{"id":60763,"date":"2024-02-28T07:07:04","date_gmt":"2024-02-28T07:07:04","guid":{"rendered":"https:\/\/medsname.com\/teravir\/"},"modified":"2026-05-08T09:18:45","modified_gmt":"2026-05-08T09:18:45","slug":"teravir","status":"publish","type":"product","link":"https:\/\/medsbase.com\/cs\/product\/teravir\/","title":{"rendered":"Teravir"},"content":{"rendered":"<p><!-- medsbase-tldr-answer --><\/p>\n<div style=\"background:#fff8e1;border-left:4px solid #f5a623;padding:16px 20px;margin:0 0 24px 0;border-radius:4px;\">\n<h3 class=\"wp-block-heading\" style=\"margin-top:0;\">Quick Answer &mdash; Teravir (Tenofovir Disoproxil 300 mg)<\/h3>\n<ul>\n<li><strong>\u00da\u010dinn\u00e1 l\u00e1tka:<\/strong> tenofovir disoproxil fumar\u00e1t (TDF) 300 mg, peror\u00e1ln\u00ed tableta, u\u017e\u00edv\u00e1 se jednou denn\u011b s j\u00eddlem.<\/li>\n<li><strong>Hlavn\u00ed indikace v tomto v\u00fdpisu:<\/strong> chronick\u00e1 infekce virem hepatitidy B (HBV) u dosp\u011bl\u00fdch \u2014 dlouhodob\u00e9 potla\u010den\u00ed virov\u00e9 replikace. Pou\u017e\u00edv\u00e1 se tak\u00e9 v re\u017eimech pro HIV, nikdy v\u0161ak jako monoterapie HIV (riziko rezistence).<\/li>\n<li><strong>Mechanismus \u00fa\u010dinku:<\/strong> inhibitor nukleotidov\u00e9 reverzn\u00ed transkript\u00e1zy (NRTI). Tenofovir-difosf\u00e1t sout\u011b\u017e\u00ed s p\u0159irozen\u00fdm dATP, za\u010dle\u0148uje se do virov\u00e9 DNA \u0159et\u011bzce a ukon\u010duje jej.<\/li>\n<li><strong>\u00da\u010dinnost proti HBV:<\/strong> &gt; 90 % pacient\u016f dos\u00e1hne nedetekovateln\u00e9 HBV DNA po 5 letech; rezistence &lt; 1 % za 8+ let \u2014 nejvy\u0161\u0161\u00ed bari\u00e9ra proti rezistenci ze v\u0161ech peror\u00e1ln\u00edch l\u00e1tek proti HBV.<\/li>\n<li><strong>Kl\u00ed\u010dov\u00e9 bezpe\u010dnostn\u00ed opat\u0159en\u00ed:<\/strong> funkce ledvin (eGFR), s\u00e9rov\u00fd fosf\u00e1t a hustota kostn\u00edch miner\u00e1l\u016f \u2014 kontrola p\u0159ed l\u00e9\u010dbou, pot\u00e9 ka\u017ed\u00e9 3\u20136 m\u011bs\u00edc\u016f. Pokud CrCl klesne pod 50 ml\/min, je nutn\u00e1 \u00faprava d\u00e1vkovac\u00edho intervalu.<\/li>\n<li><strong>Upozorn\u011bn\u00ed na vzplanut\u00ed HBV:<\/strong> n\u00e1hl\u00e9 vysazen\u00ed tenofoviru u chronick\u00e9 hepatitidy B m\u016f\u017ee vyvolat z\u00e1va\u017en\u00e9 akutn\u00ed jatern\u00ed vzplanut\u00ed \u2014 nikdy nep\u0159eru\u0161ujte l\u00e9\u010dbu bez dohledu specialisty.<\/li>\n<\/ul>\n<\/div>\n<div class=\"medsbase-trust-strip\" style=\"background:#f4f8fb;border:1px solid #d8e3eb;padding:12px 16px;margin:16px 0;border-radius:4px;font-size:14px;\">\n<strong>Co z\u00edsk\u00e1te s MedsBase:<\/strong> V\u00fdrobce certifikovan\u00fd WHO-GMP \u00b7 Diskr\u00e9tn\u00ed balen\u00ed \u00b7 Celosv\u011btov\u00e1 doprava \u00b7 V\u00edce ne\u017e 1 400 ov\u011b\u0159en\u00fdch <a href=\"https:\/\/medsbase.com\/cs\/reviews\/\">recenz\u00ed z\u00e1kazn\u00edk\u016f<\/a>\n<\/div>\n<p class=\"medsbase-reship-line\" style=\"font-size:14px;color:#444;margin:8px 0 18px;\">\ud83d\udce6 Ka\u017ed\u00e1 objedn\u00e1vka je pokryta na\u0161\u00ed <a href=\"https:\/\/medsbase.com\/cs\/medsbase-re-shipment-assurance-policy\/\"><strong>Z\u00e1rukou op\u011btovn\u00e9ho odesl\u00e1n\u00ed<\/strong><\/a> \u2014 pokud va\u0161e z\u00e1silka nedoraz\u00ed do 20 pracovn\u00edch dn\u016f, p\u0159epos\u00edl\u00e1me ji.