{"id":60544,"date":"2024-02-28T06:54:27","date_gmt":"2024-02-28T06:54:27","guid":{"rendered":"https:\/\/medsname.com\/ropark\/"},"modified":"2026-05-01T10:49:16","modified_gmt":"2026-05-01T10:49:16","slug":"ropark","status":"publish","type":"product","link":"https:\/\/medsbase.com\/cs\/product\/ropark\/","title":{"rendered":"Ropark"},"content":{"rendered":"

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\u26a1 Rychl\u00e1 odpov\u011b\u010f<\/h3>\n

Ropark<\/strong> je peror\u00e1ln\u00ed ropinirol<\/strong> (0,25 \/ 0,5 \/ 1 \/ 2 mg) tableta \u2014 a neergotov\u00fd dopaminov\u00fd agonista<\/strong> pou\u017e\u00edvan\u00e1 k l\u00e9\u010db\u011b Parkinsonova choroba<\/strong> a st\u0159edn\u011b t\u011b\u017ek\u00fd a\u017e t\u011b\u017ek\u00fd syndrom neklidn\u00fdch nohou (RLS)<\/strong>. P\u0159\u00edmo stimuluje dopaminov\u00e9 receptory D2\/D3 v mozku, \u010d\u00e1ste\u010dn\u011b nahrazuje dopamin, kter\u00fd ji\u017e nen\u00ed produkov\u00e1n. Ve srovn\u00e1n\u00ed s pramipexolem m\u00e1 ropinirol vy\u0161\u0161\u00ed z\u00e1vislost na CYP1A2 (vyvarujte se kombinace s ciprofloxacinem a fluvoxaminem; kou\u0159en\u00ed sni\u017euje hladiny). Oproti bromokriptinu ne<\/em> zp\u016fsobuj\u00ed fibr\u00f3zu srde\u010dn\u00edch chlopn\u00ed. Kritick\u00e9 bezpe\u010dnostn\u00ed sign\u00e1ly:<\/strong> poruch impulzivn\u00ed kontroly<\/em> (gambling, hypersexualita, z\u00e1chvatov\u00e9 p\u0159ej\u00edd\u00e1n\u00ed, nutkav\u00e9 nakupov\u00e1n\u00ed), n\u00e1hl\u00fd n\u00e1stup sp\u00e1nku<\/em> (z\u00e1chvaty sp\u00e1nku p\u0159i \u0159\u00edzen\u00ed) a ortostatick\u00e1 hypotenze. D\u00e1vkov\u00e1n\u00ed mus\u00ed b\u00fdt pomalu zvy\u0161ov\u00e1no a postupn\u011b sni\u017eov\u00e1no \u2014 nikdy nesm\u00ed b\u00fdt n\u00e1hle p\u0159eru\u0161eno.<\/p>\n<\/div>\n

\nCo z\u00edsk\u00e1te s MedsBase:<\/strong> V\u00fdrobce certifikovan\u00fd WHO-GMP \u00b7 Diskr\u00e9tn\u00ed balen\u00ed \u00b7 Celosv\u011btov\u00e1 doprava \u00b7 V\u00edce ne\u017e 1 400 ov\u011b\u0159en\u00fdch recenz\u00ed z\u00e1kazn\u00edk\u016f<\/a>\n<\/div>\n

\ud83d\udce6 Ka\u017ed\u00e1 objedn\u00e1vka je pokryta na\u0161\u00ed Z\u00e1rukou op\u011btovn\u00e9ho odesl\u00e1n\u00ed<\/strong><\/a> \u2014 pokud va\u0161e z\u00e1silka nedoraz\u00ed do 20 pracovn\u00edch dn\u016f, p\u0159epos\u00edl\u00e1me ji.<\/p>\n

