{"id":60802,"date":"2024-02-28T07:09:25","date_gmt":"2024-02-28T07:09:25","guid":{"rendered":"https:\/\/medsname.com\/unicontin-e\/"},"modified":"2026-04-30T10:23:42","modified_gmt":"2026-04-30T10:23:42","slug":"unicontin-e","status":"publish","type":"product","link":"https:\/\/medsbase.com\/cs\/product\/unicontin-e\/","title":{"rendered":"Unicontin-E"},"content":{"rendered":"<div class=\"medsbase-tldr-answer\" style=\"background:#fff8e1;border-left:4px solid #f5a623;padding:18px 22px;margin:0 0 28px 0;border-radius:4px;\">\n<h3 style=\"margin:0 0 10px 0;font-size:18px;color:#1a1a1a;\">\u26a1 Rychl\u00e1 odpov\u011b\u010f \u2014 Co je Unicontin-E?<\/h3>\n<p><strong>Unicontin-E<\/strong> obsahuje <strong>theophylline<\/strong>, , <strong>methylxanthinov\u00fd bronchodilatans<\/strong> s protiz\u00e1n\u011btliv\u00fdmi \u00fa\u010dinky, pou\u017e\u00edvan\u00fd jako dopl\u0148kov\u00e1 terapie u chronick\u00e9ho astmatu a COPD. Theofylin p\u016fsob\u00ed na v\u00edce c\u00edl\u016f \u2014 inhibice fosfodiester\u00e1zy (zvy\u0161ov\u00e1n\u00ed cAMP), antagonismus adenosinov\u00fdch receptor\u016f a aktivace HDAC2 (protiz\u00e1n\u011btliv\u00fd \u00fa\u010dinek). M\u00e1 <strong>\u00fazk\u00fd terapeutick\u00fd index<\/strong> (c\u00edlov\u00e9 s\u00e9rum 10\u201320 mg\/l; toxicita od 20+) a mnoho l\u00e9kov\u00fdch interakc\u00ed, vy\u017eaduj\u00edc\u00ed pe\u010dliv\u00e9 d\u00e1vkov\u00e1n\u00ed a (u n\u011bkter\u00fdch pacient\u016f) monitorov\u00e1n\u00ed hladin v krvi. Ka\u017ed\u00e1 tableta s prodlou\u017een\u00fdm uvol\u0148ov\u00e1n\u00edm obsahuje <strong>400 mg<\/strong>, vyr\u00e1b\u011bn\u00e9 spole\u010dnost\u00ed <strong>Modi-Mundipharma<\/strong> ve v\u00fdrobn\u00edch za\u0159\u00edzen\u00edch certifikovan\u00fdch WHO-GMP.<\/p>\n<\/div>\n<div class=\"medsbase-trust-strip\" style=\"background:#f4f8fb;border:1px solid #d8e3eb;padding:12px 16px;margin:16px 0;border-radius:4px;font-size:14px;\">\n<strong>Co z\u00edsk\u00e1te s MedsBase:<\/strong> V\u00fdrobce certifikovan\u00fd WHO-GMP \u00b7 Diskr\u00e9tn\u00ed balen\u00ed \u00b7 Celosv\u011btov\u00e1 doprava \u00b7 V\u00edce ne\u017e 1 400 ov\u011b\u0159en\u00fdch <a href=\"https:\/\/medsbase.com\/cs\/reviews\/\">recenz\u00ed z\u00e1kazn\u00edk\u016f<\/a>\n<\/div>\n<p class=\"medsbase-reship-line\" style=\"font-size:14px;color:#444;margin:8px 0 18px;\">\ud83d\udce6 Ka\u017ed\u00e1 objedn\u00e1vka je pokryta na\u0161\u00ed <a href=\"https:\/\/medsbase.com\/cs\/medsbase-re-shipment-assurance-policy\/\"><strong>Z\u00e1rukou op\u011btovn\u00e9ho odesl\u00e1n\u00ed<\/strong><\/a> \u2014 pokud va\u0161e z\u00e1silka nedoraz\u00ed do 20 pracovn\u00edch dn\u016f, p\u0159epos\u00edl\u00e1me ji.