{"id":60769,"date":"2024-02-28T07:07:38","date_gmt":"2024-02-28T07:07:38","guid":{"rendered":"https:\/\/medsname.com\/avonza\/"},"modified":"2026-05-08T09:18:45","modified_gmt":"2026-05-08T09:18:45","slug":"avonza","status":"publish","type":"product","link":"https:\/\/medsbase.com\/cs\/product\/avonza\/","title":{"rendered":"Avonza"},"content":{"rendered":"
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Rychl\u00e1 odpov\u011b\u010f<\/h3>\n

Avonza<\/strong> je antiretrovirov\u00e1 terapie pod odborn\u00fdm dohledem, pou\u017e\u00edvan\u00e1 jako sou\u010d\u00e1st kombinovan\u00e9 l\u00e9\u010dby HIV. P\u0159ed pou\u017eit\u00edm si p\u0159e\u010dt\u011bte sekce o d\u00e1vkov\u00e1n\u00ed, vedlej\u0161\u00edch \u00fa\u010dinc\u00edch a interakc\u00edch; nej\u010dast\u011bj\u0161\u00ed dotazy jsou pokryty v sekci FAQ dole.<\/p>\n<\/div>\n

\nCo z\u00edsk\u00e1te s MedsBase:<\/strong> V\u00fdrobce certifikovan\u00fd WHO-GMP \u00b7 Diskr\u00e9tn\u00ed balen\u00ed \u00b7 Celosv\u011btov\u00e1 doprava \u00b7 V\u00edce ne\u017e 1 400 ov\u011b\u0159en\u00fdch recenz\u00ed z\u00e1kazn\u00edk\u016f<\/a>\n<\/div>\n

\ud83d\udce6 Ka\u017ed\u00e1 objedn\u00e1vka je pokryta na\u0161\u00ed Z\u00e1rukou op\u011btovn\u00e9ho odesl\u00e1n\u00ed<\/strong><\/a> \u2014 pokud va\u0161e z\u00e1silka nedoraz\u00ed do 20 pracovn\u00edch dn\u016f, p\u0159epos\u00edl\u00e1me ji.<\/p>\n

Pro\u010d objedn\u00e1vat z MedsBase<\/h3>\n

Na\u0161e generick\u00e9 l\u00e9ky poch\u00e1zej\u00ed od v\u00fdrobc\u016f certifikovan\u00fdch WHO-GMP a jsou expedov\u00e1ny po cel\u00e9m sv\u011bt\u011b v diskr\u00e9tn\u00edm, nen\u00e1padn\u00e9m balen\u00ed \u2013 na vn\u011bj\u0161\u00ed stran\u011b bal\u00edku nen\u00ed uveden n\u00e1zev l\u00e9ku. Platby kartou jsou sm\u011brov\u00e1ny prost\u0159ednictv\u00edm regulovan\u00e9ho procesoru (popisky na v\u00fdpisu zahrnuj\u00ed regulovan\u00e9ho procesora plateb kartou \u2013 nikdy \u201cMedsBase\u201d nebo n\u00e1zev l\u00e9ku). P\u0159ij\u00edm\u00e1me tak\u00e9 kryptom\u011bny a bankovn\u00ed p\u0159evody SEPA. Ka\u017ed\u00e1 objedn\u00e1vka je zaji\u0161t\u011bna na\u0161\u00ed politikou p\u0159eposl\u00e1n\u00ed.<\/p>\n

Avonza<\/strong> is a fixed-dose combination antiretroviral tablet used for the treatment of infekce HIV-1<\/strong>. Each tablet contains three active ingredients — Lamivudine 300mg<\/strong>, Tenofovir Disoproxil Fumarate 300mg<\/strong>, a Efavirenz 600mg<\/strong> — combined into a single daily pill. As a generic equivalent of Atripla<\/strong>, Avonza delivers the same triple-drug regimen at a fraction of the cost, making effective HIV treatment more accessible worldwide.<\/p>\n

When you buy Avonza online<\/strong> from MedsBase, you receive genuine, WHO-prequalified antiretroviral tablets manufactured under strict Good Manufacturing Practice (GMP) standards, shipped with discreet packaging and worldwide delivery. Browse our full range of HIV medications<\/a> for additional antiretroviral options.<\/p>\n

