{"id":61309,"date":"2024-02-28T07:34:47","date_gmt":"2024-02-28T07:34:47","guid":{"rendered":"https:\/\/medsname.com\/kenadion-injection\/"},"modified":"2026-04-30T10:23:36","modified_gmt":"2026-04-30T10:23:36","slug":"kenadion-injection","status":"publish","type":"product","link":"https:\/\/medsbase.com\/cs\/product\/kenadion-injection\/","title":{"rendered":"Kenadion Injection"},"content":{"rendered":"<div class=\"medsbase-tldr-answer\" style=\"background:#fff8e1;border-left:4px solid #f5a623;padding:14px 18px;margin:18px 0;border-radius:4px;\">\n<h3 style=\"margin-top:0;\">Rychl\u00e1 odpov\u011b\u010f<\/h3>\n<p><strong>Kenadion Injection (phytomenadione (vitamin K1) 10 mg ampoule)<\/strong> is vitamin K1 (phytomenadione) for IV or IM injection. It is used as the antidote in warfarin overdose, to prevent and treat haemorrhagic disease of the newborn, and in vitamin K deficiency from malabsorption or cholestasis.<\/p>\n<ul style=\"margin-bottom:0;\">\n<li>Phytomenadione (vitamin K1) 10 mg per ampoule<\/li>\n<li>Indications: warfarin reversal, neonatal vitamin K prophylaxis, malabsorption-related deficiency<\/li>\n<li>IV (slow) or IM administration &mdash; specialist setting<\/li>\n<li>v\u00fdrobce certifikovan\u00e9ho WHO-GMP<\/li>\n<\/ul>\n<\/div>\n<div class=\"medsbase-trust-strip\" style=\"background:#f4f6f8;border:1px solid #e0e4e7;padding:12px 16px;margin:18px 0;border-radius:4px;font-size:14px;color:#444;\">\n<strong>v\u00fdrobce certifikovan\u00e9ho WHO-GMP<\/strong> \u00b7 Diskr\u00e9tn\u00ed balen\u00ed \u00b7 Celosv\u011btov\u00e1 doprava \u00b7 <a href=\"https:\/\/medsbase.com\/cs\/reviews\/\" style=\"color:#2c7cb0;\">1 400+ ov\u011b\u0159en\u00fdch recenz\u00ed z\u00e1kazn\u00edk\u016f<\/a>\n<\/div>\n<p class=\"medsbase-reship-line\" style=\"font-size:14px;color:#444;margin:8px 0 18px;\">\ud83d\udce6 Ka\u017ed\u00e1 objedn\u00e1vka je pokryta na\u0161\u00ed <a href=\"https:\/\/medsbase.com\/cs\/medsbase-re-shipment-assurance-policy\/\"><strong>Z\u00e1rukou op\u011btovn\u00e9ho odesl\u00e1n\u00ed<\/strong><\/a> \u2014 pokud va\u0161e z\u00e1silka nedoraz\u00ed do 20 pracovn\u00edch dn\u016f, p\u0159epos\u00edl\u00e1me ji.<\/p>\n<p style=\"font-size:13px;color:#666;margin:4px 0 18px;\">Ka\u017ed\u00e1 objedn\u00e1vka je pokryta na\u0161\u00edm <a href=\"https:\/\/medsbase.com\/cs\/medsbase-re-shipment-assurance-policy\/\" style=\"color:#2c7cb0;\">Z\u00e1rukou op\u011btovn\u00e9ho odesl\u00e1n\u00ed<\/a>.<\/p>\n<h3>Pro\u010d objedn\u00e1vat z MedsBase<\/h3>\n<p>Kenadion Injection is sourced from a WHO-GMP certified manufacturer. Every order ships in discreet, unbranded packaging worldwide and is covered by our Reshipment Assurance Policy. Pay securely with credit card, SEPA bank transfer, or cryptocurrency. See our <a href=\"https:\/\/medsbase.com\/cs\/reviews\/\">1 400+ ov\u011b\u0159en\u00fdch recenz\u00ed z\u00e1kazn\u00edk\u016f<\/a>.<\/p>\n<h2>What is Kenadion Injection?<\/h2>\n<p>Kenadion is parenteral phytomenadione (vitamin K1) &mdash; the natural form of vitamin K essential for hepatic synthesis of clotting factors II, VII, IX, X, and proteins C and S. Vitamin K1 is the antidote in warfarin overdose, the routine prophylaxis given to newborns to prevent haemorrhagic disease of the newborn, and the replacement therapy for vitamin K deficiency caused by chronic malabsorption or biliary obstruction.