<\/p>\n<h3>Pro\u010d objedn\u00e1vat z MedsBase<\/h3>\n<p>Na\u0161e generick\u00e9 l\u00e9ky poch\u00e1zej\u00ed od v\u00fdrobc\u016f certifikovan\u00fdch WHO-GMP a jsou expedov\u00e1ny po cel\u00e9m sv\u011bt\u011b v diskr\u00e9tn\u00edm, nen\u00e1padn\u00e9m balen\u00ed \u2013 na vn\u011bj\u0161\u00ed stran\u011b bal\u00edku nen\u00ed uveden n\u00e1zev l\u00e9ku. Platby kartou jsou sm\u011brov\u00e1ny prost\u0159ednictv\u00edm regulovan\u00e9ho procesoru (popisky na v\u00fdpisu zahrnuj\u00ed regulovan\u00e9ho procesora plateb kartou \u2013 nikdy \u201cMedsBase\u201d nebo n\u00e1zev l\u00e9ku). P\u0159ij\u00edm\u00e1me tak\u00e9 kryptom\u011bny a bankovn\u00ed p\u0159evody SEPA. Ka\u017ed\u00e1 objedn\u00e1vka je zaji\u0161t\u011bna na\u0161\u00ed politikou p\u0159eposl\u00e1n\u00ed.<\/p>\n<h2 class=\"wp-block-heading\">What Is Teravir?<\/h2>\n<p>Teravir is an oral tablet containing <strong>tenofovir disoproxil fumar\u00e1t 300 mg<\/strong> (TDF), vyr\u00e1b\u011bn\u00e9 spole\u010dnost\u00ed Cipla. Ka\u017ed\u00e9 balen\u00ed obvykle obsahuje 30 potahovan\u00fdch tablet.<\/p>\n<p>Tenofovir je <strong>nukleotidov\u00fd inhibitor reverzn\u00ed transkript\u00e1zy<\/strong> (NtRTI) pou\u017e\u00edvan\u00fd pro dv\u011b odli\u0161n\u00e9 chronick\u00e9 virov\u00e9 indikace \u2014 chronickou hepatitidu B (HBV) a HIV-1 \u2014 ob\u011b vyu\u017e\u00edvaj\u00ed virovou reverzn\u00ed transkript\u00e1zu pro kop\u00edrov\u00e1n\u00ed sv\u00e9ho genomu. Stejn\u00e1 molekula je prod\u00e1v\u00e1na pod origin\u00e1ln\u00ed zna\u010dkou <strong>Viread<\/strong> (Gilead, schv\u00e1leno 2001 pro HIV, 2008 pro HBV).<\/p>\n<h2 class=\"wp-block-heading\">What Is Teravir Used For?<\/h2>\n<ul>\n<li><strong>Chronick\u00e1 hepatitida B (CHB) u dosp\u011bl\u00fdch a dosp\u00edvaj\u00edc\u00edch \u2265 12 let<\/strong> \u2014 prvn\u00ed volba peror\u00e1ln\u00ed antivirotikum pro HBeAg-pozitivn\u00ed a HBeAg-negativn\u00ed chronickou infekci (dle doporu\u010den\u00ed EASL, AASLD, APASL, WHO).<\/li>\n<li><strong>infekce HIV-1<\/strong> \u2014 pouze jako sou\u010d\u00e1st kombinovan\u00e9 terapie, obvykle s emtricitabinem (FTC) nebo lamivudinem (3TC) plus t\u0159et\u00ed l\u00e1tkou (inhibitor integr\u00e1zy nebo NNRTI). Nikdy jako monoterapie HIV.<\/li>\n<li><strong>HIV pre-expozi\u010dn\u00ed profylaxe (PrEP)<\/strong> \u2014 obvykle jako fixn\u00ed kombinace TDF + FTC (Truvada\/Tenvir-EM); monoterapie TDF pro PrEP je n\u011bkter\u00fdmi doporu\u010den\u00edmi podporov\u00e1na pro cisgender heterosexu\u00e1ln\u00ed expozici, ale nen\u00ed prvn\u00ed volbou.<\/li>\n<li><strong>HIV post-expozi\u010dn\u00ed profylaxe (PEP)<\/strong> \u2014 sou\u010d\u00e1st standardn\u00edho 28denn\u00edho t\u0159\u00edl\u00e9\u010debn\u00e9ho re\u017eimu.<\/li>\n<\/ul>\n<p>Tenofovir je <strong>ne<\/strong> \u00fa\u010dinn\u00fd proti hepatitid\u011b C, herpes simplex nebo sez\u00f3nn\u00ed ch\u0159ipce \u2014 je selektivn\u00ed pro reverzn\u00ed transkript\u00e1zy HIV a HBV.