Avonza Product Overview<\/h2>\n

Avonza belongs to a class of medicines known as complete single-tablet regimens (STRs)<\/strong> for HIV-1. It combines two nucleoside reverse transcriptase inhibitors (NRTIs) with one non-nucleoside reverse transcriptase inhibitor (NNRTI), providing a complete antiretroviral therapy in one convenient tablet taken once daily.<\/p>\n\n\n\n\n\n\n\n\n\n\n\n
Property<\/th>\nDetails<\/th>\n<\/tr>\n<\/thead>\n
Brand Name<\/td>\nAvonza<\/td>\n<\/tr>\n
Aktivn\u00ed slo\u017eky<\/td>\nLamivudine 300mg + Tenofovir Disoproxil Fumarate 300mg + Efavirenz 600mg<\/td>\n<\/tr>\n
T\u0159\u00edda l\u00e9\u010div<\/td>\nCombination antiretroviral (2 NRTIs + 1 NNRTI)<\/td>\n<\/tr>\n
Reference Brand<\/td>\nAtripla<\/td>\n<\/tr>\n
item11<\/td>\nFilm-coated oral tablet<\/td>\n<\/tr>\n
D\u00e1vkov\u00e1n\u00ed<\/td>\nOne tablet once daily<\/td>\n<\/tr>\n
Indikace<\/td>\nHIV-1 treatment in adults and adolescents ≥40kg<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Avonza simplifies L\u00e9\u010dba HIV<\/strong> by replacing what would otherwise be three separate medications into a single pill, improving adherence and reducing the complexity of daily antiretroviral therapy.<\/p>\n

How Avonza Works<\/h2>\n

The Avonza tablet<\/strong> contains three antiretroviral agents that target HIV-1 at different stages of its replication cycle. By attacking the virus through multiple mechanisms simultaneously, Avonza suppresses viral load more effectively and reduces the risk of drug resistance.<\/p>\n

Lamivudine (300mg) — Nucleoside Reverse Transcriptase Inhibitor (NRTI)<\/h3>\n

Lamivudine (also known as 3TC) is a synthetic nucleoside analogue. Once inside an HIV-infected cell, it is phosphorylated to its active triphosphate form, which competes with the natural nucleoside deoxycytidine triphosphate. When incorporated into the growing viral DNA chain by reverse transcriptase<\/strong>, it causes chain termination<\/strong> — blocking further DNA synthesis and preventing the virus from replicating its genetic material.<\/p>\n

Tenofovir Disoproxil Fumarate (300mg) — Nucleotide Reverse Transcriptase Inhibitor (NtRTI)<\/h3>\n

Tenofovir is a nucleotide analogue that, like Lamivudine, inhibits HIV reverse transcriptase. However, because it is already a nucleotide (monophosphate), it requires one fewer phosphorylation step to become active. Tenofovir diphosphate competes with deoxyadenosine triphosphate and, when incorporated into viral DNA, causes obligate chain termination<\/strong>. Its distinct resistance profile complements Lamivudine, providing a robust NRTI backbone.<\/p>\n

Efavirenz (600mg) — Non-Nucleoside Reverse Transcriptase Inhibitor (NNRTI)<\/h3>\n

Efavirenz works through a different mechanism from the two NRTIs. Rather than being incorporated into the DNA chain, it binds directly to HIV-1 reverse transcriptase<\/strong> at a site away from the active site (an allosteric site), causing a conformational change that disrupts the enzyme’s function. This non-competitive inhibition effectively shuts down viral DNA synthesis through an entirely separate pathway.<\/p>\n

Triple-Action Synergy<\/h3>\n

Together, these three components create a powerful barrier to HIV replication. The dual NRTI backbone (Lamivudine + Tenofovir) blocks reverse transcription through chain termination, while Efavirenz disables the same enzyme through allosteric inhibition. This multi-target approach<\/strong> is central to modern antiretroviral therapy — it suppresses the virus more completely and makes it significantly harder for HIV to develop resistance mutations against all three drugs simultaneously.<\/p>\n

Pou\u017eit\u00ed a indikace<\/h2>\n

Avonza<\/strong> is indicated for the treatment of infekce HIV-1<\/strong> as a complete regimen in the following patient populations:<\/p>\n

    \n
  • Dosp\u011bl\u00ed<\/strong> — treatment-naïve patients starting antiretroviral therapy for the first time, or patients switching from a stable regimen with undetectable viral load<\/li>\n
  • Adolescents weighing ≥40kg<\/strong> — who can swallow the tablet whole and require a complete single-tablet regimen<\/li>\n<\/ul>\n

