{"id":61432,"date":"2024-02-28T07:40:41","date_gmt":"2024-02-28T07:40:41","guid":{"rendered":"https:\/\/medsname.com\/mefque\/"},"modified":"2026-04-30T10:23:35","modified_gmt":"2026-04-30T10:23:35","slug":"mefque","status":"publish","type":"product","link":"https:\/\/medsbase.com\/cs\/product\/mefque\/","title":{"rendered":"Mefque"},"content":{"rendered":"

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Rychl\u00e1 odpov\u011b\u010f<\/h3>\n

Mefque<\/strong> obsahuje mefloquin 250 mg<\/strong> (Cipla). Jedn\u00e1 se o t\u00fddenn\u00ed chemoprofylaktickou mo\u017enost pro mal\u00e1rii rezistentn\u00ed na chlorochin<\/strong> v subsaharsk\u00e9 Africe, Indii, jihov\u00fdchodn\u00ed Asii (krom\u011b thajsko-kambod\u017esk\u00fdch a thajsko-myanmarsk\u00fdch hranic) a v Amazonii. D\u00e1vkov\u00e1n\u00ed pro dosp\u011bl\u00e9: 250 mg jednou t\u00fddn\u011b, za\u010d\u00edn\u00e1 se 2\u20133 t\u00fddny p\u0159ed cestou<\/strong> (k identifikaci nesn\u00e1\u0161enlivosti a dosa\u017een\u00ed ust\u00e1len\u00e9ho stavu), pokra\u010duje se b\u011bhem cesty a pokra\u010duje se 4 t\u00fddny po n\u00e1vratu<\/strong>. U\u017e\u00edvejte s pln\u00fdm j\u00eddlem a vodou. Povinn\u00e1 testovac\u00ed d\u00e1vka 3 t\u00fddny p\u0159ed odjezdem<\/strong> \u2014 pokud se objev\u00ed neuropsychiatrick\u00e9 ne\u017e\u00e1douc\u00ed \u00fa\u010dinky, p\u0159ejd\u011bte p\u0159ed letem na doxycyklin nebo atovaquon-proguanil. Kontraindikov\u00e1no u pacient\u016f se sou\u010dasnou nebo minulou depres\u00ed, generalizovanou \u00fazkostnou poruchou, psych\u00f3zou, schizofreni\u00ed, bipol\u00e1rn\u00ed poruchou, epilepsi\u00ed nebo v\u00fdznamnou poruchou srde\u010dn\u00edho veden\u00ed.<\/p>\n<\/div>\n

\ud83c\udfed V\u00fdrobce certifikovan\u00fd WHO-GMP<\/strong>  \u00b7  \ud83d\udce6 Diskr\u00e9tn\u00ed balen\u00ed<\/strong>  \u00b7  \ud83c\udf0d Doprava do cel\u00e9ho sv\u011bta<\/strong>  \u00b7  \u2b50 1,400+ recenz\u00ed z\u00e1kazn\u00edk\u016f<\/a><\/strong><\/div>\n

\ud83d\udee1\ufe0f Ka\u017ed\u00e1 objedn\u00e1vka je kryta na\u0161\u00ed Z\u00e1rukou op\u011btovn\u00e9ho odesl\u00e1n\u00ed<\/strong><\/a> \u2014 pokud va\u0161e z\u00e1silka nedoraz\u00ed do 20 pracovn\u00edch dn\u016f, za\u0161leme zdarma n\u00e1hradn\u00ed z\u00e1silku prost\u0159ednictv\u00edm kur\u00fdrn\u00ed slu\u017eby EMS nebo ITPS.<\/p>\n

Pro\u010d objedn\u00e1vat z MedsBase<\/h3>\n

Mefque je dod\u00e1v\u00e1n od v\u00fdrobce certifikovan\u00e9ho WHO-GMP a expedov\u00e1n po cel\u00e9m sv\u011bt\u011b v diskr\u00e9tn\u00edm balen\u00ed. Ka\u017ed\u00e1 objedn\u00e1vka je zaji\u0161t\u011bna na\u0161\u00edm Z\u00e1rukou op\u011btovn\u00e9ho odesl\u00e1n\u00ed<\/a> a podporov\u00e1na na\u0161\u00ed 1,400+ recenz\u00ed z\u00e1kazn\u00edk\u016f<\/a>. . Celosv\u011btov\u00e1 doprava bez p\u0159edpisov\u00e9 dokumentace.<\/p>\n

