{"id":61761,"date":"2024-03-06T09:41:53","date_gmt":"2024-03-06T09:41:53","guid":{"rendered":"https:\/\/medsname.com\/temotero\/"},"modified":"2026-04-30T10:23:32","modified_gmt":"2026-04-30T10:23:32","slug":"temotero","status":"publish","type":"product","link":"https:\/\/medsbase.com\/cs\/product\/temotero\/","title":{"rendered":"Temotero"},"content":{"rendered":"<p><!-- medsbase-tldr-answer --><\/p>\n<div style=\"background:#fff8e1;border-left:4px solid #f5a623;padding:18px 22px;margin:0 0 24px 0;border-radius:4px;\">\n<h3 class=\"wp-block-heading\" style=\"margin:0 0 8px 0;font-size:16px;font-weight:700;\">&#9889; Quick Answer &mdash; What is Temotero?<\/h3>\n<p style=\"margin:0;\"><strong>Temotero<\/strong> is an oral capsule from Glenmark containing <strong>temozolomide<\/strong> na <strong>20 mg and 100 mg<\/strong> &mdash; an oral alkylating cytotoxic agent and the standard chemotherapy for <strong>glioblastoma multiforme (GBM)<\/strong> a <strong>anaplastic astrocytoma<\/strong>. Standard regimen: <strong>concurrent<\/strong> with radiotherapy (75 mg\/m&sup2; daily for 6 weeks), then <strong>maintenance<\/strong> 150&ndash;200 mg\/m&sup2; daily for days 1&ndash;5 of each 28-day cycle for 6 cycles (Stupp protocol). <strong>U\u017e\u00edvejte nala\u010dno<\/strong> at the same time each day, with antiemetic (ondansetron) 1 hour before. Mandatory: <strong>Profylaxe PCP<\/strong> with co-trimoxazole during radiotherapy phase. FBC weekly during concurrent phase, then before each maintenance cycle.<\/p>\n<\/div>\n<div class=\"medsbase-trust-strip\" style=\"background:#f4f8fb;border:1px solid #d8e3eb;padding:12px 16px;margin:16px 0;border-radius:4px;font-size:14px;\">\n<strong>Co z\u00edsk\u00e1te s MedsBase:<\/strong> V\u00fdrobce certifikovan\u00fd WHO-GMP \u00b7 Diskr\u00e9tn\u00ed balen\u00ed \u00b7 Celosv\u011btov\u00e1 doprava \u00b7 V\u00edce ne\u017e 1 400 ov\u011b\u0159en\u00fdch <a href=\"https:\/\/medsbase.com\/cs\/reviews\/\">recenz\u00ed z\u00e1kazn\u00edk\u016f<\/a>\n<\/div>\n<p class=\"medsbase-reship-line\" style=\"font-size:14px;color:#444;margin:8px 0 18px;\">\ud83d\udce6 Ka\u017ed\u00e1 objedn\u00e1vka je pokryta na\u0161\u00ed <a href=\"https:\/\/medsbase.com\/cs\/medsbase-re-shipment-assurance-policy\/\"><strong>Z\u00e1rukou op\u011btovn\u00e9ho odesl\u00e1n\u00ed<\/strong><\/a> \u2014 pokud va\u0161e z\u00e1silka nedoraz\u00ed do 20 pracovn\u00edch dn\u016f, p\u0159epos\u00edl\u00e1me ji.<\/p>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:14px 18px;margin:0 0 24px 0;border-radius:4px;font-size:14px;\"><strong>\u26a0 Vy\u017eaduje se odborn\u00fd dohled.<\/strong> L\u00e9ky na rakovinu mus\u00ed b\u00fdt p\u0159edeps\u00e1ny o\u0161et\u0159uj\u00edc\u00edm onkologem s potvrzenou diagn\u00f3zou, vstupn\u00edm stagingem a definovan\u00fdm l\u00e9\u010debn\u00fdm pl\u00e1nem. Nikdy neza\u010d\u00ednejte, nep\u0159eru\u0161ujte, nem\u011b\u0148te d\u00e1vkov\u00e1n\u00ed ani neu\u017e\u00edvejte l\u00e9ky na rakovinu mimo onkologick\u00fd l\u00e9\u010debn\u00fd pl\u00e1n. V\u011bt\u0161ina l\u00e9k\u016f na rakovinu vy\u017eaduje pravideln\u00e9 monitorov\u00e1n\u00ed krevn\u00edch test\u016f (krevn\u00ed obraz, jatern\u00ed testy, funkce ledvin), je absolutn\u011b kontraindikov\u00e1na v t\u011bhotenstv\u00ed a m\u00e1 v\u00fdznamn\u00e9 l\u00e9kov\u00e9 interakce.