{"id":68758,"date":"2026-02-21T13:56:34","date_gmt":"2026-02-21T13:56:34","guid":{"rendered":"https:\/\/medsbase.com\/?post_type=product&p=68758"},"modified":"2026-05-21T07:14:12","modified_gmt":"2026-05-21T07:14:12","slug":"tb-500","status":"publish","type":"product","link":"https:\/\/medsbase.com\/cs\/product\/tb-500\/","title":{"rendered":"TB-500 (Thymosin Beta-4)"},"content":{"rendered":"

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Rychl\u00e1 odpov\u011b\u010f \u2014 Co je TB-500?<\/h3>\n

TB-500<\/strong> je syntetick\u00fd analog Thymosin Beta-4<\/strong>, p\u0159irozen\u011b se vyskytuj\u00edc\u00edho 43-aminokyselinov\u00e9ho peptidu se syst\u00e9movou hojivou aktivitou. V publikovan\u00fdch preklinick\u00fdch studi\u00edch se v\u00e1\u017ee na G-aktin, stimuluje angiogenezi prost\u0159ednictv\u00edm VEGF\/KDR dr\u00e1hy a moduluje z\u00e1n\u011btlivou signalizaci TGF-beta. Dod\u00e1v\u00e1 se v lyofilizovan\u00fdch vialk\u00e1ch o obsahu 2 mg a\u017e 10 mg v\u00fdhradn\u011b pro laboratorn\u00ed v\u00fdzkum.<\/p>\n<\/div>\n

Co z\u00edsk\u00e1te s MedsBase:<\/strong> V\u00fdzkumn\u00e9 lyofilizovan\u00e9 peptidy \u00b7 HPLC \u010distota \u226599% (COA na vy\u017e\u00e1d\u00e1n\u00ed) \u00b7 Diskr\u00e9tn\u00ed teplotn\u011b stabiln\u00ed balen\u00ed \u00b7 Celosv\u011btov\u00e1 p\u0159eprava peptid\u016f \u00b7 1,400+ ov\u011b\u0159en\u00fdch recenz\u00ed z\u00e1kazn\u00edk\u016f<\/a><\/div>\n

\ud83d\udce6 Ka\u017ed\u00e1 objedn\u00e1vka je pokryta na\u0161\u00ed Z\u00e1rukou op\u011btovn\u00e9ho odesl\u00e1n\u00ed<\/strong><\/a> \u2014 pokud va\u0161e z\u00e1silka nedoraz\u00ed do 20 pracovn\u00edch dn\u016f, p\u0159epos\u00edl\u00e1me ji.<\/p>\n\n\n\n\n\n\n\n\n\n\n\n\n\n
Specifikace<\/th>\nDetail<\/th>\n<\/tr>\n<\/thead>\n
CAS \u010d\u00edslo<\/strong><\/td>\n77591-33-4<\/td>\n<\/tr>\n
item2<\/strong><\/td>\nC212<\/sub>H350<\/sub>N56<\/sub>O78<\/sub>S<\/td>\n<\/tr>\n
item7<\/strong><\/td>\n~4963 Da (N-acetyl Thymosin \u03b2-4 (1\u201343))<\/td>\n<\/tr>\n
item9<\/strong><\/td>\nAc-SDKPDMAEIEKFDKSKLKKTETQEKNPLPSKETIEQEKQAGES<\/td>\n<\/tr>\n
item11<\/strong><\/td>\nLyofilizovan\u00fd pr\u00e1\u0161ek (nebo v dodan\u00e9 form\u011b)<\/td>\n<\/tr>\n
item13<\/strong><\/td>\n\u226599% (HPLC ov\u011b\u0159eno, COA na vy\u017e\u00e1d\u00e1n\u00ed)<\/td>\n<\/tr>\n
Skladov\u00e1n\u00ed<\/strong><\/td>\nLyofilizovan\u00fd: 2\u20138 \u00b0C (lednice) pro pracovn\u00ed z\u00e1sobu; \u221220 \u00b0C pro dlouhodob\u00e9 skladov\u00e1n\u00ed neotev\u0159en\u00fdch vialek. Rekonstituovan\u00fd: 2\u20138 \u00b0C, pou\u017e\u00edt do ~30 dn\u016f. Vyvarujte se prudk\u00e9ho prot\u0159ep\u00e1v\u00e1n\u00ed; velk\u00e9 peptidy se t\u0159ep\u00e1n\u00edm denaturuj\u00ed. Nefreeze\u2013thaw rekonstituovan\u00fd roztok.<\/td>\n<\/tr>\n
Rozpustnost<\/strong><\/td>\nBakteriostatick\u00e1 voda (doporu\u010deno) nebo steriln\u00ed voda pro krat\u0161\u00ed dobu pou\u017eit\u00ed<\/td>\n<\/tr>\n
Pouze pro v\u00fdzkum<\/strong><\/td>\nPouze pro laboratorn\u00ed v\u00fdzkum. Nen\u00ed ur\u010deno pro diagnostick\u00e9 nebo terapeutick\u00e9 pou\u017eit\u00ed u lid\u00ed nebo zv\u00ed\u0159at.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

