{"id":61596,"date":"2024-03-03T06:01:14","date_gmt":"2024-03-03T06:01:14","guid":{"rendered":"https:\/\/medsname.com\/bicalumutide\/"},"modified":"2026-04-30T10:23:34","modified_gmt":"2026-04-30T10:23:34","slug":"bicalumutide","status":"publish","type":"product","link":"https:\/\/medsbase.com\/cs\/product\/bicalumutide\/","title":{"rendered":"Bicalumutide"},"content":{"rendered":"<p><!-- medsbase-tldr-answer --><\/p>\n<div style=\"background:#fff8e1;border-left:4px solid #f5a623;padding:18px 22px;margin:0 0 24px 0;border-radius:4px;\">\n<h3 class=\"wp-block-heading\" style=\"margin:0 0 8px 0;font-size:16px;font-weight:700;\">\u26a1 Rychl\u00e1 odpov\u011b\u010f \u2014 Co je Bicalumutid?<\/h3>\n<p style=\"margin:0;\"><strong>Bicalumutide<\/strong> je peror\u00e1ln\u00ed tableta od spole\u010dnosti Cipla obsahuj\u00edc\u00ed <strong>bikalutamid 50 mg<\/strong> \u2014 nesteroidn\u00ed <strong>antagonista androgenn\u00edho receptoru (antiandrogen)<\/strong> pou\u017e\u00edv\u00e1 se k <strong>pokro\u010dil\u00fd nebo metastatick\u00fd karcinom prostaty<\/strong>. Standardn\u00ed role: v kombinaci s <strong>agonistou LHRH<\/strong> (goserelin, leuprorelin) pro kombinovanou androgenn\u00ed blok\u00e1du (CAB). Standardn\u00ed d\u00e1vkov\u00e1n\u00ed: <strong>50 mg jednou denn\u011b (s LHRH agonistou) nebo 150 mg jednou denn\u011b (monoterapie)<\/strong>. Hlavn\u00ed vedlej\u0161\u00ed \u00fa\u010dinky: gynekomastie a citlivost prs\u016f (b\u011b\u017en\u00e9), n\u00e1valy horka, hepatotoxicita (povinn\u00e9 sledov\u00e1n\u00ed jatern\u00edch test\u016f), sn\u00ed\u017een\u00e9 libido, vz\u00e1cn\u011b interstici\u00e1ln\u00ed pneumonitida. <strong>Povinn\u00e9: vstupn\u00ed + m\u011bs\u00ed\u010dn\u00ed jatern\u00ed testy po prvn\u00ed 4 m\u011bs\u00edce, pot\u00e9 periodicky.<\/strong><\/p>\n<\/div>\n<div class=\"medsbase-trust-strip\" style=\"background:#f4f8fb;border:1px solid #d8e3eb;padding:12px 16px;margin:16px 0;border-radius:4px;font-size:14px;\">\n<strong>Co z\u00edsk\u00e1te s MedsBase:<\/strong> V\u00fdrobce certifikovan\u00fd WHO-GMP \u00b7 Diskr\u00e9tn\u00ed balen\u00ed \u00b7 Celosv\u011btov\u00e1 doprava \u00b7 V\u00edce ne\u017e 1 400 ov\u011b\u0159en\u00fdch <a href=\"https:\/\/medsbase.com\/cs\/reviews\/\">recenz\u00ed z\u00e1kazn\u00edk\u016f<\/a>\n<\/div>\n<p class=\"medsbase-reship-line\" style=\"font-size:14px;color:#444;margin:8px 0 18px;\">\ud83d\udce6 Ka\u017ed\u00e1 objedn\u00e1vka je pokryta na\u0161\u00ed <a href=\"https:\/\/medsbase.com\/cs\/medsbase-re-shipment-assurance-policy\/\"><strong>Z\u00e1rukou op\u011btovn\u00e9ho odesl\u00e1n\u00ed<\/strong><\/a> \u2014 pokud va\u0161e z\u00e1silka nedoraz\u00ed do 20 pracovn\u00edch dn\u016f, p\u0159epos\u00edl\u00e1me ji.