<\/div>\n<div style=\"background:#f4f8fb;border:1px solid #d6e4ec;padding:12px 18px;margin:14px 0;border-radius:4px;font-size:14px;color:#3a5160;text-align:center;\">\n<strong>\ud83d\udd12 \u0160ifrovan\u00e9 platby<\/strong> \u00b7 <strong>\ud83d\udcb3 Ov\u011b\u0159en\u00fd platebn\u00ed procesor<\/strong> \u00b7 <strong>\ud83d\ude9a Doprava do cel\u00e9ho sv\u011bta<\/strong> \u00b7 <strong>\u2b50 4,9\/5 od 1 400+ z\u00e1kazn\u00edk\u016f<\/strong>\n<\/div>\n<h2 class=\"wp-block-heading\">What Is Temotero?<\/h2>\n<p>Temotero is an oral capsule from Glenmark containing <strong>temozolomide<\/strong> (20 mg and 100 mg). Temozolomide is an oral alkylating cytotoxic agent of the imidazotetrazine class. It crosses the blood-brain barrier (CSF concentration ~30% of plasma) and is the only oral cytotoxic with proven survival benefit in glioblastoma multiforme. Standard combination with radiotherapy (the &ldquo;Stupp protocol&rdquo;, 2005) extended median GBM survival from 12 months to 15 months and 2-year survival from 11% to 27%.<\/p>\n<h2 class=\"wp-block-heading\">Pou\u017eit\u00ed a indikace<\/h2>\n<ul>\n<li><strong>Newly-diagnosed glioblastoma multiforme (GBM)<\/strong> &mdash; concurrent with radiotherapy then maintenance (Stupp protocol)<\/li>\n<li><strong>Anaplastic astrocytoma<\/strong> after recurrence<\/li>\n<li><strong>Recurrent high-grade glioma<\/strong><\/li>\n<li><strong>Mimo indikaci:<\/strong> melanoma brain metastases, neuroendocrine tumours<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Dosage (Stupp protocol)<\/h2>\n<ul>\n<li><strong>Concurrent phase:<\/strong> 75 mg\/m&sup2;\/day continuously during 6 weeks of radiotherapy (total ~42 days)<\/li>\n<li><strong>4-week break<\/strong> after radiotherapy completion<\/li>\n<li><strong>Udr\u017eovac\u00ed f\u00e1ze:<\/strong> 150 mg\/m&sup2;\/day for days 1&ndash;5 of a 28-day cycle (cycle 1); escalate to 200 mg\/m&sup2;\/day if tolerated for cycles 2&ndash;6 (total 6 cycles, with newer evidence supporting up to 12 cycles in younger MGMT-methylated patients)<\/li>\n<\/ul>\n<ol>\n<li><strong>Take on an empty stomach at the same time each day<\/strong> &mdash; food slows absorption and reduces peak concentration. Most patients take it at bedtime, &ge; 2 hours after the last meal.<\/li>\n<li><strong>Antiemetic:<\/strong> ondansetron 8 mg orally 1 hour before each temozolomide dose, especially during the maintenance phase 5-day pulse.<\/li>\n<li>Swallow capsules whole with water. Do NOT open or chew &mdash; powder is cytotoxic.<\/li>\n<li><strong>Profylaxe PCP<\/strong> with co-trimoxazole 480 mg three times weekly during the concurrent phase &mdash; lymphopenia risk. Continue until CD4 &gt; 200 cells\/&micro;L.<\/li>\n<li><strong>Povinn\u00e9 monitorov\u00e1n\u00ed:<\/strong> FBC weekly during concurrent phase; before each maintenance cycle (day 22 of previous cycle and day 1 of each new cycle); LFTs monthly. Hold cycle for ANC &lt; 1,500\/&micro;L or platelets &lt; 100,000\/&micro;L.<\/li>\n<li>If a dose is vomited within 1 hour, do NOT re-dose. Resume next day per schedule.<\/li>\n<\/ol>\n<h2 class=\"wp-block-heading\">Vedlej\u0161\u00ed \u00fa\u010dinky<\/h2>\n<p><strong>\u010cast\u00e9:<\/strong> nausea, vomiting (mostly preventable with ondansetron), fatigue, anorexia, constipation, headache, alopecia.