{"id":61588,"date":"2024-03-03T05:46:41","date_gmt":"2024-03-03T05:46:41","guid":{"rendered":"https:\/\/medsname.com\/atorvatin\/"},"modified":"2026-05-01T10:49:17","modified_gmt":"2026-05-01T10:49:17","slug":"atorvatin","status":"publish","type":"product","link":"https:\/\/medsbase.com\/cs\/product\/atorvatin\/","title":{"rendered":"Atorvatin"},"content":{"rendered":"<p><!-- medsbase-tldr-answer --><\/p>\n<div style=\"background:#fff8e1;border-left:4px solid #f5a623;padding:18px 22px;margin:0 0 24px 0;border-radius:4px;\">\n<h3 class=\"wp-block-heading\" style=\"margin:0 0 8px 0;font-size:16px;font-weight:700;\">&#9889; Quick Answer &mdash; What is Atorvatin?<\/h3>\n<p style=\"margin:0;\"><strong>Atorvatin<\/strong> je <strong>5 mg atorvastatin tablet<\/strong> from a WHO-GMP certified manufacturer &mdash; a high-intensity HMG-CoA reductase inhibitor (statin), lipophilic. Statins reduce cardiovascular events by <strong>20-30 % na ka\u017ed\u00e9 sn\u00ed\u017een\u00ed LDL-cholesterolu o 1 mmol\/l<\/strong> nap\u0159\u00ed\u010d prim\u00e1rn\u00ed prevenc\u00ed, sekund\u00e1rn\u00ed prevenc\u00ed, diabetem a populac\u00ed po c\u00e9vn\u00ed mozkov\u00e9 p\u0159\u00edhod\u011b. Atorvastatin byl uveden na trh spole\u010dnost\u00ed Parke-Davis\/Pfizer v roce 1996 jako <strong>Lipitor<\/strong> \u2014 nejprod\u00e1van\u011bj\u0161\u00ed l\u00e9k v\u0161ech dob na vrcholu sv\u00e9 popularity (12,5 miliardy dolar\u016f ro\u010dn\u011b v roce 2006). Lipofiln\u00ed statin, vylu\u010dovan\u00fd j\u00e1try prost\u0159ednictv\u00edm CYP3A4. D\u00e1vkovac\u00ed rozmez\u00ed 10-80 mg jednou denn\u011b; 40-80 mg jsou vysoce \u00fa\u010dinn\u00e9 dle lipidov\u00fdch doporu\u010den\u00ed AHA\/ACC z roku 2018. \u00da\u010dinnost: atorvastatin 40 mg obvykle sni\u017euje LDL-C o 50 %; 80 mg o 55 %. Typick\u00e9 d\u00e1vkov\u00e1n\u00ed: jednou denn\u011b, ve\u010der (u statin\u016f s kr\u00e1tk\u00fdm polo\u010dasem) nebo kdykoli u atorvastatinu (polo\u010das dostate\u010dn\u011b dlouh\u00fd, na\u010dasov\u00e1n\u00ed nehraje roli). Hlavn\u00ed ne\u017e\u00e1douc\u00ed \u00fa\u010dinky: svalov\u00e9 p\u0159\u00edznaky (0,1-1 % s potvrzen\u00fdm zv\u00fd\u0161en\u00edm CK; a\u017e 10 % nocebo svalov\u00fdch bolest\u00ed), m\u00edrn\u00e9 zv\u00fd\u0161en\u00ed transamin\u00e1z (3 %), nov\u011b vznikl\u00fd diabetes u rizikov\u00fdch pacient\u016f (~0,2 na 100 pacient\u016f za rok). Absolutn\u011b kontraindikov\u00e1n v t\u011bhotenstv\u00ed, p\u0159i aktivn\u00edm jatern\u00edm onemocn\u011bn\u00ed a v anamn\u00e9ze rabdomyol\u00fdzy.<\/p>\n<\/div>\n<div class=\"medsbase-trust-strip\" style=\"background:#f4f8fb;border:1px solid #d8e3eb;padding:12px 16px;margin:16px 0;border-radius:4px;font-size:14px;\">\n<strong>Co z\u00edsk\u00e1te s MedsBase:<\/strong> V\u00fdrobce certifikovan\u00fd WHO-GMP \u00b7 Diskr\u00e9tn\u00ed balen\u00ed \u00b7 Celosv\u011btov\u00e1 doprava \u00b7 V\u00edce ne\u017e 1 400 ov\u011b\u0159en\u00fdch <a href=\"https:\/\/medsbase.com\/cs\/reviews\/\">recenz\u00ed z\u00e1kazn\u00edk\u016f<\/a>\n<\/div>\n<p class=\"medsbase-reship-line\" style=\"font-size:14px;color:#444;margin:8px 0 18px;\">\ud83d\udce6 Ka\u017ed\u00e1 objedn\u00e1vka je pokryta na\u0161\u00ed <a href=\"https:\/\/medsbase.com\/cs\/medsbase-re-shipment-assurance-policy\/\"><strong>Z\u00e1rukou op\u011btovn\u00e9ho odesl\u00e1n\u00ed<\/strong><\/a> \u2014 pokud va\u0161e z\u00e1silka nedoraz\u00ed do 20 pracovn\u00edch dn\u016f, p\u0159epos\u00edl\u00e1me ji.