Pro\u010d objedn\u00e1vat z MedsBase<\/h3>\n

Na\u0161e generick\u00e9 l\u00e9ky poch\u00e1zej\u00ed od v\u00fdrobc\u016f certifikovan\u00fdch WHO-GMP a jsou expedov\u00e1ny po cel\u00e9m sv\u011bt\u011b v diskr\u00e9tn\u00edm, nen\u00e1padn\u00e9m balen\u00ed \u2013 na vn\u011bj\u0161\u00ed stran\u011b bal\u00edku nen\u00ed uveden n\u00e1zev l\u00e9ku. Platby kartou jsou sm\u011brov\u00e1ny prost\u0159ednictv\u00edm regulovan\u00e9ho procesoru (popisky na v\u00fdpisu zahrnuj\u00ed regulovan\u00e9ho procesora plateb kartou \u2013 nikdy \u201cMedsBase\u201d nebo n\u00e1zev l\u00e9ku). P\u0159ij\u00edm\u00e1me tak\u00e9 kryptom\u011bny a bankovn\u00ed p\u0159evody SEPA. Ka\u017ed\u00e1 objedn\u00e1vka je zaji\u0161t\u011bna na\u0161\u00ed politikou p\u0159eposl\u00e1n\u00ed.<\/p>\n

Co je to Ropark?<\/h2>\n

Ropark je peror\u00e1ln\u00ed tableta obsahuj\u00edc\u00ed ropinirol 0,25 \/ 0,5 \/ 1 \/ 2 mg<\/strong>. ropinirol je neergotov\u00fd agonista dopaminov\u00fdch receptor\u016f D2\/D3<\/strong>, p\u016fvodn\u011b uveden\u00fd jako Requip<\/strong>. Ropark je vyr\u00e1b\u011bn v za\u0159\u00edzen\u00ed certifikovan\u00e9m WHO-GMP a je bioekvivalentn\u00ed s origin\u00e1ln\u00ed zna\u010dkou ve stejn\u00e9 s\u00edle.<\/p>\n

Ropinirol je jedn\u00edm ze dvou nejpou\u017e\u00edvan\u011bj\u0161\u00edch neergotov\u00fdch agonist\u016f dopaminu (druh\u00fdm je pramipexol). Je vhodn\u00fd jako monoterapie u \u010dasn\u00e9 Parkinsonovy choroby \u2013 zejm\u00e9na u mlad\u0161\u00edch pacient\u016f, kde je \u017e\u00e1douc\u00ed odd\u00e1lit pod\u00e1v\u00e1n\u00ed levodopy, aby se p\u0159ede\u0161lo dyskinez\u00edm vyvolan\u00fdm levodopou \u2013 a jako p\u0159\u00eddatn\u00e1 l\u00e9\u010dba u pokro\u010dil\u00e9ho onemocn\u011bn\u00ed. M\u00e1 rovn\u011b\u017e samostatnou registraci pro st\u0159edn\u011b t\u011b\u017ek\u00fd a\u017e t\u011b\u017ek\u00fd syndrom neklidn\u00fdch nohou (RLS).<\/p>\n

Jak funguje Ropark (ropinirole)?<\/h2>\n

Ropinirole p\u0159\u00edmo stimuluje dopaminov\u00e9 D2 a D3 receptory (s nejvy\u0161\u0161\u00ed selektivitou pro D3) ve striatu a limbick\u00e9m syst\u00e9mu, \u010d\u00e1ste\u010dn\u011b nahrazuje chyb\u011bj\u00edc\u00ed dopamin u Parkinsonovy choroby. Vysok\u00e1 selektivita pro D3 je tak\u00e9 zodpov\u011bdn\u00e1 za siln\u00fd \u00fa\u010dinek na syndrom neklidn\u00fdch nohou. Neovliv\u0148uje serotoninov\u00e9 5-HT2B receptory, tak\u017ee na rozd\u00edl od ergotov\u00fdch agonist\u016f nezp\u016fsobuje fibr\u00f3zu srde\u010dn\u00edch chlopn\u00ed.<\/p>\n