O p\u0159\u00edpravku Mefque<\/h2>\n

Mefque je tableta obsahuj\u00edc\u00ed 250 mg meflochin-hydrochloridu, vyr\u00e1b\u011bn\u00e1 spole\u010dnost\u00ed Cipla v podm\u00ednk\u00e1ch certifikovan\u00fdch WHO-GMP. Meflochin byl vyvinut v 70. letech 20. stolet\u00ed americk\u00fdm Walter Reed Army Institute of Research a z\u016fst\u00e1v\u00e1 jedn\u00edm ze t\u0159\u00ed modern\u00edch prost\u0159edk\u016f (spolu s doxycyklinem a atovaquon-proguanilem) pro profylaxi v oblastech s rezistenc\u00ed na chlorochin. D\u00edky dlouh\u00e9mu polo\u010dasu rozpadu umo\u017e\u0148uje t\u00fddenn\u00ed d\u00e1vkov\u00e1n\u00ed \u2014 v\u00fdhodn\u00e9 p\u0159i dlouh\u00fdch cest\u00e1ch.<\/p>\n

Jak meflochin p\u016fsob\u00ed<\/h2>\n

Meflochin je antimalarikum ze skupiny 4-chinolinmetanol\u016f. Podobn\u011b jako chlorochin naru\u0161uje detoxifikaci hem\u016f parazita v potravn\u00ed vakuole, ale je \u00fa\u010dinn\u00fd proti mnoha kmen\u016fm rezistentn\u00edm na chlorochin, proto\u017ee nez\u00e1vis\u00ed na stejn\u00e9m transportn\u00edm mechanismu parazita. M\u00e1 tak\u00e9 \u00fa\u010dinek proti krvinkov\u00fdm stadi\u00edm P. falciparum, P. vivax, P. ovale a P. malariae. Meflochin v\u00fdrazn\u011b pronik\u00e1 do CNS \u2014 co\u017e je \u017e\u00e1douc\u00ed pro parazitologickou \u00fa\u010dinnost, ale je tak\u00e9 p\u0159\u00ed\u010dinou jeho neuropsychiatrick\u00e9ho profilu ne\u017e\u00e1douc\u00edch \u00fa\u010dink\u016f.<\/p>\n

Polo\u010das rozpadu je ~ 2\u20133 t\u00fddny. T\u00fddenn\u00ed d\u00e1vkov\u00e1n\u00ed dos\u00e1hne ust\u00e1len\u00e9ho stavu v t\u00fddnu 7\u20139; proto v\u011bt\u0161ina autorit doporu\u010duje zah\u00e1jen\u00ed 2\u20133 t\u00fddny p\u0159ed cestou.<\/p>\n

