{"id":61476,"date":"2024-02-28T07:42:25","date_gmt":"2024-02-28T07:42:25","guid":{"rendered":"https:\/\/medsname.com\/seretra\/"},"modified":"2026-04-30T10:23:34","modified_gmt":"2026-04-30T10:23:34","slug":"seretra","status":"publish","type":"product","link":"https:\/\/medsbase.com\/cs\/product\/seretra\/","title":{"rendered":"Seretra"},"content":{"rendered":"<div class=\"medsbase-tldr-answer\" style=\"background:#fff8e1;border-left:4px solid #f5a623;padding:18px 22px;margin:0 0 28px 0;border-radius:4px;\">\n<h3 style=\"margin:0 0 10px 0;font-size:18px;color:#1a1a1a;\">\u26a1 Quick Answer \u2014 What is Seretra?<\/h3>\n<p><strong>Seretra<\/strong> obsahuje <strong>seratrodast 80 mg<\/strong>, , <strong>selective thromboxane A2 (TXA2) receptor antagonist<\/strong> used as preventer therapy for asthma and allergic rhinitis. Seratrodast blocks the TXA2 receptor on bronchial smooth muscle, eosinophils, and platelets \u2014 preventing TXA2-mediated bronchoconstriction, eosinophil recruitment, and airway hyperresponsiveness. It was developed and is mainly used in Japan; less widely available outside Asia. Used as add-on preventer alongside ICS in patients with persistent asthma. Onset of preventer benefit takes <strong>1\u20132 t\u00fddny<\/strong> of daily dosing.<\/p>\n<\/div>\n<div class=\"medsbase-trust-strip\" style=\"background:#f4f8fb;border:1px solid #d8e3eb;padding:12px 16px;margin:16px 0;border-radius:4px;font-size:14px;\">\n<strong>Co z\u00edsk\u00e1te s MedsBase:<\/strong> V\u00fdrobce certifikovan\u00fd WHO-GMP \u00b7 Diskr\u00e9tn\u00ed balen\u00ed \u00b7 Celosv\u011btov\u00e1 doprava \u00b7 V\u00edce ne\u017e 1 400 ov\u011b\u0159en\u00fdch <a href=\"https:\/\/medsbase.com\/cs\/reviews\/\">recenz\u00ed z\u00e1kazn\u00edk\u016f<\/a>\n<\/div>\n<p class=\"medsbase-reship-line\" style=\"font-size:14px;color:#444;margin:8px 0 18px;\">\ud83d\udce6 Ka\u017ed\u00e1 objedn\u00e1vka je pokryta na\u0161\u00ed <a href=\"https:\/\/medsbase.com\/cs\/medsbase-re-shipment-assurance-policy\/\"><strong>Z\u00e1rukou op\u011btovn\u00e9ho odesl\u00e1n\u00ed<\/strong><\/a> \u2014 pokud va\u0161e z\u00e1silka nedoraz\u00ed do 20 pracovn\u00edch dn\u016f, p\u0159epos\u00edl\u00e1me ji.<\/p>\n<h3>Pro\u010d objedn\u00e1vat z MedsBase<\/h3>\n<p>Na\u0161e generick\u00e9 l\u00e9ky poch\u00e1zej\u00ed od v\u00fdrobc\u016f certifikovan\u00fdch WHO-GMP a jsou expedov\u00e1ny po cel\u00e9m sv\u011bt\u011b v diskr\u00e9tn\u00edm, nen\u00e1padn\u00e9m balen\u00ed \u2013 na vn\u011bj\u0161\u00ed stran\u011b bal\u00edku nen\u00ed uveden n\u00e1zev l\u00e9ku. Platby kartou jsou sm\u011brov\u00e1ny prost\u0159ednictv\u00edm regulovan\u00e9ho procesoru (popisky na v\u00fdpisu zahrnuj\u00ed regulovan\u00e9ho procesora plateb kartou \u2013 nikdy \u201cMedsBase\u201d nebo n\u00e1zev l\u00e9ku). P\u0159ij\u00edm\u00e1me tak\u00e9 kryptom\u011bny a bankovn\u00ed p\u0159evody SEPA. Ka\u017ed\u00e1 objedn\u00e1vka je zaji\u0161t\u011bna na\u0161\u00ed politikou p\u0159eposl\u00e1n\u00ed.<\/p>\n<div style=\"background:#f4f8fb;border:1px solid #e0e0e0;padding:12px 18px;margin:0 0 24px 0;border-radius:4px;font-size:14px;text-align:center;\">\n<strong>\ud83d\udd12 \u0160ifrovan\u00fd n\u00e1kup<\/strong> \u00b7 <strong>\ud83d\udcb3 Ov\u011b\u0159en\u00fd procesor<\/strong> \u00b7 <strong>\ud83d\ude9a Doprava po cel\u00e9m sv\u011bt\u011b<\/strong> \u00b7 <strong>\u2b50 4,9\/5 od 1 400+ z\u00e1kazn\u00edk\u016f<\/strong>\n<\/div>\n<h2>What Is Seretra?