<\/p>\n
Saaz<\/strong> je sulfasalazine 500 mg gastro-resistant tablet<\/strong> — a sulfa-linked prodrug of mesalazine (5-aminosalicylic acid) used for mild-to-moderate ulcerative colitis<\/strong> (induction and maintenance), Crohn’s colitis<\/strong>, and as a conventional synthetic DMARD for rheumatoid and juvenile idiopathic arthritis<\/strong>. Colonic bacteria cleave the azo bond, releasing 5-ASA (the active GI moiety) and sulfapyridine (the carrier responsible for most side effects). Standard adult dose: UC 2–4 g\/day in divided doses; RA 2–3 g\/day after slow titration over 4 weeks<\/strong>. V\u00fdrobce certifikovan\u00fd WHO-GMP.<\/p>\n<\/div>\n \ud83d\udce6 Ka\u017ed\u00e1 objedn\u00e1vka je pokryta na\u0161\u00ed Z\u00e1rukou op\u011btovn\u00e9ho odesl\u00e1n\u00ed<\/strong><\/a> \u2014 pokud va\u0161e z\u00e1silka nedoraz\u00ed do 20 pracovn\u00edch dn\u016f, p\u0159epos\u00edl\u00e1me ji.<\/p>\n Na\u0161e generick\u00e9 l\u00e9ky poch\u00e1zej\u00ed od v\u00fdrobc\u016f certifikovan\u00fdch WHO-GMP a jsou expedov\u00e1ny po cel\u00e9m sv\u011bt\u011b v diskr\u00e9tn\u00edm, nen\u00e1padn\u00e9m balen\u00ed \u2013 na vn\u011bj\u0161\u00ed stran\u011b bal\u00edku nen\u00ed uveden n\u00e1zev l\u00e9ku. Platby kartou jsou sm\u011brov\u00e1ny prost\u0159ednictv\u00edm regulovan\u00e9ho procesoru (popisky na v\u00fdpisu zahrnuj\u00ed regulovan\u00e9ho procesora plateb kartou \u2013 nikdy \u201cMedsBase\u201d nebo n\u00e1zev l\u00e9ku). P\u0159ij\u00edm\u00e1me tak\u00e9 kryptom\u011bny a bankovn\u00ed p\u0159evody SEPA. Ka\u017ed\u00e1 objedn\u00e1vka je zaji\u0161t\u011bna na\u0161\u00ed politikou p\u0159eposl\u00e1n\u00ed.<\/p>\n Saaz is supplied from a v\u00fdrobce certifikovan\u00e9ho WHO-GMP<\/strong>. Ka\u017ed\u00e1 objedn\u00e1vka je diskr\u00e9tn\u011b zas\u00edl\u00e1na po cel\u00e9m sv\u011bt\u011b a je pokryta na\u0161\u00ed Z\u00e1rukou op\u011btovn\u00e9ho odesl\u00e1n\u00ed<\/a> — if it does not arrive within 20 business days, we reship at no cost. Sulfasalazine is on the WHO Essential Medicines List for both inflammatory bowel disease and rheumatoid arthritis — it is the most extensively studied conventional DMARD with multi-decade follow-up.<\/p>\n Sulfasalazine is a prodrug: 5-ASA linked to sulfapyridine through an azo (-N=N-) bond. Less than 30 percent is absorbed in the small intestine; the remainder reaches the colon where bacterial azoreductases cleave the bond. 5-ASA<\/strong> acts locally on colonic mucosa via PPAR-γ agonism, COX\/LOX inhibition, NF-κB suppression, and reactive-oxygen scavenging — this is the IBD-relevant action. Sulfapyridine<\/strong> is absorbed systemically and accounts for most side effects (rash, photosensitivity, oligospermia, haematological); in rheumatoid arthritis the systemic sulfapyridine is thought to be the active moiety, modulating cytokine production and folate metabolism.<\/p>\n UC induction:<\/strong> 1–2 g four times daily (max 4 g\/day), reduce to 2 g\/day for maintenance. RA \/ JIA:<\/strong> start 500 mg\/day, increase by 500 mg weekly to 1 g twice daily (max 3 g\/day). Folic acid 5 mg weekly recommended on RA dose. Take with food to reduce GI upset. Hepatic or renal impairment: caution, halve the dose.<\/p>\n Yes — sulfasalazine and its metabolite sulfapyridine are coloured. Urine, sweat, tears, and contact lenses can take an orange-yellow tint. It is harmless and reverses on stopping the drug.<\/p>\n For UC: stool blood and tenesmus often improve within 2–4 weeks; full effect by 8–12 weeks. For RA: it takes 8–12 weeks to feel benefit; do not stop early.<\/p>\n Sulfasalazine inhibits folate absorption and metabolism. Folate deficiency causes megaloblastic anaemia and worsens cytopenia. 