<\/p>\n
Thioril (Thioridazine 10 \/ 25 \/ 100 mg) je antipsychotikum prvn\u00ed generace ze skupiny fenothiazin\u016f. Pou\u017e\u00edv\u00e1 se jako l\u00e9k posledn\u00ed volby druh\u00e9 linie kv\u016fli varov\u00e1n\u00ed FDA t\u00fdkaj\u00edc\u00edmu se prodlou\u017een\u00ed QT intervalu.<\/p>\n<\/div>\n
\ud83d\udce6 Ka\u017ed\u00e1 objedn\u00e1vka je pokryta na\u0161\u00ed Z\u00e1rukou op\u011btovn\u00e9ho odesl\u00e1n\u00ed<\/strong><\/a> \u2014 pokud va\u0161e z\u00e1silka nedoraz\u00ed do 20 pracovn\u00edch dn\u016f, p\u0159epos\u00edl\u00e1me ji.<\/p>\n Thioril na MedsBase je dod\u00e1v\u00e1n p\u0159\u00edmo od v\u00fdrobce certifikovan\u00e9ho WHO-GMP v jednoduch\u00e9m, diskr\u00e9tn\u00edm balen\u00ed. Ka\u017ed\u00e1 objedn\u00e1vka je pokryta na\u0161\u00edm Z\u00e1rukou op\u011btovn\u00e9ho odesl\u00e1n\u00ed<\/a> \u2014 20pracovn\u00edchdenn\u00ed lh\u016fta pro doru\u010den\u00ed, nebo v\u00e1m z\u00e1silku zdarma p\u0159epo\u0161leme \u2014 a oprav\u0148uje v\u00e1s k \u00fa\u010dasti v na\u0161em v\u011brnostn\u00edm programu<\/a>. Dod\u00e1v\u00e1me do v\u011bt\u0161iny zem\u00ed po cel\u00e9m sv\u011bt\u011b.<\/p>\n Thioril jsou tablety Thioridazine od spole\u010dnosti Sun Pharma. Dostupn\u00e9 s\u00edly: 10 \/ 25 \/ 100 mg<\/strong>.<\/p>\n Thioridazin je piperidinov\u00fd fenothiazin. Nese \u010dern\u00e9 varov\u00e1n\u00ed FDA pro fat\u00e1ln\u00ed prodlou\u017een\u00ed QT intervalu a torsades de pointes<\/strong> a je nyn\u00ed vyhrazen jako antipsychotikum posledn\u00ed volby druh\u00e9 linie \u2014 byl sta\u017een nebo omezen v mnoha jurisdikc\u00edch v letech 2000\u20132005. Atypick\u00e1 antipsychotika jsou up\u0159ednost\u0148ov\u00e1na pro t\u00e9m\u011b\u0159 v\u0161echny sou\u010dasn\u00e9 indikace.<\/p>\n Vyhrazen pro l\u00e9\u010debn\u011b rezistentn\u00ed schizofrenii, kde selhaly atypick\u00e1 i jin\u00e1 typick\u00e1 antipsychotika. Dosp\u011bl\u00ed: 50\u2013100 mg 3\u00d7 denn\u011b, max. 800 mg\/den. P\u0159ed l\u00e9\u010dbou je nutn\u00e9 EKG a korekce elektrolyt\u016f. N\u011bkter\u00e9 jurisdikce nyn\u00ed vy\u017eaduj\u00ed kontinu\u00e1ln\u00ed monitorov\u00e1n\u00ed QT intervalu b\u011bhem prvn\u00edch t\u00fddn\u016f.<\/p>\n Thioridazin nese \u010dern\u00e9 varov\u00e1n\u00ed FDA pro d\u00e1vkov\u011b z\u00e1visl\u00e9 prodlou\u017een\u00ed QT intervalu a torsades de pointes.<\/strong> Hl\u00e1\u0161eny p\u0159\u00edpady n\u00e1hl\u00e9 srde\u010dn\u00ed smrti p\u0159i terapeutick\u00fdch d\u00e1vk\u00e1ch. P\u0159ed l\u00e9\u010dbou je povinn\u00e9 EKG.