{"id":64815,"date":"2024-10-29T13:55:17","date_gmt":"2024-10-29T13:55:17","guid":{"rendered":"https:\/\/medsbase.com\/?post_type=product&p=64815"},"modified":"2026-05-10T08:48:12","modified_gmt":"2026-05-10T08:48:12","slug":"niclosig","status":"publish","type":"product","link":"https:\/\/medsbase.com\/cs\/product\/niclosig\/","title":{"rendered":"Niclosig"},"content":{"rendered":"

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Rychl\u00e1 odpov\u011b\u010f \u2014 Co je Niclosig?<\/h3>\n
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Niclosig<\/strong> je niklosamid 500 mg \u017ev\u00fdkac\u00ed<\/strong> od Sigmund Promedia<\/strong>. Niklosamid je z\u00e1kladn\u00ed l\u00e9k WHO pro st\u0159evn\u00ed tasemnici<\/strong> (Taenia saginata, Taenia solium st\u0159evn\u00ed forma, Hymenolepis nana, Diphyllobothrium latum). Standardn\u00ed d\u00e1vka pro dosp\u011bl\u00e9: 2 g (4 tablety) jako jednor\u00e1zov\u00e1 d\u00e1vka<\/strong>, d\u016fkladn\u011b roz\u017ev\u00fdkan\u00e9 a spolknut\u00e9 s mal\u00fdm mno\u017estv\u00edm vody nala\u010dno.<\/p>\n<\/div>\n<\/div>\n

Pro\u010d objedn\u00e1vat z MedsBase:<\/strong> \u2713 Zdrojeno od WHO-GMP certifikovan\u00fdch v\u00fdrobc\u016f<\/strong> \u00b7 \u2713 Diskr\u00e9tn\u00ed balen\u00ed \u00b7 \u2713 Doprava do cel\u00e9ho sv\u011bta \u00b7 \u2713 1,400+ recenz\u00ed z\u00e1kazn\u00edk\u016f<\/strong> na medsbase.com\/reviews<\/a><\/div>\n

\ud83d\udce6 Ka\u017ed\u00e1 objedn\u00e1vka je pokryta na\u0161\u00ed Z\u00e1rukou op\u011btovn\u00e9ho odesl\u00e1n\u00ed<\/strong><\/a> \u2014 pokud va\u0161e z\u00e1silka nedoraz\u00ed do 20 pracovn\u00edch dn\u016f, p\u0159epos\u00edl\u00e1me ji.<\/p>\n

Pro\u010d objedn\u00e1vat z MedsBase<\/h3>\n

Na\u0161e generick\u00e9 l\u00e9ky poch\u00e1zej\u00ed od v\u00fdrobc\u016f certifikovan\u00fdch WHO-GMP a jsou expedov\u00e1ny po cel\u00e9m sv\u011bt\u011b v diskr\u00e9tn\u00edm, nen\u00e1padn\u00e9m balen\u00ed \u2013 na vn\u011bj\u0161\u00ed stran\u011b bal\u00edku nen\u00ed uveden n\u00e1zev l\u00e9ku. Platby kartou jsou sm\u011brov\u00e1ny prost\u0159ednictv\u00edm regulovan\u00e9ho procesoru (popisky na v\u00fdpisu zahrnuj\u00ed regulovan\u00e9ho procesora plateb kartou \u2013 nikdy \u201cMedsBase\u201d nebo n\u00e1zev l\u00e9ku). P\u0159ij\u00edm\u00e1me tak\u00e9 kryptom\u011bny a bankovn\u00ed p\u0159evody SEPA. Ka\u017ed\u00e1 objedn\u00e1vka je zaji\u0161t\u011bna na\u0161\u00ed politikou p\u0159eposl\u00e1n\u00ed.<\/p>\n

Co je Niclosig?<\/h2>\n

Niclosig<\/strong> je niklosamid 500 mg \u017ev\u00fdkac\u00ed od Sigmund Promedia<\/strong>. Niclosamid je antihelmintikum ze t\u0159\u00eddy salicylanilid\u016f s \u00fazkou, ale nenahraditelnou rol\u00ed: je to nej\u010dist\u0161\u00ed a nejspolehliv\u011bj\u0161\u00ed jednor\u00e1zov\u00e1 l\u00e9\u010dba st\u0159evn\u00edch tasemnic<\/strong> (tasemnice). Je na Modelov\u00e9m seznamu z\u00e1kladn\u00edch l\u00e9k\u016f WHO a je pou\u017e\u00edv\u00e1n nep\u0159etr\u017eit\u011b od 60. let 20. stolet\u00ed.<\/p>\n