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Co je TB-500?<\/h2>\n

TB-500<\/strong> je laboratorn\u00ed ozna\u010den\u00ed pro syntetick\u00fd analog Thymosin Beta-4 (TB4)<\/strong>, p\u0159irozen\u011b se vyskytuj\u00edc\u00edho 43-aminokyselinov\u00e9ho peptidov\u00e9ho hormonu p\u0159\u00edtomn\u00e9ho t\u00e9m\u011b\u0159 v ka\u017ed\u00e9 bu\u0148ce lidsk\u00e9ho t\u011bla. TB4 je nejhojn\u011bj\u0161\u00ed v krevn\u00edch desti\u010dk\u00e1ch a uvol\u0148uje se v m\u00edstech po\u0161kozen\u00ed tk\u00e1n\u011b, kde \u0159\u00edd\u00ed migraci bun\u011bk, angiogenezi a protiz\u00e1n\u011btlivou signalizaci. Syntetick\u00e1 v\u00fdzkumn\u00e1 forma \u2014 TB-500 \u2014 reprodukuje biologickou aktivitu TB4 a je nejv\u00edce studovanou v\u00fdzkumnou slou\u010deninou v t\u00e9to t\u0159\u00edd\u011b.<\/p>\n

Sekvence TB4 je Ac-SDKPDMAEIEKFDKSKLKKTETQEKNPLPSKETIEQEKQAGES<\/em>, s molekulovou hmotnost\u00ed p\u0159ibli\u017en\u011b 4 963 Da. Dod\u00e1v\u00e1 se jako vysoce \u010dist\u00fd lyofilizovan\u00fd pr\u00e1\u0161ek pro rekonstituci s bakteriostatickou vodou. TB-500 je ur\u010den pouze pro laboratorn\u00ed v\u00fdzkum<\/strong> a nen\u00ed ur\u010den pro hum\u00e1nn\u00ed nebo veterin\u00e1rn\u00ed diagnostiku \u010di terapii. Pro mechanismus, podrobnosti publikovan\u00fdch studi\u00ed a d\u00e1vkov\u00e1n\u00ed ve v\u00fdzkumu viz n\u00e1\u0161 kompletn\u00ed v\u00fdzkumn\u00fd pr\u016fvodce TB-500<\/a>.<\/p>\n

Mechanismus \u00fa\u010dinku \u2014 syst\u00e9mov\u00e9 hojen\u00ed prost\u0159ednictv\u00edm t\u0159\u00ed drah<\/h2>\n

TB-500 se od v\u011bt\u0161iny peptid\u016f odli\u0161uje sv\u00fdm syst\u00e9mov\u00e9 roz\u0161\u00ed\u0159en\u00ed a dlouh\u00fd cirkula\u010dn\u00ed polo\u010das<\/strong>, kter\u00e9 umo\u017e\u0148uj\u00ed jedinou aplikaci ovlivnit reparativn\u00ed procesy v mnoha tk\u00e1n\u00edch sou\u010dasn\u011b. T\u0159i hlavn\u00ed mechanistick\u00e9 dr\u00e1hy podle publikovan\u00e9ho v\u00fdzkumu:<\/p>\n