<\/p>\n<h2 class=\"wp-block-heading\">How Does Teravir Work?<\/h2>\n<p>Tenofovir disoproxil je <strong>prodrog<\/strong>: po absorpci je hydrolyzov\u00e1n na tenofovir, kter\u00fd je intracelul\u00e1rn\u011b fosforylov\u00e1n na tenofovir-difosf\u00e1t (TFV-DP). TFV-DP je aktivn\u00ed metabolit. Strukturn\u011b je analogem deoxyadenosin-5\u2032-trifosf\u00e1tu (dATP).<\/p>\n<p>HBV polymer\u00e1za a HIV reverzn\u00ed transkript\u00e1za zam\u011bn\u00ed TFV-DP za dATP a za\u010dlen\u00ed ho do rostouc\u00edho \u0159et\u011bzce virov\u00e9 DNA. Po za\u010dlen\u011bn\u00ed chyb\u011bj\u00edc\u00ed 3\u2032-hydroxylov\u00e1 skupina zabr\u00e1n\u00ed p\u0159id\u00e1n\u00ed dal\u0161\u00edho nukleotidu \u2014 \u0159et\u011bzec se ukon\u010d\u00ed. Bez kompletn\u00ed virov\u00e9 DNA se nevytvo\u0159\u00ed nov\u00e9 infek\u010dn\u00ed viriony.<\/p>\n<p>Intracelul\u00e1rn\u00ed polo\u010das TFV-DP p\u0159esahuje 50 hodin, co\u017e je d\u016fvod, pro\u010d jednodenn\u00ed d\u00e1vkov\u00e1n\u00ed udr\u017euje kontinu\u00e1ln\u00ed virovou supresi a pro\u010d l\u00e9k z\u016fst\u00e1v\u00e1 aktivn\u00ed n\u011bkolik dn\u00ed po vynech\u00e1n\u00ed d\u00e1vky.<\/p>\n<h2 class=\"wp-block-heading\">Dosage and How to Take Teravir<\/h2>\n<table style=\"border-collapse:collapse;width:100%;font-size:14px;\">\n<thead>\n<tr style=\"background:#2c7cb0;color:#fff;\">\n<th style=\"padding:8px;border:1px solid #ddd;text-align:left;\">Indikace<\/th>\n<th style=\"padding:8px;border:1px solid #ddd;text-align:left;\">Standardn\u00ed d\u00e1vka pro dosp\u011bl\u00e9<\/th>\n<th style=\"padding:8px;border:1px solid #ddd;text-align:left;\">D\u00e9lka l\u00e9\u010dby<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td style=\"padding:8px;border:1px solid #ddd;\">Chronick\u00e1 hepatitida B<\/td>\n<td style=\"padding:8px;border:1px solid #ddd;\">300 mg jednou denn\u011b s j\u00eddlem<\/td>\n<td style=\"padding:8px;border:1px solid #ddd;\">Dlouhodob\u011b \u2014 obvykle neur\u010dit\u011b. Ukon\u010den\u00ed vy\u017eaduje odborn\u00fd dohled (riziko vzplanut\u00ed).<\/td>\n<\/tr>\n<tr style=\"background:#f9f9f9;\">\n<td style=\"padding:8px;border:1px solid #ddd;\">HIV (kombinovan\u00e1 l\u00e9\u010dba)<\/td>\n<td style=\"padding:8px;border:1px solid #ddd;\">300 mg jednou denn\u011b s j\u00eddlem<\/td>\n<td style=\"padding:8px;border:1px solid #ddd;\">Do\u017eivotn\u011b, jako sou\u010d\u00e1st v\u00edcel\u00e9kov\u00e9 terapie.<\/td>\n<\/tr>\n<tr>\n<td style=\"padding:8px;border:1px solid #ddd;\">PrEP \/ PEP (kombinovan\u00e1 l\u00e9\u010dba)<\/td>\n<td style=\"padding:8px;border:1px solid #ddd;\">300 mg + FTC 200 mg jednou denn\u011b<\/td>\n<td style=\"padding:8px;border:1px solid #ddd;\">Denn\u00ed PrEP p\u0159i pokra\u010duj\u00edc\u00edm riziku; PEP po dobu 28 dn\u016f.