<\/h2>\n<p>Seretra contains seratrodast \u2014 a niche anti-asthma agent introduced in Japan in 1995. Seratrodast targets the thromboxane A2 (TXA2) receptor \u2014 a contrast to leukotriene receptor antagonists (montelukast) which target the cysteinyl leukotriene receptor. Both TXA2 and leukotrienes are inflammatory mediators released during the allergic cascade.<\/p>\n<h2>How Does Seratrodast Work?<\/h2>\n<ul>\n<li><strong>TXA2 receptor blockade<\/strong> on bronchial smooth muscle prevents TXA2-mediated bronchoconstriction<\/li>\n<li><strong>Reduces eosinophil recruitment<\/strong> to airways<\/li>\n<li><strong>Decreases airway hyperresponsiveness<\/strong> over 1\u20132 weeks of dosing<\/li>\n<li><strong>Mild platelet inhibition<\/strong> \u2014 TXA2 is a potent platelet aggregator; this effect is rarely clinically significant<\/li>\n<\/ul>\n<h2>Pou\u017eit\u00ed a indikace<\/h2>\n<ul>\n<li><strong>Perzistuj\u00edc\u00ed astma<\/strong> \u2014 add-on preventer when ICS alone is inadequate<\/li>\n<li><strong>Alergick\u00e1 r\u00fdma<\/strong> \u2014 dopl\u0148kov\u00fd prost\u0159edek<\/li>\n<li><strong>Ka\u0161lov\u00e1 varianta astmatu<\/strong><\/li>\n<li><strong>Aspirin-exacerbated respiratory disease<\/strong> (AERD) \u2014 niche use<\/li>\n<\/ul>\n<h2>Seretra Dosage<\/h2>\n<table style=\"border-collapse:collapse;width:100%;margin:12px 0;\">\n<thead>\n<tr style=\"background:#2c7cb0;color:#fff;\">\n<th style=\"padding:10px;border:1px solid #ddd;text-align:left;\">Pacient<\/th>\n<th style=\"padding:10px;border:1px solid #ddd;text-align:left;\">D\u00e1vka<\/th>\n<th style=\"padding:10px;border:1px solid #ddd;text-align:left;\">Frekvence<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td style=\"padding:10px;border:1px solid #ddd;\">Dosp\u011bl\u00ed<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\"><strong>80 mg<\/strong><\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Once daily after dinner<\/td>\n<\/tr>\n<tr style=\"background:#f9f9f9;\">\n<td style=\"padding:10px;border:1px solid #ddd;\">Porucha funkce jater<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Sn\u00ed\u017eit d\u00e1vku o 50 %<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Jednou denn\u011b<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2>Side Effects of Seretra<\/h2>\n<ul>\n<li>Nausea, dyspepsia<\/li>\n<li>Bolest hlavy<\/li>\n<li>Mild dizziness<\/li>\n<li>M\u00edrn\u00e9 zv\u00fd\u0161en\u00ed jatern\u00edch enzym\u016f<\/li>\n<li>Rarely: rash, fatigue<\/li>\n<\/ul>\n<p><strong>Z\u00e1va\u017en\u00e9 \u2014 p\u0159esta\u0148te u\u017e\u00edvat a vyhledejte pomoc:<\/strong><\/p>\n<ul>\n<li>Hepatitis (jaundice, dark urine, RUQ pain)<\/li>\n<li>Z\u00e1va\u017en\u00e1 alergick\u00e1 reakce<\/li>\n<li>T\u011b\u017ek\u00e9 p\u0159etrv\u00e1vaj\u00edc\u00ed zvracen\u00ed<\/li>\n<\/ul>\n<h2>Varov\u00e1n\u00ed a opat\u0159en\u00ed<\/h2>\n<ul>\n<li><strong>Monitorov\u00e1n\u00ed funkce jater:<\/strong> baseline LFTs and periodic monitoring during long-term use.<\/li>\n<li><strong>Pokra\u010dujte v u\u017e\u00edv\u00e1n\u00ed ICS<\/strong> if previously prescribed; seratrodast is add-on, not replacement.<\/li>\n<li><strong>Nen\u00ed ur\u010deno k akutn\u00ed l\u00e9\u010db\u011b.