<\/p>\n<h2>Indikace<\/h2>\n<ul>\n<li><strong>Warfarin overdose \/ over-anticoagulation<\/strong> &mdash; INR-driven dose<\/li>\n<li><strong>Vitamin K deficiency bleeding (VKDB) of the newborn<\/strong> &mdash; routine 1 mg IM at birth (or oral 2 mg at birth and follow-up doses)<\/li>\n<li><strong>Vitamin K deficiency from malabsorption<\/strong> &mdash; coeliac disease, inflammatory bowel disease, cystic fibrosis, short-bowel<\/li>\n<li><strong>Cholestatic liver disease<\/strong> &mdash; biliary obstruction prevents bile-salt-dependent fat-soluble vitamin absorption<\/li>\n<li><strong>Chronic broad-spectrum antibiotic use<\/strong> &mdash; gut flora destroyed, vitamin K2 production lost<\/li>\n<li><strong>Total parenteral nutrition<\/strong> without adequate vitamin K supplementation<\/li>\n<li><strong>Pre-procedural reversal<\/strong> in warfarinised patients (alongside 4F-PCC for emergency reversal)<\/li>\n<\/ul>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:14px 18px;margin:18px 0;border-radius:4px;\">\n<strong>IV phytomenadione: anaphylactoid reaction risk &mdash; slow administration mandatory<\/strong><\/p>\n<p style=\"margin-bottom:0;\">Rapid IV phytomenadione has caused fatal anaphylactoid reactions (especially with the older Cremophor-containing formulations). Modern emulsion formulations are safer, but IV vitamin K1 must be given slowly &mdash; over at least 30 seconds for small doses, ideally as a 30-minute infusion in 50 ml saline for higher doses. IM is generally safer than IV but slower in onset.<\/p>\n<\/div>\n<table style=\"width:100%;border-collapse:collapse;margin:14px 0;\">\n<thead>\n<tr>\n<th style=\"background:#2c7cb0;color:#fff;padding:8px;text-align:left;\">Indikace<\/th>\n<th style=\"background:#2c7cb0;color:#fff;padding:8px;text-align:left;\">D\u00e1vka &amp; cesta pod\u00e1n\u00ed<\/th>\n<th style=\"background:#2c7cb0;color:#fff;padding:8px;text-align:left;\">N\u00e1stup \u00fa\u010dinku<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td style=\"padding:8px;border:1px solid #e0e4e7;\">Neonatal VKDB prophylaxis<\/td>\n<td style=\"padding:8px;border:1px solid #e0e4e7;\">1 mg IM at birth (or 2 mg oral at birth + follow-up)<\/td>\n<td style=\"padding:8px;border:1px solid #e0e4e7;\">Hodiny<\/td>\n<\/tr>\n<tr style=\"background:#f9f9f9;\">\n<td style=\"padding:8px;border:1px solid #e0e4e7;\">Warfarin INR &gt; 8 (no bleeding)<\/td>\n<td style=\"padding:8px;border:1px solid #e0e4e7;\">1&ndash;5 mg oral or 0.5&ndash;1 mg slow IV<\/td>\n<td style=\"padding:8px;border:1px solid #e0e4e7;\">IV: 6&ndash;12 hours; oral: 24 hours<\/td>\n<\/tr>\n<tr>\n<td style=\"padding:8px;border:1px solid #e0e4e7;\">Warfarin major bleeding<\/td>\n<td style=\"padding:8px;border:1px solid #e0e4e7;\">5&ndash;10 mg slow IV + 4F-PCC<\/td>\n<td style=\"padding:8px;border:1px solid #e0e4e7;\">IV: 6&ndash;12 hours (PCC: minutes)<\/td>\n<\/tr>\n<tr style=\"background:#f9f9f9;\">\n<td style=\"padding:8px;border:1px