<\/p>\n<h3>Pro\u010d objedn\u00e1vat z MedsBase<\/h3>\n<p>Na\u0161e generick\u00e9 l\u00e9ky poch\u00e1zej\u00ed od v\u00fdrobc\u016f certifikovan\u00fdch WHO-GMP a jsou expedov\u00e1ny po cel\u00e9m sv\u011bt\u011b v diskr\u00e9tn\u00edm, nen\u00e1padn\u00e9m balen\u00ed \u2013 na vn\u011bj\u0161\u00ed stran\u011b bal\u00edku nen\u00ed uveden n\u00e1zev l\u00e9ku. Platby kartou jsou sm\u011brov\u00e1ny prost\u0159ednictv\u00edm regulovan\u00e9ho procesoru (popisky na v\u00fdpisu zahrnuj\u00ed regulovan\u00e9ho procesora plateb kartou \u2013 nikdy \u201cMedsBase\u201d nebo n\u00e1zev l\u00e9ku). P\u0159ij\u00edm\u00e1me tak\u00e9 kryptom\u011bny a bankovn\u00ed p\u0159evody SEPA. Ka\u017ed\u00e1 objedn\u00e1vka je zaji\u0161t\u011bna na\u0161\u00ed politikou p\u0159eposl\u00e1n\u00ed.<\/p>\n<div style=\"background:#f4f8fb;border:1px solid #e0e0e0;padding:12px 18px;margin:0 0 24px 0;border-radius:4px;font-size:14px;text-align:center;\">\n<strong>\ud83d\udd12 \u0160ifrovan\u00fd n\u00e1kup<\/strong> \u00b7 <strong>\ud83d\udcb3 Ov\u011b\u0159en\u00fd procesor<\/strong> \u00b7 <strong>\ud83d\ude9a Doprava po cel\u00e9m sv\u011bt\u011b<\/strong> \u00b7 <strong>\u2b50 4,9\/5 od 1 400+ z\u00e1kazn\u00edk\u016f<\/strong>\n<\/div>\n<h2>Co je Unicontin-E?<\/h2>\n<p>Unicontin-E je peror\u00e1ln\u00ed methylxanthinov\u00fd bronchodilat\u00e1tor. Methylxanthiny jsou odvozeny od p\u0159\u00edrodn\u00edch alkaloid\u016f (theofylin je dimethylxanthin obsa\u017een\u00fd v \u010daji). Jejich pou\u017e\u00edv\u00e1n\u00ed od 90. let 20. stolet\u00ed pokleslo, proto\u017ee inhala\u010dn\u00ed \u03b22-agonist\u00e9 a kortikosteroidy se stali l\u00e9\u010dbou prvn\u00ed volby \u2014 p\u0159esto si zachov\u00e1vaj\u00ed roli jako l\u00e9\u010dba t\u0159et\u00ed volby u obt\u00ed\u017en\u011b l\u00e9\u010diteln\u00fdch p\u0159\u00edpad\u016f astmatu a CHOPN.<\/p>\n<h2>Jak Unicontin-E funguje?<\/h2>\n<ul>\n<li><strong>Inhibice fosfodiester\u00e1zy (PDE3, PDE4)<\/strong> \u2014 zvy\u0161uje cyklick\u00fd AMP v hladk\u00e9m svalstvu d\u00fdchac\u00edch cest a z\u00e1n\u011btliv\u00fdch bu\u0148k\u00e1ch; v\u00fdsledkem je bronchodilatace a sn\u00ed\u017een\u00e9 uvol\u0148ov\u00e1n\u00ed medi\u00e1tor\u016f.<\/li>\n<li><strong>Antagonismus adenosinov\u00fdch receptor\u016f<\/strong> \u2014 blokuje adenosinem zprost\u0159edkovanou bronchokonstrikci a uvol\u0148ov\u00e1n\u00ed medi\u00e1tor\u016f z mastocyt\u016f.<\/li>\n<li><strong>Aktivace HDAC2<\/strong> (teofylin p\u0159i n\u00edzk\u00fdch s\u00e9rov\u00fdch hladin\u00e1ch 5\u201310 mg\/l) \u2014 obnovuje odpov\u011b\u010f na kortikosteroidy u CHOPN a t\u011b\u017ek\u00e9ho astmatu, kde je steroidn\u00ed rezistence \u010d\u00e1ste\u010dn\u011b zp\u016fsobena sn\u00ed\u017eenou hladinou HDAC2.<\/li>\n<li><strong>Kontraktilita br\u00e1nice<\/strong> \u2014 methylxanthiny sni\u017euj\u00ed \u00fanavu br\u00e1nice, co\u017e je u\u017eite\u010dn\u00e9 u CHOPN s t\u011b\u017ekou obstrukc\u00ed d\u00fdchac\u00edch cest.