Pro koho je Ropark ur\u010den?<\/h2>\n

Ropark je vhodn\u00fd pro dosp\u011bl\u00e9 s Parkinsonovou chorobou (monoterapie v ran\u00e9m st\u00e1diu, dopln\u011bk k levodop\u011b v pokro\u010dil\u00e9m st\u00e1diu) a pro st\u0159edn\u011b t\u011b\u017ek\u00fd a\u017e t\u011b\u017ek\u00fd syndrom neklidn\u00fdch nohou, kter\u00fd nereaguje na nefarmakologick\u00e1 opat\u0159en\u00ed a dopln\u011bn\u00ed \u017eeleza. Mlad\u0161\u00ed pacienti s Parkinsonem (pod 65 let) \u010dasto nejv\u00edce t\u011b\u017e\u00ed z po\u010d\u00e1te\u010dn\u00ed l\u00e9\u010dby dopaminov\u00fdm agonistou p\u0159ed nasazen\u00edm levodopy, aby se odd\u00e1lil n\u00e1stup dyskineze vyvolan\u00e9 levodopou.<\/p>\n

D\u00e1vkov\u00e1n\u00ed a titrace<\/h2>\n

Terapie dopaminov\u00fdmi agonisty mus\u00ed<\/strong> b\u00fdt titrov\u00e1na postupn\u011b po dobu n\u011bkolika t\u00fddn\u016f, aby se p\u0159ede\u0161lo nesnesiteln\u00e9 nevolnosti, ortostatick\u00e9 hypotenzi a ospalosti. N\u00ed\u017ee uveden\u00e9 d\u00e1vkov\u00e1n\u00ed je typick\u00fd v\u00fdchoz\u00ed r\u00e1mec \u2014 v\u00e1\u0161 neurolog jej uprav\u00ed podle va\u0161\u00ed reakce.<\/p>\n\n\n\n\n\n\n\n\n\n
T\u00fdden<\/th>\nD\u00e1vkov\u00e1n\u00ed u Parkinsonovy choroby<\/th>\nD\u00e1vkov\u00e1n\u00ed u syndromu neklidn\u00fdch nohou<\/th>\n<\/tr>\n<\/thead>\n
1<\/td>\n0,25 mg t\u0159ikr\u00e1t denn\u011b (0,75 mg\/den)<\/td>\n0,25 mg jednou p\u0159ed span\u00edm<\/td>\n<\/tr>\n
2<\/td>\n0,5 mg t\u0159ikr\u00e1t denn\u011b (1,5 mg\/den)<\/td>\n0,5 mg jednou p\u0159ed span\u00edm<\/td>\n<\/tr>\n
3<\/td>\n0,75 mg t\u0159ikr\u00e1t denn\u011b (2,25 mg\/den)<\/td>\n1 mg jednou p\u0159ed span\u00edm<\/td>\n<\/tr>\n
4<\/td>\n1 mg t\u0159ikr\u00e1t denn\u011b (3 mg\/den)<\/td>\n2 mg jednou p\u0159ed span\u00edm<\/td>\n<\/tr>\n
Udr\u017eovac\u00ed d\u00e1vka<\/td>\n3\u20139 mg\/den ve 3 rozd\u011blen\u00fdch d\u00e1vk\u00e1ch (max. 24 mg\/den)<\/td>\n2\u20134 mg p\u0159ed span\u00edm; max. 4 mg\/den u syndromu neklidn\u00fdch nohou<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Ropinirol je tak\u00e9 dostupn\u00fd v prodlou\u017een\u00e9 uvol\u0148ovac\u00ed form\u011b (XL\/Modutab) pro Parkinsonovu chorobu, kter\u00e1 umo\u017e\u0148uje pod\u00e1v\u00e1n\u00ed jedn\u00e9 denn\u00ed d\u00e1vky a\u017e 24 mg\/den. Tato prezentace Roparku je tableta s okam\u017eit\u00fdm uvol\u0148ov\u00e1n\u00edm, u\u017e\u00edvan\u00e1 t\u0159ikr\u00e1t denn\u011b u Parkinsonovy choroby nebo jednou p\u0159ed span\u00edm u syndromu neklidn\u00fdch nohou.<\/p>\n