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p><strong>U\u017e\u00edvejte s j\u00eddlem<\/strong> \u2014 zvy\u0161uje biologickou dostupnost asi o 40%. Tabletu spolkn\u011bte celou s vodou; nedr\u0165te ani nerozkous\u00e1vejte. Pokud d\u00e1vku vynech\u00e1te o m\u00e9n\u011b ne\u017e 12 hodin, vezm\u011bte ji co nejd\u0159\u00edve; pokud uplynulo v\u00edce ne\u017e 12 hodin, vynechanou d\u00e1vku p\u0159esko\u010dte a pokra\u010dujte v pravideln\u00e9m d\u00e1vkov\u00e1n\u00ed. Ned\u00e1vejte dvojn\u00e1sobnou d\u00e1vku.<\/p>\n<p><strong>\u00daprava d\u00e1vkov\u00e1n\u00ed p\u0159i ren\u00e1ln\u00ed insuficienci (indikace HBV):<\/strong><\/p>\n<ul>\n<li>CrCl \u2265 50 ml\/min \u2014 300 mg ka\u017ed\u00fdch 24 hodin (beze zm\u011bny)<\/li>\n<li>CrCl 30\u201349 ml\/min \u2014 300 mg ka\u017ed\u00fdch 48 hodin<\/li>\n<li>CrCl 10\u201329 ml\/min \u2014 300 mg ka\u017ed\u00fdch 72\u201396 hodin<\/li>\n<li>Hemodial\u00fdza \u2014 300 mg ka\u017ed\u00fdch 7 dn\u00ed, po dial\u00fdze v dnech dial\u00fdzy<\/li>\n<\/ul>\n<p>P\u0159i zhor\u0161uj\u00edc\u00ed se ren\u00e1ln\u00ed funkci p\u0159i u\u017e\u00edv\u00e1n\u00ed TDF je preferov\u00e1n p\u0159echod na <a href=\"https:\/\/medsbase.com\/cs\/tenvir-af\/\" rel=\"noopener\">tenofovir alafenamid (TAF)<\/a> \u2014 stejn\u00e1 \u00fa\u010dinn\u00e1 l\u00e1tka, ni\u017e\u0161\u00ed expozice ledvin\u00e1m a kostem \u2014 je preferov\u00e1n.<\/p>\n<h2 class=\"wp-block-heading\">Vedlej\u0161\u00ed \u00fa\u010dinky<\/h2>\n<p><strong>\u010cast\u00e9 (\u2265 1 ze 100 pacient\u016f):<\/strong> nevolnost, pr\u016fjem, bolest hlavy, \u00fanava, m\u00edrn\u00e1 vyr\u00e1\u017eka, z\u00e1vrat\u011b, hypofosfat\u00e9mie (\u010dasto asymptomatick\u00e1, zji\u0161t\u011bn\u00e1 p\u0159i krevn\u00edch testech).<\/p>\n<p><strong>M\u00e9n\u011b \u010dast\u00e9 a\u017e vz\u00e1cn\u00e9, ale v\u00fdznamn\u00e9:<\/strong><\/p>\n<ul>\n<li><strong>Ren\u00e1ln\u00ed toxicita<\/strong> \u2014 m\u00edrn\u00fd, v\u011bt\u0161inou reverzibiln\u00ed pokles eGFR je b\u011b\u017en\u00fd. Proxim\u00e1ln\u00ed tubulopatie a Fanconiho syndrom (proteinurie, glykosurie s norm\u00e1ln\u00ed hladinou gluk\u00f3zy v krvi, ztr\u00e1ty fosf\u00e1t\u016f, bolesti kost\u00ed) jsou vz\u00e1cn\u00e9, ale mohou b\u00fdt z\u00e1va\u017en\u00e9. Monitorujte eGFR, b\u00edlkovinu v mo\u010di, s\u00e9rov\u00fd fosf\u00e1t na za\u010d\u00e1tku a pot\u00e9 ka\u017ed\u00e9 3\u20136 m\u011bs\u00edc\u016f.<\/li>\n<li><strong>Ztr\u00e1ta kostn\u00ed miner\u00e1ln\u00ed denzity<\/strong> \u2014 m\u00edrn\u00fd pokles BMD v prvn\u00edm roce, pot\u00e9 se stabilizuje. Klinicky v\u00fdznamn\u00e9 u pacient\u016f s preexistuj\u00edc\u00ed osteopor\u00f3zou nebo anamn\u00e9zou fraktur fragility.<\/li>\n<li><strong>Lakt\u00e1tov\u00e1 acid\u00f3za s t\u011b\u017ekou hepatomegali\u00ed \u2014 vz\u00e1cn\u00fd t\u0159\u00eddn\u00ed \u00fa\u010dinek NRTI.<\/strong> L\u00e9k okam\u017eit\u011b vysa\u010fte, pokud se objev\u00ed nevysv\u011btliteln\u00e9 progresivn\u00ed bolesti b\u0159icha, rychl\u00e9 d\u00fdch\u00e1n\u00ed, t\u011b\u017ek\u00e1 \u00fanava nebo bolesti sval\u016f.<\/li>\n<li><strong>T\u011b\u017ek\u00e1 akutn\u00ed exacerbace hepatitidy B<\/strong> \u2014 m\u016f\u017ee nastat po vysazen\u00ed TDF, i po letech suprese. Vy\u017eaduje monitorov\u00e1n\u00ed jatern\u00edch test\u016f a HBV DNA po dobu nejm\u00e9n\u011b 6 m\u011bs\u00edc\u016f po ukon\u010den\u00ed l\u00e9\u010dby.