<\/li>\n<\/ul>\n<h2>Pou\u017eit\u00ed a indikace<\/h2>\n<ul>\n<li><strong>T\u011b\u017ek\u00e9 chronick\u00e9 astma<\/strong> \u2014 dopl\u0148kov\u00e1 l\u00e9\u010dba k vysok\u00fdm d\u00e1vk\u00e1m ICS-LABA, kde je pot\u0159eba dal\u0161\u00ed bronchodilatace<\/li>\n<li><strong>\u00dadr\u017eba l\u00e9\u010dby COPD<\/strong> \u2014 dopl\u0148kov\u00e1 l\u00e9\u010dba k LAMA-LABA nebo trojkombina\u010dn\u00ed terapii<\/li>\n<li><strong>No\u010dn\u00ed astma<\/strong> \u2014 forma s prodlou\u017een\u00fdm uvol\u0148ov\u00e1n\u00edm zaji\u0161\u0165uje no\u010dn\u00ed bronchodilataci<\/li>\n<li><strong>Apnoe nedono\u0161en\u00fdch<\/strong> (teofylin) \u2014 pou\u017eit\u00ed u novorozenc\u016f<\/li>\n<li><strong>Cor pulmonale a plicn\u00ed hypertenze<\/strong> \u2014 dopl\u0148kov\u00fd prost\u0159edek<\/li>\n<\/ul>\n<h2>D\u00e1vkov\u00e1n\u00ed Unicontin-E<\/h2>\n<table style=\"border-collapse:collapse;width:100%;margin:12px 0;\">\n<thead>\n<tr style=\"background:#2c7cb0;color:#fff;\">\n<th style=\"padding:10px;border:1px solid #ddd;text-align:left;\">Pacient<\/th>\n<th style=\"padding:10px;border:1px solid #ddd;text-align:left;\">D\u00e1vka<\/th>\n<th style=\"padding:10px;border:1px solid #ddd;text-align:left;\">Frekvence<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td style=\"padding:10px;border:1px solid #ddd;\">Dosp\u011bl\u00ed \u2014 po\u010d\u00e1te\u010dn\u00ed d\u00e1vka<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\"><strong>200 mg<\/strong><\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Dvakr\u00e1t denn\u011b; titrujte na s\u00e9rovou hladinu 10\u201320 mg\/l<\/td>\n<\/tr>\n<tr style=\"background:#f9f9f9;\">\n<td style=\"padding:10px;border:1px solid #ddd;\">Dosp\u011bl\u00ed \u2014 udr\u017eovac\u00ed d\u00e1vka<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\"><strong>400 mg<\/strong><\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Dvakr\u00e1t denn\u011b (nebo 600 mg jednou denn\u011b ER)<\/td>\n<\/tr>\n<tr>\n<td style=\"padding:10px;border:1px solid #ddd;\">Senio\u0159i \/ srde\u010dn\u00ed selh\u00e1n\u00ed \/ onemocn\u011bn\u00ed jater<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Polovi\u010dn\u00ed d\u00e1vka<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Monitorujte s\u00e9rovou hladinu<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2>Vedlej\u0161\u00ed \u00fa\u010dinky Unicontin-E<\/h2>\n<ul>\n<li>Nevolnost, zvracen\u00ed, dyspepsie<\/li>\n<li>Bolest hlavy<\/li>\n<li>T\u0159es<\/li>\n<li>Nespavost, neklid<\/li>\n<li>Tachykardie, palpitace<\/li>\n<li>M\u00edrn\u00e1 hypokal\u00e9mie p\u0159i vysok\u00fdch d\u00e1vk\u00e1ch<\/li>\n<\/ul>\n<p><strong>Toxick\u00e9 hladiny (&gt;20 mg\/l) \u2014 nouzov\u00e1 situace:<\/strong><\/p>\n<ul>\n<li>Siln\u00e1 nevolnost, p\u0159etrv\u00e1vaj\u00edc\u00ed zvracen\u00ed<\/li>\n<li>Srde\u010dn\u00ed arytmie (fibrilace s\u00edn\u00ed, supraventrikul\u00e1rn\u00ed tachykardie)<\/li>\n<li>Z\u00e1chvaty (\u010dasto bez varov\u00e1n\u00ed)<\/li>\n<li>Hypotenze, hyperglyk\u00e9mie, hypokal\u00e9mie, hyperkalc\u00e9mie<\/li>\n<\/ul>\n<h2>Varov\u00e1n\u00ed a opat\u0159en\u00ed<\/h2>\n<ul>\n<li><strong>\u00dazk\u00fd terapeutick\u00fd index.