<\/strong> Use SABA (Asthalin, Levolin) for acute attacks.<\/li>\n<li><strong>T\u011bhotenstv\u00ed a kojen\u00ed:<\/strong> limited data; avoid unless benefit clear.<\/li>\n<li><strong>Bleeding disorders:<\/strong> mild TXA2 inhibition could theoretically prolong bleeding; rarely clinically significant.<\/li>\n<\/ul>\n<h2>Kontraindikace<\/h2>\n<ul>\n<li>Hypersensitivity to seratrodast<\/li>\n<li>T\u011b\u017ek\u00e9 jatern\u00ed po\u0161kozen\u00ed<\/li>\n<li>Active hepatitis<\/li>\n<\/ul>\n<h2>Interakce s l\u00e9\u010divy<\/h2>\n<ul>\n<li>Aspirin and other antiplatelet agents \u2014 additive bleeding risk (rarely clinically significant)<\/li>\n<li>Warfarin \u2014 monitor INR<\/li>\n<li>Other hepatotoxic drugs \u2014 monitor LFTs<\/li>\n<\/ul>\n<h2>Skladov\u00e1n\u00ed<\/h2>\n<ul>\n<li>Skladujte p\u0159i teplot\u011b do <strong>25\u00b0C<\/strong> na chladn\u00e9m, such\u00e9m m\u00edst\u011b, chr\u00e1n\u011bn\u00e9m p\u0159ed p\u0159\u00edm\u00fdm slune\u010dn\u00edm z\u00e1\u0159en\u00edm.<\/li>\n<li>Ponechte v p\u016fvodn\u00edm obalu a\u017e do pou\u017eit\u00ed, aby byl chr\u00e1n\u011bn p\u0159ed vlhkost\u00ed a sv\u011btlem.<\/li>\n<li>Nepou\u017e\u00edvejte po uplynut\u00ed data expirace uveden\u00e9ho na blistru.<\/li>\n<li>Uchov\u00e1vejte mimo dosah d\u011bt\u00ed.<\/li>\n<\/ul>\n<h2>Souvisej\u00edc\u00ed alternativy na MedsBase<\/h2>\n<ul>\n<li><a href=\"https:\/\/medsbase.com\/cs\/asthalin-inhaler\/\"><strong>Asthalin Inhaler \u2014 salbutamol \u00falevov\u00fd inhal\u00e1tor<\/strong><\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/budecort-inhaler\/\"><strong>Budecort Inhaler \u2014 budesonid preventivn\u00ed ICS inhal\u00e1tor<\/strong><\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/foracort-inhaler\/\"><strong>Foracort Inhaler \u2014 budesonid + formoterol ICS-LABA inhal\u00e1tor<\/strong><\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/montair\/\"><strong>Montair \u2014 montelukast LTRA tablety<\/strong><\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/tiova-inhaler\/\"><strong>Tiova Inhaler \u2014 tiotropium LAMA pro CHOPN<\/strong><\/a><\/li>\n<\/ul>\n<h2 id=\"faqs\">\u010casto kladen\u00e9 dotazy<\/h2>\n<h3>How is seratrodast different from montelukast?<\/h3>\n<p>Both block specific allergic mediators. Montelukast (Montair) blocks the cysteinyl leukotriene CysLT1 receptor. Seratrodast blocks the thromboxane A2 receptor. Different mediators, different targets, similar add-on niche. Montelukast has more global use and a stronger evidence base; seratrodast is mainly used in Japan and parts of Asia.<\/p>\n<h3>Can I take Seretra alongside montelukast?<\/h3>\n<p>Combination is not standard. Discuss with your prescriber \u2014 there is no established additional benefit over ICS-LABA + LTRA.<\/p>\n<h3>How long until Seretra works?<\/h3>\n<p>1\u20132 weeks for noticeable improvement; 4\u20138 weeks for full preventer effect on exacerbation rate.<\/p>\n<h3>Is Seretra a rescue inhaler?<\/h3>\n<p>No \u2014 onset is far too slow. Use a SABA (Asthalin, Levolin) for acute attacks.<\/p>\n<h3>Why monitor liver function?<\/h3>\n<p>Mild liver enzyme elevation is a known side effect. Baseline LFTs and periodic monitoring are recommended.<\/p>\n<h3>Will Seretra replace my inhaler?<\/h3>\n<p>No \u2014 seratrodast is an oral add-on. Continue ICS or ICS-LABA inhaler therapy.