Mechanismus \u00fa\u010dinku<\/h2>\n

Niclosamid odpojuje oxidativn\u00ed fosforylaci<\/strong> v hlavi\u010dce (scolex) tasemnice. To vy\u010derp\u00e1 ATP parazita, paralyzuje scolex a naru\u0161\u00ed jeho uchycen\u00ed na st\u011bn\u011b st\u0159eva. \u010cerv je pak \u010d\u00e1ste\u010dn\u011b str\u00e1ven hostitelsk\u00fdmi enzymy \u2014 ve stolici m\u016f\u017eete vid\u011bt fragmentovan\u00e9 proglotidy sp\u00ed\u0161e ne\u017e neporu\u0161en\u00e9ho \u010derva. Niclosamid se prakticky nevst\u0159eb\u00e1v\u00e1 ze st\u0159eva (< 5 %), co\u017e je terapeuticky ide\u00e1ln\u00ed: vysok\u00e1 lumin\u00e1ln\u00ed koncentrace, t\u00e9m\u011b\u0159 nulov\u00e1 syst\u00e9mov\u00e1 expozice.<\/p>\n

Indikace a d\u00e1vkov\u00e1n\u00ed Niclosigu<\/h2>\n\n\n\n\n\n\n\n\n
Indikace<\/th>\nD\u00e1vka<\/th>\nD\u00e1vkovac\u00ed sch\u00e9ma<\/th>\n<\/tr>\n<\/thead>\n
Hov\u011bz\u00ed tasemnice (Taenia saginata)<\/td>\n2 g (4 tablety)<\/td>\nJednor\u00e1zov\u00e1 d\u00e1vka, roz\u017ev\u00fdkat nala\u010dno<\/td>\n<\/tr>\n
St\u0159evn\u00ed forma vep\u0159ov\u00e9 tasemnice (Taenia solium)<\/td>\n2 g (4 tablety)<\/td>\nJednor\u00e1zov\u00e1 d\u00e1vka; zva\u017ete proj\u00edmadlo 2 hodiny po pod\u00e1n\u00ed ke sn\u00ed\u017een\u00ed teoretick\u00e9ho rizika cysticerk\u00f3zy<\/td>\n<\/tr>\n
\u0160kulovec \u0161irok\u00fd (Diphyllobothrium latum)<\/td>\n2 g (4 tablety)<\/td>\nJednor\u00e1zov\u00e1 d\u00e1vka<\/td>\n<\/tr>\n
Trpasli\u010d\u00ed tasemnice (Hymenolepis nana)<\/td>\n2 g prvn\u00ed den, pot\u00e9 1 g denn\u011b po dobu 6 dn\u016f<\/td>\n7denn\u00ed k\u00fara<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Tablety d\u016fkladn\u011b roz\u017ev\u00fdkejte<\/strong>, pot\u00e9 spolkn\u011bte s mal\u00fdm mno\u017estv\u00edm vody. U\u017e\u00edvejte nala\u010dno r\u00e1no nebo po lehk\u00e9 sn\u00eddani. U tasemnice bezbrann\u00e9 (Taenia solium) n\u011bkte\u0159\u00ed klinici pod\u00e1vaj\u00ed 2 hodiny po d\u00e1vce soln\u00e9 proj\u00edmadlo k evakuaci mrtv\u00fdch \u010dl\u00e1nk\u016f a sn\u00ed\u017een\u00ed (vz\u00e1cn\u00e9ho) teoretick\u00e9ho rizika uvoln\u011bn\u00ed vaj\u00ed\u010dek do st\u0159eva a n\u00e1sledn\u00e9 cysticerk\u00f3zy.<\/p>\n

Cysticerk\u00f3za je samostatn\u00e9 onemocn\u011bn\u00ed.<\/strong> Niklosamid l\u00e9\u010d\u00ed st\u0159evn\u00ed<\/em> tasemnici. Neurocysticerk\u00f3za<\/strong> (Larv\u00e1ln\u00ed cysty Taenia solium v CNS) se l\u00e9\u010d\u00ed albendazolem nebo prazikvantelem pod odborn\u00fdm dohledem s imagingem a sou\u010dasn\u00fdm pod\u00e1v\u00e1n\u00edm steroid\u016f \u2014 nikoli niklosamidem. Bolesti hlavy, z\u00e1chvaty nebo fok\u00e1ln\u00ed neurologick\u00e9 p\u0159\u00edznaky u pacienta s tasemnic\u00ed vy\u017eaduj\u00ed urgentn\u00ed zobrazen\u00ed.<\/div>\n

Vedlej\u0161\u00ed \u00fa\u010dinky<\/h2>\n