<\/p>\n<p><strong>D\u016fle\u017eit\u00e9:<\/strong><\/p>\n<ul>\n<li><strong>Myelosuprese<\/strong> &mdash; especially thrombocytopenia (the dose-limiting toxicity); lymphopenia with PCP risk<\/li>\n<li><strong>Pneumocystis jirovecii pneumonie<\/strong> &mdash; lymphopenia-driven; mandatory prophylaxis during concurrent phase<\/li>\n<li>Hepatotoxicity, including rare reactivation of hepatitis B<\/li>\n<li>Severe skin reactions including SJS\/TEN (rare)<\/li>\n<li>Secondary myelodysplastic syndrome \/ acute leukaemia (rare, long-term)<\/li>\n<li>Severe lymphopenia &gt; 6 months<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Varov\u00e1n\u00ed<\/h2>\n<ul>\n<li><strong>T\u011bhotenstv\u00ed:<\/strong> teratogenic. Reliable contraception throughout treatment + 6 months after.<\/li>\n<li><strong>Kojen\u00ed:<\/strong> vyhnout se.<\/li>\n<li><strong>T\u011b\u017ek\u00e9 po\u0161kozen\u00ed jater:<\/strong> vyhnout se.<\/li>\n<li><strong>Hepatitis B carrier status:<\/strong> screen and consider antiviral prophylaxis &mdash; reactivation risk.<\/li>\n<li><strong>\u017div\u00e9 vakc\u00edny:<\/strong> kontraindikov\u00e1no.<\/li>\n<li><strong>Severe lymphopenia \/ CD4 &lt; 200:<\/strong> continue PCP prophylaxis until lymphocyte recovery.<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Interakce s l\u00e9\u010divy<\/h2>\n<table style=\"border-collapse:collapse;width:100%;margin:12px 0;\">\n<thead>\n<tr style=\"background:#2c7cb0;color:#fff;\">\n<th style=\"padding:10px;border:1px solid #ddd;\">Kombinujte s<\/th>\n<th style=\"padding:10px;border:1px solid #ddd;\">\u00da\u010dinek<\/th>\n<th style=\"padding:10px;border:1px solid #ddd;\">Co d\u011blat<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td style=\"padding:10px;border:1px solid #ddd;\">\u017div\u00e9 vakc\u00edny<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Diseminovan\u00e1 infekce<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Kontraindikov\u00e1no.<\/td>\n<\/tr>\n<tr>\n<td style=\"padding:10px;border:1px solid #ddd;\">Dal\u0161\u00ed myelosupresivn\u00ed l\u00e9ky<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Additive marrow suppression<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Dohled specialisty.<\/td>\n<\/tr>\n<tr>\n<td style=\"padding:10px;border:1px solid #ddd;\">Valproic acid<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Mildly reduces temozolomide clearance<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">No dose adjustment usually needed.<\/td>\n<\/tr>\n<tr>\n<td style=\"padding:10px;border:1px solid #ddd;\">Co-trimoxazole (PCP prophylaxis)<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Standard combination<\/td>\n<td style=\"padding:10px;border:1px solid #ddd;\">Continue throughout concurrent phase.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2 class=\"wp-block-heading\">Skladov\u00e1n\u00ed<\/h2>\n<ul>\n<li>Room temperature, 15&ndash;30&deg;C, original blister.<\/li>\n<li>Out of reach of children, women of childbearing potential, and pets &mdash; cytotoxic powder.<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Souvisej\u00edc\u00ed alternativy na MedsBase<\/h2>\n<p>Dal\u0161\u00ed onkologick\u00e9 l\u00e9ky skladem vedle tohoto produktu:<\/p>\n<ul>\n<li><a href=\"https:\/\/medsbase.com\/cs\/endoxan\/\"><strong>Endoxan (cyklofosfamid 50 mg)<\/strong><\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/celkeran\/\"><strong>Celkeran (chlorambucil 2 \/ 5 mg)<\/strong><\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/temozol-20\/\"><strong>Temozol (temozolomid 20 mg)<\/strong><\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/lomoother\/\"><strong>Lomoother (lomustin 40 mg)<\/strong><\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/endace\/\"><strong>Endace (megestrol 40\/160 mg)<\/strong><\/a><\/li>\n<\/ul>\n<p><a href=\"https:\/\/medsbase.com\/cs\/anti-cancer-medication\/\">Prohl\u00e9dn\u011bte v\u0161echny protin\u00e1dorov\u00e9 l\u00e9ky \u2192<\/a><\/p>\n<h2 id=\"faqs\">\u010casto kladen\u00e9 dotazy<\/h2>\n<h3 class=\"wp-block-heading\">What is the Stupp protocol?