{"id":66697,"date":"2025-05-01T13:11:44","date_gmt":"2025-05-01T13:11:44","guid":{"rendered":"https:\/\/medsbase.com\/?post_type=product&#038;p=66697"},"modified":"2026-05-10T08:48:12","modified_gmt":"2026-05-10T08:48:12","slug":"dicaris-adults-tablet","status":"publish","type":"product","link":"https:\/\/medsbase.com\/cs\/product\/dicaris-adults-tablet\/","title":{"rendered":"Dicaris Adults Tablet"},"content":{"rendered":"<p><!-- medsbase-tldr-answer --><\/p>\n<div class=\"medsbase-tldr-answer\" style=\"margin:0 0 22px;padding:16px 20px;background:#fff8e1;border-left:4px solid #f5a623;border-radius:4px;\">\n<h3 class=\"wp-block-heading\" style=\"margin:0 0 8px;font-size:18px;color:#2c3e50;\">Quick Answer &mdash; What is Dicaris Adults Tablet?<\/h3>\n<div style=\"margin:0;font-size:15px;line-height:1.55;color:#333;\">\n<p><strong>Dicaris Adults Tablet<\/strong> je <strong>levamisole 150&nbsp;mg<\/strong> od <strong>Janssen<\/strong>. Levamisole is both an <strong>anthelmintic<\/strong> (first-line for ascariasis worldwide before albendazole displaced it) and an <strong>immunomodulator<\/strong> used in steroid-dependent or frequently-relapsing nephrotic syndrome to reduce relapse rate. Standard adult anthelmintic dose: <strong>150&nbsp;mg single dose<\/strong>; immunomodulatory dose: 2.5&nbsp;mg\/kg every other day in nephrotic syndrome.<\/p>\n<\/div>\n<\/div>\n<div class=\"medsbase-trust-strip\" style=\"margin:24px 0;padding:14px 18px;background:#f4f4f4;border:1px solid #e1e1e1;border-radius:4px;font-size:14px;color:#444;line-height:1.55;\"><strong>Pro\u010d objedn\u00e1vat z MedsBase:<\/strong> \u2713 Zdrojeno od <strong>WHO-GMP certifikovan\u00fdch v\u00fdrobc\u016f<\/strong> \u00b7 \u2713 Diskr\u00e9tn\u00ed balen\u00ed \u00b7 \u2713 Doprava do cel\u00e9ho sv\u011bta \u00b7 \u2713 <strong>1,400+ recenz\u00ed z\u00e1kazn\u00edk\u016f<\/strong> na <a href=\"https:\/\/medsbase.com\/cs\/reviews\/\">medsbase.com\/reviews<\/a><\/div>\n<p class=\"medsbase-reship-line\" style=\"font-size:14px;color:#444;margin:8px 0 18px;\">\ud83d\udce6 Ka\u017ed\u00e1 objedn\u00e1vka je pokryta na\u0161\u00ed <a href=\"https:\/\/medsbase.com\/cs\/medsbase-re-shipment-assurance-policy\/\"><strong>Z\u00e1rukou op\u011btovn\u00e9ho odesl\u00e1n\u00ed<\/strong><\/a> \u2014 pokud va\u0161e z\u00e1silka nedoraz\u00ed do 20 pracovn\u00edch dn\u016f, p\u0159epos\u00edl\u00e1me ji.<\/p>\n<h3>Pro\u010d objedn\u00e1vat z MedsBase<\/h3>\n<p>Na\u0161e generick\u00e9 l\u00e9ky poch\u00e1zej\u00ed od v\u00fdrobc\u016f certifikovan\u00fdch WHO-GMP a jsou expedov\u00e1ny po cel\u00e9m sv\u011bt\u011b v diskr\u00e9tn\u00edm, nen\u00e1padn\u00e9m balen\u00ed \u2013 na vn\u011bj\u0161\u00ed stran\u011b bal\u00edku nen\u00ed uveden n\u00e1zev l\u00e9ku. Platby kartou jsou sm\u011brov\u00e1ny prost\u0159ednictv\u00edm regulovan\u00e9ho procesoru (popisky na v\u00fdpisu zahrnuj\u00ed regulovan\u00e9ho procesora plateb kartou \u2013 nikdy \u201cMedsBase\u201d nebo n\u00e1zev l\u00e9ku). P\u0159ij\u00edm\u00e1me tak\u00e9 kryptom\u011bny a bankovn\u00ed p\u0159evody SEPA. Ka\u017ed\u00e1 objedn\u00e1vka je zaji\u0161t\u011bna na\u0161\u00ed politikou p\u0159eposl\u00e1n\u00ed.<\/p>\n<h2 class=\"wp-block-heading\">What is Dicaris Adults Tablet?<\/h2>\n<p><strong>Dicaris Adults Tablet<\/strong> obsahuje <strong>levamisole 150&nbsp;mg<\/strong> od <strong>Janssen<\/strong>. Originally developed as a veterinary anthelmintic, levamisole was widely used in human medicine for ascariasis from the 1960s until albendazole and mebendazole displaced it as first-line. It retains an important second indication: <strong>immunomodulation in childhood nephrotic syndrome<\/strong>, where it reduces relapse frequency in steroid-dependent disease and lets clinicians reduce cumulative steroid dose.