<\/p>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:14px 18px;margin:0 0 24px 0;border-radius:4px;font-size:14px;\"><strong>\u26a0 Vy\u017eaduje se odborn\u00fd dohled.<\/strong> L\u00e9ky na rakovinu mus\u00ed b\u00fdt p\u0159edeps\u00e1ny o\u0161et\u0159uj\u00edc\u00edm onkologem s potvrzenou diagn\u00f3zou, vstupn\u00edm stagingem a definovan\u00fdm l\u00e9\u010debn\u00fdm pl\u00e1nem. Nikdy neza\u010d\u00ednejte, nep\u0159eru\u0161ujte, nem\u011b\u0148te d\u00e1vkov\u00e1n\u00ed ani neu\u017e\u00edvejte l\u00e9ky na rakovinu mimo onkologick\u00fd l\u00e9\u010debn\u00fd pl\u00e1n. V\u011bt\u0161ina l\u00e9k\u016f na rakovinu vy\u017eaduje pravideln\u00e9 monitorov\u00e1n\u00ed krevn\u00edch test\u016f (krevn\u00ed obraz, jatern\u00ed testy, funkce ledvin), je absolutn\u011b kontraindikov\u00e1na v t\u011bhotenstv\u00ed a m\u00e1 v\u00fdznamn\u00e9 l\u00e9kov\u00e9 interakce.<\/div>\n<h2 class=\"wp-block-heading\">Co je Bicalumutid?<\/h2>\n<p>Bicalumutid je or\u00e1ln\u00ed tableta od spole\u010dnosti Cipla obsahuj\u00edc\u00ed <strong>bikalutamid 50 mg<\/strong>. Bikalutamid je nesteroidn\u00ed antiandrogen, kter\u00fd kompetitivn\u011b blokuje androgenn\u00ed receptor v bu\u0148k\u00e1ch rakoviny prostaty, \u010d\u00edm\u017e inhibuje proliferativn\u00ed \u00fa\u010dinek testosteronu a dihydrotestosteronu (DHT). Pou\u017e\u00edv\u00e1 se p\u0159i <strong>pokro\u010dil\u00fd nebo metastatick\u00fd karcinom prostaty<\/strong>, t\u00e9m\u011b\u0159 v\u017edy v kombinaci s agonistou LHRH (goserelin, leuprorelin, triptorelin) pro <strong>kombinovanou androgenn\u00ed blok\u00e1du (CAB)<\/strong>.<\/p>\n<h2 class=\"wp-block-heading\">Jak Bicalumutid funguje?<\/h2>\n<p>R\u016fst rakoviny prostaty je poh\u00e1n\u011bn signalizac\u00ed androgenn\u00edho receptoru. Standardn\u00ed terapie deprivace androgen\u016f (ADT) potla\u010duje produkci androgen\u016f ve vaje\u010dn\u00edc\u00edch pomoc\u00ed LHRH agonist\u016f. Nicm\u00e9n\u011b nadledviny st\u00e1le produkuj\u00ed p\u0159ibli\u017en\u011b 10 % celkov\u00fdch androgen\u016f v t\u011ble a tento zbytkov\u00fd sign\u00e1l sta\u010d\u00ed k podpo\u0159e progrese onemocn\u011bn\u00ed u mnoha pacient\u016f. Bicalumutid blokuje samotn\u00fd androgenn\u00ed receptor, tak\u017ee zbytkov\u00e9 nadledvinov\u00e9 androgeny nemohou signalizovat \u2014 co\u017e vytv\u00e1\u0159\u00ed \u00fapln\u011bj\u0161\u00ed blok\u00e1du androgen\u016f.<\/p>\n<ul>\n<li><strong>Kompetitivn\u00ed antagonista androgenn\u00edho receptoru<\/strong> \u2014 v\u00e1\u017ee se na AR a br\u00e1n\u00ed testosteronu \/ DHT v jeho aktivaci.<\/li>\n<li><strong>Dlouh\u00fd polo\u010das (~6 dn\u00ed)<\/strong> \u2014 jednou denn\u011b or\u00e1ln\u00ed d\u00e1vkov\u00e1n\u00ed.