{"id":66697,"date":"2025-05-01T13:11:44","date_gmt":"2025-05-01T13:11:44","guid":{"rendered":"https:\/\/medsbase.com\/?post_type=product&p=66697"},"modified":"2026-05-10T08:48:12","modified_gmt":"2026-05-10T08:48:12","slug":"dicaris-adults-tablet","status":"publish","type":"product","link":"https:\/\/medsbase.com\/cs\/product\/dicaris-adults-tablet\/","title":{"rendered":"Dicaris Adults Tablet"},"content":{"rendered":"

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Rychl\u00e1 odpov\u011b\u010f \u2014 Co je Dicaris Adults Tablet?<\/h3>\n
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Dicaris Adults Tablet<\/strong> je levamisole 150 mg<\/strong> od Janssen<\/strong>. Levamisole je z\u00e1rove\u0148 anthelmintikum<\/strong> (prvn\u00ed volba p\u0159i askari\u00f3ze celosv\u011btov\u011b p\u0159edt\u00edm, ne\u017e jej vytla\u010dil albendazol) a imunomodul\u00e1tor<\/strong> pou\u017e\u00edv\u00e1 se u steroid-dependentn\u00edho nebo \u010dasto recidivuj\u00edc\u00edho nefrotick\u00e9ho syndromu ke sn\u00ed\u017een\u00ed frekvence relaps\u016f. Standardn\u00ed d\u00e1vka pro dosp\u011bl\u00e9 jako antihelmintikum: 150 mg jednor\u00e1zov\u00e1 d\u00e1vka<\/strong>; imunomodula\u010dn\u00ed d\u00e1vka: 2,5 mg\/kg obden u nefrotick\u00e9ho syndromu.<\/p>\n<\/div>\n<\/div>\n

Pro\u010d objedn\u00e1vat z MedsBase:<\/strong> \u2713 Zdrojeno od WHO-GMP certifikovan\u00fdch v\u00fdrobc\u016f<\/strong> \u00b7 \u2713 Diskr\u00e9tn\u00ed balen\u00ed \u00b7 \u2713 Doprava do cel\u00e9ho sv\u011bta \u00b7 \u2713 1,400+ recenz\u00ed z\u00e1kazn\u00edk\u016f<\/strong> na medsbase.com\/reviews<\/a><\/div>\n

\ud83d\udce6 Ka\u017ed\u00e1 objedn\u00e1vka je pokryta na\u0161\u00ed Z\u00e1rukou op\u011btovn\u00e9ho odesl\u00e1n\u00ed<\/strong><\/a> \u2014 pokud va\u0161e z\u00e1silka nedoraz\u00ed do 20 pracovn\u00edch dn\u016f, p\u0159epos\u00edl\u00e1me ji.<\/p>\n

Pro\u010d objedn\u00e1vat z MedsBase<\/h3>\n

Na\u0161e generick\u00e9 l\u00e9ky poch\u00e1zej\u00ed od v\u00fdrobc\u016f certifikovan\u00fdch WHO-GMP a jsou expedov\u00e1ny po cel\u00e9m sv\u011bt\u011b v diskr\u00e9tn\u00edm, nen\u00e1padn\u00e9m balen\u00ed \u2013 na vn\u011bj\u0161\u00ed stran\u011b bal\u00edku nen\u00ed uveden n\u00e1zev l\u00e9ku. Platby kartou jsou sm\u011brov\u00e1ny prost\u0159ednictv\u00edm regulovan\u00e9ho procesoru (popisky na v\u00fdpisu zahrnuj\u00ed regulovan\u00e9ho procesora plateb kartou \u2013 nikdy \u201cMedsBase\u201d nebo n\u00e1zev l\u00e9ku). P\u0159ij\u00edm\u00e1me tak\u00e9 kryptom\u011bny a bankovn\u00ed p\u0159evody SEPA. Ka\u017ed\u00e1 objedn\u00e1vka je zaji\u0161t\u011bna na\u0161\u00ed politikou p\u0159eposl\u00e1n\u00ed.<\/p>\n

