. <strong>COMPASS vascular prophylaxis:<\/strong> 2.5 mg twice daily with aspirin 75-100 mg daily.<\/p>\n<h2 class=\"wp-block-heading\">Riziko krv\u00e1cen\u00ed a monitorov\u00e1n\u00ed<\/h2>\n<p>Major bleeding ~3-5%\/year in AF; GI bleeding somewhat higher than warfarin. No routine monitoring unlike warfarin &mdash; a major practical advantage. Reversal with andexanet alfa (specific antidote) where available, or 4-factor prothrombin complex concentrate.<\/p>\n<p><strong>No routine blood monitoring required<\/strong> &mdash; a major practical advantage over warfarin. Check renal function at baseline, 3 months, then annually (or sooner in acute illness or 75+ years). No dietary restrictions. Missed doses: take if within 6 hours of scheduled dose; otherwise skip &mdash; do not double up.<\/p>\n<h2 class=\"wp-block-heading\">Vedlej\u0161\u00ed \u00fa\u010dinky<\/h2>\n<ul>\n<li>Major bleeding (~3-5%\/year in AF)<\/li>\n<li>GI bleeding (higher than apixaban, slightly higher than warfarin)<\/li>\n<li>An\u00e9mie<\/li>\n<li>Minor bleeding (epistaxis, bruising)<\/li>\n<li>Hepatotoxicita (vz\u00e1cn\u011b)<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Kontraindikace<\/h2>\n<ul>\n<li>Aktivn\u00ed patologick\u00e9 krv\u00e1cen\u00ed<\/li>\n<li>Severe renal impairment (CrCl &lt;15 mL\/min)<\/li>\n<li>T\u011b\u017ek\u00e1 jatern\u00ed porucha (Child-Pugh B nebo C)<\/li>\n<li>Mechanical heart valve (use warfarin)<\/li>\n<li>Moderate-to-severe mitral stenosis<\/li>\n<li>Pregnancy (crosses placenta; use heparin \/ warfarin)<\/li>\n<li>Concurrent strong dual inhibitors of CYP3A4 + P-gp (azole antifungals, HIV protease inhibitors)<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Interakce s l\u00e9\u010divy<\/h2>\n<ul>\n<li><strong>Strong CYP3A4 + P-gp dual inhibitors &mdash; CRITICAL.<\/strong> Azole antifungals (ketoconazole, itraconazole), HIV protease inhibitors, clarithromycin &mdash; substantially raise rivaroxaban levels; contraindicated.<\/li>\n<li><strong>Siln\u00e9 induktory CYP3A4 + P-gp<\/strong> (rifampicin, phenytoin, carbamazepine, St John&#8217;s Wort) &mdash; lower levels; avoid or monitor closely.<\/li>\n<li><strong>Other anticoagulants, heparins<\/strong> &mdash; do not combine except in specific bridging situations under specialist supervision.<\/li>\n<li><strong>NSAIDs, antiplatelets<\/strong> \u2014 zv\u00fd\u0161en\u00e9 riziko krv\u00e1cen\u00ed.<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Skladov\u00e1n\u00ed<\/h2>\n<p>Store Xarelto 20 below 25&deg;C. Keep out of reach of children.<\/p>\n<h2 id=\"faqs\">\u010casto kladen\u00e9 dotazy<\/h2>\n<h3 class=\"wp-block-heading\">Do I need blood tests on Xarelto 20?<\/h3>\n<p>No routine blood tests for efficacy. Check renal function annually.<\/p>\n<h3 class=\"wp-block-heading\">What should I do if I cut myself while on Xarelto 20?<\/h3>\n<p>P\u0159ilo\u017ete pevn\u00fd p\u0159\u00edm\u00fd tlak po dobu 15-20 minut bez kontroly. V\u011bt\u0161ina drobn\u00fdch \u0159ez\u016f se norm\u00e1ln\u011b zastav\u00ed; krv\u00e1cen\u00ed trvaj\u00edc\u00ed d\u00e9le ne\u017e 20 minut nebo prosakuj\u00edc\u00ed p\u0159es v\u00edce obvaz\u016f vy\u017eaduje neodkladn\u00e9 l\u00e9ka\u0159sk\u00e9 vy\u0161et\u0159en\u00ed. Nahlaste jakoukoli \u010dernou nebo krvavou stolici, jasn\u011b \u010derven\u00e9 rekt\u00e1ln\u00ed krv\u00e1cen\u00ed, hematurii, nevysv\u011btliteln\u00e9 mod\u0159iny, krv\u00e1cen\u00ed z nosu trvaj\u00edc\u00ed d\u00e9le ne\u017e 15 minut nebo menstrua\u010dn\u00ed krv\u00e1cen\u00ed v\u00fdrazn\u011b siln\u011bj\u0161\u00ed ne\u017e obvykle.<\/p>\n<h3 class=\"wp-block-heading\">Can I take Xarelto 20 in pregnancy?<\/h3>\n<p>No &mdash; crosses placenta; DOACs are contraindicated in pregnancy. Use LMWH.<\/p>\n<h3 class=\"wp-block-heading\">Co kdy\u017e pot\u0159ebuji operaci?<\/h3>\n<p>Inform the surgical team well in advance. Rivaroxaban stopped 24-48 hours before surgery depending on bleeding risk and renal function.<\/p>\n<h3 class=\"wp-block-heading\">Where can I buy Xarelto 20 online?<\/h3>\n<p>You can buy Xarelto 20 (rivaroxaban 20 mg, 14-112 tablets) from MedsBase with discreet packaging and worldwide shipping.