<\/li>\n<li><strong>Pou\u017e\u00edv\u00e1 se k prevenci \u201cn\u00e1dorov\u00e9ho vzplanut\u00ed\u201d<\/strong> p\u0159i zah\u00e1jen\u00ed terapie agonistou LHRH \u2013 po\u010d\u00e1te\u010dn\u00ed vzestup testosteronu indukovan\u00fd LHRH m\u016f\u017ee do\u010dasn\u011b zhor\u0161it onemocn\u011bn\u00ed, a p\u0159edl\u00e9\u010dba antiandrogenem tomu zabr\u00e1n\u00ed.<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Pou\u017eit\u00ed a indikace<\/h2>\n<ul>\n<li><strong>Kombinovan\u00e1 blok\u00e1da androgen\u016f (CAB)<\/strong> u pokro\u010dil\u00e9 nebo metastatick\u00e9 rakoviny prostaty (s agonistou LHRH)<\/li>\n<li><strong>Prevence n\u00e1dorov\u00e9ho vzplanut\u00ed<\/strong> p\u0159i zah\u00e1jen\u00ed terapie agonistou LHRH (2\u20134 t\u00fddny p\u0159ed l\u00e9\u010dbou)<\/li>\n<li><strong>Monoterapie 150 mg\/den<\/strong> u lok\u00e1ln\u011b pokro\u010dil\u00e9ho nemetastazuj\u00edc\u00edho karcinomu prostaty (alternativa k agonist\u016fm LHRH pro pacienty up\u0159ednost\u0148uj\u00edc\u00ed zachov\u00e1n\u00ed sexu\u00e1ln\u00ed funkce)<\/li>\n<li><strong>Po biochemick\u00e9 recidiv\u011b<\/strong> jako sou\u010d\u00e1st p\u0159eru\u0161ovan\u00fdch nebo kontinu\u00e1ln\u00edch re\u017eim\u016f deprivace androgen\u016f<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">D\u00e1vkov\u00e1n\u00ed Bicalumutidu a zp\u016fsob u\u017e\u00edv\u00e1n\u00ed<\/h2>\n<p>Standardn\u00ed d\u00e1vka: <strong>50 mg jednou denn\u011b (s LHRH agonistou) nebo 150 mg jednou denn\u011b (monoterapie)<\/strong>.<\/p>\n<ol>\n<li><strong>Jednou denn\u011b ve stejnou dobu ka\u017ed\u00fd den.<\/strong> S j\u00eddlem nebo bez j\u00eddla.<\/li>\n<li><strong>Polykejte cel\u00e9 s vodou.<\/strong><\/li>\n<li><strong>Povinn\u00e9 monitorov\u00e1n\u00ed:<\/strong> vstupn\u00ed jatern\u00ed testy (AST, ALT) a PSA. Opakujte jatern\u00ed testy <strong>m\u011bs\u00ed\u010dn\u011b po prvn\u00ed 4 m\u011bs\u00edce<\/strong>, pot\u00e9 ka\u017ed\u00e9 3\u20136 m\u011bs\u00edc\u016f. PSA ka\u017ed\u00e9 3 m\u011bs\u00edce. P\u0159eru\u0161te l\u00e9\u010dbu a vy\u0161et\u0159ete, pokud AST\/ALT &gt; 3\u00d7 horn\u00ed hranice normy.<\/li>\n<li><strong>Prevence n\u00e1dorov\u00e9ho vzplanut\u00ed p\u0159ed LHRH agonistou:<\/strong> za\u010dn\u011bte s Bicalumutidem 2\u20134 t\u00fddny p\u0159ed zah\u00e1jen\u00edm pod\u00e1v\u00e1n\u00ed agonist\u016f LHRH, pokra\u010dujte alespo\u0148 1 m\u011bs\u00edc po.<\/li>\n<li><strong>Nep\u0159eru\u0161ujte l\u00e9\u010dbu bez pokyn\u016f onkologa.