{"id":60862,"date":"2024-02-28T07:12:27","date_gmt":"2024-02-28T07:12:27","guid":{"rendered":"https:\/\/medsname.com\/trinex\/"},"modified":"2026-05-01T10:49:16","modified_gmt":"2026-05-01T10:49:16","slug":"trinex","status":"publish","type":"product","link":"https:\/\/medsbase.com\/cs\/product\/trinex\/","title":{"rendered":"Trinex"},"content":{"rendered":"

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\u26a1 Rychl\u00e1 odpov\u011b\u010f \u2013 Co je Trinex?<\/h3>\n

Trinex<\/strong> je tizanidin 2 mg tableta<\/strong>, centr\u00e1ln\u011b p\u016fsob\u00edc\u00ed alfa-2 adrenergn\u00ed agonista<\/strong> svalov\u00fd relaxant pou\u017e\u00edvan\u00fd k l\u00e9\u010db\u011b spasticita<\/strong> (svalov\u00e9 ztuhlosti zp\u016fsoben\u00e9 onemocn\u011bn\u00edm horn\u00edho motorick\u00e9ho neuronu) a akutn\u00edm bolestiv\u00e9m svalov\u00e9m spasmu<\/strong>. Obvykl\u00e1 po\u010d\u00e1te\u010dn\u00ed d\u00e1vka je 2 mg t\u0159ikr\u00e1t denn\u011b<\/strong>, titrov\u00e1n pomalu a\u017e na maximum 36 mg\/den ve 3\u20134 d\u00edl\u010d\u00edch d\u00e1vk\u00e1ch<\/strong>. Tizanidin m\u00e1 kr\u00e1tk\u00fd polo\u010das (~2,5 hodiny), proto je nutn\u00e9 \u010dast\u00e9 d\u00e1vkov\u00e1n\u00ed. Nej\u010dast\u011bj\u0161\u00edm vedlej\u0161\u00edm \u00fa\u010dinkem je ospalost; nikdy nekombinujte s ciprofloxacinem nebo fluvoxaminem (10n\u00e1sobn\u00e9 zv\u00fd\u0161en\u00ed hladin v krvi).<\/p>\n<\/div>\n

\nCo z\u00edsk\u00e1te s MedsBase:<\/strong> V\u00fdrobce certifikovan\u00fd WHO-GMP \u00b7 Diskr\u00e9tn\u00ed balen\u00ed \u00b7 Celosv\u011btov\u00e1 doprava \u00b7 V\u00edce ne\u017e 1 400 ov\u011b\u0159en\u00fdch recenz\u00ed z\u00e1kazn\u00edk\u016f<\/a>\n<\/div>\n

\ud83d\udce6 Ka\u017ed\u00e1 objedn\u00e1vka je pokryta na\u0161\u00ed Z\u00e1rukou op\u011btovn\u00e9ho odesl\u00e1n\u00ed<\/strong><\/a> \u2014 pokud va\u0161e z\u00e1silka nedoraz\u00ed do 20 pracovn\u00edch dn\u016f, p\u0159epos\u00edl\u00e1me ji.<\/p>\n

Pro\u010d objedn\u00e1vat z MedsBase<\/h3>\n

Na\u0161e generick\u00e9 l\u00e9ky poch\u00e1zej\u00ed od v\u00fdrobc\u016f certifikovan\u00fdch WHO-GMP a jsou expedov\u00e1ny po cel\u00e9m sv\u011bt\u011b v diskr\u00e9tn\u00edm, nen\u00e1padn\u00e9m balen\u00ed \u2013 na vn\u011bj\u0161\u00ed stran\u011b bal\u00edku nen\u00ed uveden n\u00e1zev l\u00e9ku. Platby kartou jsou sm\u011brov\u00e1ny prost\u0159ednictv\u00edm regulovan\u00e9ho procesoru (popisky na v\u00fdpisu zahrnuj\u00ed regulovan\u00e9ho procesora plateb kartou \u2013 nikdy \u201cMedsBase\u201d nebo n\u00e1zev l\u00e9ku). P\u0159ij\u00edm\u00e1me tak\u00e9 kryptom\u011bny a bankovn\u00ed p\u0159evody SEPA. Ka\u017ed\u00e1 objedn\u00e1vka je zaji\u0161t\u011bna na\u0161\u00ed politikou p\u0159eposl\u00e1n\u00ed.<\/p>\n

