{"id":61261,"date":"2024-02-28T07:32:49","date_gmt":"2024-02-28T07:32:49","guid":{"rendered":"https:\/\/medsname.com\/vilano\/"},"modified":"2026-05-01T10:49:16","modified_gmt":"2026-05-01T10:49:16","slug":"vilano","status":"publish","type":"product","link":"https:\/\/medsbase.com\/cs\/product\/vilano\/","title":{"rendered":"Vilano"},"content":{"rendered":"<p><!-- medsbase-tldr-answer --><\/p>\n<div style=\"background:#fff8e1;border-left:4px solid #f5a623;padding:18px 22px;margin:0 0 24px 0;border-radius:4px;\">\n<h3 class=\"wp-block-heading\" style=\"margin:0 0 8px 0;font-size:16px;font-weight:700;\">&#9889; Quick Answer &mdash; What is Vilano?<\/h3>\n<div style=\"margin:0;\">\n<p style=\"margin:0;\"><strong>Vilano<\/strong> obsahuje <strong>vilazodone 40 mg<\/strong> from a WHO-GMP certified manufacturer (Lupin Pharmaceuticals) &mdash; a <strong>dual-mechanism antidepressant<\/strong>: SERT inhibition (SSRI) <em>plus<\/em> 5-HT<sub>1A<\/sub> partial agonism. FDA-approved 2011 for <strong>MDD only<\/strong> (no anxiety or other indications). Standard target dose: <strong>40 mg once daily with food<\/strong> (must be taken with at least 500 calories &mdash; bioavailability halves on an empty stomach). Titrate from 10 mg over 2 weeks to reduce GI side effects. <strong>Sexual side-effect rate is lower than other SSRIs<\/strong> &mdash; the 5-HT<sub>1A<\/sub> partial agonism is the proposed reason. Diarrhoea is the most common bothersome side effect. Onset 2&ndash;4 weeks; full response by 8 weeks.<\/p>\n<\/div>\n<div class=\"medsbase-trust-strip\" style=\"background:#f4f8fb;border:1px solid #d8e3eb;padding:12px 16px;margin:16px 0;border-radius:4px;font-size:14px;\">\n<strong>Co z\u00edsk\u00e1te s MedsBase:<\/strong> V\u00fdrobce certifikovan\u00fd WHO-GMP \u00b7 Diskr\u00e9tn\u00ed balen\u00ed \u00b7 Celosv\u011btov\u00e1 doprava \u00b7 V\u00edce ne\u017e 1 400 ov\u011b\u0159en\u00fdch <a href=\"https:\/\/medsbase.com\/cs\/reviews\/\">recenz\u00ed z\u00e1kazn\u00edk\u016f<\/a>\n<\/div>\n<p class=\"medsbase-reship-line\" style=\"font-size:14px;color:#444;margin:8px 0 18px;\">\ud83d\udce6 Ka\u017ed\u00e1 objedn\u00e1vka je pokryta na\u0161\u00ed <a href=\"https:\/\/medsbase.com\/cs\/medsbase-re-shipment-assurance-policy\/\"><strong>Z\u00e1rukou op\u011btovn\u00e9ho odesl\u00e1n\u00ed<\/strong><\/a> \u2014 pokud va\u0161e z\u00e1silka nedoraz\u00ed do 20 pracovn\u00edch dn\u016f, p\u0159epos\u00edl\u00e1me ji.<\/p>\n<h3>Pro\u010d objedn\u00e1vat z MedsBase<\/h3>\n<p>Na\u0161e generick\u00e9 l\u00e9ky poch\u00e1zej\u00ed od v\u00fdrobc\u016f certifikovan\u00fdch WHO-GMP a jsou expedov\u00e1ny po cel\u00e9m sv\u011bt\u011b v diskr\u00e9tn\u00edm, nen\u00e1padn\u00e9m balen\u00ed \u2013 na vn\u011bj\u0161\u00ed stran\u011b bal\u00edku nen\u00ed uveden n\u00e1zev l\u00e9ku. Platby kartou jsou sm\u011brov\u00e1ny prost\u0159ednictv\u00edm regulovan\u00e9ho procesoru (popisky na v\u00fdpisu zahrnuj\u00ed regulovan\u00e9ho procesora plateb kartou \u2013 nikdy \u201cMedsBase\u201d nebo n\u00e1zev l\u00e9ku). P\u0159ij\u00edm\u00e1me tak\u00e9 kryptom\u011bny a bankovn\u00ed p\u0159evody SEPA. Ka\u017ed\u00e1 objedn\u00e1vka je zaji\u0161t\u011bna na\u0161\u00ed politikou p\u0159eposl\u00e1n\u00ed.