<\/strong><\/li>\n<\/ol>\n<h2 class=\"wp-block-heading\">Vedlej\u0161\u00ed \u00fa\u010dinky Bicalumutidu<\/h2>\n<p><strong>\u010cast\u00e9:<\/strong><\/p>\n<ul>\n<li>Gynekomastie a citlivost prs\u016f (40\u201370% u monoterapie; m\u00e9n\u011b u CAB)<\/li>\n<li>N\u00e1valy horka<\/li>\n<li>Sn\u00ed\u017een\u00e9 libido a erektiln\u00ed dysfunkce<\/li>\n<li>\u00danava, astenie<\/li>\n<li>Pr\u016fjem (zejm\u00e9na u flutamidu)<\/li>\n<li>M\u00edrn\u00e9 za\u017e\u00edvac\u00ed pot\u00ed\u017ee<\/li>\n<\/ul>\n<p><strong>D\u016fle\u017eit\u00e9 \u2013 povinn\u00e9 monitorov\u00e1n\u00ed:<\/strong><\/p>\n<ul>\n<li><strong>Hepatotoxicita<\/strong> \u2014 m\u016f\u017ee b\u00fdt z\u00e1va\u017en\u00e1 a nep\u0159edv\u00eddateln\u00e1. Okam\u017eit\u011b p\u0159eru\u0161te l\u00e9\u010dbu p\u0159i \u017eloutence, tmav\u00e9 mo\u010di, siln\u00e9 \u00fanav\u011b nebo hodnot\u00e1ch AST\/ALT &gt; 3\u00d7 ULN. V\u011bt\u0161ina p\u0159\u00edpad\u016f se objev\u00ed b\u011bhem prvn\u00edch 4 m\u011bs\u00edc\u016f.<\/li>\n<li>Vz\u00e1cn\u011b interstici\u00e1ln\u00ed pneumonitida \u2014 nov\u011b vznikl\u00fd ka\u0161el, du\u0161nost<\/li>\n<\/ul>\n<p><strong>Vz\u00e1cn\u00e9:<\/strong> hemolytick\u00e1 an\u00e9mie, fotosenzitivita, z\u00e1va\u017en\u00e9 ko\u017en\u00ed reakce.<\/p>\n<h2 class=\"wp-block-heading\">Varov\u00e1n\u00ed a opat\u0159en\u00ed<\/h2>\n<ul>\n<li><strong>T\u011bhotenstv\u00ed a kojen\u00ed:<\/strong> nepou\u017eiteln\u00e9 (indikace pouze pro mu\u017ee), ale antiandrogeny jsou fetotoxick\u00e9, pokud jsou omylem u\u017e\u00edv\u00e1ny b\u011bhem t\u011bhotenstv\u00ed.<\/li>\n<li><strong>Funkce jater:<\/strong> povinn\u00e9 m\u011bs\u00ed\u010dn\u00ed testy jatern\u00edch funkc\u00ed po prvn\u00ed 4 m\u011bs\u00edce. P\u0159eru\u0161te p\u0159i hodnot\u00e1ch AST\/ALT &gt; 3\u00d7 ULN.<\/li>\n<li><strong>Diabetes:<\/strong> m\u016f\u017ee zhor\u0161it glykemickou kontrolu.<\/li>\n<li><strong>Kardiovaskul\u00e1rn\u00ed:<\/strong> ADT obecn\u011b je spojeno se zv\u00fd\u0161en\u00fdm v\u00fdskytem kardiovaskul\u00e1rn\u00edch p\u0159\u00edhod. Optimalizujte modifikovateln\u00e9 rizikov\u00e9 faktory.<\/li>\n<li><strong>Profylaxe gynekomastie:<\/strong> n\u00edzkod\u00e1vkovan\u00fd tamoxifen 10\u201320 mg\/den nebo profylaktick\u00e1 radioterapie prsu sni\u017euje incidenci (specialista).<\/li>\n<li><strong>\u0158\u00edzen\u00ed vozidla:<\/strong> opatrnost \u2014 \u00fanava a z\u00e1vrat\u011b mohou ovlivnit schopnost \u0159\u00eddit.<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Interakce s l\u00e9\u010divy<\/h2>\n<table style=\"border-collapse:collapse;width:100%;margin:12px 0;\">\n<thead>\n<tr style=\"background:#2c7cb0;color:#fff;\">\n<th style=\"padding:10px;border:1px solid #ddd;\">Kombinujte s<\/th>\n<th style=\"padding:10px;border:1px solid #ddd;\">\u00da\u010dinek<\/th>\n<th style=\"padding:10px;border:1px solid #ddd;\">Co d\u011blat<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td style=\"padding:10px;border:1px solid #ddd;\">Warfarin a dal\u0161\u00ed kumarinov\u00e9 antikoagulancia<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">V\u00fdznamn\u00e9 zv\u00fd\u0161en\u00ed INR \u2014 riziko krv\u00e1cen\u00ed<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Kontrolujte INR t\u00fddn\u011b zpo\u010d\u00e1tku. Sni\u017ete d\u00e1vku warfarinu o 30\u201350 %.