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Trinicalm Plus<\/strong> obsahuje sumatriptan 85 mg + naproxen sodium 500 mg<\/strong> in a single tablet from WHO-GMP certified manufacturer — the generic equivalent of Treximet<\/strong>. It combines a triptan (attacks the serotonergic 5-HT1B\/1D<\/sub> receptor arm of the migraine cascade) with an NSAID (attacks the prostaglandin-inflammation arm). The combination shows higher 2-hour pain freedom, higher sustained pain freedom at 24 hours, and less migraine recurrence than either component alone<\/strong> in head-to-head RCTs (Brandes 2007; Silberstein 2008). Take one tablet at first sign of migraine pain<\/strong>. May repeat after 2 hours if migraine recurs; maximum 2 tablets in 24 hours. Inherits the full contraindications and cautions of both constituents: cardiovascular disease, peptic ulcer disease, severe hepatic \/ renal impairment, and the triptan-ergot \/ triptan-MAOI interactions. Medication-overuse headache limit is 10 days\/month.<\/p>\n<\/div>\n Headset is an oral combination tablet containing sumatriptan 85 mg + naproxen sodium 500 mg<\/strong> from WHO-GMP certified manufacturer, supplied in 2-24 tablet packs. It is the generic equivalent of Treximet<\/strong> (GSK, US) — the first and only branded fixed-dose triptan-NSAID combination approved for acute migraine.<\/p>\n The pharmacological rationale is attacking migraine at two separate points in the attack cascade:<\/p>\n In the pivotal phase 3 trials, sumatriptan + naproxen outperformed sumatriptan alone, naproxen alone, and placebo for 2-hour pain freedom, 2-hour pain relief, sustained pain freedom 2-24 hours, and reduction of migraine-associated symptoms (photophobia, phonophobia, nausea).<\/p>\n When Headset is NOT the right choice:<\/strong> mild migraine (use simpler analgesia), peptic ulcer disease or high GI-bleeding risk, uncontrolled hypertension, ischaemic heart disease, severe hepatic or renal impairment, third-trimester pregnancy.<\/p>\n Inherits side-effect profiles of both components.<\/strong><\/p>\n From sumatriptan (triptan side effects):<\/strong><\/p>\n From naproxen (NSAID side effects):<\/strong><\/p>\n T\u011bhotenstv\u00ed:<\/strong> avoid in third trimester. First and second trimester use should be under obstetric guidance. Not routinely recommended.<\/p>\n Kojen\u00ed:<\/strong> both components pass into breast milk in small amounts. Generally considered compatible for occasional use. Avoid if the baby is premature or has a bleeding tendency.<\/p>\nWhat Is Headset?<\/h2>\n
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When to Use Headset Instead of a Plain Triptan<\/h2>\n
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Headset Dosage<\/h2>\n
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Vedlej\u0161\u00ed \u00fa\u010dinky<\/h2>\n
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Kontraindikace<\/h2>\n
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Headset vs Single-Drug Alternatives<\/h2>\n