{"id":68840,"date":"2026-02-25T16:10:01","date_gmt":"2026-02-25T16:10:01","guid":{"rendered":"https:\/\/medsbase.com\/?post_type=product&p=68840"},"modified":"2026-05-21T07:14:12","modified_gmt":"2026-05-21T07:14:12","slug":"nad","status":"publish","type":"product","link":"https:\/\/medsbase.com\/cs\/product\/nad\/","title":{"rendered":"NAD\u207a"},"content":{"rendered":"

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Rychl\u00e1 odpov\u011b\u010f \u2014 Co je NAD+?<\/h3>\n

NAD+<\/strong> (nikotinamidadenindinukleotid) je z\u00e1kladn\u00ed koenzym p\u0159\u00edtomn\u00fd v ka\u017ed\u00e9 bu\u0148ce, kl\u00ed\u010dov\u00fd pro energetick\u00fd metabolismus, signalizaci dlouhov\u011bkosti prost\u0159ednictv\u00edm sirtuinov\u00fdch drah a opravu DNA zprost\u0159edkovanou PARP. Bun\u011b\u010dn\u00e9 hladiny NAD+ s v\u011bkem v\u00fdrazn\u011b klesaj\u00ed, co\u017e z n\u011bj \u010din\u00ed jednu z nejstudovan\u011bj\u0161\u00edch molekul ve v\u00fdzkumu dlouhov\u011bkosti. Dod\u00e1v\u00e1 se v lyofilizovan\u00fdch vialk\u00e1ch o obsahu 100 mg a\u017e 1000 mg v\u00fdhradn\u011b pro laboratorn\u00ed v\u00fdzkum.<\/p>\n<\/div>\n

Co z\u00edsk\u00e1te s MedsBase:<\/strong> V\u00fdzkumn\u00e9 lyofilizovan\u00e9 peptidy \u00b7 HPLC \u010distota \u226599% (COA na vy\u017e\u00e1d\u00e1n\u00ed) \u00b7 Diskr\u00e9tn\u00ed teplotn\u011b stabiln\u00ed balen\u00ed \u00b7 Celosv\u011btov\u00e1 p\u0159eprava peptid\u016f \u00b7 1,400+ ov\u011b\u0159en\u00fdch recenz\u00ed z\u00e1kazn\u00edk\u016f<\/a><\/div>\n

\ud83d\udce6 Ka\u017ed\u00e1 objedn\u00e1vka je pokryta na\u0161\u00ed Z\u00e1rukou op\u011btovn\u00e9ho odesl\u00e1n\u00ed<\/strong><\/a> \u2014 pokud va\u0161e z\u00e1silka nedoraz\u00ed do 20 pracovn\u00edch dn\u016f, p\u0159epos\u00edl\u00e1me ji.<\/p>\n\n\n\n\n\n\n\n\n\n\n\n\n\n
Specifikace<\/th>\nDetail<\/th>\n<\/tr>\n<\/thead>\n
CAS \u010d\u00edslo<\/strong><\/td>\n53-84-9<\/td>\n<\/tr>\n
item2<\/strong><\/td>\nC21<\/sub>H27<\/sub>N7<\/sub>O14<\/sub>P2<\/sub><\/td>\n<\/tr>\n
item7<\/strong><\/td>\n663.43 Da<\/td>\n<\/tr>\n
item9<\/strong><\/td>\nn\/a (dinukleotidov\u00fd koenzym \u2014 nikoliv peptid)<\/td>\n<\/tr>\n
item11<\/strong><\/td>\nLyofilizovan\u00fd pr\u00e1\u0161ek (nebo v dodan\u00e9 form\u011b)<\/td>\n<\/tr>\n
item13<\/strong><\/td>\n\u226599% (HPLC ov\u011b\u0159eno, COA na vy\u017e\u00e1d\u00e1n\u00ed)<\/td>\n<\/tr>\n
Skladov\u00e1n\u00ed<\/strong><\/td>\nLyofilizovan\u00fd p\u0159\u00edpravek: 2\u20138 \u00b0C (lednice) pro pracovn\u00ed z\u00e1sobu; \u221220 \u00b0C pro dlouhodob\u00e9 skladov\u00e1n\u00ed neotev\u0159en\u00fdch vialek. Rekonstituovan\u00fd roztok: 2\u20138 \u00b0C, pou\u017e\u00edt do ~30 dn\u016f. Chra\u0148te p\u0159ed sv\u011btlem \u2014 NAD se snadno oxiduje. Roztok po rekonstituci nezmrazujte a nerozmrazujte.+<\/sup> Snadno oxiduje. Rekonstituovan\u00fd roztok nezmrazujte a nerozmrazujte.<\/td>\n<\/tr>\n
Rozpustnost<\/strong><\/td>\nBakteriostatick\u00e1 voda (doporu\u010deno) nebo steriln\u00ed voda pro krat\u0161\u00ed dobu pou\u017eit\u00ed<\/td>\n<\/tr>\n
Pouze pro v\u00fdzkum<\/strong><\/td>\nPouze pro laboratorn\u00ed v\u00fdzkum. Nen\u00ed ur\u010deno pro diagnostick\u00e9 nebo terapeutick\u00e9 pou\u017eit\u00ed u lid\u00ed nebo zv\u00ed\u0159at.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