<\/strong> C\u00edlov\u00e9 s\u00e9rum 10\u201320 mg\/l. Hladinu v krvi kontrolujte 5 dn\u00ed po zah\u00e1jen\u00ed l\u00e9\u010dby, po zm\u011bn\u011b d\u00e1vky, p\u0159i nasazen\u00ed nov\u00e9ho interaguj\u00edc\u00edho l\u00e9ku, p\u0159i ukon\u010den\u00ed kou\u0159en\u00ed a b\u011bhem nemoci\/hore\u010dky (clearance kles\u00e1).<\/li>\n<li><strong>Mnoho l\u00e9kov\u00fdch interakc\u00ed<\/strong> \u2014 viz tabulka interakc\u00ed. V\u011bt\u0161ina metabolizov\u00e1na CYP1A2; mnoho inhibitor\u016f a induktor\u016f v\u00fdznamn\u011b m\u011bn\u00ed hladiny.<\/li>\n<li><strong>Kou\u0159en\u00ed<\/strong> indukuje CYP1A2 a sni\u017euje hladinu teofylinu p\u0159ibli\u017en\u011b o 50 % \u2014 p\u0159etitrujte p\u0159i ukon\u010den\u00ed kou\u0159en\u00ed.<\/li>\n<li><strong>Onemocn\u011bn\u00ed srdce:<\/strong> pou\u017e\u00edvejte opatrn\u011b u arytmi\u00ed, srde\u010dn\u00edho selh\u00e1n\u00ed, t\u011b\u017ek\u00e9 hypertenze.<\/li>\n<li><strong>Hypertyre\u00f3za:<\/strong> zv\u00fd\u0161en\u00e1 clearance spolu se zes\u00edlen\u00fdmi adrenergn\u00edmi \u00fa\u010dinky.<\/li>\n<li><strong>T\u011bhotenstv\u00ed a kojen\u00ed:<\/strong> obecn\u011b se nedoporu\u010duje; pou\u017e\u00edvejte pouze v p\u0159\u00edpad\u011b jasn\u00e9ho p\u0159\u00ednosu.<\/li>\n<li><strong>Onemocn\u011bn\u00ed jater:<\/strong> sni\u017ete d\u00e1vku \u2014 methylxanthiny jsou metabolizov\u00e1ny v j\u00e1trech.<\/li>\n<\/ul>\n<h2>Kontraindikace<\/h2>\n<ul>\n<li>P\u0159ecitliv\u011blost na theofylin nebo jin\u00e9 xantiny (kofein, theobromin)<\/li>\n<li>Aktivn\u00ed peptick\u00fd v\u0159ed<\/li>\n<li>Nekontrolovan\u00e9 tachyarytmie<\/li>\n<li>T\u011b\u017ek\u00e9 srde\u010dn\u00ed selh\u00e1n\u00ed (NYHA IV)<\/li>\n<\/ul>\n<h2>Interakce s l\u00e9\u010divy<\/h2>\n<table style=\"border-collapse:collapse;width:100%;margin:12px 0;\">\n<thead>\n<tr style=\"background:#2c7cb0;color:#fff;\">\n<th style=\"padding:10px;border:1px solid #ddd;text-align:left;\">Interaguj\u00edc\u00ed l\u00e9k<\/th>\n<th style=\"padding:10px;border:1px solid #ddd;text-align:left;\">\u00da\u010dinek<\/th>\n<th style=\"padding:10px;border:1px solid #ddd;text-align:left;\">Co d\u011blat<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td style=\"padding:10px;border:1px solid #ddd;\">Ciprofloxacin, erythromycin, clarithromycin, fluvoxamin<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Inhibuj\u00ed CYP1A2 \u2192 zvy\u0161uj\u00ed hladiny theofylinu \u2192 toxicita (nevolnost, arytmie, k\u0159e\u010de)<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Vyhn\u011bte se nebo sni\u017ete d\u00e1vku theofylinu o 50%; kontrolujte