<\/strong> Kontraindikov\u00e1n u zn\u00e1m\u00e9ho dlouh\u00e9ho QT intervalu, poruch veden\u00ed, hypokal\u00e9mie, hypomagnez\u00e9mie, p\u0159i sou\u010dasn\u00e9 terapii jin\u00fdmi l\u00e9ky prodlu\u017euj\u00edc\u00edmi QT interval, u \u0161patn\u00fdch metaboliz\u00e1tor\u016f CYP2D6 a p\u0159i sou\u010dasn\u00e9m pod\u00e1v\u00e1n\u00ed siln\u00fdch inhibitor\u016f CYP2D6 (paroxetin, fluoxetin, bupropion, chinidin \u2014 v\u0161echny dramaticky zvy\u0161uj\u00ed hladiny thioridazinu). Mnoho regula\u010dn\u00edch agentur st\u00e1hlo thioridazin z trhu nebo jej omezilo na pou\u017eit\u00ed jako posledn\u00ed mo\u017enost; p\u0159echod na bezpe\u010dn\u011bj\u0161\u00ed atypikum, pokud je to klinicky mo\u017en\u00e9<\/strong>.<\/p>\n<\/div>\n V\u0161echny fenothiaziny maj\u00ed v\u00fdznamnou anticholinergn\u00ed, antihistaminovou a \u03b11-blokuj\u00edc\u00ed aktivitu. Zvl\u00e1\u0161t\u011b problematick\u00e9 u star\u0161\u00edch pacient\u016f \u2013 \u010dast\u00e9 jsou p\u00e1dy, delirium, retence mo\u010di a z\u00e1cpa. Vyvarovat se u demence, BPH, uzav\u0159en\u00e9ho \u00fahlu glaukomu, t\u011b\u017ek\u00e9ho jatern\u00edho onemocn\u011bn\u00ed.<\/p>\n<\/div>\n Fenothiaziny zp\u016fsobuj\u00ed fotosenzitivitu (t\u011b\u017ek\u00e9 sp\u00e1len\u00ed sluncem) a p\u0159i dlouhodob\u00e9m u\u017e\u00edv\u00e1n\u00ed modro\u0161edou pigmentaci k\u016f\u017ee, vz\u00e1cn\u011b i pigmentaci \u010do\u010dky\/rohovky (zejm\u00e9na chlorpromazin). Nutn\u00e1 ochrana p\u0159ed sluncem.<\/p>\n<\/div>\n T\u011bhotenstv\u00ed: omezen\u00e9 \u00fadaje; chlorpromazin se historicky pou\u017e\u00edval u hyperemezis s opatrnost\u00ed. Kojen\u00ed: p\u0159ech\u00e1z\u00ed do ml\u00e9ka; obvykle se nedoporu\u010duje. Pediatrie: nen\u00ed prvn\u00ed volbou; chlorpromazin se ob\u010das pou\u017e\u00edv\u00e1 v n\u00edzk\u00fdch d\u00e1vk\u00e1ch u t\u011b\u017ek\u00e9 pediatrick\u00e9 agitace pod odborn\u00fdm dohledem.<\/p>\n Skladujte p\u0159i 15\u201330 \u00b0C, chr\u00e1n\u011bno p\u0159ed sv\u011btlem, v p\u016fvodn\u00edm obalu.<\/p>\n Thioridazin nese \u010dernou v\u00fdstrahu FDA pro d\u00e1vkov\u011b z\u00e1visl\u00e9 prodlou\u017een\u00ed QT intervalu s rizikem \u00famrt\u00ed. Atypick\u00e1 antipsychotika dosahuj\u00ed podobn\u00e9ho antipsychotick\u00e9ho \u00fa\u010dinku s mnohem ni\u017e\u0161\u00edm kardiovaskul\u00e1rn\u00edm rizikem, men\u0161\u00ed anticholinergn\u00ed z\u00e1t\u011b\u017e\u00ed a ni\u017e\u0161\u00ed m\u00edrou tardivn\u00ed dyskineze. Thioridazin je proto vyhrazen pro l\u00e9\u010dbu rezistentn\u00ed schizofrenie, kdy selhala atypick\u00e1 i jin\u00e1 typick\u00e1 antipsychotika.<\/p>\n Obecn\u011b nen\u00ed preferov\u00e1n \u2014 anticholinergn\u00ed z\u00e1t\u011b\u017e, p\u00e1dy, ortostatick\u00e1 hypotenze a riziko TD se s v\u011bkem zvy\u0161uj\u00ed. Beersova krit\u00e9ria ozna\u010duj\u00ed oba jako potenci\u00e1ln\u011b nevhodn\u00e9 l\u00e9ky pro star\u0161\u00ed dosp\u011bl\u00e9. Pokud se pou\u017e\u00edv\u00e1, za\u010dn\u011bte s n\u00edzkou d\u00e1vkou a p\u0159ehodnocujte t\u00fddn\u011b.