<\/h3>\n<p>The Stupp protocol (2005) is the standard combined chemoradiotherapy regimen for newly-diagnosed glioblastoma multiforme: <strong>radiotherapy (60 Gy in 30 fractions) + concurrent temozolomide (75 mg\/m&sup2;\/day) for 6 weeks, then 4-week break, then maintenance temozolomide (150&ndash;200 mg\/m&sup2;\/day for days 1&ndash;5 of each 28-day cycle) for 6 cycles<\/strong>. The protocol extended median survival from 12 to 15 months and remains the global standard in 2026.<\/p>\n<h3 class=\"wp-block-heading\">Why must I take Temotero on an empty stomach?<\/h3>\n<p>Food slows temozolomide absorption and reduces peak plasma concentration. For consistent dosing, take temozolomide at the same time each day with no food for at least 2 hours before. Most patients take it at bedtime &ge; 2 hours after the last meal. Take ondansetron 8 mg orally 1 hour before each dose to prevent nausea.<\/p>\n<h3 class=\"wp-block-heading\">Why do I need PCP prophylaxis?<\/h3>\n<p>The continuous 6-week concurrent phase causes prolonged lymphopenia &mdash; particularly low CD4 counts &mdash; that creates a real risk of <strong>Pneumocystis jirovecii pneumonia (PCP)<\/strong>, a potentially fatal opportunistic infection. Standard prophylaxis: <strong>co-trimoxazole 480 mg three times weekly<\/strong> throughout concurrent phase, continued until CD4 recovery (often takes 6+ months).<\/p>\n<h3 class=\"wp-block-heading\">What does &ldquo;MGMT methylation&rdquo; mean for my treatment?<\/h3>\n<p>MGMT (O6-methylguanine-DNA methyltransferase) is a DNA repair enzyme that undoes temozolomide&#39;s alkylation damage. <strong>MGMT-methylated<\/strong> tumours have low MGMT expression &mdash; they cannot repair the damage, so respond much better to temozolomide. <strong>MGMT-unmethylated<\/strong> tumours have high MGMT expression and are relatively temozolomide-resistant. MGMT status is determined on the surgical biopsy and influences treatment intensity (longer maintenance, more aggressive regimens) and prognosis.<\/p>\n<h3 class=\"wp-block-heading\">Jak\u00e9 krevn\u00ed testy pot\u0159ebuji?<\/h3>\n<p>FBC weekly during the concurrent radiotherapy phase. Before each maintenance cycle: FBC on day 22 of the previous cycle and day 1 of the new cycle. LFTs monthly. Hold cycle for ANC &lt; 1,500\/&micro;L or platelets &lt; 100,000\/&micro;L &mdash; thrombocytopenia is the dose-limiting toxicity.<\/p>\n<h3 class=\"wp-block-heading\">What if I vomit a dose?<\/h3>\n<p>If you vomit within 1 hour of taking Temotero, do NOT re-dose &mdash; the safety risk of double-dosing is greater than the modest loss of efficacy from one missed dose. Resume the next dose at the scheduled time. Speak to your oncology team about pre-medication adjustment if vomiting recurs.<\/p>\n<h3 class=\"wp-block-heading\">Can I drink alcohol on Temotero?