<\/p>\n<\/div>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:14px 18px;margin:0 0 22px 0;border-radius:4px;font-size:14px;\"><strong>Important &mdash; this is not a situational-anxiety medication.<\/strong> Vilano is a <strong>SSRI plus 5-HT1A partial agonist<\/strong>, prescribed and titrated over weeks for <strong>major depressive disorder (MDD)<\/strong>. It is <strong>ne<\/strong> the right drug for acute, performance-related anxiety (flying, public speaking, exams) &mdash; for those use cases beta-blockers (propranolol), benzodiazepines, or hydroxyzine are clinically appropriate. If you do not have a diagnosed mood, anxiety, or psychiatric disorder, do not start this medication.<\/div>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:14px 18px;margin:0 0 22px 0;border-radius:4px;font-size:14px;\"><strong>FDA black-box warning &mdash; suicidality.<\/strong> All antidepressants carry an FDA black-box warning for increased risk of suicidal thinking and behaviour in children, adolescents, and young adults under 25, particularly during the first weeks of treatment or after dose changes. Family members and prescribers should monitor closely for worsening mood, agitation, or suicidal ideation in this age group.<\/div>\n<h2 class=\"wp-block-heading\">What Is Vilano?<\/h2>\n<p>Vilano is an oral tablet of <strong>vilazodone hydrochloride 40 mg<\/strong> manufactured by Lupin Pharmaceuticals. Vilazodone (US brand <strong>Viibryd<\/strong>) was FDA-approved in 2011 as a dual-mechanism antidepressant: it combines selective serotonin reuptake inhibition (SSRI) with <strong>5-HT<sub>1A<\/sub> partial agonism<\/strong>, similar to the partial agonism of buspirone. The 5-HT<sub>1A<\/sub> partial agonism is proposed to reduce the sexual side-effect burden seen with classical SSRIs.<\/p>\n<h2 class=\"wp-block-heading\">Schv\u00e1len\u00e9 indikace<\/h2>\n<ul>\n<li><strong>Major depressive disorder (MDD) in adults<\/strong> &mdash; only on-label indication<\/li>\n<li>Off-label: GAD, social anxiety (small evidence base)<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">D\u00e1vkov\u00e1n\u00ed<\/h2>\n<table style=\"width:100%;border-collapse:collapse;margin:0 0 22px 0;font-size:14px;\">\n<thead>\n<tr>\n<th style=\"background:#2c7cb0;color:#fff;padding:8px 10px;border:1px solid #2c7cb0;text-align:left;\">Krok<\/th>\n<th style=\"background:#2c7cb0;color:#fff;padding:8px 10px;border:1px solid #2c7cb0;text-align:left;\">D\u00e1vka<\/th>\n<th style=\"background:#2c7cb0;color:#fff;padding:8px 10px;border:1px solid #2c7cb0;text-align:left;\">D\u00e9lka<\/th>\n<th style=\"background:#2c7cb0;color:#fff;padding:8px 10px;border:1px solid #2c7cb0;text-align:left;\">Pozn\u00e1mky<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr style=\"background:#ffffff;\">\n<td style=\"padding:8px 10px;border:1px solid #ddd;vertical-align:top;\">T\u00fdden 1<\/td>\n<td style=\"padding:8px 10px;border:1px solid #ddd;vertical-align:top;\">10 mg once daily with food<\/td>\n<td style=\"padding:8px 10px;border:1px solid #ddd;vertical-align:top;\">7 