<\/p>\n<h2 class=\"wp-block-heading\">Mechanismus \u00fa\u010dinku<\/h2>\n<p>As an anthelmintic, levamisole is a <strong>nicotinic acetylcholine receptor agonist<\/strong> on parasite muscle, causing spastic paralysis (similar mechanism to pyrantel). The paralysed worm is passed in stool.<\/p>\n<p>As an immunomodulator, levamisole appears to <strong>restore depressed cell-mediated immunity<\/strong> &mdash; it enhances T-cell function, monocyte and macrophage activity, and natural killer cell response. The exact mechanism in nephrotic syndrome remains incompletely understood but the clinical effect (reduced relapse) is well-established in randomised trials.<\/p>\n<h2 class=\"wp-block-heading\">Dicaris Adults Tablet indications and dose<\/h2>\n<table style=\"width:100%;border-collapse:collapse;margin:14px 0;font-size:14px;\">\n<thead>\n<tr style=\"background:#2c7cb0;color:#fff;\">\n<th style=\"padding:8px;text-align:left;border:1px solid #ddd;\">Indikace<\/th>\n<th style=\"padding:8px;text-align:left;border:1px solid #ddd;\">D\u00e1vka<\/th>\n<th style=\"padding:8px;text-align:left;border:1px solid #ddd;\">D\u00e1vkovac\u00ed sch\u00e9ma<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td style=\"padding:8px;border:1px solid #ddd;\">Ascariasis (adults)<\/td>\n<td style=\"padding:8px;border:1px solid #ddd;\">150&nbsp;mg<\/td>\n<td style=\"padding:8px;border:1px solid #ddd;\">Jednor\u00e1zov\u00e1 d\u00e1vka<\/td>\n<\/tr>\n<tr style=\"background:#f9f9f9;\">\n<td style=\"padding:8px;border:1px solid #ddd;\">Ascariasis (children)<\/td>\n<td style=\"padding:8px;border:1px solid #ddd;\">2.5&nbsp;mg\/kg<\/td>\n<td style=\"padding:8px;border:1px solid #ddd;\">Jednor\u00e1zov\u00e1 d\u00e1vka<\/td>\n<\/tr>\n<tr>\n<td style=\"padding:8px;border:1px solid #ddd;\">Hookworm (light burden)<\/td>\n<td style=\"padding:8px;border:1px solid #ddd;\">150&nbsp;mg<\/td>\n<td style=\"padding:8px;border:1px solid #ddd;\">Single dose, repeat at 7 days if needed<\/td>\n<\/tr>\n<tr style=\"background:#f9f9f9;\">\n<td style=\"padding:8px;border:1px solid #ddd;\">Steroid-dependent nephrotic syndrome (specialist)<\/td>\n<td style=\"padding:8px;border:1px solid #ddd;\">2.5&nbsp;mg\/kg<\/td>\n<td style=\"padding:8px;border:1px solid #ddd;\">Every other day for 12&ndash;24 months under nephrologist supervision<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>Take with or after a meal to reduce nausea.<\/p>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:14px 18px;margin:18px 0;border-radius:4px;font-size:14px;line-height:1.55;color:#444;\"><strong>Specialist supervision for nephrotic syndrome.<\/strong> Long-course levamisole for nephrotic syndrome requires nephrology supervision. Mandatory neutrophil monitoring (FBC every 4&ndash;6 weeks for the first 6 months, then every 3 months) is essential because of the well-described risk of agranulocytosis. Stop immediately at signs of infection or oral ulceration.