<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Interakce s l\u00e9\u010divy<\/h2>\n<p>Tenofovir m\u00e1 m\u00e1lo interakc\u00ed s cytochromem P450, ale n\u011bkolik klinicky v\u00fdznamn\u00fdch farmakokinetick\u00fdch interakc\u00ed:<\/p>\n<ul>\n<li><strong>Didanosin (ddI)<\/strong> \u2014 tenofovir zvy\u0161uje hladiny ddI; riziko pankreatitidy. Tato kombinace se obecn\u011b nedoporu\u010duje.<\/li>\n<li><strong>Atazanavir (neboostovan\u00fd)<\/strong> \u2014 tenofovir sni\u017euje hladiny atazanaviru. Atazanavir mus\u00ed b\u00fdt pod\u00e1v\u00e1n s ritonavirem jako booster p\u0159i kombinaci s TDF.<\/li>\n<li><strong>Jin\u00e9 nefrotoxick\u00e9 l\u00e9ky<\/strong> \u2014 sou\u010dasn\u00e9 pod\u00e1v\u00e1n\u00ed aminoglykosid\u016f, vysok\u00fdch d\u00e1vek NSAID (zejm\u00e9na dlouhodob\u00fd diklofenak nebo ibuprofen), cidofoviru, foscarnetu, intraven\u00f3zn\u00edho vankomycinu, intraven\u00f3zn\u00ed amfotericinu B, cisplatiny zvy\u0161uje riziko po\u0161kozen\u00ed ledvin.<\/li>\n<li><strong>Adefovir<\/strong> \u2014 nekombinujte s TDF; ob\u011b l\u00e1tky pat\u0159\u00ed do t\u0159\u00eddy tenofoviru. Stejn\u00fd aktivn\u00ed metabolit.<\/li>\n<li><strong>Probenecid, ledipasvir, ranitidin<\/strong> \u2014 zvy\u0161uj\u00ed expozici tenofoviru; obvykle st\u00e1le bezpe\u010dn\u00e9, ale sledujte ren\u00e1ln\u00ed funkce.<\/li>\n<\/ul>\n<p><strong>Pozn\u00e1mka k hepatitid\u011b C p\u0159i ko-infekci:<\/strong> re\u017eimy DAA na b\u00e1zi sofosbuviru (v\u010detn\u011b <a href=\"https:\/\/medsbase.com\/cs\/hepcinat-lp\/\" rel=\"noopener\">Hepcinat LP<\/a>) jsou s TDF bezpe\u010dn\u00e9, ale ledipasvir m\u00edrn\u011b zvy\u0161uje expozici tenofoviru \u2014 b\u011bhem 12t\u00fddenn\u00edho kurzu DAA \u010dast\u011bji kontrolujte eGFR.<\/p>\n<h2 class=\"wp-block-heading\">Who Should Not Take Teravir?<\/h2>\n<ul>\n<li>T\u011b\u017ek\u00e9 ren\u00e1ln\u00ed po\u0161kozen\u00ed (CrCl &lt; 10 ml\/min) bez \u00fapravy d\u00e1vkov\u00e1n\u00ed nebo p\u0159\u00edstupu k dial\u00fdze<\/li>\n<li>Zn\u00e1m\u00e1 p\u0159ecitliv\u011blost na tenofovir disoproxil<\/li>\n<li>Sou\u010dasn\u00e1 l\u00e9\u010dba adefovirem nebo didanosinem bez odborn\u00e9ho dohledu<\/li>\n<li>Dekompenzovan\u00e1 cirh\u00f3za \u2014 specialista by m\u011bl zv\u00e1\u017eit entecavir vs TDF; ob\u011b jsou mo\u017enosti.<\/li>\n<\/ul>\n<p>T\u011bhotenstv\u00ed: tenofovir disoproxil m\u00e1 nejsiln\u011bj\u0161\u00ed bezpe\u010dnostn\u00ed data pro t\u011bhotenstv\u00ed a kojen\u00ed ze v\u0161ech peror\u00e1ln\u00edch l\u00e1tek proti HBV\/HIV \u2014 preferov\u00e1n v t\u011bhotenstv\u00ed, kdy\u017e je l\u00e9\u010dba pot\u0159ebn\u00e1 (nap\u0159. matka s vysokou virovou n\u00e1lo\u017e\u00ed k prevenci vertik\u00e1ln\u00edho p\u0159enosu HBV od 28. t\u00fddne).<\/p>\n<h2 class=\"wp-block-heading\">Skladov\u00e1n\u00ed<\/h2>\n<p>Skladujte p\u0159i pokojov\u00e9 teplot\u011b, do 30\u00b0C, v p\u016fvodn\u00ed lahvi\u010dce s vysou\u0161edlem. Uchov\u00e1vejte mimo dosah d\u011bt\u00ed. Ned\u00e1vejte dlouhodob\u011b do t\u00fddenn\u00edch organiz\u00e9r\u016f na l\u00e9ky \u2014 vysou\u0161edlo je d\u016fle\u017eit\u00e9.