<\/p>\n<h3>Pro\u010d objedn\u00e1vat z MedsBase<\/h3>\n<p>Na\u0161e generick\u00e9 l\u00e9ky poch\u00e1zej\u00ed od v\u00fdrobc\u016f certifikovan\u00fdch WHO-GMP a jsou expedov\u00e1ny po cel\u00e9m sv\u011bt\u011b v diskr\u00e9tn\u00edm, nen\u00e1padn\u00e9m balen\u00ed \u2013 na vn\u011bj\u0161\u00ed stran\u011b bal\u00edku nen\u00ed uveden n\u00e1zev l\u00e9ku. Platby kartou jsou sm\u011brov\u00e1ny prost\u0159ednictv\u00edm regulovan\u00e9ho procesoru (popisky na v\u00fdpisu zahrnuj\u00ed regulovan\u00e9ho procesora plateb kartou \u2013 nikdy \u201cMedsBase\u201d nebo n\u00e1zev l\u00e9ku). P\u0159ij\u00edm\u00e1me tak\u00e9 kryptom\u011bny a bankovn\u00ed p\u0159evody SEPA. Ka\u017ed\u00e1 objedn\u00e1vka je zaji\u0161t\u011bna na\u0161\u00ed politikou p\u0159eposl\u00e1n\u00ed.<\/p>\n<h2 class=\"wp-block-heading\">What Is Atorvatin?<\/h2>\n<p>Atorvatin is an oral 5 mg atorvastatin tablet from a WHO-GMP certified manufacturer, supplied in 30-180 tablets. Atorvastatin was introduced by Parke-Davis\/Pfizer in 1996 as <strong>Lipitor<\/strong> \u2014 nejprod\u00e1van\u011bj\u0161\u00ed l\u00e9k v\u0161ech dob na vrcholu sv\u00e9 popularity (12,5 miliardy dolar\u016f ro\u010dn\u011b v roce 2006). Lipofiln\u00ed statin, vylu\u010dovan\u00fd j\u00e1try prost\u0159ednictv\u00edm CYP3A4. D\u00e1vkovac\u00ed rozmez\u00ed 10-80 mg jednou denn\u011b; 40-80 mg jsou vysoce \u00fa\u010dinn\u00e9 dle lipidov\u00fdch doporu\u010den\u00ed AHA\/ACC z roku 2018.<\/p>\n<h2 class=\"wp-block-heading\">Jak atorvastatin funguje<\/h2>\n<p>Atorvastatin inhibuje <strong>HMG-CoA redukt\u00e1zy<\/strong>, limituj\u00edc\u00ed enzym jatern\u00ed biosynt\u00e9zy cholesterolu. Downstream:<\/p>\n<ul>\n<li><strong>Sn\u00ed\u017een\u00fd intracelul\u00e1rn\u00ed cholesterol v hepatocytech<\/strong> \u2014 aktivuje sterol-regula\u010dn\u00ed element v\u00e1zaj\u00edc\u00ed protein (SREBP) a zvy\u0161uje expresi LDL-receptor\u016f na povrchu hepatocyt\u016f<\/li>\n<li><strong>Zv\u00fd\u0161en\u00e9 odstra\u0148ov\u00e1n\u00ed cirkuluj\u00edc\u00edho LDL-C<\/strong> \u2014 prim\u00e1rn\u00ed mechanismus sni\u017eov\u00e1n\u00ed LDL<\/li>\n<li><strong>M\u00edrn\u00e9 sn\u00ed\u017een\u00ed triglycerid\u016f<\/strong> (10-20 %) a m\u00edrn\u00e9 zv\u00fd\u0161en\u00ed HDL (5-10 %)<\/li>\n<li><strong>Pleiotropn\u00ed \u00fa\u010dinky<\/strong> mimo sni\u017eov\u00e1n\u00ed LDL \u2014 sn\u00ed\u017een\u00ed c\u00e9vn\u00edho z\u00e1n\u011btu (pokles hs-CRP), zlep\u0161en\u00e1 endoteli\u00e1ln\u00ed funkce, stabilizace pl\u00e1t\u016f, sn\u00ed\u017een\u00e1 reaktivita trombocyt\u016f. Rozsah klinick\u00e9ho p\u0159\u00ednosu v studi\u00edch p\u0159esahuje to, co lze vysv\u011btlit pouze zm\u011bnou LDL-C.