<\/td>\n<\/tr>\n<tr>\n<td style=\"padding:10px;border:1px solid #ddd;\">Inhibitory CYP3A4 (men\u0161\u00ed \u00fa\u010dinek)<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Zvy\u0161uj\u00ed hladinu bikalutamidu<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Monitorujte hepatotoxicitu.<\/td>\n<\/tr>\n<tr>\n<td style=\"padding:10px;border:1px solid #ddd;\">Analoga LHRH (goserelin, leuprorelin)<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Standardn\u00ed kombinace \u2014 kombinovan\u00e1 androgenn\u00ed blok\u00e1da<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Standardn\u00ed re\u017eim CAB.<\/td>\n<\/tr>\n<tr>\n<td style=\"padding:10px;border:1px solid #ddd;\">Alkohol<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Aditivn\u00ed hepatotoxicita<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Omezte p\u0159\u00edjem alkoholu b\u011bhem l\u00e9\u010dby.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2 class=\"wp-block-heading\">Skladov\u00e1n\u00ed<\/h2>\n<ul>\n<li>Skladujte p\u0159i pokojov\u00e9 teplot\u011b, 15\u201325 \u00b0C, v p\u016fvodn\u00edm blistru.<\/li>\n<li>Uchov\u00e1vejte mimo dosah d\u011bt\u00ed, \u017een a dom\u00e1c\u00edch zv\u00ed\u0159at \u2014 antiandrogeny jsou fetotoxick\u00e9.<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Souvisej\u00edc\u00ed alternativy na MedsBase<\/h2>\n<p>Dal\u0161\u00ed onkologick\u00e9 l\u00e9ky skladem vedle tohoto produktu:<\/p>\n<ul>\n<li><a href=\"https:\/\/medsbase.com\/cs\/bdenza\/\"><strong>Bdenza (enzalutamid 40 mg)<\/strong><\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/cytomid\/\"><strong>Cytomid (flutamid 250 mg)<\/strong><\/a><\/li>\n<\/ul>\n<p><a href=\"https:\/\/medsbase.com\/cs\/anti-cancer-medication\/\">Prohl\u00e9dn\u011bte v\u0161echny protin\u00e1dorov\u00e9 l\u00e9ky \u2192<\/a><\/p>\n<h2 id=\"faqs\">\u010casto kladen\u00e9 dotazy<\/h2>\n<h3 class=\"wp-block-heading\">Pro\u010d se Bicalumutid obvykle kombinuje s agonistou LHRH?<\/h3>\n<p>Agonist\u00e9 LHRH (goserelin, leuprorelin) potla\u010duj\u00ed testikul\u00e1rn\u00ed produkci androgen\u016f, ale nadledviny nad\u00e1le produkuj\u00ed ~10 % t\u011blesn\u00fdch androgen\u016f, kter\u00e9 mohou podporovat r\u016fst karcinomu prostaty. Bicalumutid blokuje samotn\u00fd androgenn\u00ed receptor, tak\u017ee adren\u00e1ln\u00ed androgeny nemohou signalizovat. Tato kombinace se naz\u00fdv\u00e1 <strong>kombinovanou androgenn\u00ed blok\u00e1du (CAB)<\/strong> a poskytuje hlub\u0161\u00ed potla\u010den\u00ed androgen\u016f ne\u017e samotn\u00fd agonista LHRH u pokro\u010dil\u00e9ho onemocn\u011bn\u00ed.