s\u00e9rov\u00e9 hladiny<\/td>\n<\/tr>\n<tr style=\"background:#f9f9f9;\">\n<td style=\"padding:10px;border:1px solid #ddd;\">Cimetidin, allopurinol<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Zvy\u0161uj\u00ed hladiny theofylinu<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Sni\u017ete d\u00e1vku; monitorujte hladiny<\/td>\n<\/tr>\n<tr>\n<td style=\"padding:10px;border:1px solid #ddd;\">Fenytoin, karbamazepin, rifampicin<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Indukuj\u00ed CYP \u2014 ni\u017e\u0161\u00ed hladiny<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">M\u016f\u017ee b\u00fdt pot\u0159eba vy\u0161\u0161\u00ed d\u00e1vka<\/td>\n<\/tr>\n<tr style=\"background:#f9f9f9;\">\n<td style=\"padding:10px;border:1px solid #ddd;\">Kou\u0159en\u00ed<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Indukuje CYP1A2 \u2014 ni\u017e\u0161\u00ed hladiny<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">P\u0159ehodno\u0165te d\u00e1vkov\u00e1n\u00ed p\u0159i ukon\u010den\u00ed kou\u0159en\u00ed<\/td>\n<\/tr>\n<tr>\n<td style=\"padding:10px;border:1px solid #ddd;\">\u03b2-agonist\u00e9, diuretika<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Aditivn\u00ed hypokal\u00e9mie<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Monitorujte hladinu drasl\u00edku<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2>Skladov\u00e1n\u00ed<\/h2>\n<ul>\n<li>Skladujte p\u0159i teplot\u011b do <strong>25\u00b0C<\/strong> na chladn\u00e9m, such\u00e9m m\u00edst\u011b, chr\u00e1n\u011bn\u00e9m p\u0159ed p\u0159\u00edm\u00fdm slune\u010dn\u00edm z\u00e1\u0159en\u00edm.<\/li>\n<li>Ponechte v p\u016fvodn\u00edm obalu a\u017e do pou\u017eit\u00ed, aby byl chr\u00e1n\u011bn p\u0159ed vlhkost\u00ed a sv\u011btlem.<\/li>\n<li>Nepou\u017e\u00edvejte po uplynut\u00ed data expirace uveden\u00e9ho na blistru.<\/li>\n<li>Uchov\u00e1vejte mimo dosah d\u011bt\u00ed.<\/li>\n<\/ul>\n<h2>Souvisej\u00edc\u00ed alternativy na MedsBase<\/h2>\n<ul>\n<li><a href=\"https:\/\/medsbase.com\/cs\/asthalin-inhaler\/\"><strong>Asthalin Inhaler \u2014 salbutamol \u00falevov\u00fd inhal\u00e1tor<\/strong><\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/budecort-inhaler\/\"><strong>Budecort Inhaler \u2014 budesonid preventivn\u00ed ICS inhal\u00e1tor<\/strong><\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/foracort-inhaler\/\"><strong>Foracort Inhaler \u2014 budesonid + formoterol ICS-LABA inhal\u00e1tor<\/strong><\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/tiova-inhaler\/\"><strong>Tiova Inhaler \u2014 tiotropium LAMA pro CHOPN<\/strong><\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/montair\/\"><strong>Montair \u2014 montelukast LTRA tablety<\/strong><\/a><\/li>\n<\/ul>\n<h2 id=\"faqs\">\u010casto kladen\u00e9 dotazy<\/h2>\n<h3>Pou\u017e\u00edv\u00e1 se theofylin v modern\u00ed l\u00e9\u010db\u011b astmatu?