solid #e0e4e7;\">Vitamin K deficiency, established<\/td>\n<td style=\"padding:8px;border:1px solid #e0e4e7;\">5&ndash;10 mg IV\/IM, may repeat<\/td>\n<td style=\"padding:8px;border:1px solid #e0e4e7;\">6&ndash;12 hours<\/td>\n<\/tr>\n<tr>\n<td style=\"padding:8px;border:1px solid #e0e4e7;\">Cholestatic disease maintenance<\/td>\n<td style=\"padding:8px;border:1px solid #e0e4e7;\">10 mg IM monthly (or oral phytomenadione daily)<\/td>\n<td style=\"padding:8px;border:1px solid #e0e4e7;\">Hours-to-days<\/td>\n<\/tr>\n<tr style=\"background:#f9f9f9;\">\n<td style=\"padding:8px;border:1px solid #e0e4e7;\">TPN supplementation<\/td>\n<td style=\"padding:8px;border:1px solid #e0e4e7;\">Per parenteral nutrition protocol<\/td>\n<td style=\"padding:8px;border:1px solid #e0e4e7;\">Udr\u017eovac\u00ed d\u00e1vka<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2>Vedlej\u0161\u00ed \u00fa\u010dinky<\/h2>\n<ul>\n<li><strong>Anaphylactoid reaction<\/strong> with rapid IV &mdash; the dominant safety concern; mandatory slow administration<\/li>\n<li><strong>Nepohodl\u00ed v m\u00edst\u011b vpichu<\/strong><\/li>\n<li><strong>Hypersensitivity reaction<\/strong> &mdash; rare but reported<\/li>\n<li><strong>Warfarin resistance<\/strong> &mdash; high-dose K1 may make subsequent re-anticoagulation harder; smaller doses preferred when bridging is anticipated<\/li>\n<\/ul>\n<h2>Interakce l\u00e9k\u016f<\/h2>\n<ul>\n<li><strong>Warfarin<\/strong> &mdash; vitamin K1 reverses anticoagulation; this is intentional in overdose but problematic if anticoagulation is therapeutically needed. Choose dose carefully when reversing.<\/li>\n<li><strong>Other vitamin K antagonists<\/strong> (acenocoumarol, phenprocoumon) &mdash; same antagonism<\/li>\n<li><strong>Direct oral anticoagulants (apixaban, rivaroxaban, dabigatran)<\/strong> &mdash; vitamin K1 has NO effect on these; reversal needs different agents (andexanet, idarucizumab, 4F-PCC)<\/li>\n<\/ul>\n<h2>Kontraindikace<\/h2>\n<ul>\n<li>Hypersensitivity to phytomenadione<\/li>\n<li>Caution in severe hepatic impairment (response may be limited if hepatic synthesis itself is failing)<\/li>\n<\/ul>\n<h2>Skladov\u00e1n\u00ed<\/h2>\n<p>Skladujte p\u0159i teplot\u011b do 25\u00b0C, chra\u0148te p\u0159ed sv\u011btlem. Ampule pou\u017eijte ihned po otev\u0159en\u00ed.<\/p>\n<h2 id=\"faqs\">\u010casto kladen\u00e9 dotazy<\/h2>\n<h3>Why is it given to newborns?<\/h3>\n<p>Newborns are vitamin K-deficient at birth (poor placental transfer, sterile gut at birth, low K1 in breast milk). Vitamin K deficiency bleeding (VKDB) of the newborn was a major cause of catastrophic intracranial bleeding before routine prophylaxis. WHO and national guidelines recommend 1 mg IM at birth (or oral 2 mg at birth followed by additional doses); IM is more reliable than oral for prevention.<\/p>\n<h3>Why is rapid IV dangerous?<\/h3>\n<p>Older Cremophor-containing formulations of phytomenadione caused anaphylactoid reactions (acute hypotension, bronchospasm, rarely fatal). Modern aqueous-emulsion formulations are safer but slow administration is still mandatory. Where possible, oral or IM is preferred.