<\/p>\n<h3 class=\"wp-block-heading\">Co je \u201cn\u00e1dorov\u00fd vzplanut\u00ed\u201d a pro\u010d jej Bicalumutid p\u0159edch\u00e1z\u00ed?<\/h3>\n<p>Kdy\u017e za\u010dne terapie agonistou LHRH, hypof\u00fdza je zpo\u010d\u00e1tku stimulov\u00e1na a hladina testosteronu vzroste na 1\u20132 t\u00fddny, ne\u017e dojde k downregulaci. U pacient\u016f s v\u00fdznamnou z\u00e1t\u011b\u017e\u00ed onemocn\u011bn\u00ed (kostn\u00ed metast\u00e1zy, obstrukce mo\u010dov\u00fdch cest, riziko komprese m\u00edchy) m\u016f\u017ee tento p\u0159echodn\u00fd vzestup testosteronu akutn\u011b zhor\u0161it p\u0159\u00edznaky. Zah\u00e1jen\u00ed pod\u00e1v\u00e1n\u00ed Bicalumutidu 2\u20134 t\u00fddny p\u0159ed agonistou LHRH blokuje receptor a zabra\u0148uje vzplanut\u00ed.<\/p>\n<h3 class=\"wp-block-heading\">Jak se \u0159e\u0161\u00ed gynekomastie?<\/h3>\n<p>Citlivost prsou a gynekomastie postihuje 40\u201370 % pacient\u016f na monoterapii bikalutamidem ve vy\u0161\u0161\u00edch d\u00e1vk\u00e1ch. Mo\u017enosti profylaxe: <strong>n\u00edzk\u00e1 d\u00e1vka tamoxifenu 10\u201320 mg\/den<\/strong> (nejv\u00edce d\u016fkaz\u016f) nebo <strong>profylaktick\u00e9 oza\u0159ov\u00e1n\u00ed prsou<\/strong> jako jednor\u00e1zov\u00e1 frakce 8\u201312 Gy p\u0159ed zah\u00e1jen\u00edm antiandrogenn\u00ed terapie. P\u0159ed zah\u00e1jen\u00edm l\u00e9\u010dby proberte s onkologem, pokud jsou kosmetick\u00e9 obavy v\u00fdznamn\u00e9.<\/p>\n<h3 class=\"wp-block-heading\">Jak\u00e9 krevn\u00ed testy pot\u0159ebuji?<\/h3>\n<p><strong>Povinn\u00e9:<\/strong> z\u00e1kladn\u00ed jatern\u00ed testy (AST, ALT) a PSA. Pot\u00e9 jatern\u00ed testy <strong>m\u011bs\u00ed\u010dn\u011b po prvn\u00ed 4 m\u011bs\u00edce<\/strong>, pot\u00e9 ka\u017ed\u00e9 3\u20136 m\u011bs\u00edc\u016f. PSA ka\u017ed\u00e9 3 m\u011bs\u00edce. Okam\u017eit\u011b p\u0159esta\u0148te u\u017e\u00edvat Bicalumutid a kontaktujte sv\u00e9ho onkologa, pokud AST\/ALT &gt; 3\u00d7 ULN, nebo p\u0159i jak\u00e9mkoli v\u00fdskytu \u017eloutenky, tmav\u00e9 mo\u010di nebo siln\u00e9 \u00fanavy.<\/p>\n<h3 class=\"wp-block-heading\">Mohu p\u00edt alkohol p\u0159i u\u017e\u00edv\u00e1n\u00ed Bicalumutidu?<\/h3>\n<p>Omezte alkohol \u2014 jak alkohol, tak bikalutamid jsou hepatotoxick\u00e9 a jejich kombinace zvy\u0161uje riziko z\u00e1va\u017en\u00e9ho po\u0161kozen\u00ed jater vyvolan\u00e9ho l\u00e9ky. Ob\u010dasn\u00e9 mal\u00e9 mno\u017estv\u00ed je obvykle tolerovateln\u00e9; b\u011bhem l\u00e9\u010dby by se m\u011blo vyvarovat t\u011b\u017ek\u00e9ho nebo denn\u00edho pit\u00ed.