<\/p>\n Kumulativn\u00ed riziko TD u typick\u00fdch antipsychotik je p\u0159ibli\u017en\u011b 5 %\/rok expozice (u atypick\u00fdch p\u0159ibli\u017en\u011b 1 %\/rok). Po 5 letech expozice typick\u00fdm antipsychotik\u016fm se u p\u0159ibli\u017en\u011b 25 % pacient\u016f objev\u00ed n\u011bjak\u00e9 p\u0159\u00edznaky TD. Riziko je vy\u0161\u0161\u00ed s v\u011bkem a u \u017een. TD m\u016f\u017ee b\u00fdt nevratn\u00e9 \u2014 p\u0159i prvn\u00edch p\u0159\u00edznac\u00edch p\u0159ejd\u011bte na klozapin nebo atypikum s n\u00edzk\u00fdm rizikem EPS.<\/p>\n Fenothiaziny se ukl\u00e1daj\u00ed v k\u016f\u017ei a p\u0159i vystaven\u00ed UV z\u00e1\u0159en\u00ed podl\u00e9haj\u00ed fotochemick\u00e9mu po\u0161kozen\u00ed \u2014 co\u017e vede k t\u011b\u017ek\u00fdm sp\u00e1lenin\u00e1m a p\u0159i dlouhodob\u00e9m u\u017e\u00edv\u00e1n\u00ed k modro-\u0161ed\u00e9 pigmentaci. Je nutn\u00e9 pou\u017e\u00edvat opalovac\u00ed kr\u00e9m, ochrann\u00e9 oble\u010den\u00ed a omezit vystaven\u00ed UV z\u00e1\u0159en\u00ed.<\/p>\n Postupn\u011b sni\u017eujte d\u00e1vku po dobu 2\u20134 t\u00fddn\u016f. N\u00e1hl\u00e9 vysazen\u00ed zp\u016fsobuje cholinergn\u00ed rebound (nevolnost, pocen\u00ed, nespavost) a relaps psych\u00f3zy. Odstoupen\u00ed dyskineze m\u016f\u017ee tak\u00e9 odhalit TD, kter\u00e9 bylo potla\u010deno l\u00e9kem.<\/p>\n N\u011bkolik v\u00fdznamn\u00fdch interakc\u00ed: (1) jin\u00e9 l\u00e9ky prodlu\u017euj\u00edc\u00ed QT interval (aditivn\u00ed \u00fa\u010dinek); (2) siln\u00e9 inhibitory CYP2D6 jako paroxetin a fluoxetin (v\u00fdrazn\u011b zvy\u0161uj\u00ed hladiny); (3) antihypertenziva (aditivn\u00ed ortostatick\u00fd efekt). V\u017edy zkontrolujte cel\u00fd seznam l\u00e9k\u016f s p\u0159edepisuj\u00edc\u00edm l\u00e9ka\u0159em.<\/p>\n Nen\u00ed b\u011b\u017en\u011b pou\u017e\u00edv\u00e1n pro \u0161kytavku \u2013 chlorpromazin je fenothiazin volby pro toto neschv\u00e1len\u00e9 indikaci.<\/p>\n Zklid\u0148uj\u00edc\u00ed a sedativn\u00ed \u00fa\u010dinek b\u011bhem hodin. Antipsychotick\u00fd efekt na pozitivn\u00ed symptomy za 1\u20132 t\u00fddny. Pln\u00fd \u00fa\u010dinek nast\u00e1v\u00e1 za 4\u20136 t\u00fddn\u016f.<\/p>\n Ne \u2013 thioridazin se nepou\u017e\u00edv\u00e1 pro akutn\u00ed agitaci. Riziko prodlou\u017een\u00ed QT intervalu a pomalej\u0161\u00ed n\u00e1stup \u00fa\u010dinku jej \u010din\u00ed nevhodn\u00fdm.<\/p>\n Siln\u00e1 sedace v prvn\u00edch 1\u20132 t\u00fddnech. V\u011bt\u0161ina pacient\u016f na stabiln\u00ed d\u00e1vce \u0159\u00edd\u00ed norm\u00e1ln\u011b, ale ortostatick\u00e1 hypotenze a sedace mohou p\u0159etrv\u00e1vat.