<\/h3>\n<p>Avoid during active treatment. Both alcohol and temozolomide are hepatotoxic, and alcohol increases nausea. Even after treatment finishes, limit alcohol given the hepatic and bone marrow recovery period.<\/p>\n<h3 class=\"wp-block-heading\">Will Temotero cure my brain tumour?<\/h3>\n<p>Glioblastoma multiforme remains one of the most aggressive cancers. The Stupp protocol is the established standard and improves median survival, but cure is uncommon at present. Specific situations carry better prognosis: younger age, MGMT methylation, complete surgical resection, IDH mutation. Discuss prognosis honestly with your neuro-oncologist &mdash; treatment goals depend on individual disease characteristics.<\/p>\n<p><!-- medsbase-why-order --><\/p>\n<h3>Pro\u010d objedn\u00e1vat z MedsBase<\/h3>\n<p>Ka\u017ed\u00e1 \u0161ar\u017ee je dod\u00e1v\u00e1na od <strong>v\u00fdrobce certifikovan\u00e9ho WHO-GMP<\/strong>. Objedn\u00e1vky jsou expedov\u00e1ny v nen\u00e1padn\u00fdch obalech bez loga od na\u0161ich partnersk\u00fdch sklad\u016f a jsou pokryty na\u0161\u00ed <a href=\"\/cs\/medsbase-re-shipment-assurance-policy\/\">Z\u00e1rukou op\u011btovn\u00e9ho odesl\u00e1n\u00ed<\/a>: pokud z\u00e1silka nedoraz\u00ed do 20 pracovn\u00edch dn\u016f, za\u0161leme zdarma n\u00e1hradn\u00ed z\u00e1silku, bez dotaz\u016f.<\/p>\n<p><!-- medsbase-related-alts-v1 --><\/p>\n<h3 class=\"wp-block-heading\">Souvisej\u00edc\u00ed protin\u00e1dorov\u00e9 l\u00e9ky<\/h3>\n<p>Dal\u0161\u00ed onkologick\u00e9 l\u00e9ky skladem vedle tohoto produktu:<\/p>\n<ul>\n<li><a href=\"https:\/\/medsbase.com\/cs\/temozol-20\/\">Temozol 20 (temozolomide 20 mg)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/lomoother\/\">Lomoother (lomustin 40 mg)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/endoxan\/\">Endoxan (cyklofosfamid 50 mg)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/hydrosar\/\">Hydrosar (hydroxyurea 500 mg)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/folitrax\/\">Folitrax (methotrex\u00e1t 2,5\/7,5\/10 mg)<\/a><\/li>\n<\/ul>","protected":false},"excerpt":{"rendered":"<p>\u2705 Fights brain tumors<br \/>\n\u2705 Slows tumor growth<br \/>\n\u2705 Increases survival rates<br \/>\n\u2705 Oral chemotherapy option<br \/>\n\u2705 Well-tolerated treatment<\/p>\n<p>Temotero contains Temozolomide.<\/p>","protected":false},"featured_media":61762,"comment_status":"closed","ping_status":"open","template":"","meta":[],"product_brand":[],"product_cat":[3595,3141,3223],"product_tag":[5085,4915],"class_list":{"0":"post-61761","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-anti-cancer-medication","7":"product_cat-category-overview","8":"product_cat-chronic-conditions","9":"product_tag-temotero","10":"product_tag-temozolomide","12":"first","13":"instock","14":"shipping-taxable","15":"purchasable","16":"product-type-variable","17":"has-default-attributes"},"acf":[],"_links":{"self":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product\/61761","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/comments?post=61761"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/media\/61762"}],"wp:attachment":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/media?parent=61761"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product_brand?post=61761"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product_cat?post=61761"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product_tag?post=61761"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}