<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Atorvatin Dosage<\/h2>\n<p><strong>Prim\u00e1rn\u00ed prevence (bez p\u0159edchoz\u00ed kardiovaskul\u00e1rn\u00ed p\u0159\u00edhody):<\/strong> za\u010dn\u011bte s 10-20 mg jednou denn\u011b; upravte d\u00e1vku podle c\u00edlov\u00e9 hodnoty na z\u00e1klad\u011b 10let\u00e9ho rizika ASCVD. U diabetik\u016f nebo p\u0159i riziku ASCVD &gt;7,5 % je typick\u00e1 st\u0159edn\u011b intenzivn\u00ed l\u00e9\u010dba (20-40 mg).<\/p>\n<p><strong>Sekund\u00e1rn\u00ed prevence (p\u0159edchoz\u00ed IM, CMP, PAD nebo diabetick\u00e1 KVO):<\/strong> vysoce intenzivn\u00ed terapie \u2014 40-80 mg jednou denn\u011b. C\u00edlov\u00e9 LDL-C &lt;1,8 mmol\/l (&lt;70 mg\/dl) dle ESC 2019 a &lt;1,4 mmol\/l (&lt;55 mg\/dl) pro velmi vysok\u00e9 riziko ASCVD dle aktualizace ESC 2021.<\/p>\n<p><strong>Famili\u00e1rn\u00ed hypercholesterolemie:<\/strong> maxim\u00e1ln\u011b tolerovan\u00fd statin (obvykle 80 mg) \u010dasto kombinovan\u00fd s ezetimibem 10 mg a\/nebo inhibitorem PCSK9 (alirocumab\/evolocumab\/inclisiran) k dosa\u017een\u00ed c\u00edlov\u00fdch hodnot doporu\u010den\u00ed.<\/p>\n<p><strong>Pod\u00e1v\u00e1n\u00ed:<\/strong> jednou denn\u011b s j\u00eddlem nebo bez j\u00eddla. Ve\u010dern\u00ed d\u00e1vkov\u00e1n\u00ed ji\u017e nen\u00ed vy\u017eadov\u00e1no; jak\u00fdkoli konzistentn\u00ed \u010das dne je v po\u0159\u00e1dku.<\/p>\n<p><strong>Monitorov\u00e1n\u00ed:<\/strong><\/p>\n<ul>\n<li><strong>Vstupn\u00ed vy\u0161et\u0159en\u00ed:<\/strong> \u00fapln\u00fd lipidov\u00fd panel, jatern\u00ed testy (ALT), kreatinkin\u00e1za (CK) pouze p\u0159i st\u00ed\u017enostech na svaly; nikoli rutinn\u011b.<\/li>\n<li><strong>4-12 t\u00fddn\u016f:<\/strong> opakujte lipidy, abyste posoudili odpov\u011b\u010f. P\u0159edpokl\u00e1dejte, \u017ee atorvastatin 40 mg obvykle sni\u017euje LDL-C o 50%; 80 mg o 55%. D\u00e1vku zvy\u0161te, pokud c\u00edl nen\u00ed dosa\u017een.<\/li>\n<li><strong>Ro\u010dn\u011b:<\/strong> d\u016fkaz pro atorvastatin.<\/li>\n<li><strong>P\u0159eru\u0161te a vy\u0161et\u0159ete:<\/strong> CARDS (2004).<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">\u2014 atorvastatin 10 mg u 2 838 pacient\u016f s diabetem 2. typu bez zjevn\u00e9ho CVD sn\u00ed\u017eil hlavn\u00ed kardiovaskul\u00e1rn\u00ed p\u0159\u00edhody o 37% (prim\u00e1rn\u00ed prevence u diabetu).<\/h2>\n<p><strong>ASCOT-LLA (2003)<\/strong> \u2014 80 mg vs 10 mg u stabiln\u00ed ICHS; vysok\u00e1 d\u00e1vka sn\u00ed\u017eila p\u0159\u00edhody o 22%. <strong>TNT (2005)<\/strong> \u2014 80 mg vs 10 mg u stabiln\u00ed ICHS; vysok\u00e1 d\u00e1vka sn\u00ed\u017eila p\u0159\u00edhody o 22%. <strong>PROVE-IT (2004)<\/strong> \u2014 atorvastatin 80 mg vs 10 mg u stabiln\u00ed ICHS; vysok\u00e1 d\u00e1vka sn\u00ed\u017eila p\u0159\u00edhody o 22%. <strong>TNT (2005)<\/strong> \u2014 80 mg vs 10 mg u stabiln\u00ed ICHS; vysok\u00e1 d\u00e1vka sn\u00ed\u017eila p\u0159\u00edhody o 22%. <strong>SPARCL (2006)<\/strong> \u2014 atorvastatin 80 mg po c\u00e9vn\u00ed mozkov\u00e9 p\u0159\u00edhod\u011b\/TIA sn\u00ed\u017eil opakovanou c\u00e9vn\u00ed mozkovou p\u0159\u00edhodu o 16 %.