<\/h3>\n<p>Ano, ale jako l\u00e9\u010dba t\u0159et\u00ed volby. Inhala\u010dn\u00ed \u03b22-agonist\u00e9, ICS, ICS-LABA, LTRA a LAMA jsou prvn\u00ed volbou; theofylin se p\u0159id\u00e1v\u00e1 u refraktern\u00edch onemocn\u011bn\u00ed, zejm\u00e9na no\u010dn\u00edho astmatu. \u00dazk\u00fd terapeutick\u00fd rozsah a \u010detn\u00e9 l\u00e9kov\u00e9 interakce omezuj\u00ed jeho pou\u017eit\u00ed.<\/p>\n<h3>Jak se stanov\u00ed d\u00e1vka?<\/h3>\n<p>Upravuje se podle s\u00e9rov\u00e9 hladiny theofylinu 10\u201320 mg\/l. Kontrolujte 5 dn\u00ed po zah\u00e1jen\u00ed l\u00e9\u010dby, po zm\u011bn\u011b d\u00e1vky, p\u0159i nasazen\u00ed nov\u00e9ho interaguj\u00edc\u00edho l\u00e9ku, p\u0159i ukon\u010den\u00ed kou\u0159en\u00ed a b\u011bhem onemocn\u011bn\u00ed\/hore\u010dky.<\/p>\n<h3>Pro\u010d tolik interakc\u00ed?<\/h3>\n<p>Theofylin je metabolizov\u00e1n CYP1A2 \u2014 mnoho l\u00e9k\u016f zvy\u0161uje jeho hladinu (ciprofloxacin, erytromycin, fluvoxamin, cimetidin) nebo sni\u017euje (rifampicin, fenytoin, kou\u0159en\u00ed).<\/p>\n<h3>Jak dlouho Unicontin-E p\u016fsob\u00ed?<\/h3>\n<p>Tableta s \u0159\u00edzen\u00fdm uvol\u0148ov\u00e1n\u00edm poskytuje 12hodinov\u00e9 pokryt\u00ed. Dvakr\u00e1t denn\u00ed d\u00e1vkov\u00e1n\u00ed udr\u017euje stabiln\u00ed hladiny v s\u00e9ru.<\/p>\n<h3>Jak\u00e9 jsou p\u0159\u00edznaky toxicity?<\/h3>\n<p>Siln\u00e1 nevolnost, p\u0159etrv\u00e1vaj\u00edc\u00ed zvracen\u00ed, tachykardie, palpitace, t\u0159es, hyperaktivita, z\u00e1chvaty (\u010dasto bez varov\u00e1n\u00ed), arytmie, hypotenze. Toxicita nad 20 mg\/l je stav nouze \u2014 vynechejte d\u00e1vku, zkontrolujte hladinu, poskytn\u011bte podp\u016frnou p\u00e9\u010di.<\/p>\n<h3>M\u016f\u017eu to u\u017e\u00edvat s kofeinem?<\/h3>\n<p>Kofein a theofylin jsou oba methylxanthiny s p\u0159ekr\u00fdvaj\u00edc\u00edmi se \u00fa\u010dinky. Vysok\u00fd p\u0159\u00edjem kofeinu m\u016f\u017ee zes\u00edlit t\u0159es, tachykardii a nespavost. P\u0159i p\u0159\u00edznac\u00edch sni\u017ete p\u0159\u00edjem kofeinu.<\/p>\n<h3>Pro\u010d kou\u0159en\u00ed ovliv\u0148uje d\u00e1vkov\u00e1n\u00ed?<\/h3>\n<p>Kou\u0159en\u00ed indukuje CYP1A2 (enzym, kter\u00fd metabolizuje theofylin). Ku\u0159\u00e1ci pot\u0159ebuj\u00ed vy\u0161\u0161\u00ed d\u00e1vky; po ukon\u010den\u00ed kou\u0159en\u00ed hladiny stoupaj\u00ed \u2014 p\u0159eupravte d\u00e1vkov\u00e1n\u00ed.<\/p>\n<h3>Je Unicontin-E bezpe\u010dn\u00fd v t\u011bhotenstv\u00ed?<\/h3>\n<p>Obecn\u011b se nedoporu\u010duje, pokud nen\u00ed z\u0159ejm\u00fd p\u0159\u00ednos. Preferuje se inhala\u010dn\u00ed terapie.<\/p>\n<h3>Mohu rozdrtit nebo rozd\u011blit tablety Unicontin-E?<\/h3>\n<p>Ne \u2014 tablety s \u0159\u00edzen\u00fdm uvol\u0148ov\u00e1n\u00edm mus\u00ed b\u00fdt spolknuty vcelku. Drcen\u00ed ni\u010d\u00ed matrici uvol\u0148ov\u00e1n\u00ed a hroz\u00ed akutn\u00ed toxicitou.