\u26a0 Poruchy impulzivn\u00ed kontroly \u2014 varov\u00e1n\u00ed, kter\u00e9 by m\u011bl sly\u0161et ka\u017ed\u00fd pacient (i partner)<\/strong> A\u017e 14\u201317 %<\/strong> pacient\u016f u\u017e\u00edvaj\u00edc\u00edch dopaminov\u00e9 agonisty vyvine jeden nebo v\u00edce poruch impulzivn\u00ed kontroly<\/em>: patologick\u00e9 hr\u00e1\u010dstv\u00ed, nutkav\u00e9 nakupov\u00e1n\u00ed, hypersexualita, z\u00e1chvatov\u00e9 p\u0159ej\u00edd\u00e1n\u00ed nebo punding (opakovan\u00e9 bez\u00fa\u010deln\u00e9 chov\u00e1n\u00ed). Riziko je z\u00e1visl\u00e9 na d\u00e1vce a nejvy\u0161\u0161\u00ed je u neergotn\u00edch agonist\u016f. Pacienti si zm\u011bny \u010dasto neuv\u011bdomuj\u00ed \u2014 jako prvn\u00ed ji mohou zaznamenat partne\u0159i nebo rodinn\u00ed p\u0159\u00edslu\u0161n\u00edci. Pokud vy nebo n\u011bkdo z va\u0161eho okol\u00ed pozoruje jak\u00e9koli nov\u00e9 nutkav\u00e9 chov\u00e1n\u00ed, neprodlen\u011b kontaktujte sv\u00e9ho neurologa.<\/strong> Sn\u00ed\u017een\u00ed d\u00e1vky nebo vysazen\u00ed obvykle chov\u00e1n\u00ed normalizuje b\u011bhem n\u011bkolika t\u00fddn\u016f.<\/div>\n
\u26a0 N\u00e1hl\u00e9 usnut\u00ed (\u201csp\u00e1nkov\u00e9 ataky\u201d)<\/strong> V\u0161echny neergotn\u00ed dopaminov\u00e9 agonisty mohou zp\u016fsobit n\u00e1hl\u00e9, neovladateln\u00e9 epizody sp\u00e1nku bez varov\u00e1n\u00ed \u2014 v\u010detn\u011b b\u011bhem \u0159\u00edzen\u00ed, j\u00eddla nebo rozhovoru. Tento jev je \u010dast\u011bj\u0161\u00ed v prvn\u00edch m\u011bs\u00edc\u00edch l\u00e9\u010dby, p\u0159i vy\u0161\u0161\u00edch d\u00e1vk\u00e1ch a v kombinaci s levodopou. Dokud nebudete alespo\u0148 2 t\u00fddny na stabiln\u00ed d\u00e1vce a nebudete v\u011bd\u011bt, jak na l\u00e9k reagujete, ne\u0159i\u010fte, neobsluhujte stroje ani se nev\u011bnujte \u010dinnostem, p\u0159i nich\u017e by usnut\u00ed mohlo b\u00fdt nebezpe\u010dn\u00e9.<\/strong><\/div>\n

B\u011b\u017en\u00e9 ne\u017e\u00e1douc\u00ed \u00fa\u010dinky<\/h2>\n

\u010cast\u00e9 (>10%):<\/strong> nevolnost, z\u00e1vrat\u011b, ospalost, ortostatick\u00e1 hypotenze, perifern\u00ed ed\u00e9my (otoky kotn\u00edk\u016f), z\u00e1cpa, halucinace (\u010dast\u011bji vizu\u00e1ln\u00ed ne\u017e sluchov\u00e9), dyskineze (v kombinaci s levodopou).<\/p>\n

M\u00e9n\u011b \u010dast\u00e9, ale z\u00e1va\u017en\u00e9:<\/strong> n\u00e1hl\u00e9 usnut\u00ed, poruchy impulzivn\u00ed kontroly, livedo reticularis (mramorovan\u00e1 k\u016f\u017ee), \u017eiv\u00e9 sny, otoky nohou, synkopa, dyskineze, halucinace, paranoia.<\/p>\n

Vz\u00e1cn\u00e9:<\/strong> syndrom z vysazen\u00ed dopaminov\u00fdch agonist\u016f (DAWS) p\u0159i rychl\u00e9m sni\u017eov\u00e1n\u00ed d\u00e1vek \u2014 deprese, \u00fazkost, panika, \u00fanava, ba\u017een\u00ed po l\u00e9ku, autonomn\u00ed nestabilita. Z tohoto d\u016fvodu je nutn\u00e9 agonisty vysazovat postupn\u011b.<\/p>\n

Interakce s l\u00e9\u010divy<\/h2>\n