    Important limitations:<\/strong><\/p>\n

      \n
    • Avonza is not indicated for pre-exposure prophylaxis (PrEP)<\/strong> — Efavirenz is not appropriate for HIV prevention in uninfected individuals<\/li>\n
    • Avonza is not effective against HIV-2<\/strong> — Efavirenz has no activity against HIV-2 reverse transcriptase<\/li>\n
    • Avonza should not be used as monotherapy<\/strong> or co-administered with other products containing the same active ingredients (e.g., separate Lamivudine, Tenofovir, or Efavirenz tablets)<\/li>\n<\/ul>\n

      Avonza Dosage<\/h2>\n

      The recommended dose of Avonza<\/strong> je one tablet taken once daily<\/strong>, on an empty stomach. Dosing at bedtime is strongly recommended to minimize central nervous system (CNS) side effects associated with Efavirenz, such as dizziness and vivid dreams.<\/p>\n

        \n
      • Na\u010dasov\u00e1n\u00ed:<\/strong> Take at bedtime, preferably 2–3 hours after the last meal<\/li>\n
      • Food:<\/strong> Take on an empty stomach — taking with food (especially high-fat meals) increases Efavirenz absorption by up to 50%, which may worsen side effects<\/li>\n
      • Swallow whole:<\/strong> Do not crush, break, or chew the tablet<\/li>\n
      • D\u016fslednost:<\/strong> Take at the same time every day to maintain steady drug levels<\/li>\n
      • Vynechan\u00e1 d\u00e1vka:<\/strong> If you miss a dose, take it as soon as you remember unless it is almost time for the next dose — do not double up<\/li>\n<\/ul>\n

        No dose adjustment is needed for patients with mild renal impairment (creatinine clearance ≥50 mL\/min). Avonza should not be used<\/strong> in patients with moderate or severe renal impairment, as the Tenofovir component requires dose adjustment that cannot be achieved with a fixed-dose combination.<\/p>\n

        Benefits of a Single-Pill Regimen<\/h2>\n

        Taking a single tablet daily<\/strong> instead of multiple pills offers significant advantages for long-term HIV management:<\/p>\n

          \n
        • Improved adherence<\/strong> — simpler regimens lead to better medication-taking behaviour, which is critical for maintaining viral suppression<\/li>\n
        • Reduced pill burden<\/strong> — one tablet replaces three separate medications, reducing the daily reminder of living with HIV<\/li>\n
        • Lower risk of resistance<\/strong> — better adherence means fewer missed doses, which reduces the chance of the virus developing drug-resistant mutations<\/li>\n
        • Pohodl\u00ed<\/strong> — easier to incorporate into a daily routine, especially for patients managing other health conditions<\/li>\n
        • N\u00e1kladov\u011b efektivn\u00ed<\/strong> — as a generic equivalent of Atripla, Avonza<\/strong> provides the same proven triple-drug combination at significantly lower cost<\/li>\n
        • Discreet<\/strong> — a single tablet is easier to store and take discreetly compared to multiple pill bottles<\/li>\n<\/ul>\n

          Avonza Side Effects<\/h2>\n

          Like all antiretroviral medications, Avonza<\/strong> can cause side effects. Most are mild to moderate and tend to improve within the first 2–4 weeks of treatment. The Efavirenz component is responsible for the majority of early side effects, particularly those affecting the central nervous system.<\/p>\n

          B\u011b\u017en\u00e9 ne\u017e\u00e1douc\u00ed \u00fa\u010dinky<\/h3>\n\n\n\n\n\n\n\n\n\n
          Category<\/th>\nVedlej\u0161\u00ed \u00fa\u010dinky<\/th>\nFrekvence<\/th>\n<\/tr>\n<\/thead>\n
          Central Nervous System (Efavirenz)<\/td>\nDizziness, vivid or abnormal dreams, insomnia, impaired concentration, drowsiness<\/td>\nVery common (up to 50% in first weeks)<\/td>\n<\/tr>\n
          Gastrointestinal<\/td>\nNausea, diarrhoea, vomiting, abdominal pain<\/td>\nB\u011b\u017en\u00e9<\/td>\n<\/tr>\n
          Skin<\/td>\nRash (usually mild to moderate, resolves without stopping treatment)<\/td>\nB\u011b\u017en\u00e9<\/td>\n<\/tr>\n
          Metabolic<\/td>\nElevated liver enzymes, elevated cholesterol and triglycerides<\/td>\nB\u011b\u017en\u00e9<\/td>\n<\/tr>\n
          General<\/td>\n\u00danava, bolest hlavy<\/td>\nB\u011b\u017en\u00e9<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