<\/p>\n<h2 class=\"wp-block-heading\">Schv\u00e1len\u00e9 a v\u011bdecky podlo\u017een\u00e9 indikace<\/h2>\n<ul>\n<li>Prim\u00e1rn\u00ed a sekund\u00e1rn\u00ed prevence kardiovaskul\u00e1rn\u00edch onemocn\u011bn\u00ed u pacient\u016f s dyslipid\u00e9mi\u00ed<\/li>\n<li>Diabetes 2. typu (CARDS) i p\u0159i \u201cnorm\u00e1ln\u00ed\u201d hladin\u011b LDL<\/li>\n<li>Sekund\u00e1rn\u00ed prevence po c\u00e9vn\u00ed mozkov\u00e9 p\u0159\u00edhod\u011b (SPARCL)<\/li>\n<li>Famili\u00e1rn\u00ed hypercholesterolemie (80 mg; \u010dasto vy\u017eaduje kombinaci s ezetimibem nebo inhibitorem PCSK9)<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Praktick\u00e9 aspekty<\/h2>\n<p><strong>Grapefruitov\u00e1 \u0161\u0165\u00e1va interaguje<\/strong> \u2014 inhibuje st\u0159evn\u00ed CYP3A4, \u010d\u00edm\u017e zvy\u0161uje hladinu atorvastatinu 2-3kr\u00e1t. Mal\u00e9 mno\u017estv\u00ed (jedna sklenice, jednor\u00e1zov\u011b) obvykle nevad\u00ed; pravideln\u00e9 denn\u00ed pit\u00ed grapefruitov\u00e9 \u0161\u0165\u00e1vy by se m\u011blo vyhnout. <strong>Siln\u00e9 inhibitory CYP3A4<\/strong> (klarithromycin, ritonavir, ketokonazol) v\u00fdrazn\u011b zvy\u0161uj\u00ed hladinu atorvastatinu a riziko myopatie.<\/p>\n<h2 class=\"wp-block-heading\">Vedlej\u0161\u00ed \u00fa\u010dinky<\/h2>\n<p><strong>\u010cast\u00e9 (&gt;1 %):<\/strong><\/p>\n<ul>\n<li><strong>Myalgie (bolest sval\u016f)<\/strong> \u2014 obt\u011b\u017euj\u00edc\u00ed u 5-10 % u\u017eivatel\u016f; potvrzen\u00e9 statinem asociovan\u00e9 svalov\u00e9 p\u0159\u00edznaky s vzestupem CK u 0,1-1 %. Vysok\u00e1 nocebo slo\u017eka: studie SAMSON (2020) neprok\u00e1zala rozd\u00edl mezi statinem a placebem v dvojit\u011b zaslepen\u00fdch n-of-1 k\u0159\u00ed\u017eov\u00fdch studi\u00edch u mnoha \u201cstatin-intolerantn\u00edch\u201d pacient\u016f.<\/li>\n<li><strong>M\u00edrn\u00e9 zv\u00fd\u0161en\u00ed transamin\u00e1z<\/strong> \u2014 u 3 % doch\u00e1z\u00ed k vzestupu ALT pod 3\u00d7 ULN; obvykle p\u0159echodn\u00fd a nevy\u017eaduje zm\u011bnu d\u00e1vkov\u00e1n\u00ed.<\/li>\n<li><strong>Nov\u011b vznikl\u00fd diabetes<\/strong> \u2014 absolutn\u00ed nadbytek ~0,2 na 100 pacient-rok\u016f, v\u011bt\u0161inou u prediabetick\u00fdch pacient\u016f. Kardiovaskul\u00e1rn\u00ed benefit v\u00fdrazn\u011b p\u0159evy\u0161uje riziko diabetu.<\/li>\n<li><strong>Bolest hlavy, dyspepsie, nevolnost<\/strong><\/li>\n<li><strong>Erektiln\u00ed dysfunkce<\/strong> (neobvykl\u00e9; mechanismus nejasn\u00fd)<\/li>\n<li><strong>Poruchy sp\u00e1nku, kognitivn\u00ed mlha<\/strong> (hl\u00e1\u0161eny, ale nekonzistentn\u00ed v RCT)<\/li>\n<\/ul>\n<p><strong>Nep\u0159\u00edli\u0161 \u010dast\u00e9, ale klinicky v\u00fdznamn\u00e9:<\/strong><\/p>\n<ul>\n<li><strong>Rabdomyol\u00fdza<\/strong> (10\u00d7 ULN.<\/li>\n<li><strong>Imunitn\u011b zprost\u0159edkovan\u00e1 nekrotizuj\u00edc\u00ed myopatie<\/strong> \u2014 vz\u00e1cn\u00e1 p\u0159etrv\u00e1vaj\u00edc\u00ed myopatie, kter\u00e1 pokra\u010duje po vysazen\u00ed statinu; zprost\u0159edkovan\u00e1 protil\u00e1tkami anti-HMGCR. Vy\u017eaduje imunosupresivn\u00ed l\u00e9\u010dbu.