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(nikotinamidadenindinukleotid) nen\u00ed striktn\u011b peptid \u2014 jde o dinukleotidov\u00fd koenzym slo\u017een\u00fd ze dvou nukleotid\u016f spojen\u00fdch fosf\u00e1tov\u00fdmi skupinami. Je v\u0161ak nejv\u00edce studovanou jednotlivou molekulou v literatu\u0159e o dlouhov\u011bkosti a bun\u011b\u010dn\u00e9m st\u00e1rnut\u00ed a b\u011b\u017en\u011b se dod\u00e1v\u00e1 prost\u0159ednictv\u00edm dodavatel\u016f peptidov\u00e9ho v\u00fdzkumu spolu s peptidov\u00fdmi slou\u010deninami pro pohodl\u00ed v\u00fdzkumn\u00edk\u016f pracuj\u00edc\u00edch na multifaktori\u00e1ln\u00edch studi\u00edch bun\u011b\u010dn\u00e9ho st\u00e1rnut\u00ed.<\/h2>\n

NAD+<\/strong> (nikotinamidadenindinukleotid) nen\u00ed striktn\u011b peptid \u2014 je to dinukleotidov\u00fd koenzym slo\u017een\u00fd ze dvou nukleotid\u016f spojen\u00fdch p\u0159es sv\u00e9 fosf\u00e1tov\u00e9 skupiny. Je to v\u0161ak nejv\u00edce zkouman\u00e1 jednotliv\u00e1 molekula v literatu\u0159e o dlouhov\u011bkosti a bun\u011b\u010dn\u00e9m st\u00e1rnut\u00ed a b\u011b\u017en\u011b se dod\u00e1v\u00e1 prost\u0159ednictv\u00edm dodavatel\u016f peptidov\u00e9ho v\u00fdzkumu spolu s peptidov\u00fdmi slou\u010deninami pro pohodl\u00ed v\u00fdzkumn\u00edk\u016f pracuj\u00edc\u00edch na multifaktori\u00e1ln\u00edch studi\u00edch bun\u011b\u010dn\u00e9ho st\u00e1rnut\u00ed.<\/p>\n

NAD+ se nach\u00e1z\u00ed v ka\u017ed\u00e9 \u017eiv\u00e9 bu\u0148ce a funguje jako substr\u00e1t pro t\u0159i hlavn\u00ed enzymov\u00e9 rodiny: oxidoredukt\u00e1zy<\/strong> (energetick\u00fd metabolismus), sirtuiny<\/strong> (signalizace dlouhov\u011bkosti, uml\u010dov\u00e1n\u00ed gen\u016f), a PARPs<\/strong> (reakce na po\u0161kozen\u00ed DNA). Hladiny bun\u011b\u010dn\u00e9ho NAD+ klesaj\u00ed p\u0159ibli\u017en\u011b o 50 % mezi 30. a 70. rokem v\u011bku ve v\u011bt\u0161in\u011b tk\u00e1n\u00ed \u2013 tzv. \u201cpokles NAD+\u201d \u2013 a obnova t\u00e9to hladiny je kl\u00ed\u010dovou hypot\u00e9zou ve v\u00fdzkumu dlouhov\u011bkosti (Yoshino, Baur & Imai, Cell Metab 2018).<\/p>\n

Molekulov\u00e1 hmotnost 663,4 Da, empirick\u00fd vzorec C21<\/sub>H27<\/sub>N7<\/sub>O14<\/sub>P2<\/sub>. Dod\u00e1v\u00e1 se jako vysoce \u010dist\u00fd lyofilizovan\u00fd pr\u00e1\u0161ek pro rekonstituci s bakteriostatickou vodou. NAD+ je ur\u010den pouze pro laboratorn\u00ed v\u00fdzkum<\/strong> a nen\u00ed ur\u010den pro hum\u00e1nn\u00ed nebo veterin\u00e1rn\u00ed diagnostiku \u010di terapii. Pro hlub\u0161\u00ed mechanismus, kontext v\u00fdzkumu dlouhov\u011bkosti a alternativn\u00ed prekurzorov\u00e9 slou\u010deniny (NR, NMN) viz n\u00e1\u0161 kompletn\u00ed pr\u016fvodce v\u00fdzkumem NAD+<\/a>.<\/p>\n

Mechanismus \u00fa\u010dinku \u2014 t\u0159i kl\u00ed\u010dov\u00e9 dr\u00e1hy<\/h2>\n

NAD+ se pod\u00edl\u00ed na bun\u011b\u010dn\u00e9 biologii prost\u0159ednictv\u00edm t\u0159\u00ed mechanicky odli\u0161n\u00fdch, ale vz\u00e1jemn\u011b z\u00e1visl\u00fdch enzymov\u00fdch rodin:<\/p>\n