Trinex 2 mg<\/strong> je peror\u00e1ln\u00ed tableta tizanidin<\/strong>, centr\u00e1ln\u011b p\u016fsob\u00edc\u00ed myorelaxans. Na rozd\u00edl od cyklobenzaprimu (tricyklick\u00e9ho deriv\u00e1tu s tlumiv\u00fdm \u00fa\u010dinkem na CNS) nebo metokarbamolu a metaxalonu (obecn\u00fdch polysynaptick\u00fdch reflexn\u00edch depresant\u016f) p\u016fsob\u00ed tizanidin odli\u0161n\u00fdm a c\u00edlen\u011bj\u0161\u00edm mechanismem: jde o agonistu alfa-2 adrenergn\u00edch receptor\u016f<\/strong>, bl\u00edzce p\u0159\u00edbuzn\u00e9ho antihypertenzivu klonidinu, ale s selektivn\u011bj\u0161\u00edm \u00fa\u010dinkem na spin\u00e1ln\u00ed motorick\u00e9 reflexy.<\/p>\n

Tizanidin je jedn\u00edm z l\u00e9k\u016f prvn\u00ed volby pro spasticita<\/strong> \u2014 svalovou ztuhlost, kter\u00e1 se vyv\u00edj\u00ed u roztrou\u0161en\u00e9 skler\u00f3zy, poran\u011bn\u00ed m\u00edchy, c\u00e9vn\u00ed mozkov\u00e9 p\u0159\u00edhody, d\u011btsk\u00e9 mozkov\u00e9 obrny a traumatick\u00e9ho po\u0161kozen\u00ed mozku. Pou\u017e\u00edv\u00e1 se tak\u00e9 p\u0159i akutn\u00edch bolestiv\u00fdch svalov\u00fdch spasmech (bolesti zad, bolesti krku, svalov\u00e9 nap\u011bt\u00ed) a jako dopln\u011bk p\u0159i l\u00e9\u010db\u011b chronick\u00e9 bolesti.<\/p>\n

K \u010demu se Trinex pou\u017e\u00edv\u00e1?<\/h2>\n
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  • Spasticita u roztrou\u0161en\u00e9 skler\u00f3zy<\/strong> \u2014 jedno z nej\u010dast\u011bj\u0161\u00edch indikac\u00ed<\/li>\n
  • Spasticita po c\u00e9vn\u00ed mozkov\u00e9 p\u0159\u00edhod\u011b<\/strong> (hemiplegick\u00e1 spasticita)<\/li>\n
  • Spasticita zp\u016fsoben\u00e1 poran\u011bn\u00edm m\u00edchy<\/strong><\/li>\n
  • Spasticita u d\u011btsk\u00e9 mozkov\u00e9 obrny<\/strong> (d\u011bti, pod odborn\u00fdm dohledem pediatra)<\/li>\n
  • Akutn\u00ed bolest zad a svalov\u00e9 k\u0159e\u010de<\/strong><\/li>\n
  • Akutn\u00ed bolest krku, cervik\u00e1ln\u00ed distenze, torticollis<\/strong><\/li>\n
  • Ten\u010dn\u00ed bolest hlavy s v\u00fdraznou cervik\u00e1ln\u00ed svalovou slo\u017ekou<\/strong><\/li>\n
  • Myofasci\u00e1ln\u00ed bolestiv\u00fd syndrom<\/strong> \u2014 jako dopln\u011bk<\/li>\n
  • Fibromyalgie<\/strong> \u2014 off-label, pod\u00e1v\u00e1n\u00ed p\u0159ed span\u00edm<\/li>\n
  • Neuralgie trojklann\u00e9ho nervu<\/strong> \u2014 jako dopln\u011bk karbamazepinu<\/li>\n
  • Chronickou neuropatickou bolest\u00ed<\/strong> \u2014 off-label dopl\u0148kov\u00e1 terapie<\/li>\n<\/ul>\n

    Jak Tizanidin Funguje?<\/h2>\n

    Tizanidin je agonista centr\u00e1ln\u00edch alfa-2 adrenergn\u00edch receptor\u016f. P\u016fsob\u00ed na \u00farove\u0148 m\u00edchy<\/strong>, kde alfa-2 receptory na presynaptick\u00fdch zakon\u010den\u00edch excita\u010dn\u00edch interneuron\u016f sni\u017euj\u00ed uvol\u0148ov\u00e1n\u00ed excita\u010dn\u00edch aminokyselin (glutam\u00e1t, aspart\u00e1t) k motoneuron\u016fm. T\u00edm se sni\u017euje reflexn\u00ed dr\u00e1\u017edivost spin\u00e1ln\u00edch motoneuron\u016f, co\u017e vede ke sn\u00ed\u017een\u00ed svalov\u00e9ho tonu a spasticity bez v\u00fdznamn\u00e9ho ovlivn\u011bn\u00ed svalov\u00e9 s\u00edly nebo nervosvalov\u00e9 plot\u00e9nky.<\/p>\n