<\/div>\n<h2 class=\"wp-block-heading\">Vedlej\u0161\u00ed \u00fa\u010dinky<\/h2>\n<ul>\n<li><strong>Common (single-dose):<\/strong> mild nausea, abdominal pain, headache, transient dizziness<\/li>\n<li><strong>M\u00e9n\u011b \u010dast\u00e9:<\/strong> rash, fatigue, transient transaminase rise, mild flu-like symptoms<\/li>\n<li><strong>Rare but serious (long-course):<\/strong> agranulocytosis (~3% in long courses, monitoring mandatory), vasculitis with cutaneous necrosis, leukoencephalopathy, hepatitis, Stevens-Johnson syndrome<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Interakce l\u00e9k\u016f<\/h2>\n<ul>\n<li><strong>Fenytoin<\/strong> &mdash; levamisole increases phenytoin levels; monitor<\/li>\n<li><strong>Warfarin<\/strong> &mdash; potential INR rise; monitor<\/li>\n<li><strong>Alkohol<\/strong> &mdash; rare disulfiram-like reaction; abstain during the treatment course<\/li>\n<li><strong>Steroids<\/strong> &mdash; in nephrotic syndrome, levamisole is added to steroid backbone; the combination is intentional and monitored<\/li>\n<\/ul>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:14px 18px;margin:18px 0;border-radius:4px;font-size:14px;line-height:1.55;color:#444;\"><strong>T\u011bhotenstv\u00ed &amp; kojen\u00ed.<\/strong> Albendazol a mebendazol se v prvn\u00edm trimestru NEdoporu\u010duj\u00ed (\u00fadaje o teratogenit\u011b u zv\u00ed\u0159at). Pou\u017eit\u00ed je p\u0159ijateln\u00e9 ve 2. a 3. trimestru p\u0159i st\u0159edn\u00ed a\u017e t\u011b\u017ek\u00e9 helmintick\u00e9 z\u00e1t\u011b\u017ei. \u00dadaje o ivermektinu v t\u011bhotenstv\u00ed jsou omezen\u00e9, ale v programech hromadn\u00e9 l\u00e9\u010dby WHO jsou uklid\u0148uj\u00edc\u00ed; vyhn\u011bte se v prvn\u00edm trimestru, pokud existuj\u00ed alternativy. Praziquantel a pyrantel jsou kompatibiln\u00ed s t\u011bhotenstv\u00edm.<\/div>\n<h2 class=\"wp-block-heading\">Kontraindikace<\/h2>\n<ul>\n<li>Hypersensitivity to levamisole or other imidazothiazoles<\/li>\n<li>Pre-existing neutropenia or bone marrow suppression<\/li>\n<li>T\u011b\u017ek\u00e9 jatern\u00ed nebo ren\u00e1ln\u00ed po\u0161kozen\u00ed<\/li>\n<li>Pregnancy &mdash; first trimester avoidance; long-course immunomodulatory use should not start in pregnancy<\/li>\n<li>Concurrent alcohol use during the treatment window<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Skladov\u00e1n\u00ed<\/h2>\n<p>Store Dicaris Adults Tablet below 30&deg;C, away from light and moisture.<\/p>\n<h3 class=\"wp-block-heading\">Pro\u010d objedn\u00e1vat z MedsBase<\/h3>\n<p>Dicaris Adults Tablet is supplied from a <strong>v\u00fdrobce certifikovan\u00e9ho WHO-GMP<\/strong>, balen diskr\u00e9tn\u011b a expedov\u00e1n po cel\u00e9m sv\u011bt\u011b. Ka\u017ed\u00e1 objedn\u00e1vka je kryta na\u0161\u00edm <a href=\"https:\/\/medsbase.com\/cs\/medsbase-re-shipment-assurance-policy\/\">Z\u00e1rukou op\u011btovn\u00e9ho odesl\u00e1n\u00ed<\/a> \u2014 nikdy nenese\u0161 n\u00e1klady za ztracenou z\u00e1silku.<\/p>\n<h2 id=\"faqs\">\u010casto kladen\u00e9 dotazy<\/h2>\n<h3 class=\"wp-block-heading\">Why is levamisole still used when albendazole exists?<\/h3>\n<p>For routine ascariasis, albendazole has displaced levamisole as first-line because of broader spectrum and equivalent single-dose efficacy. Levamisole&rsquo;s persisting role is in <strong>steroid-dependent or frequently-relapsing nephrotic syndrome<\/strong>, where it reduces relapse rate and steroid burden. It is also used in some veterinary settings.<\/p>\n<h3 class=\"wp-block-heading\">How does Dicaris Adults Tablet treat nephrotic syndrome?<\/h3>\n<p>Levamisole appears to restore cell-mediated immunity, reducing the immunological dysregulation underlying minimal-change nephrotic syndrome. Randomised trials show meaningful reduction in relapse rate at doses around 2.5&nbsp;mg\/kg every other day for 12&ndash;24 months. This is a specialist-supervised therapy with mandatory neutrophil monitoring.