<\/p>\n<h2 class=\"wp-block-heading\">Souvisej\u00edc\u00ed kardiovaskul\u00e1rn\u00ed l\u00e9ky<\/h2>\n<ul>\n<li><a href=\"https:\/\/medsbase.com\/cs\/aldactone\/\">Aldactone \u2014 Spironolakton<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/cordarone\/\">Cordarone \u2014 Amiodarone 100\/200 mg<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/ivabrad\/\">Ivabrad \u2014 Ivabradine 7,5 mg<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/lonitab\/\">Lonitab \u2014 Minoxidil 5 mg (or\u00e1ln\u00ed vazodilat\u00e1tor)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/rioci-1\/\">Rioci 1 \u2014 Riociguat 1 mg (stimul\u00e1tor sGC pro PAH)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/vymada\/\">Vymada \u2014 Sacubitril\/Valsartan ARNI<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/high-blood-pressure-medication\/\"><strong>Prohl\u00e9dnout v\u0161echny l\u00e9ky na vysok\u00fd krevn\u00ed tlak<\/strong><\/a><\/li>\n<\/ul>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:16px 20px;margin:24px 0;border-radius:4px;\"><strong>\u2695 L\u00e9ka\u0159sk\u00e9 upozorn\u011bn\u00ed.<\/strong> Tato str\u00e1nka slou\u017e\u00ed pouze pro informa\u010dn\u00ed \u00fa\u010dely a nenahrazuje l\u00e9ka\u0159skou p\u00e9\u010di kvalifikovan\u00e9ho zdravotnick\u00e9ho pracovn\u00edka. Hypertenze, srde\u010dn\u00ed selh\u00e1n\u00ed a arytmie vy\u017eaduj\u00ed diagn\u00f3zu, monitorov\u00e1n\u00ed a individu\u00e1ln\u00ed d\u00e1vkov\u00e1n\u00ed l\u00e9ka\u0159em \u2014 v\u017edy u\u017e\u00edvejte betablok\u00e1tory pod l\u00e9ka\u0159sk\u00fdm dohledem.<\/div>\n<p><!-- medsbase-related-alts-v1 --><\/p>\n<h3 class=\"wp-block-heading\">Souvisej\u00edc\u00ed alternativy<\/h3>\n<p>Dal\u0161\u00ed produkty v <strong>Chronick\u00e1 onemocn\u011bn\u00ed<\/strong> kter\u00e9 z\u00e1kazn\u00edci tak\u00e9 prohl\u00ed\u017eej\u00ed:<\/p>\n<ul>\n<li><a href=\"https:\/\/medsbase.com\/cs\/ivrea-shampoo\/\">Ivrea Shampoo<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/rosu-hdl\/\">Rozucor<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/tiova-rotacaps\/\">Tiova Rotacaps<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/glynase-xl\/\">Glynase Xl<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/trajenta-duo\/\">Trajenta Duo<\/a><\/li>\n<\/ul>","protected":false},"excerpt":{"rendered":"<p>Xarelto 20 is Bayer&#8217;s rivaroxaban 20 mg tablets \u2014 the first oral direct factor Xa inhibitor. ROCKET-AF (2011) non-inferior to warfarin in non-valvular AF; EINSTEIN-DVT\/PE (2010) established single-drug treatment for VTE. COMPASS (2017) showed 2.5 mg twice daily + aspirin reduced CV events in stable CAD\/PAD. No routine blood monitoring needed (vs warfarin INR). Contraindicated in mechanical valves, pregnancy, severe CKD. Andexanet alfa reverses in emergencies.<\/p>","protected":false},"featured_media":60452,"comment_status":"open","ping_status":"open","template":"","meta":[],"product_brand":[],"product_cat":[3635,3141,3223,3342,3260,3356],"product_tag":[4863,4864],"class_list":{"0":"post-60451","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-anti-coagulants","7":"product_cat-category-overview","8":"product_cat-chronic-conditions","9":"product_cat-general-health","10":"product_cat-heart-blood-pressure","11":"product_cat-high-blood-pressure-medication","12":"product_tag-rivaroxaban","13":"product_tag-xarelto","15":"first","16":"instock","17":"shipping-taxable","18":"purchasable","19":"product-type-variable","20":"has-default-attributes"},"acf":[],"_links":{"self":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product\/60451","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/comments?post=60451"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/media\/60452"}],"wp:attachment":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/media?parent=60451"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product_brand?post=60451"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product_cat?post=60451"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product_tag?post=60451"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}