<\/p>\n<h2 id=\"faqs\">\u010casto kladen\u00e9 dotazy<\/h2>\n<h3 class=\"wp-block-heading\">Is Teravir the same as Viread?<\/h3>\n<p>Yes &mdash; same molecule, same strength, same indication. Viread is the originator (Gilead). Teravir is a Cipla generic of the same tenofovir disoproxil fumarate 300 mg formulation. Bioequivalence studies are required to register the generic in regulated markets.<\/p>\n<h3 class=\"wp-block-heading\">Will Teravir cure my hepatitis B?<\/h3>\n<p>Ne. Tenofovir potla\u010duje replikaci HBV tak \u00fa\u010dinn\u011b, \u017ee virov\u00e1 DNA obvykle p\u0159estane b\u00fdt detekovateln\u00e1, ALT se normalizuje a progrese k cirh\u00f3ze nebo hepatocelul\u00e1rn\u00edmu karcinomu se v\u00fdrazn\u011b zpomal\u00ed. Ale rezervo\u00e1r cccDNA v infikovan\u00fdch hepatocytech nen\u00ed eliminov\u00e1n \u2014 vysazen\u00ed l\u00e9ku umo\u017en\u00ed obnoven\u00ed replikace. Funk\u010dn\u00ed vyl\u00e9\u010den\u00ed (ztr\u00e1ta HBsAg) nast\u00e1v\u00e1 u p\u0159ibli\u017en\u011b 1\u20133 % pacient\u016f ro\u010dn\u011b l\u00e9\u010dby; steriln\u00ed vyl\u00e9\u010den\u00ed je v sou\u010dasnosti nemo\u017en\u00e9. L\u00e9\u010dba je proto dlouhodob\u00e1 \u2014 v mnoha p\u0159\u00edpadech celo\u017eivotn\u00ed.<\/p>\n<h3 class=\"wp-block-heading\">Can I use Teravir alone for HIV?<\/h3>\n<p>No. Tenofovir monotherapy for established HIV-1 infection causes rapid resistance. HIV requires a minimum of three active drugs from at least two different classes. Teravir is one component of that regimen, never the whole thing.<\/p>\n<h3 class=\"wp-block-heading\">How long does it take for Teravir to work?<\/h3>\n<p>HBV DNA obvykle za\u010dne klesat do 4 t\u00fddn\u016f. Do 6 m\u011bs\u00edc\u016f dos\u00e1hne 70\u201380 % pacient\u016f nedetekovateln\u00e9 virov\u00e9 n\u00e1lo\u017ee; v 5 letech &gt; 90 %. Normalizace ALT obvykle n\u00e1sleduje potla\u010den\u00ed DNA za 3\u20136 m\u011bs\u00edc\u016f. HBeAg s\u00e9rokonverze (\u010d\u00e1ste\u010dn\u00fd marker vyl\u00e9\u010den\u00ed) nast\u00e1v\u00e1 u p\u0159ibli\u017en\u011b 20\u201330 % HBeAg-pozitivn\u00edch pacient\u016f v pr\u016fb\u011bhu 5 let.<\/p>\n<h3 class=\"wp-block-heading\">Pro\u010d je tak d\u016fle\u017eit\u00e9 sledov\u00e1n\u00ed funkce ledvin?<\/h3>\n<p>TDF se koncentruje v proxim\u00e1ln\u00edch ren\u00e1ln\u00edch tubulech. Nov\u011bj\u0161\u00ed formulace alafenamidu (TAF) byla navr\u017eena speci\u00e1ln\u011b pro sn\u00ed\u017een\u00ed expozice tubul\u016fm \u2014 stejn\u00e1 \u00fa\u010dinn\u00e1 l\u00e1tka, ale plazmatick\u00e9 hladiny jsou o 90 % ni\u017e\u0161\u00ed. V\u011bt\u0161ina ren\u00e1ln\u00edho poklesu souvisej\u00edc\u00edho s TDF je mal\u00e1 a reverzibiln\u00ed, pokud je zachycena v\u010das; c\u00edlem t\u0159\u00edm\u011bs\u00ed\u010dn\u00edho sledov\u00e1n\u00ed eGFR a s\u00e9rov\u00e9ho fosf\u00e1tu je zachytit vz\u00e1cn\u00e9 progresivn\u00ed p\u0159\u00edpady p\u0159ed vznikem struktur\u00e1ln\u00edho po\u0161kozen\u00ed.