<\/p>\n<h3>How does it reverse warfarin?<\/h3>\n<p>Warfarin blocks vitamin-K-epoxide reductase in the liver, preventing recycling of reduced vitamin K needed to gamma-carboxylate clotting factors II, VII, IX, X. Phytomenadione bypasses this block by providing reduced vitamin K1, allowing fresh clotting factor synthesis. Onset is hours-to-days; emergency reversal needs 4F-PCC for the immediate factor replacement.<\/p>\n<h3>Will it work for DOAC bleeding?<\/h3>\n<p>No. Apixaban, rivaroxaban, edoxaban, dabigatran do NOT involve vitamin K. Phytomenadione has no effect on them. Reversal needs andexanet alfa (Xa inhibitors) or idarucizumab (dabigatran), with 4F-PCC as backup.<\/p>\n<h3>Can patients on warfarin take vitamin K?<\/h3>\n<p>Vitamin K-rich foods (leafy greens, broccoli) are not forbidden &mdash; the rule is consistency. Patients on warfarin should keep vitamin K intake stable so the warfarin dose can be matched. Sudden multivitamin starts\/stops or major dietary swings cause INR instability. Multivitamins with vitamin K should be discussed with the warfarin clinic.<\/p>\n<h3>How quickly does INR drop after vitamin K?<\/h3>\n<p>Oral vitamin K1: INR begins falling at 6&ndash;12 hours, normalises by 24&ndash;48 hours. IV vitamin K1: faster, INR begins falling at 6&ndash;12 hours. Emergency reversal (active bleeding) needs 4F-PCC for immediate factor replacement &mdash; vitamin K is supportive but slow.<\/p>\n<h3>Je bezpe\u010dn\u00fd v t\u011bhotenstv\u00ed?<\/h3>\n<p>Yes &mdash; commonly given in malabsorption \/ cholestasis-of-pregnancy. Crosses placenta poorly so does not cause fetal effects acutely.<\/p>\n<h3>Why does cholestatic liver disease cause vitamin K deficiency?<\/h3>\n<p>Vitamin K is fat-soluble. Bile salts are needed for fat absorption. Biliary obstruction (gallstone, primary biliary cholangitis, cholangiocarcinoma) blocks bile flow, preventing fat-soluble vitamin absorption. Vitamin K deficiency causes elevated INR even before clinical bleeding.<\/p>\n<h3>Can I take vitamin K orally instead?<\/h3>\n<p>Yes &mdash; oral phytomenadione tablets exist for non-emergency replacement (e.g. cholestatic-disease maintenance, mild warfarin over-anticoagulation without bleeding). The injection is for emergencies, neonatal prophylaxis, severe malabsorption, or when oral cannot be tolerated.<\/p>\n<h3>Will it interact with my other medicines?<\/h3>\n<p>Mainly warfarin and other vitamin K antagonists. No clinically significant interactions with most other drugs &mdash; including antibiotics, statins, antihypertensives, or oral contraceptives.<\/p>\n<p><!-- medsbase-related-alts-v1 --><\/p>\n<h2>Ostatn\u00ed vitam\u00edny a miner\u00e1ly<\/h2>\n<ul>\n<li><a href=\"https:\/\/medsbase.com\/cs\/vitamin-b12-1500-mcg-tablets-nerve-health-energy\/\">Vitamin B12 1500 mcg<\/a> &mdash; oral cyanocobalamin<\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/walcobal-injection\/\">Walcobal Injekce<\/a> \u2014 methylkobalamin IM<\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/polybion-ampoule\/\">Polybion Ampule<\/a> \u2014 parenter\u00e1ln\u00ed B-komplex<\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/celin\/\">Celin<\/a> &mdash; vitamin