          CNS side effects from Efavirenz — particularly dizziness and vivid dreams — are very common during the first 1–2 weeks but typically resolve within 2–4 weeks<\/strong> of continued use. Taking the tablet at bedtime significantly reduces the impact of these effects on daily activities.<\/p>\n

          Z\u00e1va\u017en\u00e9 vedlej\u0161\u00ed \u00fa\u010dinky (vz\u00e1cn\u00e9)<\/h3>\n

          Seek immediate medical attention if you experience any of the following:<\/p>\n

            \n
          • Lakt\u00e1tov\u00e1 acid\u00f3za<\/strong> — symptoms include unusual muscle pain, difficulty breathing, stomach pain with nausea\/vomiting, cold or blue skin, and dizziness. This is a rare but potentially life-threatening complication of NRTIs (Lamivudine and Tenofovir).<\/li>\n
          • Hepatotoxicita<\/strong> — severe liver damage presenting as jaundice (yellowing of skin or eyes), dark urine, pale stools, or persistent abdominal pain<\/li>\n
          • Hepatitis B flare<\/strong> — patients co-infected with Hepatitis B may experience severe acute exacerbations of hepatitis if Avonza is discontinued (see Warnings section below)<\/li>\n
          • Severe skin reactions<\/strong> — Stevens-Johnson syndrome (SJS) has been reported rarely with Efavirenz. Discontinue immediately if blistering or mucosal lesions develop.<\/li>\n
          • Psychiatric symptoms<\/strong> — severe depression, suicidal thoughts, or psychosis (uncommon but reported with Efavirenz)<\/li>\n
          • Porucha funkce ledvin<\/strong> — Tenofovir can affect kidney function, particularly proximal renal tubular function (Fanconi syndrome)<\/li>\n<\/ul>\n

            Important Warnings and Precautions<\/h2>\n

            Before starting Avonza HIV treatment<\/strong>, your healthcare provider should evaluate several important factors:<\/p>\n

              \n
            • Test for Hepatitis B before starting treatment<\/strong> — Lamivudine and Tenofovir are both active against Hepatitis B virus (HBV). If Avonza is stopped in a co-infected patient, the sudden removal of HBV suppression can trigger a severe hepatitis B flare<\/strong>. Monitor liver function closely for at least several months after discontinuation.<\/li>\n
            • Renal function monitoring<\/strong> — Tenofovir Disoproxil Fumarate can cause nephrotoxicity, including Fanconi syndrome and acute renal failure. Check serum creatinine and estimated creatinine clearance before starting therapy and at regular intervals during treatment. Avoid co-administration with other nephrotoxic agents.<\/li>\n
            • Bone density monitoring<\/strong> — Tenofovir has been associated with decreases in bone mineral density (BMD)<\/strong>. Consider monitoring in patients with a history of pathologic fracture or at risk for osteoporosis. Calcium and vitamin D supplementation may be beneficial.<\/li>\n
            • CNS effects<\/strong> — Efavirenz causes neuropsychiatric side effects in many patients. These usually resolve within 2–4 weeks<\/strong> but can persist in some individuals. Avoid driving or operating heavy machinery until you know how the medication affects you. Patients with a history of psychiatric disorders should be monitored closely.<\/li>\n
            • T\u011bhotenstv\u00ed<\/strong> — Efavirenz was previously associated with neural tube defects in animal studies. While more recent human data are reassuring, discuss the risks and benefits with your healthcare provider if you are pregnant or planning pregnancy.<\/li>\n
            • Immune reconstitution syndrome<\/strong> — when antiretroviral therapy is initiated, the recovering immune system may produce an inflammatory response to pre-existing infections (e.g., MAC, CMV, TB). This is not a reason to stop treatment.<\/li>\n<\/ul>\n

              Interakce s l\u00e9\u010divy<\/h2>\n

              Efavirenz is a moderate inducer of CYP3A4<\/strong> and an inhibitor and inducer of CYP2B6<\/strong>, which means it can significantly alter the blood levels of many other medications. Lamivudine and Tenofovir have fewer drug interactions but should still be reviewed.<\/p>\n

              Contraindicated combinations (do NOT use with Avonza):<\/strong><\/p>\n