<\/li>\n<li><strong>T\u011b\u017ek\u00e1 transaminitida \/ po\u0161kozen\u00ed jater vyvolan\u00e9 l\u00e9ky<\/strong> \u2014 vz\u00e1cn\u00e9; p\u0159eru\u0161te, pokud ALT &gt;3\u00d7 ULN s p\u0159\u00edznaky nebo rostouc\u00ed trajektori\u00ed.<\/li>\n<li><strong>Perifern\u00ed neuropatie<\/strong> (vz\u00e1cn\u00e9)<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Kontraindikace<\/h2>\n<ul>\n<li><strong>T\u011bhotenstv\u00ed a kojen\u00ed<\/strong> \u2014 statiny jsou kontraindikov\u00e1ny; cholesterol je nezbytn\u00fd pro neurov\u00fdvoj plodu.<\/li>\n<li><strong>Aktivn\u00ed jatern\u00ed onemocn\u011bn\u00ed<\/strong> nebo nevysv\u011btliteln\u00fd p\u0159etrv\u00e1vaj\u00edc\u00ed ALT &gt;3\u00d7 ULN.<\/li>\n<li><strong>P\u0159edchoz\u00ed rabdomyol\u00fdza nebo t\u011b\u017ek\u00e1 intolerance na statiny<\/strong> potvrzeno v dvojit\u011b zaslepen\u00e9m re-expozici.<\/li>\n<li><strong>Sou\u010dasn\u00e9 u\u017e\u00edv\u00e1n\u00ed siln\u00fdch inhibitor\u016f CYP3A4<\/strong> (pro atorvastatin): klarithromycin, itrakonazol, ritonavir \u2014 vysa\u010fte statin nebo p\u0159ejd\u011bte na rosuvastatin\/pravastatin.<\/li>\n<li>P\u0159ecitliv\u011blost na statin.<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Interakce s l\u00e9\u010divy<\/h2>\n<ul>\n<li><strong>Siln\u00e9 inhibitory CYP3A4 \u2014 KRITICK\u00c9.<\/strong> Klarithromycin, erytromycin, itrakonazol, ketokonazol, ritonavir, kobicistat, cyklosporin \u2014 zvy\u0161uj\u00ed hladinu atorvastatinu 2-10kr\u00e1t. Vysa\u010fte statin b\u011bhem kr\u00e1tk\u00fdch antibiotick\u00fdch k\u00far; u dlouhodob\u00e9 terapie s inhibitorem CYP3A4 p\u0159ejd\u011bte na rosuvastatin nebo pravastatin.<\/li>\n<li><strong>Grapefruitov\u00e1 \u0161\u0165\u00e1va<\/strong> \u2014 vyvarujte se pravideln\u00e9 denn\u00ed konzumace s atorvastatinem (interakce 2-3kr\u00e1t).<\/li>\n<li><strong>Fibr\u00e1ty (gemfibrozil, fenofibr\u00e1t)<\/strong> \u2014 zv\u00fd\u0161en\u00e9 riziko myopatie. Gemfibrozil je nejhor\u0161\u00ed; fenofibr\u00e1t je preferovan\u00fd fibr\u00e1t pro kombinaci. Kombinace vyhra\u010fte pro specializovanou l\u00e9\u010dbu dyslipid\u00e9mie.<\/li>\n<li><strong>Vysok\u00e9 d\u00e1vky niacinu<\/strong> \u2014 zv\u00fd\u0161en\u00e9 riziko myopatie. N\u00edzk\u00e9 d\u00e1vky niacinu (1-2 g) jsou obvykle tolerov\u00e1ny.<\/li>\n<li><strong>Warfarin<\/strong> \u2014 m\u00edrn\u00e9 zv\u00fd\u0161en\u00ed INR po zah\u00e1jen\u00ed statinu; zkontrolujte INR po 1 t\u00fddnu. Nen\u00ed kontraindikac\u00ed.<\/li>\n<li><strong>Digoxin<\/strong> \u2014 m\u00edrn\u00e9 zv\u00fd\u0161en\u00ed hladiny digoxinu s atorvastatinem (P-glykoprotein); obvykle nen\u00ed klinicky v\u00fdznamn\u00e9.<\/li>\n<li><strong>Alkohol<\/strong> \u2014 vysok\u00e1 konzumace zvy\u0161uje riziko po\u0161kozen\u00ed jater. St\u0159\u00eddm\u00e1 konzumace je p\u0159ijateln\u00e1.<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Skladov\u00e1n\u00ed<\/h2>\n<p>Store Atorvatin below 25&deg;C in the original blister pack. Keep out of reach of children.<\/p>\n<h2 id=\"faqs\">\u010casto kladen\u00e9 dotazy<\/h2>\n<h3 class=\"wp-block-heading\">Do I have to take Atorvatin at night?