C 500 mg<\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/arachitol-6l-injection\/\">Arachitol 6L Injekce<\/a> \u2014 cholekalciferol IM depot<\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/multivite-gold\/\">Multivite Gold<\/a> \u2014 komplexn\u00ed multivitamin<\/li>\n<\/ul>\n<h2>L\u00e9ka\u0159sk\u00e9 upozorn\u011bn\u00ed<\/h2>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:14px 18px;margin:18px 0;border-radius:4px;font-size:14px;color:#444;\">\nTato str\u00e1nka slou\u017e\u00ed pouze pro vzd\u011bl\u00e1vac\u00ed \u00fa\u010dely a nenahrazuje odbornou l\u00e9ka\u0159skou pomoc. Dopln\u011bn\u00ed vitam\u00edn\u016f a miner\u00e1l\u016f by m\u011blo b\u00fdt ide\u00e1ln\u011b vedeno laboratorn\u00edmi testy, pokud je podez\u0159en\u00ed na nedostatek. Megad\u00e1vky dopl\u0148k\u016f nejsou ne\u0161kodn\u00e9 \u2014 vitamin A je teratogenn\u00ed, vitamin E zvy\u0161uje riziko krv\u00e1cen\u00ed, beta-karoten zvy\u0161uje riziko rakoviny plic u ku\u0159\u00e1k\u016f a vysok\u00e9 d\u00e1vky v\u00e1pn\u00edku maj\u00ed kardiovaskul\u00e1rn\u00ed \u00fa\u010dinky. T\u011bhotn\u00e9 nebo koj\u00edc\u00ed pacientky by m\u011bly dodr\u017eovat doporu\u010den\u00ed pro prenat\u00e1ln\u00ed suplementaci. Pacienti u\u017e\u00edvaj\u00edc\u00ed warfarin mus\u00ed udr\u017eovat stabiln\u00ed p\u0159\u00edjem vitaminu K. Pacienti u\u017e\u00edvaj\u00edc\u00ed levothyroxin, fluorochinolony nebo tetracykliny mus\u00ed odd\u011blit p\u0159\u00edjem \u017eeleza a v\u00e1pn\u00edku o 4 hodiny. V\u017edy informujte sv\u00e9ho l\u00e9ka\u0159e a l\u00e9k\u00e1rn\u00edka o v\u0161ech dopl\u0148c\u00edch stravy.\n<\/div>","protected":false},"excerpt":{"rendered":"<p>\u2705 Aids blood clotting<br \/>\n\u2705 Prevents bleeding<br \/>\n\u2705 Treats vitamin K deficiency<br \/>\n\u2705 Supports bone health<br \/>\n\u2705 Essential for newborns<\/p>\n<p>Kenadion Injection contains Vitamin K.<\/p>","protected":false},"featured_media":61310,"comment_status":"open","ping_status":"open","template":"","meta":[],"product_brand":[],"product_cat":[3141,3342,3863],"product_tag":[5012,5013,5014],"class_list":{"0":"post-61309","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-category-overview","7":"product_cat-general-health","8":"product_cat-vitamins-and-minerals","9":"product_tag-kenadion","10":"product_tag-kenadion-injection","11":"product_tag-vitamin-k","13":"first","14":"instock","15":"shipping-taxable","16":"purchasable","17":"product-type-variable","18":"has-default-attributes"},"acf":[],"_links":{"self":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product\/61309","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/comments?post=61309"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/media\/61310"}],"wp:attachment":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/media?parent=61309"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product_brand?post=61309"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product_cat?post=61309"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product_tag?post=61309"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}