<\/p>\n<h3 class=\"wp-block-heading\">Bicalumutid vs flutamid vs enzalutamid \u2014 jak\u00fd je mezi nimi rozd\u00edl?<\/h3>\n<p>V\u0161echny t\u0159i jsou peror\u00e1ln\u00ed antiandrogeny pro l\u00e9\u010dbu rakoviny prostaty. <strong>Bikalutamid:<\/strong> jednou denn\u011b, dob\u0159e sn\u00e1\u0161en, standardn\u00ed volba prvn\u00ed generace. <strong>Flutamid:<\/strong> t\u0159ikr\u00e1t denn\u011b, vy\u0161\u0161\u00ed riziko pr\u016fjm\u016f a hepatotoxicity \u2014 v\u011bt\u0161inou nahrazen bikalutamidem. <strong>Enzalutamid:<\/strong> druh\u00e1 generace, \u00fa\u010dinn\u011bj\u0161\u00ed, pou\u017e\u00edv\u00e1 se u kastra\u010dn\u011b rezistentn\u00edho onemocn\u011bn\u00ed (po selh\u00e1n\u00ed CAB) \u2014 viz <a href=\"https:\/\/medsbase.com\/cs\/bdenza\/\">Bdenza<\/a>.<\/p>\n<h3 class=\"wp-block-heading\">Ovlivn\u00ed Bicalumutid m\u00e9 srdce?<\/h3>\n<p>Monoterapie antiandrogeny m\u00e1 minim\u00e1ln\u00ed p\u0159\u00edm\u00fd kardiovaskul\u00e1rn\u00ed \u00fa\u010dinek, ale \u0161ir\u0161\u00ed androgenn\u00ed depriva\u010dn\u00ed terapie (LHRH agonista + antiandrogen) je spojena se zv\u00fd\u0161en\u00fdm v\u00fdskytem kardiovaskul\u00e1rn\u00edch p\u0159\u00edhod v\u010detn\u011b infarktu myokardu a c\u00e9vn\u00ed mozkov\u00e9 p\u0159\u00edhody. Optimalizujte kardiovaskul\u00e1rn\u00ed rizikov\u00e9 faktory: kontrolu krevn\u00edho tlaku, u\u017e\u00edv\u00e1n\u00ed statin\u016f p\u0159i hyperlipidemii, odvyk\u00e1n\u00ed kou\u0159en\u00ed, cvi\u010den\u00ed a spr\u00e1vnou hmotnost.<\/p>\n<h3 class=\"wp-block-heading\">Mohu p\u0159estat u\u017e\u00edvat Bicalumutid, pokud z\u016fstane PSA n\u00edzk\u00e9?<\/h3>\n<p>Proberte se sv\u00fdm onkologem. U n\u011bkter\u00fdch p\u0159eru\u0161ovan\u00fdch protokol\u016f CAB se CAB p\u0159eru\u0161\u00ed, kdy\u017e je PSA potla\u010deno pod prahovou hodnotu, a obnov\u00ed se p\u0159i vzestupu PSA \u2014 to m\u016f\u017ee sn\u00ed\u017eit vedlej\u0161\u00ed \u00fa\u010dinky bez kompromitace p\u0159e\u017eit\u00ed. Nikdy nep\u0159eru\u0161ujte jednostrann\u011b \u2014 monitorov\u00e1n\u00ed PSA a na\u010dasov\u00e1n\u00ed obnoven\u00ed jsou kl\u00ed\u010dov\u00e9.<\/p>\n<div style=\"background:#f4f8fb;border:1px solid #d6e4ec;padding:12px 18px;margin:14px 0;border-radius:4px;font-size:14px;color:#3a5160;text-align:center;\">\n<strong>\ud83d\udd12 \u0160ifrovan\u00e9 platby<\/strong> \u00b7 <strong>\ud83d\udcb3 Ov\u011b\u0159en\u00fd platebn\u00ed procesor<\/strong> \u00b7 <strong>\ud83d\ude9a Doprava do cel\u00e9ho sv\u011bta<\/strong> \u00b7 <strong>\u2b50 4,9\/5 od 1 400+ z\u00e1kazn\u00edk\u016f<\/strong>\n<\/div>\n<p><!