dnech<\/td>\n<td style=\"padding:8px 10px;border:1px solid #ddd;vertical-align:top;\">Start low to limit GI side effects<\/td>\n<\/tr>\n<tr style=\"background:#f9f9f9;\">\n<td style=\"padding:8px 10px;border:1px solid #ddd;vertical-align:top;\">T\u00fdden 2<\/td>\n<td style=\"padding:8px 10px;border:1px solid #ddd;vertical-align:top;\">20 mg once daily with food<\/td>\n<td style=\"padding:8px 10px;border:1px solid #ddd;vertical-align:top;\">7 dnech<\/td>\n<td style=\"padding:8px 10px;border:1px solid #ddd;vertical-align:top;\">Move up if tolerated<\/td>\n<\/tr>\n<tr style=\"background:#ffffff;\">\n<td style=\"padding:8px 10px;border:1px solid #ddd;vertical-align:top;\">Week 3 onward<\/td>\n<td style=\"padding:8px 10px;border:1px solid #ddd;vertical-align:top;\">40 mg once daily with food<\/td>\n<td style=\"padding:8px 10px;border:1px solid #ddd;vertical-align:top;\">Udr\u017eovac\u00ed d\u00e1vka<\/td>\n<td style=\"padding:8px 10px;border:1px solid #ddd;vertical-align:top;\">Target dose &mdash; full effect by week 8<\/td>\n<\/tr>\n<tr style=\"background:#f9f9f9;\">\n<td style=\"padding:8px 10px;border:1px solid #ddd;vertical-align:top;\">Hepatic impairment (moderate-severe)<\/td>\n<td style=\"padding:8px 10px;border:1px solid #ddd;vertical-align:top;\">Maximum 20 mg\/day<\/td>\n<td style=\"padding:8px 10px;border:1px solid #ddd;vertical-align:top;\">\u2014<\/td>\n<td style=\"padding:8px 10px;border:1px solid #ddd;vertical-align:top;\">Reduced clearance<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2 class=\"wp-block-heading\">Why Vilazodone Must Be Taken with Food<\/h2>\n<p>Vilazodone bioavailability is <strong>72% with a 500-calorie meal but only 40% on an empty stomach<\/strong>. Taking the dose without food roughly halves the active drug exposure, blunting both efficacy and dose-response. Patients counselled to take vilazodone with a substantive meal &mdash; not a small snack &mdash; will have a far better treatment trajectory.<\/p>\n<h2 class=\"wp-block-heading\">Vedlej\u0161\u00ed \u00fa\u010dinky<\/h2>\n<h2 class=\"wp-block-heading\">Side-effect profile<\/h2>\n<table style=\"width:100%;border-collapse:collapse;margin:0 0 22px 0;font-size:14px;\">\n<thead>\n<tr>\n<th style=\"background:#2c7cb0;color:#fff;padding:8px 10px;border:1px solid #2c7cb0;text-align:left;\">Frekvence<\/th>\n<th style=\"background:#2c7cb0;color:#fff;padding:8px 10px;border:1px solid #2c7cb0;text-align:left;\">\u00da\u010dinek<\/th>\n<th style=\"background:#2c7cb0;color:#fff;padding:8px 10px;border:1px solid #2c7cb0;text-align:left;\">Pozn\u00e1mky<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr style=\"background:#ffffff;\">\n<td style=\"padding:8px 10px;border:1px solid #ddd;vertical-align:top;\">Common (&gt;10%)<\/td>\n<td style=\"padding:8px 10px;border:1px solid #ddd;vertical-align:top;\">Pr\u016fjem, nevolnost<\/td>\n<td style=\"padding:8px 10px;border:1px solid #ddd;vertical-align:top;\">Most common reason for discontinuation; usually subsides over 1&ndash;2 weeks<\/td>\n<\/tr>\n<tr style=\"background:#f9f9f9;\">\n<td style=\"padding:8px 10px;border:1px solid #ddd;vertical-align:top;\">B\u011b\u017en\u00e9<\/td>\n<td