<\/p>\n<h3 class=\"wp-block-heading\">Teravir vs TAF (tenofovir alafenamide) &mdash; which should I take?<\/h3>\n<p>Oba p\u0159\u00edpravky dod\u00e1vaj\u00ed tenofovir do hepatocyt\u016f (HBV) a lymfocyt\u016f (HIV). TAF dosahuje vy\u0161\u0161\u00edch intracelul\u00e1rn\u00edch hladin p\u0159i v\u00fdrazn\u011b ni\u017e\u0161\u00ed plazmatick\u00e9 expozici, co\u017e sni\u017euje ren\u00e1ln\u00ed a kostn\u00ed toxicitu. TAF je preferov\u00e1n, pokud m\u00e1te CKD st\u00e1dium 2\u20133, osteopor\u00f3zu nebo jste star\u0161\u00ed 60 let. TDF (tento produkt) m\u00e1 20letou bezpe\u010dnostn\u00ed datab\u00e1zi, je levn\u011bj\u0161\u00ed a m\u016f\u017ee b\u00fdt m\u00edrn\u011b preferov\u00e1n v t\u011bhotenstv\u00ed, kde data o TAF st\u00e1le dozr\u00e1vaj\u00ed. Proberte se sv\u00fdm hepatologem nebo HIV specialistou p\u0159\u00edpadn\u00fd p\u0159echod, pokud se u v\u00e1s objev\u00ed toxicita souvisej\u00edc\u00ed s TDF.<\/p>\n<h3 class=\"wp-block-heading\">Can I drink alcohol on Teravir?<\/h3>\n<p>Alkohol p\u0159\u00edmo neinteraguje s tenofovirem, ale nadm\u011brn\u00e9 pit\u00ed urychluje po\u0161kozen\u00ed jater u chronick\u00e9 HBV. Omezte alkohol na m\u00edrnou konzumaci nebo se mu zcela vyhn\u011bte, pokud m\u00e1te jak\u00e9koli zn\u00e1mky fibr\u00f3zy nebo cirh\u00f3zy.<\/p>\n<h3 class=\"wp-block-heading\">Can I stop Teravir once my HBV DNA is undetectable?<\/h3>\n<p>Obecn\u011b ne. P\u0159eru\u0161en\u00ed l\u00e9\u010dby vyvol\u00e1 virovou rebound u &gt; 90 % pacient\u016f do 3 m\u011bs\u00edc\u016f a u men\u0161iny m\u016f\u017ee doj\u00edt k z\u00e1va\u017en\u00fdm akutn\u00edm vzplanut\u00edm s rizikem jatern\u00ed dekompenzace. Uva\u017euje se o ukon\u010den\u00ed l\u00e9\u010dby a\u017e po vymizen\u00ed HBsAg s serokonverz\u00ed anti-HBs (funk\u010dn\u00ed vyl\u00e9\u010den\u00ed), a to pouze pod odborn\u00fdm dohledem s \u010dast\u00fdm monitorov\u00e1n\u00edm po dobu 6\u201312 m\u011bs\u00edc\u016f.<\/p>\n<h3 class=\"wp-block-heading\">Does Teravir prevent mother-to-child transmission of HBV?<\/h3>\n<p>Ano \u2014 u vysoce viremick\u00fdch matek (HBV DNA &gt; 200 000 IU\/ml) zah\u00e1jen\u00ed pod\u00e1v\u00e1n\u00ed tenofovir disoproxilu od 28. t\u00fddne t\u011bhotenstv\u00ed a pokra\u010dov\u00e1n\u00ed v \u010dasn\u00e9m poporodn\u00edm obdob\u00ed sn\u00ed\u017e\u00ed vertik\u00e1ln\u00ed p\u0159enos t\u00e9m\u011b\u0159 na nulu, pokud je kombinov\u00e1no s aktivn\u00ed a pasivn\u00ed imunizac\u00ed d\u00edt\u011bte. Toto je uzn\u00e1van\u00e1 indikace v doporu\u010den\u00edch WHO, EASL a AASLD.<\/p>\n<h3 class=\"wp-block-heading\">Where can I order Teravir?<\/h3>\n<p>You can order Teravir directly from MedsBase. We supply genuine Cipla stock with worldwide shipping. We strongly recommend treatment under the supervision of a hepatologist or infectious-diseases specialist for HBV monitoring (LFTs, HBV DNA, fibroscan) and renal monitoring while on therapy.