<\/p>\n<h3 class=\"wp-block-heading\">Can I take Dicaris Adults Tablet with alcohol?<\/h3>\n<p>Avoid alcohol during the treatment window. A disulfiram-like reaction (flushing, palpitations, nausea) is uncommon but well-documented &mdash; not worth the risk.<\/p>\n<h3 class=\"wp-block-heading\">Will my child take Dicaris Adults Tablet for nephrotic syndrome?<\/h3>\n<p>Long-course levamisole for nephrotic syndrome is dosed by weight (2.5&nbsp;mg\/kg every other day) and requires regular blood testing. The 150&nbsp;mg adult tablet may need to be quartered for paediatric doses; the paediatric tablet (Dicaris Children, 50&nbsp;mg) is purpose-made for this. Consult the nephrology team.<\/p>\n<h3 class=\"wp-block-heading\">What signs should I watch for?<\/h3>\n<p>Stop and seek medical advice immediately for any of: fever, mouth ulcers, sore throat, easy bruising, unexplained tiredness, jaundice, rash with skin breakdown. These can signal agranulocytosis or vasculitis &mdash; serious but reversible if caught early.<\/p>\n<h3 class=\"wp-block-heading\">Is Dicaris Adults Tablet an appetite suppressant?<\/h3>\n<p>No. Some weight loss can occur as a knock-on of severe worm-burden eradication (the parasites were stealing nutrients), but levamisole is not used for weight loss.<\/p>\n<h3 class=\"wp-block-heading\">Can I take Dicaris Adults Tablet during pregnancy?<\/h3>\n<p>Avoid in the first trimester. Single-dose anthelmintic use later in pregnancy is acceptable for moderate-to-heavy worm burden under medical supervision. Long-course immunomodulatory use should not start during pregnancy.<\/p>\n<h3 class=\"wp-block-heading\">How quickly does Dicaris Adults Tablet work for worms?<\/h3>\n<p>Adult worms are paralysed within hours and passed within 24&ndash;72 hours. A single 150&nbsp;mg dose is usually enough for ascariasis. Re-test stool 2&ndash;4 weeks later if symptoms persist.<\/p>\n<h3 class=\"wp-block-heading\">Will Dicaris Adults Tablet treat scabies or ringworm?<\/h3>\n<p>No. Levamisole is for nematodes (especially ascaris) and immunomodulation. Scabies needs ivermectin or permethrin; ringworm is fungal and needs an antifungal (clotrimazole, terbinafine).<\/p>\n<h3 class=\"wp-block-heading\">What is the cocaine adulterant warning about?<\/h3>\n<p>Levamisole was historically used as a cocaine adulterant, which caused agranulocytosis cases in users worldwide. This is a public-health concern about illicit drug supply &mdash; the therapeutic use of levamisole under medical supervision (with monitoring) is well-established and safe.<\/p>\n<p class=\"medsbase-link-boost-2026-05-04\" data-marker=\"mb-link-boost-ivermectin-fenbendazole-combo-pack\"><a href=\"https:\/\/medsbase.com\/cs\/dicaris-adults-tablet\/\">Dicaris Adults Tablet<\/a> is levamisole 150 mg, a single-dose anthelmintic with secondary immunomodulator use in nephrotic syndrome; users running a stacked anthelmintic protocol that adds ivermectin and fenbendazole alongside levamisole can pick up the <a href=\"https:\/\/medsbase.com\/cs\/ivermectin-fenbendazole-combo-pack\/\">Ivermectin + Fenbendazole Combo Pack (Iverheal 12 mg + Wormentel 222 mg)<\/a> as the avermectin-benzimidazole add-on.<\/p>\n<p class=\"medsbase-link-boost-2026-05-10\" data-marker=\"mb-link-boost-iverheal\">For patients whose threadworm burden spans multiple species, specialists sometimes combine <a href=\"https:\/\/medsbase.com\/cs\/dicaris-adults-tablet\/\">Dicaris Adults Tablet (levamisole 150 mg)<\/a> s <a href=\"https:\/\/medsbase.com\/cs\/iverheal\/\">Iverheal (ivermectin 3 \/ 6 \/ 12 mg)<\/a> when levamisole alone is insufficient for strongyloidiasis or tissue-migrating larval forms.