    Na rozd\u00edl od baklofenu (GABA-B agonista, tak\u00e9 pou\u017e\u00edvan\u00fd p\u0159i spasticit\u011b) tizanidin nezp\u016fsobuje stejn\u00fd stupe\u0148 svalov\u00e9 slabosti \u2014 proto jej pacienti \u010dasto preferuj\u00ed, kdy\u017e st\u00e1le pot\u0159ebuj\u00ed pou\u017e\u00edvat posti\u017eenou kon\u010detinu.<\/p>\n

    D\u00e1vkov\u00e1n\u00ed Trinexu<\/h2>\n
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    • Po\u010d\u00e1te\u010dn\u00ed d\u00e1vka:<\/strong> 2 mg t\u0159ikr\u00e1t denn\u011b<\/li>\n
    • Titrace:<\/strong> zvy\u0161ovat o 2\u20134 mg ka\u017ed\u00fdch 1\u20134 dny podle tolerance<\/li>\n
    • Efektivn\u00ed d\u00e1vkovac\u00ed rozmez\u00ed:<\/strong> 2\u20138 mg t\u0159ikr\u00e1t a\u017e \u010dty\u0159ikr\u00e1t denn\u011b<\/li>\n
    • Maxim\u00e1ln\u00ed d\u00e1vka:<\/strong> 36 mg denn\u011b, ve 3\u20134 rozd\u011blen\u00fdch d\u00e1vk\u00e1ch, ne v\u00edce ne\u017e 12 mg na jednu d\u00e1vku<\/li>\n
    • ~1,5 hodiny; jatern\u00ed metabolismus s ~80% ren\u00e1ln\u00ed exkrec\u00ed metabolit\u016f<\/strong> p\u0159ibli\u017en\u011b 2,5 hodiny \u2014 proto mus\u00ed b\u00fdt d\u00e1vkov\u00e1n\u00ed \u010dast\u00e9 (3\u20134kr\u00e1t denn\u011b) pro trval\u00fd \u00fa\u010dinek<\/li>\n
    • Porucha funkce ledvin (CrCl < 25 ml\/min):<\/strong> za\u010d\u00edt s 2 mg jednou denn\u011b; titrovat velmi opatrn\u011b<\/li>\n
    • Porucha funkce jater:<\/strong> pou\u017e\u00edvat s opatrnost\u00ed; monitorovat jatern\u00ed enzymy<\/li>\n
    • Star\u0161\u00ed pacienti:<\/strong> za\u010d\u00edt s 2 mg jednou nebo dvakr\u00e1t denn\u011b; titrovat opatrn\u011b<\/li>\n<\/ul>\n

      U\u017e\u00edvejte tizanidin pravideln\u011b<\/strong>: bu\u010f v\u017edy s j\u00eddlem, nebo v\u017edy bez j\u00eddla \u2014 ne oboj\u00ed. J\u00eddlo m\u011bn\u00ed maxim\u00e1ln\u00ed plazmatickou koncentraci a\u017e o 30 % a p\u0159echod mezi stavem nasycen\u00ed a la\u010dn\u011bn\u00ed b\u011bhem l\u00e9\u010dby zp\u016fsob\u00ed nep\u0159edv\u00eddateln\u00e9 \u00fa\u010dinky. V\u011bt\u0161ina pacient\u016f sn\u00e1\u0161\u00ed l\u00e9k l\u00e9pe s j\u00eddlem.<\/p>\n

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      Kritick\u00e9 l\u00e9kov\u00e9 interakce.<\/strong> Tizanidin je metabolizov\u00e1n t\u00e9m\u011b\u0159 v\u00fdhradn\u011b jatern\u00edm enzymem CYP1A2. L\u00e9ky blokuj\u00edc\u00ed CYP1A2 mohou zv\u00fd\u0161it hladinu tizanidinu v krvi 10kr\u00e1t i v\u00edce \u2014 co\u017e zp\u016fsob\u00ed t\u011b\u017ekou hypotenzi, extr\u00e9mn\u00ed ospalost nebo ztr\u00e1tu v\u011bdom\u00ed. Nikdy nekombinujte tizanidin s:<\/strong> ciprofloxacinem, fluvoxaminem (SSRI). Extr\u00e9mn\u00ed opatrnost je nutn\u00e1 u: norfloxacinu, mexiletinu, zileutonu, peror\u00e1ln\u00edch kontraceptiv, cimetidinu, propafenonu, amiodaronu a ticlopidinu. V\u017edy informujte ka\u017ed\u00e9ho nov\u00e9ho p\u0159edepisuj\u00edc\u00edho l\u00e9ka\u0159e, \u017ee u\u017e\u00edv\u00e1te tizanidin.<\/p>\n<\/div>\n

      Kdo by nem\u011bl u\u017e\u00edvat Trinex?<\/h2>\n