Co je Dicaris Adults Tablet?<\/h2>\n

Dicaris Adults Tablet<\/strong> obsahuje levamisole 150 mg<\/strong> od Janssen<\/strong>. P\u016fvodn\u011b vyvinut\u00fd jako veterin\u00e1rn\u00ed antihelmintikum byl levamisol \u0161iroce pou\u017e\u00edv\u00e1n v hum\u00e1nn\u00ed medic\u00edn\u011b pro askari\u00f3zu od 60. let 20. stolet\u00ed, dokud ho albendazol a mebendazol nevytla\u010dily jako l\u00e9ky prvn\u00ed volby. Zachoval si v\u0161ak d\u016fle\u017eitou druhou indikaci: imunomodulace u d\u011btsk\u00e9ho nefrotick\u00e9ho syndromu<\/strong>, kde sni\u017euje frekvenci relaps\u016f u steroid-dependentn\u00edho onemocn\u011bn\u00ed a umo\u017e\u0148uje klinik\u016fm sn\u00ed\u017eit kumulativn\u00ed d\u00e1vku steroid\u016f.<\/p>\n

Mechanismus \u00fa\u010dinku<\/h2>\n

Jako antihelmintikum je levamisol agonistou nikotinov\u00e9ho acetylcholinov\u00e9ho receptoru<\/strong> na svaly parazita, co\u017e zp\u016fsobuje spastickou paral\u00fdzu (podobn\u00fd mechanismus jako u pyrantelu). Ochrnut\u00fd \u010derv je vylou\u010den stolic\u00ed.<\/p>\n

Jako imunomodul\u00e1tor levamizol pravd\u011bpodobn\u011b obnovuje potla\u010denou bun\u011b\u010dnou imunitu<\/strong> \u2014 zlep\u0161uje funkci T-lymfocyt\u016f, aktivitu monocyt\u016f a makrof\u00e1g\u016f a odpov\u011b\u010f p\u0159irozen\u00fdch zab\u00edje\u010dsk\u00fdch bun\u011bk. P\u0159esn\u00fd mechanismus u nefrotick\u00e9ho syndromu nen\u00ed zcela objasn\u011bn, ale klinick\u00fd efekt (sn\u00ed\u017een\u00ed relaps\u016f) je dob\u0159e prok\u00e1z\u00e1n v randomizovan\u00fdch studi\u00edch.<\/p>\n

Indikace a d\u00e1vkov\u00e1n\u00ed tablet Dicaris pro dosp\u011bl\u00e9<\/h2>\n\n\n\n\n\n\n\n\n
Indikace<\/th>\nD\u00e1vka<\/th>\nD\u00e1vkovac\u00ed sch\u00e9ma<\/th>\n<\/tr>\n<\/thead>\n
Askari\u00f3za (dosp\u011bl\u00ed)<\/td>\n150 mg<\/td>\nJednor\u00e1zov\u00e1 d\u00e1vka<\/td>\n<\/tr>\n
Askari\u00f3za (d\u011bti)<\/td>\n2,5 mg\/kg<\/td>\nJednor\u00e1zov\u00e1 d\u00e1vka<\/td>\n<\/tr>\n
M\u011bchovec (lehk\u00e1 infekce)<\/td>\n150 mg<\/td>\nJednor\u00e1zov\u00e1 d\u00e1vka, opakovat po 7 dnech v p\u0159\u00edpad\u011b pot\u0159eby<\/td>\n<\/tr>\n
Steroid-dependentn\u00ed nefrotick\u00fd syndrom (specializovan\u00e1 p\u00e9\u010de)<\/td>\n2,5 mg\/kg<\/td>\nObden po dobu 12\u201324 m\u011bs\u00edc\u016f pod dohledem nefrologa<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

U\u017e\u00edvejte s j\u00eddlem nebo po j\u00eddle ke sn\u00ed\u017een\u00ed nevolnosti.<\/p>\n

Specializovan\u00fd dohled u nefrotick\u00e9ho syndromu.<\/strong> Dlouhodob\u00e1 l\u00e9\u010dba levamizolem u nefrotick\u00e9ho syndromu vy\u017eaduje dohled nefrologa. Povinn\u00e9 je monitorov\u00e1n\u00ed neutrofil\u016f (kompletn\u00ed krevn\u00ed obraz ka\u017ed\u00e9 4\u20136 t\u00fddn\u016f prvn\u00edch 6 m\u011bs\u00edc\u016f, pot\u00e9 ka\u017ed\u00e9 3 m\u011bs\u00edce) z d\u016fvodu dob\u0159e popsan\u00e9ho rizika agranulocyt\u00f3zy. P\u0159i prvn\u00edch zn\u00e1mk\u00e1ch infekce nebo ulcerace v \u00fastech okam\u017eit\u011b p\u0159eru\u0161te l\u00e9\u010dbu.<\/div>\n

Vedlej\u0161\u00ed \u00fa\u010dinky<\/h2>\n