<\/p>\n <\/p>\n Thioril (Thioridazine 10\/25\/100 mg) \u2014 piperidinov\u00fd fenothiazin pro l\u00e9\u010dbu schizofrenie rezistentn\u00ed na terapii. L\u00e9k posledn\u00ed volby druh\u00e9 linie \u2014 FDA varov\u00e1n\u00ed (\u010dern\u00fd r\u00e1me\u010dek) pro riziko fat\u00e1ln\u00edho prodlou\u017een\u00ed QT intervalu.<\/p>","protected":false},"featured_media":61085,"comment_status":"open","ping_status":"open","template":"","meta":[],"product_brand":[],"product_cat":[3141,3342,3906],"product_tag":[4974,4975,4976],"class_list":{"0":"post-61084","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-category-overview","7":"product_cat-general-health","8":"product_cat-mental-health-and-psychiatric-medications","9":"product_tag-thioridazine","10":"product_tag-thioridazine-hydrochloride","11":"product_tag-thioril","13":"first","14":"instock","15":"shipping-taxable","16":"purchasable","17":"product-type-variable","18":"has-default-attributes"},"acf":[],"_links":{"self":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product\/61084","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/comments?post=61084"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/media\/61085"}],"wp:attachment":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/media?parent=61084"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product_brand?post=61084"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product_cat?post=61084"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product_tag?post=61084"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}Pro\u010d objedn\u00e1vat z MedsBase<\/h3>\n
Co je Thioril a jak funguje<\/h2>\n
Indikace a d\u00e1vkov\u00e1n\u00ed<\/h2>\n
D\u016fle\u017eit\u00e9 bezpe\u010dnostn\u00ed aspekty<\/h2>\n
\u010cast\u00e9 ne\u017e\u00e1douc\u00ed \u00fa\u010dinky<\/h2>\n
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Interakce l\u00e9k\u016f<\/h2>\n
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T\u011bhotenstv\u00ed, kojen\u00ed, pediatrie<\/h2>\n
Skladov\u00e1n\u00ed<\/h2>\n
\u010casto kladen\u00e9 dotazy<\/h2>\n
Pro\u010d je thioridazin nyn\u00ed pova\u017eov\u00e1n za l\u00e9k druh\u00e9 volby?<\/h3>\n
Je thioridazin bezpe\u010dn\u00fd pro star\u0161\u00ed dosp\u011bl\u00e9?<\/h3>\n
Zp\u016fsob\u00ed thioridazin tardivn\u00ed dyskinezi?<\/h3>\n
Pro\u010d thioridazin zp\u016fsobuje zv\u00fd\u0161enou citlivost na slunce?<\/h3>\n
Lze thioridazin n\u00e1hle vysadit?<\/h3>\n
Bude thioridazin interagovat s m\u00fdmi dal\u0161\u00edmi l\u00e9ky?<\/h3>\n
Pro\u010d thioridazin na \u0161kytavku?<\/h3>\n
Za jak dlouho za\u010dne thioridazin p\u016fsobit?<\/h3>\n
Lze thioridazin pou\u017e\u00edt pro kr\u00e1tkodob\u00e9 zvl\u00e1dnut\u00ed t\u011b\u017ek\u00e9 agitace?<\/h3>\n
Ovlivn\u00ed thioridazin m\u00e9 \u0159\u00edzen\u00ed vozidla?<\/h3>\n
Dal\u0161\u00ed l\u00e9ky na du\u0161evn\u00ed zdrav\u00ed<\/h2>\n
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