<\/p>\n<h3>Is Seretra evidence-based?<\/h3>\n<p>Yes, but mainly through Japanese trials. Evidence base is smaller than for montelukast or ICS-LABA combinations. Reasonable as add-on in selected patients.<\/p>\n<h3>Can children take Seretra?<\/h3>\n<p>Limited paediatric data; specialist supervision required.<\/p>\n<h3>Is Seretra safe in pregnancy?<\/h3>\n<p>Limited data; avoid unless benefit clear.<\/p>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:14px 18px;margin:24px 0;border-radius:4px;font-size:13px;\"><strong>Zdravotn\u00ed upozorn\u011bn\u00ed:<\/strong> Tato str\u00e1nka je vzd\u011bl\u00e1vac\u00ed a nenahrazuje odbornou l\u00e9ka\u0159skou pomoc. P\u0159ed zah\u00e1jen\u00edm, ukon\u010den\u00edm nebo zm\u011bnou jak\u00e9hokoli inhal\u00e1toru nebo respira\u010dn\u00edho l\u00e9ku se v\u017edy pora\u010fte s kvalifikovan\u00fdm zdravotnick\u00fdm pracovn\u00edkem, zejm\u00e9na pokud m\u00e1te jin\u00e9 zdravotn\u00ed pot\u00ed\u017ee, u\u017e\u00edv\u00e1te jin\u00e9 l\u00e9ky, jste t\u011bhotn\u00e1 nebo koj\u00edte, nebo je v\u00e1m v\u00edce ne\u017e 65 let.<\/div>\n<p><!-- medsbase-related-alts-v1 --><\/p>\n<h3 class=\"wp-block-heading\">Souvisej\u00edc\u00ed alternativy<\/h3>\n<p>Dal\u0161\u00ed produkty v <strong>Chronick\u00e1 onemocn\u011bn\u00ed<\/strong> kter\u00e9 z\u00e1kazn\u00edci tak\u00e9 prohl\u00ed\u017eej\u00ed:<\/p>\n<ul>\n<li><a href=\"https:\/\/medsbase.com\/cs\/tenof-em\/\">Tenof EM<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/headset\/\">Trinicalm Plus<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/maxiflo-rotacaps\/\">Maxiflo Rotacaps<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/neomercazole\/\">Neomercazole<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/tridon\/\">Tridon<\/a><\/li>\n<\/ul>","protected":false},"excerpt":{"rendered":"<p>\u2705 Sni\u017euje z\u00e1n\u011bt d\u00fdchac\u00edch cest<br \/>\n\u2705 Zlep\u0161uje funkci plic<br \/>\n\u2705 Ulevuje od p\u0159\u00edznak\u016f astmatu<br \/>\n\u2705 Prevents bronchoconstriction<br \/>\n\u2705 Enhances respiratory health<\/p>\n<p>Seretra contains Seratrodast.<\/p>","protected":false},"featured_media":61477,"comment_status":"open","ping_status":"open","template":"","meta":[],"product_brand":[],"product_cat":[3681,3141,3223],"product_tag":[5040,5041],"class_list":{"0":"post-61476","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-asthma-copd-treatment","7":"product_cat-category-overview","8":"product_cat-chronic-conditions","9":"product_tag-seratrodast","10":"product_tag-seretra","12":"first","13":"instock","14":"shipping-taxable","15":"purchasable","16":"product-type-variable","17":"has-default-attributes"},"acf":[],"_links":{"self":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product\/61476","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/comments?post=61476"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/media\/61477"}],"wp:attachment":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/media?parent=61476"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product_brand?post=61476"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product_cat?post=61476"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product_tag?post=61476"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}