5 mg weekly is standard with the RA dose.<\/p>\n Yes — among the safest DMARDs in pregnancy. Continue through pregnancy if needed for IBD or RA. Folic acid supplementation 5 mg\/day is essential. Sulfasalazine causes reversible oligospermia in men and should be stopped 3 months before conception attempts in male partners.<\/p>\n Baseline FBC, LFTs, U&E, and G6PD if of African, Asian, or Mediterranean ancestry. Then FBC and LFTs at 2 weeks, 4 weeks, then 3-monthly for the first year, then 6-monthly thereafter.<\/p>\n Light to moderate alcohol is acceptable; heavy alcohol increases hepatotoxicity. Discuss with the prescriber.<\/p>\n Mesalamine is just the 5-ASA portion without the sulfa carrier. Mesalamine has fewer side effects (no sulfa allergy risk, no oligospermia) but is more expensive. Sulfasalazine is preferred when DMARD effect is needed for joint disease in addition to gut disease.<\/p>\n No. Switch to mesalamine (Asacol, Mesacol, or Pentasa) for IBD; switch to a different DMARD (methotrexate, leflunomide) for arthritis.<\/p>\n Below 30°C in a dry place. Keep tablets in the original blister.<\/p>\n Take it as soon as you remember unless it is close to the next dose. Do not double up.<\/p>\n <\/p>\n Saaz (Sulfasalazine 500 mg gastro-resistant tablet) \u2014 5-ASA prodrug for mild-to-moderate ulcerative colitis, Crohn’s colitis, and conventional synthetic DMARD for rheumatoid and juvenile idiopathic arthritis. WHO Essential Medicine. Worldwide shipping from MedsBase.<\/p>","protected":false},"featured_media":60670,"comment_status":"open","ping_status":"open","template":"","meta":[],"product_brand":[],"product_cat":[3141,3542,3342],"product_tag":[4902,4682],"class_list":{"0":"post-60669","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-category-overview","7":"product_cat-gastro-health","8":"product_cat-general-health","9":"product_tag-saaz","10":"product_tag-sulfasalazine","12":"first","13":"instock","14":"shipping-taxable","15":"purchasable","16":"product-type-variable","17":"has-default-attributes"},"acf":[],"_links":{"self":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product\/60669","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/comments?post=60669"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/media\/60670"}],"wp:attachment":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/media?parent=60669"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product_brand?post=60669"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product_cat?post=60669"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product_tag?post=60669"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}Pro\u010d objedn\u00e1vat z MedsBase<\/h3>\n
Pro\u010d objedn\u00e1vat z MedsBase<\/h3>\n
Mechanismus \u00fa\u010dinku<\/h2>\n
Indikace<\/h2>\n
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D\u00e1vka<\/h2>\n
Vedlej\u0161\u00ed \u00fa\u010dinky<\/h2>\n
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Interakce l\u00e9k\u016f<\/h2>\n
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\u010casto kladen\u00e9 dotazy<\/h2>\n
Will my urine really turn orange?<\/h3>\n
Za jak dlouho se budu c\u00edtit l\u00e9pe?<\/h3>\n
Why do I need folic acid with it?<\/h3>\n
Je bezpe\u010dn\u00fd v t\u011bhotenstv\u00ed?<\/h3>\n
Jak\u00e9 krevn\u00ed testy pot\u0159ebuji?<\/h3>\n
M\u016f\u017eu p\u0159i u\u017e\u00edv\u00e1n\u00ed p\u00edt alkohol?<\/h3>\n
How is it different from mesalamine (Asacol\/Mesacol)?<\/h3>\n
I have a sulfa allergy. Can I take it?<\/h3>\n
Skladov\u00e1n\u00ed<\/h3>\n
Co kdy\u017e vynech\u00e1m d\u00e1vku?<\/h3>\n
Dal\u0161\u00ed l\u00e9ky na za\u017e\u00edvac\u00ed pot\u00ed\u017ee<\/h3>\n
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