style=\"padding:8px 10px;border:1px solid #ddd;vertical-align:top;\">Bolest hlavy<\/td>\n<td style=\"padding:8px 10px;border:1px solid #ddd;vertical-align:top;\">Transient<\/td>\n<\/tr>\n<tr style=\"background:#ffffff;\">\n<td style=\"padding:8px 10px;border:1px solid #ddd;vertical-align:top;\">B\u011b\u017en\u00e9<\/td>\n<td style=\"padding:8px 10px;border:1px solid #ddd;vertical-align:top;\">Sucho v \u00fastech<\/td>\n<td style=\"padding:8px 10px;border:1px solid #ddd;vertical-align:top;\">M\u00edrn\u00fd<\/td>\n<\/tr>\n<tr style=\"background:#f9f9f9;\">\n<td style=\"padding:8px 10px;border:1px solid #ddd;vertical-align:top;\">B\u011b\u017en\u00e9<\/td>\n<td style=\"padding:8px 10px;border:1px solid #ddd;vertical-align:top;\">Nespavost<\/td>\n<td style=\"padding:8px 10px;border:1px solid #ddd;vertical-align:top;\">Take in the morning if activating; or with breakfast<\/td>\n<\/tr>\n<tr style=\"background:#ffffff;\">\n<td style=\"padding:8px 10px;border:1px solid #ddd;vertical-align:top;\">Less common (vs other SSRIs)<\/td>\n<td style=\"padding:8px 10px;border:1px solid #ddd;vertical-align:top;\">Sexual dysfunction<\/td>\n<td style=\"padding:8px 10px;border:1px solid #ddd;vertical-align:top;\">5-HT<sub>1A<\/sub> partial agonism reduces but does not eliminate sexual side effects<\/td>\n<\/tr>\n<tr style=\"background:#f9f9f9;\">\n<td style=\"padding:8px 10px;border:1px solid #ddd;vertical-align:top;\">M\u00e9n\u011b \u010dast\u00e9<\/td>\n<td style=\"padding:8px 10px;border:1px solid #ddd;vertical-align:top;\">Zm\u011bny hmotnosti<\/td>\n<td style=\"padding:8px 10px;border:1px solid #ddd;vertical-align:top;\">Modest<\/td>\n<\/tr>\n<tr style=\"background:#ffffff;\">\n<td style=\"padding:8px 10px;border:1px solid #ddd;vertical-align:top;\">M\u00e9n\u011b \u010dast\u00e9<\/td>\n<td style=\"padding:8px 10px;border:1px solid #ddd;vertical-align:top;\">Bleeding risk<\/td>\n<td style=\"padding:8px 10px;border:1px solid #ddd;vertical-align:top;\">Caution with NSAIDs \/ anticoagulants<\/td>\n<\/tr>\n<tr style=\"background:#f9f9f9;\">\n<td style=\"padding:8px 10px;border:1px solid #ddd;vertical-align:top;\">Vz\u00e1cn\u00e9<\/td>\n<td style=\"padding:8px 10px;border:1px solid #ddd;vertical-align:top;\">Hyponatraemia (SIADH)<\/td>\n<td style=\"padding:8px 10px;border:1px solid #ddd;vertical-align:top;\">Older adults at risk<\/td>\n<\/tr>\n<tr style=\"background:#ffffff;\">\n<td style=\"padding:8px 10px;border:1px solid #ddd;vertical-align:top;\">Vz\u00e1cn\u00e9<\/td>\n<td style=\"padding:8px 10px;border:1px solid #ddd;vertical-align:top;\">Serotonin syndrome<\/td>\n<td style=\"padding:8px 10px;border:1px solid #ddd;vertical-align:top;\">See interactions<\/td>\n<\/tr>\n<tr style=\"background:#f9f9f9;\">\n<td style=\"padding:8px 10px;border:1px solid #ddd;vertical-align:top;\">Vz\u00e1cn\u00e9<\/td>\n<td style=\"padding:8px 10px;border:1px solid #ddd;vertical-align:top;\">Activation of mania in undiagnosed bipolar<\/td>\n<td style=\"padding:8px 10px;border:1px solid #ddd;vertical-align:top;\">Screen before starting<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2 class=\"wp-block-heading\">Interakce s l\u00e9\u010divy<\/h2>\n<p><strong>Absolute contraindications<\/strong>: MAOIs (14-day washout), linezolid, methylene blue.