Indikace a d\u00e1vkov\u00e1n\u00ed<\/h2>\n
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Indikace<\/th>\nD\u00e1vka<\/th>\nD\u00e1vkovac\u00ed sch\u00e9ma<\/th>\n<\/tr>\n<\/thead>\n
Chemoprofylaxe, dosp\u011bl\u00ed<\/td>\n250 mg jednou t\u00fddn\u011b<\/td>\nZa\u010dn\u011bte 2\u20133 t\u00fddny p\u0159ed vstupem do malarick\u00e9 oblasti; pokra\u010dujte t\u00fddn\u011b b\u011bhem expozice; pokra\u010dujte 4 t\u00fddny po n\u00e1vratu.<\/td>\n<\/tr>\n
D\u011btsk\u00e1 chemoprofylaxe (\u2265 5 kg)<\/td>\n5 mg\/kg jednou t\u00fddn\u011b (max 250 mg)<\/td>\nStejn\u00fd re\u017eim zah\u00e1jen\u00ed\/pokra\u010dov\u00e1n\u00ed\/ukon\u010den\u00ed. Pro men\u0161\u00ed d\u011bti polovina tablety \u2014 p\u0159esn\u00e9 mg\/kg jsou d\u016fle\u017eit\u00e9.<\/td>\n<\/tr>\n
Akutn\u00ed nekomplikovan\u00e1 mal\u00e1rie zp\u016fsoben\u00e1 chlorochin-rezistentn\u00edm P. falciparum, dosp\u011bl\u00ed<\/td>\n750 mg jednor\u00e1zov\u00e1 d\u00e1vka, pot\u00e9 500 mg za 6\u201312 hodin (celkem 1 250 mg)<\/td>\nL\u00e9\u010debn\u00e9 d\u00e1vky zp\u016fsobuj\u00ed v\u00fdrazn\u011b v\u00edce vedlej\u0161\u00edch \u00fa\u010dink\u016f ne\u017e profylaktick\u00e9 d\u00e1vky. Modern\u00ed doporu\u010den\u00ed WHO up\u0159ednost\u0148uje artemisininovou kombinovanou terapii, je-li dostupn\u00e1.<\/td>\n<\/tr>\n
Pohotovostn\u00ed samol\u00e9\u010dba p\u0159edpokl\u00e1dan\u00e9 mal\u00e1rie<\/td>\n750 mg + 500 mg jako v\u00fd\u0161e<\/td>\nPro cestovatele v oblastech bez rychl\u00e9ho l\u00e9ka\u0159sk\u00e9ho p\u0159\u00edstupu, u kter\u00fdch se rozvine hore\u010dnat\u00e9 onemocn\u011bn\u00ed kompatibiln\u00ed s mal\u00e1ri\u00ed. Nen\u00ed n\u00e1hradou l\u00e9ka\u0159sk\u00e9ho vy\u0161et\u0159en\u00ed.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n
Neuropsychiatrick\u00e9 varov\u00e1n\u00ed \u2014 p\u0159e\u010dt\u011bte p\u0159ed n\u00e1kupem.<\/strong> Meflochin je spojov\u00e1n s \u00fazkost\u00ed, \u017eiv\u00fdmi sny, no\u010dn\u00edmi m\u016frami, nespavost\u00ed, zm\u011bnami n\u00e1lady, depres\u00ed, sebevra\u017eedn\u00fdmi my\u0161lenkami, paranoiou, halucinacemi a vz\u00e1cn\u00fdmi z\u00e1chvaty. V\u011bt\u0161ina reakc\u00ed se objev\u00ed b\u011bhem prvn\u00edch 3 d\u00e1vek. N\u011bkte\u0159\u00ed pacienti popisuj\u00ed dlouhotrvaj\u00edc\u00ed p\u0159\u00edznaky (\u201cpost-meflochinov\u00fd syndrom\u201d) po vysazen\u00ed l\u00e9ku. Kontraindikov\u00e1no u:<\/strong> sou\u010dasn\u00e9 nebo minul\u00e9 deprese, generalizovan\u00e9 \u00fazkostn\u00e9 poruchy, psych\u00f3zy, schizofrenie, bipol\u00e1rn\u00ed poruchy, epilepsie, z\u00e1va\u017en\u00e9 poruchy srde\u010dn\u00edho veden\u00ed, ned\u00e1vn\u00e9ho traumatick\u00e9ho poran\u011bn\u00ed mozku, anamn\u00e9zy z\u00e1va\u017en\u00e9ho psychiatrick\u00e9ho onemocn\u011bn\u00ed v bl\u00edzk\u00e9 rodin\u011b. V\u017edy prove\u010fte 3t\u00fddenn\u00ed testovac\u00ed d\u00e1vku p\u0159ed cestou<\/strong>: pokud se objev\u00ed \u00fazkost, dysforie, \u017eiv\u00e9 sny nebo poruchy sp\u00e1nku, p\u0159ejd\u011bte p\u0159ed odletem na doxycyklin nebo atovaquon-proguanil.<\/div>\n
Upozorn\u011bn\u00ed t\u00fdkaj\u00edc\u00ed se srdce.<\/strong> Meflochin prodlu\u017euje PR interval a m\u00edrn\u011b prodlu\u017euje QTc. Vyhn\u011bte se kombinaci s dal\u0161\u00edmi l\u00e9ky prodlu\u017euj\u00edc\u00edmi QT interval (azithromycin, ondansetron, fluorochinolony, antipsychotika, SSRI \/ TCA ve vysok\u00fdch d\u00e1vk\u00e1ch). Vyhn\u011bte se u pacient\u016f s bradykardi\u00ed, AV blok\u00e1dou nebo z\u00e1vislost\u00ed na kardiostimul\u00e1toru bez konzultace s kardiologem.<\/div>\n

Vedlej\u0161\u00ed \u00fa\u010dinky<\/h2>\n