<\/p>\n<h2 class=\"wp-block-heading\">Odm\u00edtnut\u00ed odpov\u011bdnosti<\/h2>\n<p>Informace na t\u00e9to str\u00e1nce slou\u017e\u00ed pouze pro vzd\u011bl\u00e1vac\u00ed \u00fa\u010dely a nenahrazuj\u00ed odbornou l\u00e9ka\u0159skou pomoc. L\u00e9\u010dba chronick\u00e9 hepatitidy B a HIV vy\u017eaduje vstupn\u00ed vy\u0161et\u0159en\u00ed, pr\u016fb\u011b\u017en\u00e9 monitorov\u00e1n\u00ed a odborn\u00fd dohled. Neza\u010d\u00ednejte, nep\u0159eru\u0161ujte ani nem\u011b\u0148te l\u00e9\u010dbu zalo\u017eenou na tenofoviru bez konzultace s kvalifikovan\u00fdm l\u00e9ka\u0159em.<\/p>\n<p class=\"medsbase-link-boost-2026-05-08\" data-marker=\"mb-link-boost-tenvir-em\">Pacienti u\u017e\u00edvaj\u00edc\u00ed <a href=\"https:\/\/medsbase.com\/cs\/teravir\/\">Teravir<\/a> (tenofovir disoproxil fumarate 300&nbsp;mg) for hepatitis B who also require HIV pre-exposure prophylaxis can consider <a href=\"https:\/\/medsbase.com\/cs\/tenvir-em\/\">Tenvir EM (tenofovir disoproxil fumarate 300&nbsp;mg + emtricitabine 200&nbsp;mg)<\/a>, which adds the emtricitabine co-formulation required for approved dual-component PrEP efficacy.<\/p>\n<p><!-- medsbase-related-alts-v1 --><\/p>\n<h3 class=\"wp-block-heading\">Souvisej\u00edc\u00ed alternativy<\/h3>\n<p>Dal\u0161\u00ed produkty v <strong>Chronick\u00e1 onemocn\u011bn\u00ed<\/strong> kter\u00e9 z\u00e1kazn\u00edci tak\u00e9 prohl\u00ed\u017eej\u00ed:<\/p>\n<ul>\n<li><a href=\"https:\/\/medsbase.com\/cs\/betapro-sr\/\">Betapro-SR<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/simlo-5\/\">Simlo 5<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/topaz\/\">Topaz<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/budecort-rotacaps\/\">Budecort Rotacaps<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/nucoxia-sp\/\">Nucoxia SP<\/a><\/li>\n<\/ul>","protected":false},"excerpt":{"rendered":"<p>\u2705 Suppresses HIV replication<br \/>\n\u2705 Sni\u017euje virovou n\u00e1lo\u017e<br \/>\n\u2705 Boosts immune function<br \/>\n\u2705 Delays disease progression<br \/>\n\u2705 Prevents opportunistic infections<\/p>\n<p>Teravir contains Tenofovir.<\/p>","protected":false},"featured_media":60764,"comment_status":"open","ping_status":"open","template":"","meta":[],"product_brand":[],"product_cat":[3141,3223,3334,3304],"product_tag":[3335,4917],"class_list":{"0":"post-60763","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-category-overview","7":"product_cat-chronic-conditions","8":"product_cat-hepatitis-medication","9":"product_cat-hiv-medication","10":"product_tag-tenofovir","11":"product_tag-teravir","13":"first","14":"instock","15":"shipping-taxable","16":"purchasable","17":"product-type-variable","18":"has-default-attributes"},"acf":[],"_links":{"self":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product\/60763","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/comments?post=60763"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/media\/60764"}],"wp:attachment":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/media?parent=60763"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product_brand?post=60763"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product_cat?post=60763"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product_tag?post=60763"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}