<\/p>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:14px 18px;margin:24px 0;border-radius:4px;font-size:13px;\"><strong>Zdravotn\u00ed upozorn\u011bn\u00ed:<\/strong> Tato str\u00e1nka je vzd\u011bl\u00e1vac\u00ed a nenahrazuje odbornou l\u00e9ka\u0159skou pomoc. P\u0159ed zah\u00e1jen\u00edm, ukon\u010den\u00edm nebo zm\u011bnou jak\u00e9hokoli inhal\u00e1toru nebo respira\u010dn\u00edho l\u00e9ku se v\u017edy pora\u010fte s kvalifikovan\u00fdm zdravotnick\u00fdm pracovn\u00edkem, zejm\u00e9na pokud m\u00e1te jin\u00e9 zdravotn\u00ed pot\u00ed\u017ee, u\u017e\u00edv\u00e1te jin\u00e9 l\u00e9ky, jste t\u011bhotn\u00e1 nebo koj\u00edte, nebo je v\u00e1m v\u00edce ne\u017e 65 let.<\/div>\n<p><!-- medsbase-related-alts-v1 --><\/p>\n<h3 class=\"wp-block-heading\">Souvisej\u00edc\u00ed alternativy<\/h3>\n<p>Dal\u0161\u00ed produkty v <strong>Chronick\u00e1 onemocn\u011bn\u00ed<\/strong> kter\u00e9 z\u00e1kazn\u00edci tak\u00e9 prohl\u00ed\u017eej\u00ed:<\/p>\n<ul>\n<li><a href=\"https:\/\/medsbase.com\/cs\/topme-xl\/\">Topme XL<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/amifru\/\">Amifru<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/unibrom-eye-drops\/\">Unibrom Eye Drops<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/nise-gel\/\">Nise Gel<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/dynapar\/\">Dynapar<\/a><\/li>\n<\/ul>","protected":false},"excerpt":{"rendered":"<p>\u2705 Uvol\u0148uje bronchospazmus<br \/>\n\u2705 Zlep\u0161uje funkci plic<br \/>\n\u2705 Sni\u017euje du\u0161nost<br \/>\n\u2705 Zlep\u0161uje pr\u016ftok d\u00fdchac\u00edch cest<br \/>\n\u2705 Zm\u00edr\u0148uje p\u0159\u00edznaky astmatu<\/p>\n<p>Unicontin-E obsahuje Theophylline.<\/p>","protected":false},"featured_media":60803,"comment_status":"open","ping_status":"open","template":"","meta":[],"product_brand":[],"product_cat":[3681,3141,3223],"product_tag":[3731,4926],"class_list":{"0":"post-60802","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-asthma-copd-treatment","7":"product_cat-category-overview","8":"product_cat-chronic-conditions","9":"product_tag-theophylline","10":"product_tag-unicontin-e","12":"first","13":"instock","14":"shipping-taxable","15":"purchasable","16":"product-type-variable","17":"has-default-attributes"},"acf":[],"_links":{"self":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product\/60802","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/comments?post=60802"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/media\/60803"}],"wp:attachment":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/media?parent=60802"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product_brand?post=60802"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product_cat?post=60802"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product_tag?post=60802"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}