<\/h3>\n<p>Ne \u2014 atorvastatin m\u00e1 polo\u010das rozpadu 20\u201330 hodin, co\u017e je dostate\u010dn\u011b dlouh\u00e9 na to, aby pokryl p\u0159ibli\u017en\u011b 24hodinov\u00fd cyklus no\u010dn\u00ed synt\u00e9zy cholesterolu bez ohledu na \u010das pod\u00e1n\u00ed. Rann\u00ed u\u017e\u00edv\u00e1n\u00ed spolu s dal\u0161\u00edmi l\u00e9ky je v po\u0159\u00e1dku. Pravidlo \u201cu\u017e\u00edvejte statiny ve\u010der\u201d poch\u00e1z\u00ed od statin\u016f s kr\u00e1tk\u00fdm polo\u010dasem rozpadu (simvastatin, lovastatin).<\/p>\n<h3 class=\"wp-block-heading\">What if I get muscle aches on Atorvatin?<\/h3>\n<p>B\u011b\u017en\u00e9 a jen z\u0159\u00eddka nebezpe\u010dn\u00e9. Zkontrolujte hladinu kreatinkin\u00e1zy (CK). Pokud je CK norm\u00e1ln\u00ed, bolesti obvykle nesouvisej\u00ed se statiny \u2014 studie SAMSON (2020) uk\u00e1zala, \u017ee v\u011bt\u0161ina pacient\u016f s \u201cnesn\u00e1\u0161enlivost\u00ed statin\u016f\u201d m\u011bla stejn\u00e9 bolesti i p\u0159i u\u017e\u00edv\u00e1n\u00ed placeba v dvojit\u011b zaslepen\u00e9m k\u0159\u00ed\u017eov\u00e9m testu. Mo\u017enosti: pokra\u010dovat ve statinu s dopln\u011bn\u00edm vitaminu D (p\u0159i nedostatku), vyzkou\u0161et koenzym Q10 (slab\u00e9 d\u016fkazy, ale n\u00edzk\u00e9 riziko), p\u0159ej\u00edt na jin\u00fd statin (rosuvastatin m\u00e1 v n\u011bkter\u00fdch studi\u00edch ni\u017e\u0161\u00ed v\u00fdskyt svalov\u00fdch p\u0159\u00edznak\u016f ne\u017e simvastatin a atorvastatin), sn\u00ed\u017eit d\u00e1vku nebo p\u0159ej\u00edt na obdenn\u00ed u\u017e\u00edv\u00e1n\u00ed. P\u0159eru\u0161te l\u00e9\u010dbu pouze, pokud je CK &gt;10\u00d7 horn\u00ed hranice norm\u00e1lu, p\u0159\u00edznaky jsou vysiluj\u00edc\u00ed nebo je p\u0159\u00edtomna objektivn\u00ed svalov\u00e1 slabost.<\/p>\n<h3 class=\"wp-block-heading\">Will Atorvatin give me diabetes?<\/h3>\n<p>Statiny zp\u016fsobuj\u00ed m\u00edrn\u011b vy\u0161\u0161\u00ed v\u00fdskyt nov\u011b diagnostikovan\u00e9 cukrovky \u2014 p\u0159ibli\u017en\u011b 1 p\u0159\u00edpad nav\u00edc na 1 000 lid\u00ed ro\u010dn\u011b, zejm\u00e9na u t\u011bch s ji\u017e vysok\u00fdm rizikem cukrovky (nadv\u00e1ha, prediabetes, rodinn\u00e1 anamn\u00e9za). Stejn\u00e1 l\u00e9\u010dba v\u0161ak v t\u011bchto populac\u00edch zabr\u00e1n\u00ed p\u0159ibli\u017en\u011b 5\u201310 kardiovaskul\u00e1rn\u00edm p\u0159\u00edhod\u00e1m na 1 000 lid\u00ed ro\u010dn\u011b \u2014 \u010dist\u00fd p\u0159\u00ednos je tedy v\u00fdrazn\u011b pozitivn\u00ed. Nep\u0159est\u00e1vejte u\u017e\u00edvat statin pouze kv\u016fli riziku cukrovky.<\/p>\n<h3 class=\"wp-block-heading\">Can I take Atorvatin with grapefruit juice?<\/h3>\n<p>Ob\u010dasn\u00e9 mal\u00e9 mno\u017estv\u00ed grapefruitov\u00e9ho d\u017eusu (jedna sklenice) je obvykle v po\u0159\u00e1dku. Denn\u00ed konzumace v\u00fdrazn\u011b zvy\u0161uje hladinu atorvastatinu (2\u20133\u00d7 kv\u016fli inhibici st\u0159evn\u00edho CYP3A4) a zvy\u0161uje riziko myopatie. Pokud grapefruitov\u00fd d\u017eus pijete pravideln\u011b, p\u0159ejd\u011bte na rosuvastatin nebo pravastatin, kter\u00e9 s grapefruitem t\u00e9m\u011b\u0159 neinteraguj\u00ed.<\/p>\n<h3 class=\"wp-block-heading\">How long will I need to take Atorvatin?