<\/p>\n<p><!-- medsbase-related-alts-v1 --><\/p>\n<h3 class=\"wp-block-heading\">Dal\u0161\u00ed antiparazit\u00e1rn\u00ed l\u00e9ky<\/h3>\n<ul>\n<li><a href=\"https:\/\/medsbase.com\/cs\/dicaris-adults-tablet\/\">Dicaris Adults Tablet (levamisole 150 mg)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/abd-400-albendazole\/\">ABD 400 (albendazol 400 mg)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/mebex\/\">Mebex (mebendazol 100 mg)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/iverheal\/\">Iverheal (ivermectin)<\/a><\/li>\n<li><a href=\"https:\/\/medsbase.com\/cs\/nemocid\/\">Nemocid (pyrantel pamoate)<\/a><\/li>\n<\/ul>\n<div style=\"background:#fff3f3;border-left:4px solid #d9534f;padding:14px 18px;margin:22px 0;border-radius:4px;font-size:14px;color:#444;\"><strong>Zdravotn\u00ed prohl\u00e1\u0161en\u00ed.<\/strong> Tato str\u00e1nka slou\u017e\u00ed pouze pro vzd\u011bl\u00e1vac\u00ed \u00fa\u010dely a nenahrazuje odborn\u00e9 l\u00e9ka\u0159sk\u00e9 poradenstv\u00ed. P\u0159ed zah\u00e1jen\u00edm jak\u00e9koli l\u00e9\u010dby proti parazit\u016fm se pora\u010fte s kvalifikovan\u00fdm l\u00e9ka\u0159em, zejm\u00e9na pokud jste t\u011bhotn\u00e1 nebo koj\u00edte, m\u00e1te oslabenou imunitu, l\u00e9\u010d\u00edte d\u00edt\u011b mlad\u0161\u00ed 2 let, nebo pokud p\u0159\u00edznaky p\u0159etrv\u00e1vaj\u00ed po ukon\u010den\u00ed l\u00e9\u010dby. Eozinofilie, \u00fabytek hmotnosti, p\u0159etrv\u00e1vaj\u00edc\u00ed bolesti b\u0159icha nebo p\u0159\u00edznaky spojen\u00e9 s cestov\u00e1n\u00edm vy\u017eaduj\u00ed klinick\u00e9 vy\u0161et\u0159en\u00ed. Z\u00e1va\u017en\u00e1 parazit\u00e1rn\u00ed onemocn\u011bn\u00ed (neurocysticerk\u00f3za, hyperinfekce strongyloidy, schistosom\u00f3za s posti\u017een\u00edm org\u00e1n\u016f) vy\u017eaduj\u00ed specializovanou p\u00e9\u010di.<\/div>","protected":false},"excerpt":{"rendered":"<p>Dicaris Adults Tablet (levamisole 150 mg) \u2014 dual-indication anthelmintic and immunomodulator. Single-dose treatment for ascariasis; long-course nephrology use to reduce nephrotic syndrome relapses.<\/p>","protected":false},"featured_media":66703,"comment_status":"open","ping_status":"closed","template":"","meta":[],"product_brand":[],"product_cat":[3856,3342],"product_tag":[5357,5355,5356],"class_list":{"0":"post-66697","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-threadworm-treatment","7":"product_cat-general-health","8":"product_tag-dicaris","9":"product_tag-dicaris-adults-tablet","10":"product_tag-levamisole","12":"first","13":"instock","14":"shipping-taxable","15":"purchasable","16":"product-type-variable","17":"has-default-attributes"},"acf":[],"_links":{"self":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product\/66697","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/comments?post=66697"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/media\/66703"}],"wp:attachment":[{"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/media?parent=66697"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product_brand?post=66697"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product_cat?post=66697"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/medsbase.com\/cs\/wp-json\/wp\/v2\/product_tag?post=66697"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}