<\/p>\n<p><strong>CYP3A4 substrate<\/strong>: maximum 20 mg\/day with strong CYP3A4 inhibitors (ketoconazole, ritonavir, clarithromycin); avoid combination with strong CYP3A4 inducers (rifampin, phenytoin, carbamazepine) &mdash; loss of efficacy.<\/p>\n<p><strong>Serotonergic interactions<\/strong>: triptans, tramadol, dextromethorphan, St John&#8217;s wort, lithium &mdash; serotonin syndrome risk.<\/p>\n<p><strong>Bleeding risk<\/strong>: NSAIDs, aspirin, warfarin, DOACs.<\/p>\n<h2 id=\"faqs\">\u010casto kladen\u00e9 dotazy<\/h2>\n<h3 class=\"wp-block-heading\">How long does Vilano take to work?<\/h3>\n<p>Onset 2&ndash;4 weeks; full effect by 8 weeks at the 40 mg target dose. Patients on incomplete titration (still at 10&ndash;20 mg) may see less benefit.<\/p>\n<h3 class=\"wp-block-heading\">Why is taking Vilano with food so important?<\/h3>\n<p>Vilazodone bioavailability roughly halves on an empty stomach (40% vs 72% with a 500-calorie meal). Taking it without food dramatically reduces both efficacy and dose-response &mdash; a common reason for treatment failure.<\/p>\n<h3 class=\"wp-block-heading\">Will Vilano cause sexual side effects?<\/h3>\n<p>Less than other SSRIs &mdash; the 5-HT<sub>1A<\/sub> partial agonism reduces but does not eliminate sexual dysfunction. Patients sensitive to SSRI-induced sexual side effects often try vilazodone for this reason.<\/p>\n<h3 class=\"wp-block-heading\">Why is diarrhoea such a common Vilano side effect?<\/h3>\n<p>The 5-HT<sub>1A<\/sub> partial agonism activates GI serotonin pathways. Slow up-titration over 2 weeks, dosing with food, and dietary fibre adjustments help &mdash; if persistent and bothersome, switch is reasonable.<\/p>\n<h3 class=\"wp-block-heading\">Can I drink alcohol on Vilano?<\/h3>\n<p>Light occasional alcohol is generally tolerated. Heavy use worsens depression and increases bleeding risk.<\/p>\n<h3 class=\"wp-block-heading\">Is Vilano safe in pregnancy?<\/h3>\n<p>Limited safety data &mdash; sertraline is preferred when antidepressant treatment is needed in pregnancy.<\/p>\n<h3 class=\"wp-block-heading\">Does Vilano cause weight gain?<\/h3>\n<p>Modest changes &mdash; less than paroxetine or mirtazapine. Some patients see no change at all.<\/p>\n<h3 class=\"wp-block-heading\">Can I stop Vilano abruptly?<\/h3>\n<p>Better to taper. Vilazodone has a moderate half-life (~25 h) and the discontinuation syndrome is milder than paroxetine or venlafaxine but still real.<\/p>\n<h3 class=\"wp-block-heading\">How is Vilano different from sertraline or escitalopram?<\/h3>\n<p>All are SSRIs at the molecular level. Vilazodone adds 5-HT<sub>1A<\/sub> partial agonism (similar to buspirone), proposed to reduce sexual side-effects. Trade-off: more diarrhoea, food-dependent absorption, and only one approved indication (MDD).<\/p>\n<h3 class=\"wp-block-heading\">How should Vilano be stored?<\/h3>\n<p>Store at 15&ndash;30 &deg;C in the original blister packaging, away from moisture and sunlight. Keep out of reach of children.