<\/h3>\n<p>V naprost\u00e9 v\u011bt\u0161in\u011b p\u0159\u00edpad\u016f neomezen\u011b dlouho. P\u0159eru\u0161en\u00ed u\u017e\u00edv\u00e1n\u00ed statinu vede k n\u00e1vratu LDL-C b\u011bhem t\u00fddn\u016f a ztr\u00e1t\u011b kardiovaskul\u00e1rn\u00ed ochrany b\u011bhem m\u011bs\u00edc\u016f. Statiny jsou celo\u017eivotn\u00ed preventivn\u00ed l\u00e9\u010dbou aterosklerotick\u00e9ho onemocn\u011bn\u00ed, nikoli kr\u00e1tkodobou k\u00farou.<\/p>\n<h3 class=\"wp-block-heading\">Can I take Atorvatin in pregnancy?<\/h3>\n<p>Ne \u2014 statiny jsou kontraindikov\u00e1ny v t\u011bhotenstv\u00ed a b\u011bhem kojen\u00ed. Cholesterol je nezbytn\u00fd pro neurov\u00fdvoj plodu; statiny prostupuj\u00ed placentou. P\u0159eru\u0161te u\u017e\u00edv\u00e1n\u00ed statinu p\u0159ed pl\u00e1novan\u00fdm t\u011bhotenstv\u00edm; pokud je t\u011bhotenstv\u00ed nepl\u00e1novan\u00e9, okam\u017eit\u011b p\u0159esta\u0148te a proberte rizika s odborn\u00edkem. Pacienti s famili\u00e1rn\u00ed hypercholesterol\u00e9mi\u00ed mohou obvykle bezpe\u010dn\u011b odlo\u017eit l\u00e9\u010dbu statiny b\u011bhem t\u011bhotenstv\u00ed a kojen\u00ed.<\/p>\n<h3 class=\"wp-block-heading\">Where can I buy Atorvatin online?<\/h3>\n<p>You can buy Atorvatin (atorvastatin 5 mg, 30-180 tablets) from MedsBase with discreet packaging and worldwide shipping.<\/p>\n<h2 class=\"wp-block-heading\">Souvisej\u00edc\u00ed kardiologick\u00e1 a hypertenzn\u00ed l\u00e9\u010diva<\/h2>\n<ul>\n<li><a href=\"https:\/\/medsbase.com\/cs\/aldactone\/\">Aldactone \u2014 Spironolakton (neselektivn\u00ed MR antagonista)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/amlode\/\">Amlode \u2014 Amlodipin (CCB)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/lanoxin\/\">Lanoxin \u2014 Digoxin 0,25 mg (kardioaktivn\u00ed glykosid)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/lotensyl\/\">Lotensyl \u2014 Cilnidipin 10\/20 mg (L+N typov\u00fd blok\u00e1tor kalciov\u00fdch kan\u00e1l\u016f)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/tenoric\/\">Tenoric \u2014 kombinace atenololu a chlortalidonu<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/zivast-am\/\">Zivast AM \u2014 kombinace atorvastatinu a amlodipinu<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/high-blood-pressure-medication\/\"><strong>Prohl\u00e9dnout v\u0161echny l\u00e9ky na vysok\u00fd krevn\u00ed tlak<\/strong><\/a><\/li>\n<\/ul>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:16px 20px;margin:24px 0;border-radius:4px;\"><strong>\u2695 L\u00e9ka\u0159sk\u00e9 upozorn\u011bn\u00ed.<\/strong> Tato str\u00e1nka slou\u017e\u00ed pouze pro informa\u010dn\u00ed \u00fa\u010dely a nenahrazuje l\u00e9ka\u0159skou p\u00e9\u010di kvalifikovan\u00e9ho zdravotnick\u00e9ho pracovn\u00edka. Hypertenze, srde\u010dn\u00ed selh\u00e1n\u00ed a arytmie vy\u017eaduj\u00ed diagn\u00f3zu, monitorov\u00e1n\u00ed a individu\u00e1ln\u00ed d\u00e1vkov\u00e1n\u00ed l\u00e9ka\u0159em \u2014 v\u017edy u\u017e\u00edvejte betablok\u00e1tory pod l\u00e9ka\u0159sk\u00fdm dohledem.