-- medsbase-why-order --><\/p>\n<h3>Pro\u010d objedn\u00e1vat z MedsBase<\/h3>\n<p>Ka\u017ed\u00e1 \u0161ar\u017ee je dod\u00e1v\u00e1na od <strong>v\u00fdrobce certifikovan\u00e9ho WHO-GMP<\/strong>. Objedn\u00e1vky jsou expedov\u00e1ny v nen\u00e1padn\u00fdch obalech bez loga od na\u0161ich partnersk\u00fdch sklad\u016f a jsou pokryty na\u0161\u00ed <a href=\"\/cs\/medsbase-re-shipment-assurance-policy\/\">Z\u00e1rukou op\u011btovn\u00e9ho odesl\u00e1n\u00ed<\/a>: pokud z\u00e1silka nedoraz\u00ed do 20 pracovn\u00edch dn\u016f, za\u0161leme zdarma n\u00e1hradn\u00ed z\u00e1silku, bez dotaz\u016f.<\/p>\n<p><!-- medsbase-related-alts-v1 --><\/p>\n<h3 class=\"wp-block-heading\">Souvisej\u00edc\u00ed alternativy<\/h3>\n<p>Dal\u0161\u00ed produkty v <strong>Chronick\u00e1 onemocn\u011bn\u00ed<\/strong> kter\u00e9 z\u00e1kazn\u00edci tak\u00e9 prohl\u00ed\u017eej\u00ed:<\/p>\n<ul>\n<li><a href=\"https:\/\/medsbase.com\/cs\/riborea\/\">Riborea<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/bacloheal\/\">Bacloheal<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/amlode\/\">Amlode<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/nicerbium\/\">Nicerbium<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/lipril-h\/\">Lipril-H<\/a><\/li>\n<\/ul>","protected":false},"excerpt":{"rendered":"<p>\u2705 L\u00e9\u010d\u00ed rakovinu prostaty<br \/>\n\u2705 Blokuje mu\u017esk\u00e9 hormony<br \/>\n\u2705 Zpomaluje r\u016fst n\u00e1doru<br \/>\n\u2705 Zlep\u0161uje m\u00edru p\u0159e\u017eit\u00ed<br \/>\n\u2705 Zm\u00edr\u0148uje p\u0159\u00edznaky rakoviny<\/p>\n<p>Bicalumutide obsahuje Bicalutamid.<\/p>","protected":false},"featured_media":61597,"comment_status":"closed","ping_status":"open","template":"","meta":[],"product_brand":[],"product_cat":[3595,3614,3141,3223,3342],"product_tag":[5066,5067],"class_list":{"0":"post-61596","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-anti-cancer-medication","7":"product_cat-bladder-prostate","8":"product_cat-category-overview","9":"product_cat-chronic-conditions","10":"product_cat-general-health","11":"product_tag-bicalumutide","12":"product_tag-bicalutamide","14":"first","15":"instock","16":"shipping-taxable","17":"purchasable","18":"product-type-variable","19":"has-default-attributes"},"acf":[],"_links":{"self":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product\/61596","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/comments?post=61596"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/media\/61597"}],"wp:attachment":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/media?parent=61596"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product_brand?post=61596"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product_cat?post=61596"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product_tag?post=61596"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}