<\/p>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:14px 18px;margin:24px 0 0 0;border-radius:4px;font-size:13.5px;line-height:1.55;\"><strong>Zdravotn\u00ed upozorn\u011bn\u00ed:<\/strong> Information on this page is intended for adults using prescribed psychiatric medication and is not a substitute for individualised medical care. Antidepressants, antipsychotics, and related medications can interact with other drugs, alcohol, and pre-existing conditions. Discuss any new medication, dose change, or planned discontinuation with a qualified prescriber. If you experience suicidal thoughts, mania, severe akathisia, signs of serotonin syndrome (high fever, confusion, muscle rigidity, rapid heart rate), or neuroleptic malignant syndrome, seek emergency care immediately.<\/div>\n<p><!-- medsbase-related-alts-v1 --><\/p>\n<h3 class=\"wp-block-heading\">Souvisej\u00edc\u00ed alternativy<\/h3>\n<p>Dal\u0161\u00ed produkty v <strong>Chronick\u00e1 onemocn\u011bn\u00ed<\/strong> kter\u00e9 z\u00e1kazn\u00edci tak\u00e9 prohl\u00ed\u017eej\u00ed:<\/p>\n<ul>\n<li><a href=\"https:\/\/medsbase.com\/cs\/trinicalm-plus\/\">Objednejte si Glynase XL (5 mg nebo 10 mg (XL)) od spole\u010dnosti MedsBase v balen\u00edch po 30, 60, 90 nebo 180 tablet\u00e1ch. Dod\u00e1v\u00e1me po cel\u00e9m sv\u011bt\u011b, s diskr\u00e9tn\u00edm balen\u00edm a certifikovan\u00fdm v\u00fdrobcem WHO-GMP.<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/rioci-1\/\">Rioci 1<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/olmeheal\/\">Olmeheal<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/opiprol\/\">Opiprol<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/glynase\/\">Glynase<\/a><\/li>\n<\/ul>","protected":false},"excerpt":{"rendered":"<p>\u2705 Zlep\u0161uje n\u00e1ladu<br \/>\n\u2705 Reduces anxiety<br \/>\n\u2705 Enhances well-being<br \/>\n\u2705 Manages depression symptoms<br \/>\n\u2705 Increases serotonin levels<\/p>\n<p>Vilano contains Vilazodone.<\/p>","protected":false},"featured_media":61262,"comment_status":"open","ping_status":"open","template":"","meta":[],"product_brand":[],"product_cat":[3141,3223,4647],"product_tag":[5004,5005],"class_list":{"0":"post-61261","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-category-overview","7":"product_cat-chronic-conditions","8":"product_cat-situational-anxiety-treatment","9":"product_tag-vilano","10":"product_tag-vilazodone","12":"first","13":"instock","14":"shipping-taxable","15":"purchasable","16":"product-type-variable","17":"has-default-attributes"},"acf":[],"_links":{"self":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product\/61261","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/comments?post=61261"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/media\/61262"}],"wp:attachment":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/media?parent=61261"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product_brand?post=61261"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product_cat?post=61261"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product_tag?post=61261"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}