<\/div>\n<h3 class=\"wp-block-heading\">Pro\u010d objedn\u00e1vat z MedsBase<\/h3>\n<p>Atorvatin is supplied through a WHO-GMP certified manufacturer with full COA documentation. We ship worldwide in plain, discreet packaging, and every order is covered by our <a href=\"\/cs\/medsbase-re-shipment-assurance-policy\/\">Z\u00e1rukou op\u011btovn\u00e9ho odesl\u00e1n\u00ed<\/a>. V\u00e1\u0161 popis transakce p\u0159i platb\u011b kartou zobrazuje regulovan\u00e9ho zpracovatele plateb (regulovan\u00e9ho zpracovatele plateb kartou), nikdy \u201cMedsBase\u201d nebo n\u00e1zev l\u00e9ku.<\/p>\n<p><!-- medsbase-related-alts-v1 --><\/p>\n<h3 class=\"wp-block-heading\">Souvisej\u00edc\u00ed alternativy<\/h3>\n<p>Dal\u0161\u00ed produkty v <strong>Chronick\u00e1 onemocn\u011bn\u00ed<\/strong> kter\u00e9 z\u00e1kazn\u00edci tak\u00e9 prohl\u00ed\u017eej\u00ed:<\/p>\n<ul>\n<li><a href=\"https:\/\/medsbase.com\/cs\/glycomet-sr\/\">Glycomet SR<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/tegrital\/\">Tegrital 100 mg \u017ev\u00fdkac\u00ed (karbamazepin) \u2014 trigemin\u00e1ln\u00ed neuralgie a z\u00e1chvaty<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/ramisave\/\">Ramisave<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/diamox\/\">Diamox<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/laregab-at\/\">Laregab AT (Gabapentin 300 mg + Amitriptylin 10 mg) \u2014 Refraktern\u00ed nervov\u00e1 bolest<\/a><\/li>\n<\/ul>","protected":false},"excerpt":{"rendered":"<p>Atorvatin is atorvastatin 5 mg tablets \u2014 useful sub-therapeutic starting dose for patients requiring gentle titration (frail elderly, CYP3A4 interaction-prone, history of myalgia on higher statin doses). Standard atorvastatin monotherapy starts at 10-20 mg; 5 mg is a stepping-stone for tolerability-limited initiation. LDL reduction roughly 30-35% vs placebo at 5 mg. Full indication profile of atorvastatin \u2014 CV primary and secondary prevention.<\/p>","protected":false},"featured_media":61589,"comment_status":"closed","ping_status":"open","template":"","meta":[],"product_brand":[],"product_cat":[3141,3223,3260,3356,3953],"product_tag":[3435,5065],"class_list":{"0":"post-61588","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-category-overview","7":"product_cat-chronic-conditions","8":"product_cat-heart-blood-pressure","9":"product_cat-high-blood-pressure-medication","10":"product_cat-high-cholesterol-treatments","11":"product_tag-atorvastatin","12":"product_tag-atorvatin","14":"first","15":"instock","16":"shipping-taxable","17":"purchasable","18":"product-type-variable","19":"has-default-attributes"},"acf":[],"_links":{"self":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product\/61588","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/comments?post=61588"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/media\/61589"}],"wp:attachment":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/media?parent=61588"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product_brand?post=61588"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product_cat?post=61588"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product_tag?post=61588"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}